ATE63126T1 - Tetra- und penta-peptide mit der sequenz lysylarginyl-aspartyl, und ihre verwendung als antithrombotika. - Google Patents

Tetra- und penta-peptide mit der sequenz lysylarginyl-aspartyl, und ihre verwendung als antithrombotika.

Info

Publication number: ATE63126T1
Authority: AT; Austria
Prior art keywords: configuration; peptides; lysylarginyl; antitrombotics; aspartyl
Prior art date: 1987-10-30

Application number

AT88402713T

Other languages

English (en)

Inventor

Pierre Jolles

Anne-Marie Fiat

Claudine Soria

Sylviane Levy-Toledano

Sanghamitra Indian Instit Raha

Elizabeth Mazoyer

Ludovic Drouet

Original Assignee

Inst Vaisseaux Et Du Sang

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-30

Filing date

1988-10-27

Publication date

1991-05-15

1988-10-27 Application filed by Inst Vaisseaux Et Du Sang, Centre Nat Rech Scient filed Critical Inst Vaisseaux Et Du Sang

1991-05-15 Application granted granted Critical

1991-05-15 Publication of ATE63126T1 publication Critical patent/ATE63126T1/de

Links

235000001014 amino acid Nutrition 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 4
125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Zoology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT88402713T 1987-10-30 1988-10-27 Tetra- und penta-peptide mit der sequenz lysylarginyl-aspartyl, und ihre verwendung als antithrombotika. ATE63126T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8715061A FR2622587B1 (fr)	1987-10-30	1987-10-30	Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
EP88402713A EP0314576B1 (de)	1987-10-30	1988-10-27	Tetra- und Penta-peptide mit der Sequenz Lysyl-Arginyl-Aspartyl, und ihre Verwendung als Antithrombotika

Publications (1)

Publication Number	Publication Date
ATE63126T1 true ATE63126T1 (de)	1991-05-15

Family

ID=9356340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88402713T ATE63126T1 (de)	1987-10-30	1988-10-27	Tetra- und penta-peptide mit der sequenz lysylarginyl-aspartyl, und ihre verwendung als antithrombotika.

Country Status (6)

Country	Link
US (1)	US4943562A (de)
EP (1)	EP0314576B1 (de)
JP (1)	JPH01149799A (de)
AT (1)	ATE63126T1 (de)
DE (1)	DE3862637D1 (de)
FR (1)	FR2622587B1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU639409B2 (en) *	1987-12-10	1993-07-29	La Jolla Cancer Research Foundation	Conformationally stabilized cell adhesion peptides
US5827821A (en)	1987-12-10	1998-10-27	The Burnham Institute	Conformationally stabilized cell adhesion peptides
GB8905606D0 (en) *	1989-03-11	1989-04-26	Scras	Peptides
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
US5807828A (en) *	1989-06-16	1998-09-15	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
US5686569A (en) *	1989-06-16	1997-11-11	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
US5672585A (en) *	1990-04-06	1997-09-30	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5648330A (en) *	1990-04-06	1997-07-15	La Jolla Cancer Research Foundation	Method and composition for treating vascular graft occlusion
DE69126871T2 (de) *	1990-04-06	1998-03-12	Jolla Cancer Res Found	Verfahren und verbindung zur behandlung von thrombose
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5612311A (en) *	1990-04-06	1997-03-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5492894A (en) *	1991-03-21	1996-02-20	The Procter & Gamble Company	Compositions for treating wrinkles comprising a peptide
US5338725A (en) *	1992-06-30	1994-08-16	The Research Foundation Of The State University Of New York	Anti-aggregatory agents for platelets
US5705486A (en) *	1996-03-14	1998-01-06	Yoshihide Hagiwara	Isolation of novel peptides from green barley leaf extract and use same to inhibit human platelet aggregation
US6210904B1 (en) *	1997-10-14	2001-04-03	Merck & Co., Inc.	Anticoagulant test
US7148197B2 (en) *	2000-08-24	2006-12-12	The Regents Of The University Of California	Orally administered small peptides synergize statin activity
US8209514B2 (en) *	2008-02-04	2012-06-26	Qnx Software Systems Limited	Media processing system having resource partitioning

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4190646A (en) *	1975-11-11	1980-02-26	Sloan-Kettering Institute For Cancer Research	Polypeptide compositions and methods
US4190647A (en) *	1979-01-26	1980-02-26	Sloan-Kettering Institute For Cancer Research	Polypeptides and methods
US4298523A (en) *	1980-06-17	1981-11-03	Ortho Pharmaceutical Corporation	Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R
US4305852A (en) *	1980-10-20	1981-12-15	American Home Products Corporation	Polypeptide compositions
HU185263B (en) *	1981-06-12	1984-12-28	Richter Gedeon Vegyeszet	Process for producing peptides effective on the immuncontroll analogous with the tp5
US4792525A (en) *	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
US4683291A (en) *	1985-10-28	1987-07-28	Scripps Clinic And Research Foundation	Platelet binding inhibitors

1987
- 1987-10-30 FR FR8715061A patent/FR2622587B1/fr not_active Expired - Lifetime
1988
- 1988-10-27 EP EP88402713A patent/EP0314576B1/de not_active Expired - Lifetime
- 1988-10-27 AT AT88402713T patent/ATE63126T1/de not_active IP Right Cessation
- 1988-10-27 DE DE8888402713T patent/DE3862637D1/de not_active Expired - Lifetime
- 1988-10-28 US US07/263,859 patent/US4943562A/en not_active Expired - Fee Related
- 1988-10-28 JP JP63271086A patent/JPH01149799A/ja active Pending

Also Published As

Publication number	Publication date
DE3862637D1 (de)	1991-06-06
FR2622587B1 (fr)	1990-12-21
JPH01149799A (ja)	1989-06-12
EP0314576B1 (de)	1991-05-02
EP0314576A1 (de)	1989-05-03
FR2622587A1 (fr)	1989-05-05
US4943562A (en)	1990-07-24

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Legal Events

Date	Code	Title	Description
1991-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties