ATE63818T1 - 3'-azido-3'-deoxythymidin-formulierungen mit gesteuerter freigabe. - Google Patents

3'-azido-3'-deoxythymidin-formulierungen mit gesteuerter freigabe.

Info

Publication number
ATE63818T1
ATE63818T1 AT88302657T AT88302657T ATE63818T1 AT E63818 T1 ATE63818 T1 AT E63818T1 AT 88302657 T AT88302657 T AT 88302657T AT 88302657 T AT88302657 T AT 88302657T AT E63818 T1 ATE63818 T1 AT E63818T1
Authority
AT
Austria
Prior art keywords
controlled release
formulations
deoxythymidine
azido
units
Prior art date
Application number
AT88302657T
Other languages
English (en)
Inventor
Harry Phillip Jones
Robert Judson Mackey
Michael John Desmond Gamlen
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE63818T1 publication Critical patent/ATE63818T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT88302657T 1987-03-27 1988-03-25 3'-azido-3'-deoxythymidin-formulierungen mit gesteuerter freigabe. ATE63818T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878707421A GB8707421D0 (en) 1987-03-27 1987-03-27 Pharmaceutical formulations
EP88302657A EP0284407B1 (de) 1987-03-27 1988-03-25 3'-Azido-3'-deoxythymidin-Formulierungen mit gesteuerter Freigabe

Publications (1)

Publication Number Publication Date
ATE63818T1 true ATE63818T1 (de) 1991-06-15

Family

ID=10614823

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88302657T ATE63818T1 (de) 1987-03-27 1988-03-25 3'-azido-3'-deoxythymidin-formulierungen mit gesteuerter freigabe.

Country Status (17)

Country Link
US (1) US4917900A (de)
EP (1) EP0284407B1 (de)
JP (1) JP2719344B2 (de)
KR (1) KR960013434B1 (de)
AT (1) ATE63818T1 (de)
AU (1) AU607474B2 (de)
CA (1) CA1308026C (de)
DE (1) DE3862974D1 (de)
DK (1) DK175348B1 (de)
ES (1) ES2033426T3 (de)
GB (1) GB8707421D0 (de)
GR (1) GR3002030T3 (de)
IE (1) IE60605B1 (de)
IL (1) IL85870A (de)
NZ (1) NZ224026A (de)
PT (1) PT87081B (de)
ZA (1) ZA882168B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051361A (en) * 1988-10-19 1991-09-24 Sigma Chemical Company AZT immunoassays, derivatives, conjugates and antibodies
US4938966A (en) * 1988-11-30 1990-07-03 Riker Laboratories, Inc. Controlled release flecainide acetate formulation
GB8912420D0 (en) 1989-05-31 1989-07-19 Schram Cornelius J Ultrasonic systems
EP0452862B1 (de) * 1990-04-18 1995-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Kugelförmige Keimkerne, kugelförmige Granulate sowie Verfahren zu deren Herstellung
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
HUT63852A (en) * 1991-06-21 1993-10-28 Acic Canada Inc Process for producing antiviral compounds and pharmaceutical compositions comprising same as active ingredient
KR100221695B1 (ko) * 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
ATE186544T1 (de) * 1992-08-04 1999-11-15 James M Dunn Pharmazeutische formulierungen mit kontrollierter freigabe von 3'-azido-3'-deoxythymidin und verfahren zur verwendung
FR2698560B1 (fr) * 1992-11-30 1995-02-03 Virbac Laboratoires Principes actifs pulvérulents stabilisés, compositions les contenant, leur procédé d'obtention et leurs applications.
US6245351B1 (en) * 1996-03-07 2001-06-12 Takeda Chemical Industries, Ltd. Controlled-release composition
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
AU2277101A (en) * 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
AU2276801A (en) 1999-12-20 2001-07-03 Schering Corporation Extended release oral dosage composition
CA2404687A1 (en) * 2000-03-30 2001-10-11 Nemichand B. Jain Sustained release beadlets containing stavudine
WO2004000973A1 (ja) * 2002-06-24 2003-12-31 Asahi Denka Co., Ltd. 難燃剤組成物及び該組成物を含有した難燃性樹脂組成物
ATE361059T1 (de) * 2002-11-08 2007-05-15 Glaxo Group Ltd Antivirale zusammensetzungen
CN1863512A (zh) * 2003-10-01 2006-11-15 鲁宾有限公司 控释药物组合物及其制备方法
GB0403247D0 (en) * 2004-02-13 2004-03-17 Tillotts Pharma Ag A pharmaceutical composition
WO2005095950A1 (en) * 2004-03-30 2005-10-13 Pfizer Products Inc. Method and device for evaluation of pharmaceutical compositions
WO2008065502A1 (en) * 2006-11-29 2008-06-05 Pfizer Products Inc. Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
WO2008135828A2 (en) * 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2162120B1 (de) * 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
US20100215747A1 (en) * 2007-07-13 2010-08-26 Corey Jay Bloom Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
WO2009073215A1 (en) * 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2240162A4 (de) * 2007-12-06 2013-10-09 Bend Res Inc Nanoteilchen mit einem nicht-ionisierbaren polymer und einem amin-funktionalisierten methacrylat-copolymer
US20140271893A1 (en) * 2013-03-15 2014-09-18 Mcneil-Ppc, Inc. Coated phenylephrine particles and use thereof in pharmaceutical formulations
ITUA20161799A1 (it) * 2016-03-18 2017-09-18 Recordati Ind Chimica E Farmaceutica S P A Composizione farmaceutica a rilascio prolungato comprendente cisteamina o un suo sale
CN106333957A (zh) * 2016-08-19 2017-01-18 丁静 齐多夫定用于制备自身免疫性神经炎治疗药物的应用
EP3672575A1 (de) * 2017-08-25 2020-07-01 Eleonor SPRL Zusammensetzung mit mindestens einem protoberberin-alkaloid und ihr herstellungsverfahren

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE145365C (de) *
BE785702A (fr) * 1971-07-14 1972-10-16 Roehm Gmbh Produits de revetement de formes medicamenteuses et leur utilisation
BE787973A (fr) * 1971-09-04 1973-02-26 Beecham Group Ltd Comprimes pharmaceutiques a effet retard
ES438635A1 (es) * 1974-06-24 1977-02-16 Shinetsu Chemical Co Procedimiento para el revestimiento de moldes solidos de do-sificacion.
EP0052076B1 (de) * 1980-11-12 1985-05-29 Ciba-Geigy Ag Schnellzerfallende Arzneimittel-Presslinge
EP0052075A1 (de) * 1980-11-12 1982-05-19 Ciba-Geigy Ag Körnige Arzneimittel-Retardform
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
DE3126703A1 (de) * 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach Bromhexin-retardform und verfahren zu ihrer herstellung
ZA825384B (en) * 1981-07-31 1983-05-25 Tillott J B Ltd Orally administrable pharmaceutical compositions
IT1168014B (it) * 1981-08-05 1987-05-20 Erba Farmitalia Forme farmaceutiche a cessione protratta
DK150008C (da) * 1981-11-20 1987-05-25 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat
JPS59193831A (ja) * 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
JPS59227817A (ja) * 1983-06-07 1984-12-21 Toyo Jozo Co Ltd 持続性経口用ブレデニン製剤
JPH075457B2 (ja) * 1983-08-16 1995-01-25 ザ ウエルカム フアウンデ−シヨン リミテツド 調節された方法による有効成分の放出を可能にする医薬組成物
CH658188A5 (de) * 1984-03-23 1986-10-31 Ciba Geigy Ag Lagerstabile schnellzerfallende pharmazeutische presslinge.
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
NZ215486A (en) * 1985-03-16 1988-09-29 Wellcome Found 3'-azido-3'-deoxythymidine antiretroviral compositions (zidovudine, azt)
GB8506869D0 (en) * 1985-03-16 1985-04-17 Wellcome Found Antiviral compound
IE73219B1 (en) * 1985-03-16 1997-05-07 Wellcome Found Therapeutic nucleosides
GB8519310D0 (en) * 1985-07-31 1985-09-04 Zyma Sa Granular active substances
IT1227336B (it) * 1987-09-11 1991-04-08 Squibb & Sons Inc Composizione farmaceutica contenente un carico elevato di medicamento e procedimento per la sua preparazione

Also Published As

Publication number Publication date
DK164388D0 (da) 1988-03-25
US4917900A (en) 1990-04-17
NZ224026A (en) 1991-03-26
IE880899L (en) 1988-09-27
DE3862974D1 (de) 1991-07-04
KR960013434B1 (ko) 1996-10-05
ZA882168B (en) 1989-11-29
EP0284407A3 (en) 1988-12-14
EP0284407A2 (de) 1988-09-28
EP0284407B1 (de) 1991-05-29
JP2719344B2 (ja) 1998-02-25
IE60605B1 (en) 1994-07-27
GR3002030T3 (en) 1992-12-30
JPS63255230A (ja) 1988-10-21
AU1375688A (en) 1988-09-29
IL85870A (en) 1992-02-16
DK164388A (da) 1988-09-28
PT87081A (pt) 1988-04-01
GB8707421D0 (en) 1987-04-29
PT87081B (pt) 1992-07-31
CA1308026C (en) 1992-09-29
ES2033426T3 (es) 1993-03-16
AU607474B2 (en) 1991-03-07
DK175348B1 (da) 2004-09-06
KR880010759A (ko) 1988-10-24

Similar Documents

Publication Publication Date Title
DE3862974D1 (de) 3'-azido-3'-deoxythymidin-formulierungen mit gesteuerter freigabe.
AU572019B2 (en) 3'-azido-3'-deoxythymidine
NO883918L (no) Beleggsformulering for bioaktive stoffer med kontrollert frigjoering.
DK1308170T3 (da) Törret blodfaktorpræparat indeholdende trehalose
IT8419316A0 (it) Dispositivo per variare la flessibilita' particolarmente per scarpe da sci.
ATE186544T1 (de) Pharmazeutische formulierungen mit kontrollierter freigabe von 3'-azido-3'-deoxythymidin und verfahren zur verwendung
FI881413A7 (fi) Menetelmä 3'-atsido-3'-deoksitymidiinin valmistamiseksi.
IT8821374A0 (it) Impianto di condizionamento dell'aria.
IT1227029B (it) Distributore d'aria esteso in lunghezza
IT1226580B (it) Scarpone da sci.
IT213316Z2 (it) Maggiordomo da camera per bambini
IT9040438A1 (it) Artifizio per migliorare la penetrazione di corpi nell'aria.
IT8120673A0 (it) Impianto di trattamento di articoli azionati da aria.
ITFI950239A0 (it) Acceleratore per sci comandato dagli arti dello sciatore
IT213319Z2 (it) Forno con dispositivi di distribuzione dell'aria riscaldata perfezionati
IT219114Z2 (it) Articolo da divertimento galleggiante isostaticamente nell'aria
ES1002157Y (es) Boquilla para monederos infantiles
NO950388L (no) Kontrollert frigjorte farmasöytiske formuleringer av 3'-azido-3'-deoksythythymidin og metoder for anvendelse
ITRM920094A0 (it) Gioco individuale basato sul principio matematico dei gruppi di simmetria.
IT8902127A0 (it) Applicazione del principio di bernoulli e degli effetti derivati, per la realizzazione di giocattoli o mezzi pubblicitari
BR8807597A (pt) Bocal vaporizador
IT218177Z2 (it) Gioco educativo per la composizione di pannelli decorativi.
ITFI950123V0 (it) Acceleratore per sci comandato dagli arti dello sciatore
IT8311881V0 (it) Completo di carte da gioco o simili per il gioco "nodo ferroviario"
ES1002810Y (es) Juguete de composicion

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time