PH23660A - Homodisaccharide hypoglycemic agents - Google Patents

Homodisaccharide hypoglycemic agents

Info

Publication number: PH23660A
Authority: PH; Philippines
Prior art keywords: homodisaccharide; hypoglycemic agents; homonojirimycin; protected; inhibitors
Prior art date: 1984-12-18

Application number

PH33204A

Other languages

English (en)

Inventor

Paul S Liu

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-18

Filing date

1985-12-18

Publication date

1989-09-27

1985-12-18 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-09-27 Publication of PH23660A publication Critical patent/PH23660A/en

Links

239000003472 antidiabetic agent Substances 0.000 title 1
229940126904 hypoglycaemic agent Drugs 0.000 title 1
-1 Homonojirimycin glycosides Chemical class 0.000 abstract 2
CLVUFWXGNIFGNC-QTSLKERKSA-N (2r,3s,5r,6r)-2,6-bis(hydroxymethyl)piperidine-3,4,5-triol Chemical compound OC[C@H]1N[C@H](CO)[C@H](O)C(O)[C@@H]1O CLVUFWXGNIFGNC-QTSLKERKSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
102000038379 digestive enzymes Human genes 0.000 abstract 1
108091007734 digestive enzymes Proteins 0.000 abstract 1
229930182470 glycoside Natural products 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Luminescent Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

PH33204A 1984-12-18 1985-12-18 Homodisaccharide hypoglycemic agents PH23660A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/683,127 US4634765A (en)	1984-12-18	1984-12-18	Homodisaccharide hypoglycemic agents

Publications (1)

Publication Number	Publication Date
PH23660A true PH23660A (en)	1989-09-27

Family

ID=24742682

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH33204A PH23660A (en)	1984-12-18	1985-12-18	Homodisaccharide hypoglycemic agents

Country Status (20)

Country	Link
US (1)	US4634765A (de)
EP (1)	EP0186103B1 (de)
JP (1)	JPS61158994A (de)
KR (1)	KR900005607B1 (de)
CN (1)	CN1016784B (de)
AT (1)	ATE62249T1 (de)
AU (1)	AU574246B2 (de)
CA (1)	CA1240989A (de)
DE (1)	DE3582420D1 (de)
DK (1)	DK587085A (de)
ES (1)	ES8706164A1 (de)
FI (1)	FI80707C (de)
GR (1)	GR853032B (de)
HU (1)	HU194263B (de)
IE (1)	IE58186B1 (de)
NO (1)	NO162387B (de)
NZ (1)	NZ214570A (de)
PH (1)	PH23660A (de)
PT (1)	PT81689B (de)
ZA (1)	ZA859573B (de)

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GB2181729B (en) *	1985-10-12	1990-04-04	Nippon Shinyaku Co Ltd	Glucosylmoranoline derivatives and production thereof
JPS62242692A (ja) *	1986-04-15	1987-10-23	Nippon Shinyaku Co Ltd	モラノリン誘導体の製造法
EP0345104B1 (de) *	1988-06-02	1995-11-02	Merrell Dow Pharmaceuticals Inc.	Alpha-glukosidase-Inhibitoren
EP0344383A1 (de) *	1988-06-02	1989-12-06	Merrell Dow Pharmaceuticals Inc.	Alpha-Glucosidase-Inhibitoren
US4880917A (en) *	1988-07-01	1989-11-14	Merrell Dow Pharmaceuticals Inc.	Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) *	1988-09-16	1990-03-13	Merrell Dow Pharmaceuticals Inc.	Synthesis of intermediate useful in the preparation of nojirimycin and related compounds
US5227479A (en) *	1989-12-20	1993-07-13	Merrell Dow Pharmaceuticals Inc.	Process for the preparation of nojirimycin and related compounds
US5504078A (en) *	1990-06-08	1996-04-02	Merrell Dow Pharmaceuticals Inc.	α-glucosidase inhibitors
SK141899A3 (en) *	1997-04-15	2000-09-12	Csir Corporate Building	Pharmaceutical compositions having appetite suppressant activity
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
KR100446483B1 (ko)	2000-03-31	2004-09-01	미시간 스테이트 유니버시티	옥심 또는 이민으로부터 1,5-디데옥시-1,5-이미노 헥시톨제조방법
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
ATE439347T1 (de) *	2004-11-23	2009-08-15	Warner Lambert Co	7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptansäure- derivate als hmg-co-a-reductase-inhibitoren zur behandlung von lipidemia
WO2008045015A1 (en)	2005-06-08	2008-04-17	Amicus Therapeutics, Inc.	Imino and amino sugar purification
JP2008543784A (ja) *	2005-06-08	2008-12-04	アミカスセラピューティックスインコーポレイテッド	結晶性糖組成物および作製方法
CN101228173A (zh) *	2005-06-08	2008-07-23	阿米库斯治疗学公司	三氟甲磺酸酯化的化合物的稳定化
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
EP2120980B1 (de)	2007-03-12	2011-08-03	Zadec APS	Rotbusch-extrakt gegen diabetes
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
AU2008261102B2 (en)	2007-06-04	2013-11-28	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
EP2571860A1 (de)	2010-05-21	2013-03-27	Pfizer Inc	2-phenyl-benzoylamide
WO2012027331A1 (en)	2010-08-27	2012-03-01	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN102462726B (zh) *	2010-11-04	2016-03-09	中国医学科学院药物研究所	白树总生物碱及多羟基生物碱化合物的提取、分离及用途
US20130345392A1 (en)	2011-03-04	2013-12-26	Pfizer Inc	Edn3-like peptides and uses thereof
CN103703012A (zh) *	2011-05-13	2014-04-02	格礼卡姆股份公司	乳糖-n-四糖的制造
US20150050371A1 (en)	2012-03-09	2015-02-19	Biotropics Malaysia Berhad	Extract Formulations of Rhodamnia Cinerea And Uses Thereof
HK1220611A1 (zh)	2013-03-15	2017-05-12	Bausch Health Ireland Limited	用於治疗胃肠道病症的组成物
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
BR112015026513A2 (pt)	2013-04-17	2017-07-25	Pfizer	derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
EP3004138B1 (de)	2013-06-05	2024-03-13	Bausch Health Ireland Limited	Ultrareine agonisten von guanylatcyclase c, verfahren zur herstellung und verwendung davon
CA2959208C (en)	2014-08-29	2023-09-19	Tes Pharma S.R.L.	Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CN104530150A (zh) *	2015-01-14	2015-04-22	佛山市赛维斯医药科技有限公司	含胺基苯和双葡萄糖苷结构化合物、其制备方法和用途
CA3038185A1 (en)	2016-10-14	2018-04-19	Tes Pharma S.R.L.	Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
IT201700078102A1 (it)	2017-07-11	2019-01-11	Dipharma Francis Srl	Sintesi di un azazucchero e suoi intermedi
CN108828121B (zh) *	2018-06-14	2020-06-05	华润三九医药股份有限公司	一种白树药材中α-高野尻霉素的含量检测方法
EP3883930A1 (de)	2018-11-20	2021-09-29	Tes Pharma S.r.l.	Inhibitoren der alpha-amino-beta-carboxymuconsäure-semialdehyddecarboxylase
CR20210441A (es)	2019-01-18	2022-03-11	Astrazeneca Ab	Inhibidores de la pcsk9 y métodos de uso de los mismos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4065562A (en) *	1975-12-29	1977-12-27	Nippon Shinyaku Co., Ltd.	Method and composition for reducing blood glucose levels
NO154918C (no) *	1977-08-27	1987-01-14	Bayer Ag	Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2848117A1 (de) *	1978-11-06	1980-05-14	Bayer Ag	Derivate des 2-hydroxymethyl-3,4,5- trihydroxy-piperidins, ihre herstellung und verwendung zur beeinflussung des kohlenhydrat- und fettstoffwechsels
DE2942365A1 (de) *	1979-10-19	1981-05-14	Bayer Ag, 5090 Leverkusen	2-hydroxyalkyl-3,4,5-trihydroxy-(pi)-peridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB2064527B (en) *	1979-12-08	1984-05-02	Nippon Shinyaku Co Ltd	Moranoline derivatives and process for preparation thereof
IT1210476B (it) *	1981-05-28	1989-09-14	Erba Farmitalia	Antracicline.

1984
- 1984-12-18 US US06/683,127 patent/US4634765A/en not_active Expired - Lifetime
1985
- 1985-12-05 AU AU50810/85A patent/AU574246B2/en not_active Ceased
- 1985-12-13 FI FI854944A patent/FI80707C/fi not_active IP Right Cessation
- 1985-12-13 CA CA000497607A patent/CA1240989A/en not_active Expired
- 1985-12-13 ZA ZA859573A patent/ZA859573B/xx unknown
- 1985-12-16 PT PT81689A patent/PT81689B/pt not_active IP Right Cessation
- 1985-12-16 IE IE317985A patent/IE58186B1/en not_active IP Right Cessation
- 1985-12-16 NZ NZ214570A patent/NZ214570A/en unknown
- 1985-12-16 HU HU854804A patent/HU194263B/hu not_active IP Right Cessation
- 1985-12-17 AT AT85116117T patent/ATE62249T1/de not_active IP Right Cessation
- 1985-12-17 GR GR853032A patent/GR853032B/el unknown
- 1985-12-17 CN CN85109548A patent/CN1016784B/zh not_active Expired
- 1985-12-17 DE DE8585116117T patent/DE3582420D1/de not_active Expired - Fee Related
- 1985-12-17 EP EP85116117A patent/EP0186103B1/de not_active Expired - Lifetime
- 1985-12-17 JP JP60282167A patent/JPS61158994A/ja active Granted
- 1985-12-17 NO NO855087A patent/NO162387B/no unknown
- 1985-12-17 ES ES550060A patent/ES8706164A1/es not_active Expired
- 1985-12-17 DK DK587085A patent/DK587085A/da not_active Application Discontinuation
- 1985-12-18 KR KR1019850009529A patent/KR900005607B1/ko not_active Expired
- 1985-12-18 PH PH33204A patent/PH23660A/en unknown

Also Published As

Publication number	Publication date
ATE62249T1 (de)	1991-04-15
FI854944L (fi)	1986-06-19
JPH0565519B2 (de)	1993-09-17
HU194263B (en)	1988-01-28
NO855087L (no)	1986-06-19
PT81689B (pt)	1987-11-30
DK587085D0 (da)	1985-12-17
FI854944A0 (fi)	1985-12-13
NO162387B (no)	1989-09-11
JPS61158994A (ja)	1986-07-18
ZA859573B (en)	1986-08-27
KR860004921A (ko)	1986-07-16
DK587085A (da)	1986-06-19
NZ214570A (en)	1988-03-30
US4634765A (en)	1987-01-06
EP0186103A2 (de)	1986-07-02
FI80707B (fi)	1990-03-30
IE853179L (en)	1986-06-18
PT81689A (en)	1986-01-01
ES8706164A1 (es)	1987-06-01
CA1240989A (en)	1988-08-23
CN1016784B (zh)	1992-05-27
CN85109548A (zh)	1986-07-09
KR900005607B1 (ko)	1990-07-31
HUT40137A (en)	1986-11-28
ES550060A0 (es)	1987-06-01
EP0186103B1 (de)	1991-04-03
AU5081085A (en)	1986-06-26
IE58186B1 (en)	1993-07-28
GR853032B (de)	1986-04-18
AU574246B2 (en)	1988-06-30
FI80707C (fi)	1990-07-10
EP0186103A3 (en)	1988-02-03
DE3582420D1 (de)	1991-05-08

Publication	Publication Date	Title
EP0186103A3 (en)	1988-02-03	Homodisaccharide hypoglycemic agents
AU6911187A (en)	1987-08-27	Protected enzyme systems
AU550080B2 (en)	1986-02-27	Elastomeric active agent delivery system
AU575668B2 (en)	1988-08-04	N - acylpyrrolidine compound
AU573300B2 (en)	1988-06-02	Sodium hypophosphite modified acryic acid copolymers
AU576280B2 (en)	1988-08-18	Inhibition of decomposition of hydrogen peroxide systems
AU4825285A (en)	1986-04-10	Surfactant containing anhydrous drug systems
AU536200B2 (en)	1984-04-19	Compound having anthelmintic and acaricidal activities
DE3372774D1 (en)	1987-09-03	Modified oligosaccharides used as substrate for measuring alpha-amylase activity
AU574864B2 (en)	1988-07-14	Multiple solution intravenous system
AU545275B2 (en)	1985-07-11	Protection of substrates from microorganisms
AU5358786A (en)	1986-08-13	Active hydrogen containing compositions
AU563995B2 (en)	1987-07-30	Hypotriglyceridemically active polysaccharides
AU4477385A (en)	1986-01-23	4h-1,4-benzothiazines as inhibitors/stimulators of enzymatic reactions
AU3994085A (en)	1985-09-10	Compositions contenant des lipides actifs
JPS5785084A (en)	1982-05-27	Wiring of active matrix substrate
SU1166473A1 (ru)	1996-09-27	ДИТИОАЦЕТИЛГИДРАЗОН α -КАМФОРХИНОНА, ПРОЯВЛЯЮЩИЙ ПРОТИВОГИПОКСИЧЕСКУЮ АКТИВНОСТЬ
PL239327A1 (en)	1984-07-30	Method of isolation of polyfungine from the culture of highefficient mutant of streptomyces noursei var. polifungini strain
AU2557084A (en)	1984-09-20	Production of alpha-amylase inhibitor-tendamistat from streptomyces
GB8417649D0 (en)	1984-08-15	Active vibration cancelling mount
CA1266642C (en)	1990-03-13	MONOSACCHARIDE COMPOUNDS WITH IMMUNOSTIMULATING ACTION
AU8315687A (en)	1988-06-30	Propagation of seedlings
IT8320903A0 (it)	1983-05-03	Composizione di policarbonato autoestinguente.
IT8422517A0 (it)	1984-09-04	Composizione di policarbonato autoestinguente.
FI915516A0 (fi)	1991-11-22	Foerfarande foer framstaellning av farmaceutiskt aktiva 2-pyridylalkensulfinyl) benzimidazoler.