ATE66003T1 - Regelung der herstellung einer linearer kombination von aminosaeureresten. - Google Patents

Regelung der herstellung einer linearer kombination von aminosaeureresten.

Info

Publication number
ATE66003T1
ATE66003T1 AT87901087T AT87901087T ATE66003T1 AT E66003 T1 ATE66003 T1 AT E66003T1 AT 87901087 T AT87901087 T AT 87901087T AT 87901087 T AT87901087 T AT 87901087T AT E66003 T1 ATE66003 T1 AT E66003T1
Authority
AT
Austria
Prior art keywords
alpha
pct
amino acid
amino
protecting group
Prior art date
Application number
AT87901087T
Other languages
English (en)
Inventor
Robert Sheppard
Morten Meldahl
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE66003T1 publication Critical patent/ATE66003T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
AT87901087T 1986-02-03 1987-02-03 Regelung der herstellung einer linearer kombination von aminosaeureresten. ATE66003T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB08602586A GB2187461A (en) 1986-02-03 1986-02-03 Monitoring method for the synthesis of a linear of amino acid residues
PCT/GB1987/000078 WO1987004713A2 (en) 1986-02-03 1987-02-03 Monitoring method for the synthesis of a linear combination of amino acid residues
EP87901087A EP0257053B1 (de) 1986-02-03 1987-02-03 Regelung der herstellung einer linearer kombination von aminosäureresten

Publications (1)

Publication Number Publication Date
ATE66003T1 true ATE66003T1 (de) 1991-08-15

Family

ID=10592426

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87901087T ATE66003T1 (de) 1986-02-03 1987-02-03 Regelung der herstellung einer linearer kombination von aminosaeureresten.

Country Status (11)

Country Link
US (1) US5126273A (de)
EP (1) EP0257053B1 (de)
JP (1) JPS63502694A (de)
AT (1) ATE66003T1 (de)
AU (1) AU597031B2 (de)
DE (1) DE3771959D1 (de)
DK (1) DK518587D0 (de)
FI (1) FI874330A0 (de)
GB (1) GB2187461A (de)
NO (1) NO874149L (de)
WO (1) WO1987004713A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3618218A1 (de) * 1986-05-30 1987-12-03 Hoechst Ag Aminosaeure-oobt-ester, verfahren zu deren herstellung und deren verwendung
US5233044A (en) * 1989-06-08 1993-08-03 Millipore Corporation Active esters for solid phase peptide synthesis
SE8902842D0 (sv) * 1989-08-28 1989-08-28 Pharmacia Ab A method for monitoring in peptide synthesis
AU6456496A (en) * 1995-08-17 1997-03-12 Hybridon, Inc. Apparatus and process for multi-stage solid-phase synthesis of long-chained organic molecules
US5807525A (en) * 1995-08-17 1998-09-15 Hybridon, Inc. Apparatus and process for multi stage solid phase synthesis of long chained organic molecules
ATE376556T1 (de) * 2003-12-31 2007-11-15 Hoffmann La Roche Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU164903B (de) * 1969-04-05 1974-05-28
BE754343A (fr) * 1969-08-01 1971-02-03 Hoechst Ag Procede de preparation de peptides
DE2202613C3 (de) * 1972-01-20 1974-06-20 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Verfahren zur Herstellung von Peptiden
US4105602A (en) * 1975-02-10 1978-08-08 Armour Pharmaceutical Company Synthesis of peptides with parathyroid hormone activity
US4108846A (en) * 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
US4242507A (en) * 1978-02-23 1980-12-30 Fujisawa Pharmaceutical Co., Ltd. Sulfonic acid esters
DE2830442A1 (de) * 1978-07-11 1980-01-24 Max Planck Gesellschaft Verfahren zur herstellung von polypeptiden
US4192798A (en) * 1978-11-20 1980-03-11 Bioresearch, Inc. Rapid, large scale, automatable high pressure peptide synthesis
DE2905502C2 (de) * 1979-02-14 1982-07-15 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von LH-RH bzw. LH-RH-Analoga und Pyroglutamyl-N↑i↑m↑-dinitrophenyl-histidin
DE3117985A1 (de) * 1981-05-07 1982-11-25 Hoechst Ag, 6000 Frankfurt "verfahren zur phlegmatisierung von hydroxy-benzotriazolen und hydroxy-oxo-dihydro-benzotriazinen"
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
GB2169901A (en) * 1984-12-11 1986-07-23 Lkb Biochrom Ltd method for a solid phase synthesis of a linear combination of amino acid residues.
US4701304A (en) * 1985-04-19 1987-10-20 Applied Protein Technologies, Inc. Apparatus for automated synthesis of peptides
DE3542442A1 (de) * 1985-11-30 1987-06-04 Hoechst Ag Verfahren zur herstellung von peptiden unter der verwendung von perchloraten
US4755558A (en) * 1986-05-30 1988-07-05 Beckman Instruments, Inc. Using internal marker

Also Published As

Publication number Publication date
FI874330A7 (fi) 1987-10-02
GB2187461A (en) 1987-09-09
AU597031B2 (en) 1990-05-24
DK518587A (da) 1987-10-02
DE3771959D1 (de) 1991-09-12
FI874330A0 (fi) 1987-10-02
WO1987004713A2 (en) 1987-08-13
US5126273A (en) 1992-06-30
EP0257053A1 (de) 1988-03-02
EP0257053B1 (de) 1991-08-07
NO874149L (no) 1987-12-03
GB8602586D0 (en) 1986-03-12
WO1987004713A3 (en) 1987-11-05
AU6930387A (en) 1987-08-25
JPS63502694A (ja) 1988-10-06
DK518587D0 (da) 1987-10-02
NO874149D0 (no) 1987-10-02

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