ATE66229T1 - Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. - Google Patents

Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Info

Publication number: ATE66229T1
Authority: AT; Austria
Prior art keywords: biopterin; tetrahydro; amine; acyl groups; production
Prior art date: 1985-01-28

Application number

AT86100944T

Other languages

English (en)

Inventor

Hideaki Sakai

Tadashi Kanai

Original Assignee

Shiratori Pharm

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-28

Filing date

1986-01-24

Publication date

1991-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26348109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE66229(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-01-28 Priority claimed from JP60012478A external-priority patent/JPS61172877A/ja

1985-01-28 Priority claimed from JP60012477A external-priority patent/JPS61172876A/ja

1986-01-24 Application filed by Shiratori Pharm, Suntory Ltd filed Critical Shiratori Pharm

1991-08-15 Application granted granted Critical

1991-08-15 Publication of ATE66229T1 publication Critical patent/ATE66229T1/de

Links

125000002252 acyl group Chemical group 0.000 abstract 3
150000001412 amines Chemical class 0.000 abstract 2
LHQIJBMDNUYRAM-UHFFFAOYSA-N L-erythro-Biopterin Natural products N1=C(N)NC(=O)C2=NC(C(O)C(O)C)=CN=C21 LHQIJBMDNUYRAM-UHFFFAOYSA-N 0.000 abstract 1
LHQIJBMDNUYRAM-DZSWIPIPSA-N L-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@@H](O)[C@@H](O)C)=CN=C21 LHQIJBMDNUYRAM-DZSWIPIPSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
229910017053 inorganic salt Inorganic materials 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT86100944T 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. ATE66229T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP60012478A JPS61172877A (ja)	1985-01-28	1985-01-28	（６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法
JP60012477A JPS61172876A (ja)	1985-01-28	1985-01-28	（６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
EP86100944A EP0191335B1 (de)	1985-01-28	1986-01-24	Verfahren zur Herstellung von (6R)-Tetrahydro-L-biopterin

Publications (1)

Publication Number	Publication Date
ATE66229T1 true ATE66229T1 (de)	1991-08-15

Family

ID=26348109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86100944T ATE66229T1 (de)	1985-01-28	1986-01-24	Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Country Status (6)

Country	Link
US (1)	US4713454A (de)
EP (1)	EP0191335B1 (de)
AT (1)	ATE66229T1 (de)
AU (1)	AU581052B2 (de)
CA (1)	CA1262347A (de)
DE (1)	DE3680800D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4550109A (en) *	1984-05-31	1985-10-29	The Board Of Regents, The University Of Texas System	Lipoidal biopterin compounds
DE3853711T2 (de) *	1987-11-30	1996-01-11	Vitamin Kenkyusho Kk	Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate.
US7442372B2 (en)	2003-08-29	2008-10-28	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
PL1708690T3 (pl)	2003-11-17	2017-01-31	Biomarin Pharmaceutical Inc.	Leczenie fenyloketonurii za pomocą BH4
EP1687308B1 (de)	2003-11-17	2019-06-12	Merck & Cie	Verfahren zur Herstellung von (6R)-L-Erythrotetrahydrobiopterin Hydrochlorid kristalliner Form B aus anderen kristallinen Formen
AU2012200512C1 (en) *	2003-11-17	2020-04-30	Merck & Cie	Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
KR20070084270A (ko)	2004-11-17	2007-08-24	바이오마린 파머수티컬 인크.	안정한 정제 제형물
JP2008523090A (ja) *	2004-12-08	2008-07-03	バイオマリンファーマシューティカルインコーポレイテッド	新生児肺高血圧症の治療のための方法および組成物
PT1869048E (pt) *	2005-04-14	2009-03-05	Asubio Pharma Co Ltd	Método de produção de cristais de cloridrato de sapropterina na forma alfa
WO2007067570A1 (en) *	2005-12-05	2007-06-14	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of disease
US20100009997A1 (en) *	2007-01-12	2010-01-14	Biomarin Pharmaceutical Inc.	Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug
CA2675134A1 (en) *	2007-01-12	2008-07-24	Biomarin Pharmaceutical Inc.	Pterin analogs
LT2545939T (lt)	2007-04-11	2021-03-10	Biomarin Pharmaceutical Inc.	Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu
RU2470642C2 (ru) *	2008-01-03	2012-12-27	Байомарин Фармасьютикл Инк.	Аналоги птерина для лечения состояния, чувствительного к вн4
BRPI0907247A2 (pt) *	2008-01-07	2015-07-14	Biomarin Pharm Inc	Métodos para preparar biopterina e para preparar tetraidrobiopterina
IT1400964B1 (it)	2010-06-15	2013-07-05	Dipharma Francis Srl	Procedimento per la preparazione di derivati pteridinici
CN102443006B (zh) *	2010-10-13	2016-02-24	因华生技制药股份有限公司	(6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) *	2010-10-15	2015-04-21	Innopharmax Inc	（６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
TW201241005A (en)	2011-02-18	2012-10-16	Alexion Pharma Inc	Methods for synthesizing molybdopterin precursor Z derivatives
US9216178B2 (en)	2011-11-02	2015-12-22	Biomarin Pharmaceutical Inc.	Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) *	2012-04-10	2014-04-16	凯莱英医药集团（天津）股份有限公司	一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh) *	2012-04-10	2014-06-25	凯莱英医药集团（天津）股份有限公司	一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
CN104736539B (zh)	2012-05-07	2017-09-01	白鸟制药株式会社	墨蝶呤和四氢乳酰蝶呤的制造法
WO2016189542A1 (en)	2015-05-28	2016-12-01	Natco Pharma Ltd	Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
WO2017138588A1 (ja) *	2016-02-10	2017-08-17	住友化学株式会社	１－メチルピロリジン－３－オールの製造方法
WO2019175332A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60178887A (ja) *	1984-02-23	1985-09-12	Kanegafuchi Chem Ind Co Ltd	５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

1986
- 1986-01-23 US US06/824,288 patent/US4713454A/en not_active Expired - Lifetime
- 1986-01-23 CA CA000500218A patent/CA1262347A/en not_active Expired
- 1986-01-24 DE DE8686100944T patent/DE3680800D1/de not_active Expired - Lifetime
- 1986-01-24 AT AT86100944T patent/ATE66229T1/de not_active IP Right Cessation
- 1986-01-24 EP EP86100944A patent/EP0191335B1/de not_active Expired
- 1986-01-24 AU AU52720/86A patent/AU581052B2/en not_active Expired

Also Published As

Publication number	Publication date
AU5272086A (en)	1986-07-31
CA1262347A (en)	1989-10-17
US4713454A (en)	1987-12-15
DE3680800D1 (de)	1991-09-19
EP0191335A3 (en)	1988-02-10
EP0191335A2 (de)	1986-08-20
EP0191335B1 (de)	1991-08-14
AU581052B2 (en)	1989-02-09

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Legal Events

Date	Code	Title	Description
1992-11-15	UEP	Publication of translation of european patent specification
2006-04-15	EELA	Cancelled due to lapse of time