ATE64619T1 - Menschliches apolipoprotein a1 sowie dessen variante, exprimiert in escherichia coli. - Google Patents
Menschliches apolipoprotein a1 sowie dessen variante, exprimiert in escherichia coli.Info
- Publication number
- ATE64619T1 ATE64619T1 AT87309318T AT87309318T ATE64619T1 AT E64619 T1 ATE64619 T1 AT E64619T1 AT 87309318 T AT87309318 T AT 87309318T AT 87309318 T AT87309318 T AT 87309318T AT E64619 T1 ATE64619 T1 AT E64619T1
- Authority
- AT
- Austria
- Prior art keywords
- sequence
- protein
- escherichia coli
- human apoai
- human apolipoprotein
- Prior art date
Links
- 241000588724 Escherichia coli Species 0.000 title 1
- 101000733802 Homo sapiens Apolipoprotein A-I Proteins 0.000 title 1
- 101100379247 Salmo trutta apoa1 gene Proteins 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 238000002965 ELISA Methods 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 102000005936 beta-Galactosidase Human genes 0.000 abstract 1
- 108010005774 beta-Galactosidase Proteins 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868625435A GB8625435D0 (en) | 1986-10-23 | 1986-10-23 | Human apolipoprotein ai |
| EP87309318A EP0267703B1 (de) | 1986-10-23 | 1987-10-21 | Menschliches Apolipoprotein A1 sowie dessen Variante, exprimiert in Escherichia coli |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE64619T1 true ATE64619T1 (de) | 1991-07-15 |
Family
ID=10606217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87309318T ATE64619T1 (de) | 1986-10-23 | 1987-10-21 | Menschliches apolipoprotein a1 sowie dessen variante, exprimiert in escherichia coli. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0267703B1 (de) |
| JP (2) | JP2706247B2 (de) |
| KR (1) | KR890700163A (de) |
| CN (1) | CN87107991A (de) |
| AT (1) | ATE64619T1 (de) |
| AU (1) | AU8230587A (de) |
| CZ (1) | CZ761587A3 (de) |
| DE (1) | DE3770915D1 (de) |
| ES (1) | ES2044950T3 (de) |
| GB (1) | GB8625435D0 (de) |
| IL (1) | IL84229A0 (de) |
| NO (1) | NO882763L (de) |
| PT (1) | PT85977B (de) |
| WO (1) | WO1988003166A1 (de) |
| YU (1) | YU193887A (de) |
| ZA (1) | ZA877911B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8712540D0 (en) * | 1987-05-28 | 1987-07-01 | Ucb Sa | Expression of human proapolipoprotein a-i |
| GB8717791D0 (en) * | 1987-07-28 | 1987-09-03 | Baralle F E | Immunoassay method |
| IT1229996B (it) * | 1989-04-20 | 1991-09-20 | Cesare Sirtori | Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine. |
| AU662885B2 (en) * | 1990-06-07 | 1995-09-21 | Scripps Research Institute, The | APO AI polypeptides, antibodies, and immunoassays |
| US5270181A (en) * | 1991-02-06 | 1993-12-14 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| US5292646A (en) * | 1991-02-06 | 1994-03-08 | Genetics Institute, Inc. | Peptide and protein fusions to thioredoxin and thioredoxin-like molecules |
| EP0516443A1 (de) * | 1991-05-31 | 1992-12-02 | Eli Lilly And Company | Vektoren und Verfahren um die Regulation von Apolipoprotein-AI-Synthese zu Testen |
| WO1993000443A1 (en) * | 1991-06-26 | 1993-01-07 | Bio-Technology General Corp. | Purification of recombinant apolipoprotein e from bacteria |
| US5408038A (en) * | 1991-10-09 | 1995-04-18 | The Scripps Research Institute | Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides |
| SE9103701D0 (sv) | 1991-12-13 | 1991-12-13 | Kabi Pharmacia Ab | Apolipoprotein |
| SE9203753D0 (sv) * | 1992-12-11 | 1992-12-11 | Kabi Pharmacia Ab | Expression system for producing apolipoprotein ai-m |
| SE9500778D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Process for producing a protein |
| SE9603068D0 (sv) * | 1996-08-23 | 1996-08-23 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603303D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a protein |
| SE9603304D0 (sv) | 1996-09-11 | 1996-09-11 | Pharmacia & Upjohn Ab | Process for purifying a compound |
| UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| BR0115257A (pt) * | 2000-11-10 | 2003-08-12 | Proteopharma Aps | Análogos de apolipoproteìna |
| PL372925A1 (en) | 2001-09-28 | 2005-08-08 | Esperion Therapeutics Inc. | Prevention and treatment of restenosis by local administration of drug |
| US7052849B2 (en) | 2001-11-23 | 2006-05-30 | Syn X Pharma, Inc. | Protein biopolymer markers predictive of insulin resistance |
| JP2007531537A (ja) | 2004-04-06 | 2007-11-08 | セダーズ−シナイ メディカル センター | アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置 |
| US7759315B2 (en) | 2005-03-09 | 2010-07-20 | Csl Behring Ag | Treatment of inflammatory conditions of the intestine |
| EP2465519B1 (de) | 2007-03-01 | 2013-10-23 | CSL Limited | Behandlung von endothelialer Dysfunktion bei Diabetes-Patienten |
| US20130137628A1 (en) | 2010-05-11 | 2013-05-30 | Esperion Therapeutics, Inc. | Dimeric Oxidation-Resistant Apolipoprotein A1 Variants |
| HUE042314T2 (hu) | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| CN112940090B (zh) * | 2021-03-18 | 2023-02-24 | 广州康盛生物科技股份有限公司 | 耐受辐照灭菌及高效消毒的蛋白a免疫吸附介质 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU580145B2 (en) * | 1985-02-13 | 1989-01-05 | Scios Nova Inc. | Human metallothionein-ii promoter in mammalian expression system |
-
1986
- 1986-10-23 GB GB868625435A patent/GB8625435D0/en active Pending
-
1987
- 1987-10-20 IL IL84229A patent/IL84229A0/xx unknown
- 1987-10-21 WO PCT/EP1987/000621 patent/WO1988003166A1/en not_active Ceased
- 1987-10-21 DE DE8787309318T patent/DE3770915D1/de not_active Expired - Lifetime
- 1987-10-21 AU AU82305/87A patent/AU8230587A/en not_active Abandoned
- 1987-10-21 JP JP62506754A patent/JP2706247B2/ja not_active Expired - Fee Related
- 1987-10-21 AT AT87309318T patent/ATE64619T1/de not_active IP Right Cessation
- 1987-10-21 ES ES87309318T patent/ES2044950T3/es not_active Expired - Lifetime
- 1987-10-21 EP EP87309318A patent/EP0267703B1/de not_active Expired - Lifetime
- 1987-10-21 ZA ZA877911A patent/ZA877911B/xx unknown
- 1987-10-22 PT PT85977A patent/PT85977B/pt unknown
- 1987-10-22 CN CN198787107991A patent/CN87107991A/zh active Pending
- 1987-10-22 CZ CS877615A patent/CZ761587A3/cs unknown
- 1987-10-22 YU YU01938/87A patent/YU193887A/xx unknown
-
1988
- 1988-06-21 KR KR1019880700705A patent/KR890700163A/ko not_active Withdrawn
- 1988-06-22 NO NO882763A patent/NO882763L/no unknown
-
1997
- 1997-05-26 JP JP9134703A patent/JP2777126B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1988003166A1 (en) | 1988-05-05 |
| YU193887A (en) | 1989-06-30 |
| JPH02500797A (ja) | 1990-03-22 |
| CZ761587A3 (en) | 1994-11-16 |
| CN87107991A (zh) | 1988-09-21 |
| JPH1052287A (ja) | 1998-02-24 |
| NO882763D0 (no) | 1988-06-22 |
| JP2777126B2 (ja) | 1998-07-16 |
| ES2044950T3 (es) | 1994-01-16 |
| EP0267703A1 (de) | 1988-05-18 |
| KR890700163A (ko) | 1989-03-10 |
| PT85977A (en) | 1987-11-01 |
| JP2706247B2 (ja) | 1998-01-28 |
| GB8625435D0 (en) | 1986-11-26 |
| IL84229A0 (en) | 1988-03-31 |
| NO882763L (no) | 1988-08-22 |
| EP0267703B1 (de) | 1991-06-19 |
| AU8230587A (en) | 1988-05-25 |
| PT85977B (en) | 1990-01-19 |
| ZA877911B (en) | 1988-04-25 |
| DE3770915D1 (de) | 1991-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |