DK3688A - Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf - Google Patents

Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf

Info

Publication number
DK3688A
DK3688A DK003688A DK3688A DK3688A DK 3688 A DK3688 A DK 3688A DK 003688 A DK003688 A DK 003688A DK 3688 A DK3688 A DK 3688A DK 3688 A DK3688 A DK 3688A
Authority
DK
Denmark
Prior art keywords
recombinant
pancreatic
pharmaceutical use
trypsin inhibitor
secretoric
Prior art date
Application number
DK003688A
Other languages
English (en)
Other versions
DK3688D0 (da
Inventor
John Collins
Helmut Bloecker
Ronald Frank
Friedhelm Maywald
Hans Fritz
Wolfgang Brune
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK3688D0 publication Critical patent/DK3688D0/da
Publication of DK3688A publication Critical patent/DK3688A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK003688A 1987-01-07 1988-01-06 Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf DK3688A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08700204A GB2199582A (en) 1987-01-07 1987-01-07 Analogues of pancreatic secretory trypsin inhibitor

Publications (2)

Publication Number Publication Date
DK3688D0 DK3688D0 (da) 1988-01-06
DK3688A true DK3688A (da) 1988-07-08

Family

ID=10610323

Family Applications (1)

Application Number Title Priority Date Filing Date
DK003688A DK3688A (da) 1987-01-07 1988-01-06 Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf

Country Status (15)

Country Link
US (1) US5126322A (da)
EP (1) EP0278112B1 (da)
JP (2) JPS63169994A (da)
KR (1) KR960010949B1 (da)
CN (1) CN1030999C (da)
AT (1) ATE97421T1 (da)
AU (1) AU592486B2 (da)
DE (1) DE3788216D1 (da)
DK (1) DK3688A (da)
ES (1) ES2059356T3 (da)
FI (1) FI97139C (da)
GB (1) GB2199582A (da)
HU (1) HUT46068A (da)
IL (1) IL85020A (da)
ZA (1) ZA8860B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988003171A1 (en) * 1986-10-30 1988-05-05 Synergen Biologicals, Inc. Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
JPS6427473A (en) * 1987-07-23 1989-01-30 Mochida Pharm Co Ltd Human pancreas-secreting trypsin inhibitor and production thereof
GB2208511A (en) * 1987-08-07 1989-04-05 Bayer Ag Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology
US5591603A (en) * 1987-08-28 1997-01-07 Novo Nordisk A/S Process for preparing aprotinin and aprotinin analogs in yeast cells
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
JPH07102137B2 (ja) * 1988-07-19 1995-11-08 塩野義製薬株式会社 修飾ヒトｐｓｔｉ
DE3907492A1 (de) * 1989-03-08 1990-09-13 Biotechnolog Forschung Gmbh Verfahren zur isolierung und reinigung von hpsti und hpsti-varianten
US5231010A (en) * 1989-09-13 1993-07-27 Bayer Aktiengesellschaft Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof
IL104314A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them
EP0699750A1 (en) * 1994-06-07 1996-03-06 Gesellschaft für biotechnologische Forschung mbH (GBF) A collection of phagemids, a collection of Escherichia coli cells carrying the phagemids, a collection of phagemid particles produced from said collection and phagemid particles obtained according to the process
JPH09124698A (ja) 1995-10-27 1997-05-13 Sagami Chem Res Center ヒトｐｅｃ−６０様蛋白質およびそれをコードするｄｎａ
US6703201B1 (en) 1995-10-27 2004-03-09 Sagami Chemical Research Center Human PEC-60-like protein and DNA encoding this protein
US5851987A (en) * 1997-04-14 1998-12-22 Incyte Pharmaceuticals, Inc. Human tumor-associated Kazal inhibitor-like polypeptides and encoding polynucleotides
WO2008052238A1 (en) * 2006-11-01 2008-05-08 The University Of Sydney Treatment of urological cancer
ES2753183T3 (es) * 2007-02-12 2020-04-07 Csl Behring Gmbh Aplicación terapéutica de inhibidores de la proteasa de serina de tipo Kazal
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
WO2015161243A2 (en) 2014-04-17 2015-10-22 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
EP3186379B1 (en) 2014-08-28 2020-04-08 Synthetic Biologics, Inc. E. coli-based production of beta-lactamase
MX2017004473A (es) 2014-10-08 2017-10-12 Synthetic Biologics Inc Formulaciones de betalactamasa y usos de las mismas.
WO2016105498A1 (en) 2014-12-23 2016-06-30 Synthetic Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
WO2016137993A1 (en) 2015-02-23 2016-09-01 Synthetic Biologics, Inc. Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
US12263192B2 (en) 2019-02-26 2025-04-01 Pantheryx, Inc. Compositions for management of disorders of the gastrointestinal tract

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2701890C2 (de) * 1977-01-19 1983-08-04 Hoechst Ag, 6230 Frankfurt Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
DE3429430A1 (de) * 1984-08-10 1986-02-20 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
AU590238B2 (en) * 1984-12-06 1989-11-02 Amgen, Inc. Recombinant methods for production of serine protease inhibitors and dna sequences useful for same
US4760130A (en) * 1984-12-06 1988-07-26 Synergen Biologicals, Inc. Serine protease inhibitors and methods for isolation of same
ES2059340T3 (es) * 1986-10-14 1994-11-16 Shionogi & Co Un metodo de preparacion de proteinas.
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトｐｓｔｉの製造法
WO1988003171A1 (en) * 1986-10-30 1988-05-05 Synergen Biologicals, Inc. Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same

Also Published As

Publication number Publication date
IL85020A (en) 1993-02-21
IL85020A0 (en) 1988-06-30
JPH10117786A (ja) 1998-05-12
GB8700204D0 (en) 1987-02-11
FI97139C (fi) 1996-10-25
AU1003888A (en) 1988-09-01
FI97139B (fi) 1996-07-15
AU592486B2 (en) 1990-01-11
CN88100146A (zh) 1988-08-31
HUT46068A (en) 1988-09-28
EP0278112B1 (de) 1993-11-18
FI880017L (fi) 1988-07-08
ZA8860B (en) 1988-10-26
ES2059356T3 (es) 1994-11-16
EP0278112A3 (en) 1990-01-10
KR960010949B1 (ko) 1996-08-14
EP0278112A2 (de) 1988-08-17
GB2199582A (en) 1988-07-13
KR880009125A (ko) 1988-09-14
JPS63169994A (ja) 1988-07-13
FI880017A0 (fi) 1988-01-05
DK3688D0 (da) 1988-01-06
ATE97421T1 (de) 1993-12-15
CN1030999C (zh) 1996-02-14
US5126322A (en) 1992-06-30
DE3788216D1 (de) 1993-12-23

Similar Documents

Publication Publication Date Title
DK3688D0 (da) Pankreatisk sekretorisk trypsininhibitor og varianter deraf fremstillet af en rekombinant vaert, fremgangsmaade, ekspressionsvektor og rekombinant vaert samt farmaceutisk anvendelse deraf
ES2124685T3 (es) Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.
ES2061446T3 (es) Procedimiento para la produccion de productos proteinicos en aspergillus oryzae y un promotor para empleo en el mismo.
DK0461165T3 (da) Gærspaltningssystem
DK0532587T3 (da) Fremgangsmåder til trans-destabilisering af specifikke proteiner in vivo
DK0387231T3 (da) Hidtil ukendte inhibitorer for retroviral protease
ATE64619T1 (de) Menschliches apolipoprotein a1 sowie dessen variante, exprimiert in escherichia coli.
NO930428L (no) Proteinstrukturen til plantetoksingelonin
DK0652903T3 (da) Nyt humant rekombinant gammainterferon
EP0330700A4 (en) Human prourokinase-like polypeptide.
DK450187D0 (da) Fremgangsmaade til fremstilling af proteiner
ATE78872T1 (de) Herstellung von polypeptiden.
DK0467839T3 (da) In-vitro-behandling af fusionsproteiner
ATE143974T1 (de) Peptide des hiv-gag proteins, ihre herstellung und verwendung
DK0717048T3 (da) Cyclohexapeptider og deres blandinger, fremgangsmåde til fremstilling deraf samt deres anvendelse
ATE112290T1 (de) Peptiden von retinblastoma gen produkten und antikoerper dagegen.

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment