ATE62249T1 - Homodisaccharide hypoglycemische mittel. - Google Patents

Homodisaccharide hypoglycemische mittel.

Info

Publication number: ATE62249T1
Authority: AT; Austria
Prior art keywords: homodisaccharid; hypoglycemic agent; homonojirimycin; protected; inhibitors
Prior art date: 1984-12-18

Application number

AT85116117T

Other languages

English (en)

Inventor

Paul S Liu

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-18

Filing date

1985-12-17

Publication date

1991-04-15

1985-12-17 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-04-15 Application granted granted Critical

1991-04-15 Publication of ATE62249T1 publication Critical patent/ATE62249T1/de

Links

239000003472 antidiabetic agent Substances 0.000 title 1
229940126904 hypoglycaemic agent Drugs 0.000 title 1
-1 Homonojirimycin glycosides Chemical class 0.000 abstract 2
CLVUFWXGNIFGNC-QTSLKERKSA-N (2r,3s,5r,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol Chemical compound OC[C@H]1N[C@H](CO)[C@H](O)C(O)[C@@H]1O CLVUFWXGNIFGNC-QTSLKERKSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
102000038379 digestive enzymes Human genes 0.000 abstract 1
108091007734 digestive enzymes Proteins 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Luminescent Compositions (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT85116117T 1984-12-18 1985-12-17 Homodisaccharide hypoglycemische mittel. ATE62249T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/683,127 US4634765A (en)	1984-12-18	1984-12-18	Homodisaccharide hypoglycemic agents
EP85116117A EP0186103B1 (de)	1984-12-18	1985-12-17	Homodisaccharide hypoglycemische Mittel

Publications (1)

Publication Number	Publication Date
ATE62249T1 true ATE62249T1 (de)	1991-04-15

Family

ID=24742682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85116117T ATE62249T1 (de)	1984-12-18	1985-12-17	Homodisaccharide hypoglycemische mittel.

Country Status (20)

Country	Link
US (1)	US4634765A (de)
EP (1)	EP0186103B1 (de)
JP (1)	JPS61158994A (de)
KR (1)	KR900005607B1 (de)
CN (1)	CN1016784B (de)
AT (1)	ATE62249T1 (de)
AU (1)	AU574246B2 (de)
CA (1)	CA1240989A (de)
DE (1)	DE3582420D1 (de)
DK (1)	DK587085A (de)
ES (1)	ES8706164A1 (de)
FI (1)	FI80707C (de)
GR (1)	GR853032B (de)
HU (1)	HU194263B (de)
IE (1)	IE58186B1 (de)
NO (1)	NO162387B (de)
NZ (1)	NZ214570A (de)
PH (1)	PH23660A (de)
PT (1)	PT81689B (de)
ZA (1)	ZA859573B (de)

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GB2181729B (en) *	1985-10-12	1990-04-04	Nippon Shinyaku Co Ltd	Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) *	1986-04-15	1987-10-23	Nippon Shinyaku Co Ltd	モラノリン誘導体の製造法
EP0345104B1 (de) *	1988-06-02	1995-11-02	Merrell Dow Pharmaceuticals Inc.	Alpha-glukosidase-Inhibitoren
EP0344383A1 (de) *	1988-06-02	1989-12-06	Merrell Dow Pharmaceuticals Inc.	Alpha-Glucosidase-Inhibitoren
US4880917A (en) *	1988-07-01	1989-11-14	Merrell Dow Pharmaceuticals Inc.	Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) *	1988-09-16	1990-03-13	Merrell Dow Pharmaceuticals Inc.	Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) *	1989-12-20	1993-07-13	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of nojirimycin and related compounds
US5504078A (en) *	1990-06-08	1996-04-02	Merrell Dow Pharmaceuticals Inc.	α-glucosidase inhibitors
SK141899A3 (en) *	1997-04-15	2000-09-12	Csir Corporate Building	Pharmaceutical compositions having appetite suppressant activity
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
KR100446483B1 (ko)	2000-03-31	2004-09-01	미시간 스테이트 유니버시티	옥심 또는 이민으로부터 1,5-디데옥시-1,5-이미노 헥시톨제조방법
GB2363985B (en) *	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
ES2328384T3 (es) *	2004-11-23	2009-11-12	Warner-Lambert Company Llc	Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
PL2027137T3 (pl) *	2005-06-08	2015-08-31	Amicus Therapeutics Inc	Oczyszczanie imino- i aminocukrów
US20060293250A1 (en) *	2005-06-08	2006-12-28	Michael Major	Crystalline sugar compositions and method of making
JP2008545800A (ja) *	2005-06-08	2008-12-18	アミカスセラピューティックスインコーポレイテッド	トリフラート化化合物の安定化
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
EP2368560A1 (de)	2007-03-12	2011-09-28	Zadec ApS	Antidiabetes-Extrakt von Rooibos
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
WO2011145022A1 (en)	2010-05-21	2011-11-24	Pfizer Inc.	2-phenyl benzoylamides
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) *	2010-11-04	2016-03-09	中国医学科学院药物研究所	白树总生物碱及多羟基生物碱化合物的提取、分离及用途
US20130345392A1 (en)	2011-03-04	2013-12-26	Pfizer Inc	Edn3-like peptides and uses thereof
EP2712362A4 (de) *	2011-05-13	2014-12-24	Glycom As	Herstellung von lacto-n-tetraose
MY188344A (en)	2012-03-09	2021-12-01	Biotropics Malaysia Berhad	Extract formulations of rhodamnia cinerea and uses thereof
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (de)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Zusammensetzungen zur behandlung von magen-darm-störungen
CN105143203A (zh)	2013-04-17	2015-12-09	辉瑞大药厂	用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
BR112017003745A2 (pt)	2014-08-29	2017-12-05	Tes Pharma S R L	inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CN104530150A (zh) *	2015-01-14	2015-04-22	佛山市赛维斯医药科技有限公司	含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
AU2017342083A1 (en)	2016-10-14	2019-04-11	Tes Pharma S.R.L.	Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it)	2017-07-11	2019-01-11	Dipharma Francis Srl	Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) *	2018-06-14	2020-06-05	华润三九医药股份有限公司	一种白树药材中α-高野尻霉素的含量检测方法
EP3883930A1 (de)	2018-11-20	2021-09-29	Tes Pharma S.r.l.	Inhibitoren der alpha-amino-beta-carboxymuconsäure-semialdehyddecarboxylase
WO2020150473A2 (en)	2019-01-18	2020-07-23	Dogma Therapeutics, Inc.	Pcsk9 inhibitors and methods of use thereof

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US4065562A (en) *	1975-12-29	1977-12-27	Nippon Shinyaku Co., Ltd.	Method and composition for reducing blood glucose levels
NO154918C (no) *	1977-08-27	1987-01-14	Bayer Ag	Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) *	1978-11-06	1980-05-14	Bayer Ag	Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) *	1979-10-19	1981-05-14	Bayer Ag, 5090 Leverkusen	2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) *	1979-12-08	1984-05-02	Nippon Shinyaku Co Ltd	Moranoline derivatives and process for preparation thereof
IT1210476B (it) *	1981-05-28	1989-09-14	Erba Farmitalia	Antracicline.

1984
- 1984-12-18 US US06/683,127 patent/US4634765A/en not_active Expired - Lifetime
1985
- 1985-12-05 AU AU50810/85A patent/AU574246B2/en not_active Ceased
- 1985-12-13 CA CA000497607A patent/CA1240989A/en not_active Expired
- 1985-12-13 FI FI854944A patent/FI80707C/fi not_active IP Right Cessation
- 1985-12-13 ZA ZA859573A patent/ZA859573B/xx unknown
- 1985-12-16 PT PT81689A patent/PT81689B/pt not_active IP Right Cessation
- 1985-12-16 IE IE317985A patent/IE58186B1/en not_active IP Right Cessation
- 1985-12-16 NZ NZ214570A patent/NZ214570A/en unknown
- 1985-12-16 HU HU854804A patent/HU194263B/hu not_active IP Right Cessation
- 1985-12-17 NO NO855087A patent/NO162387B/no unknown
- 1985-12-17 AT AT85116117T patent/ATE62249T1/de not_active IP Right Cessation
- 1985-12-17 JP JP60282167A patent/JPS61158994A/ja active Granted
- 1985-12-17 DK DK587085A patent/DK587085A/da not_active Application Discontinuation
- 1985-12-17 CN CN85109548A patent/CN1016784B/zh not_active Expired
- 1985-12-17 GR GR853032A patent/GR853032B/el unknown
- 1985-12-17 DE DE8585116117T patent/DE3582420D1/de not_active Expired - Fee Related
- 1985-12-17 ES ES550060A patent/ES8706164A1/es not_active Expired
- 1985-12-17 EP EP85116117A patent/EP0186103B1/de not_active Expired - Lifetime
- 1985-12-18 KR KR1019850009529A patent/KR900005607B1/ko not_active Expired
- 1985-12-18 PH PH33204A patent/PH23660A/en unknown

Also Published As

Publication number	Publication date
PT81689A (en)	1986-01-01
KR900005607B1 (ko)	1990-07-31
DK587085D0 (da)	1985-12-17
DK587085A (da)	1986-06-19
IE58186B1 (en)	1993-07-28
EP0186103A3 (en)	1988-02-03
FI80707B (fi)	1990-03-30
ES550060A0 (es)	1987-06-01
FI854944A0 (fi)	1985-12-13
GR853032B (de)	1986-04-18
HUT40137A (en)	1986-11-28
NO855087L (no)	1986-06-19
KR860004921A (ko)	1986-07-16
JPS61158994A (ja)	1986-07-18
AU574246B2 (en)	1988-06-30
CN85109548A (zh)	1986-07-09
PH23660A (en)	1989-09-27
FI854944L (fi)	1986-06-19
CA1240989A (en)	1988-08-23
EP0186103A2 (de)	1986-07-02
FI80707C (fi)	1990-07-10
US4634765A (en)	1987-01-06
ES8706164A1 (es)	1987-06-01
EP0186103B1 (de)	1991-04-03
JPH0565519B2 (de)	1993-09-17
CN1016784B (zh)	1992-05-27
DE3582420D1 (de)	1991-05-08
AU5081085A (en)	1986-06-26
PT81689B (pt)	1987-11-30
NO162387B (no)	1989-09-11
ZA859573B (en)	1986-08-27
IE853179L (en)	1986-06-18
NZ214570A (en)	1988-03-30
HU194263B (en)	1988-01-28

Legal Events

Date	Code	Title	Description
1991-12-15	UEP	Publication of translation of european patent specification
1994-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
AU574246B2 (en)	1988-06-30	Homodisaccharide hypoglycemic agents
AU536200B2 (en)	1984-04-19	Compound having anthelmintic and acaricidal activities
FI870726A7 (fi)	1987-08-21	Suojattuja entsyymijärjestelmiä.
AU4559785A (en)	1986-02-06	N - acylpyrrolidine compound
IT1226726B (it)	1991-02-05	Composti attivi come inibitori della biosintesi del colesterolo.
AU3502278A (en)	1979-10-18	Benzimidazoles having anthelmintic activity
MA19088A1 (fr)	1981-10-01	Systeme de transmission rapide de messages entre calculateurs .
TR25600A (tr)	1993-04-15	Aktif katki maddesi olarak sikloheksan dion sini- findan bir herbisid bilesik ihtiva eden herbisid bilesim
ATE53495T1 (de)	1990-06-15	Moraxella bovis-bakterin.
EP0345081A3 (de)	1990-03-28	Wirkstoff zur Unterdrückung der Bildung eines Enzyms
AU585279B2 (en)	1989-06-15	Pesticidal biphenylyloxy and biphenylylalkoxy aryl acyl urea compounds
SU1259652A1 (ru)	1996-11-10	Гидрохлорид 5-этокси-2-этилтиобензимидазола, обладающий антигипоксической и стрессопротекторной активностью
AU485489B2 (en)	1976-01-08	1, 5(6)-DISUBSTITUTED BENZIMIDAZOLE-2 CARBAMATE DERIVATIVES HAVING ANTHELMINTIC activity
EP0264017A3 (en)	1989-11-15	Pharmaceutical compositions having healing activity
SU1166473A1 (ru)	1996-09-27	ДИТИОАЦЕТИЛГИДРАЗОН α -КАМФОРХИНОНА, ПРОЯВЛЯЮЩИЙ ПРОТИВОГИПОКСИЧЕСКУЮ АКТИВНОСТЬ
IT8320426A0 (it)	1983-04-01	Composizione di policarbonato autoestinguente.
IT8320903A0 (it)	1983-05-03	Composizione di policarbonato autoestinguente.
IT8422516A0 (it)	1984-09-04	Composizione di policarbonato autoestinguente.
SU1557961A1 (ru)	2001-06-10	П-хлорфениламид 3-дифенилметил-4-(п-хлорфенил)-2,4-диоксобутановой кислоты, проявляющий противогипоксическую активность
IT208932Z2 (it)	1988-05-28	Piastra di protezione rientrante per connettori.
IT8221699A0 (it)	1982-06-04	Composizione di policarbonato autoestinguente.
IT8222968A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.
IT8222964A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.
IT8222965A0 (it)	1982-08-25	Composizione di policarbonato autoestinguente.
IT8222987A0 (it)	1982-08-26	Composizione di policarbonato autoestinguente.