ATE66229T1 - Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. - Google Patents

Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Info

Publication number: ATE66229T1
Authority: AT; Austria
Prior art keywords: biopterin; tetrahydro; amine; acyl groups; production
Prior art date: 1985-01-28

Application number

AT86100944T

Other languages

English (en)

Inventor

Hideaki Sakai

Tadashi Kanai

Original Assignee

Shiratori Pharm

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-28

Filing date

1986-01-24

Publication date

1991-08-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26348109&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE66229(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-01-28 Priority claimed from JP60012477A external-priority patent/JPS61172876A/ja

1985-01-28 Priority claimed from JP60012478A external-priority patent/JPS61172877A/ja

1986-01-24 Application filed by Shiratori Pharm, Suntory Ltd filed Critical Shiratori Pharm

1991-08-15 Application granted granted Critical

1991-08-15 Publication of ATE66229T1 publication Critical patent/ATE66229T1/de

Links

125000002252 acyl group Chemical group 0.000 abstract 3
150000001412 amines Chemical class 0.000 abstract 2
LHQIJBMDNUYRAM-UHFFFAOYSA-N L-erythro-Biopterin Natural products N1=C(N)NC(=O)C2=NC(C(O)C(O)C)=CN=C21 LHQIJBMDNUYRAM-UHFFFAOYSA-N 0.000 abstract 1
LHQIJBMDNUYRAM-DZSWIPIPSA-N L-erythro-biopterin Chemical compound N1=C(N)NC(=O)C2=NC([C@@H](O)[C@@H](O)C)=CN=C21 LHQIJBMDNUYRAM-DZSWIPIPSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000013078 crystal Substances 0.000 abstract 1
229910017053 inorganic salt Inorganic materials 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT86100944T 1985-01-28 1986-01-24 Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin. ATE66229T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP60012477A JPS61172876A (ja)	1985-01-28	1985-01-28	（６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造法
JP60012478A JPS61172877A (ja)	1985-01-28	1985-01-28	（６ｒ）−テトラヒドロ−ｌ−バイオプテリンの製造方法
EP86100944A EP0191335B1 (de)	1985-01-28	1986-01-24	Verfahren zur Herstellung von (6R)-Tetrahydro-L-biopterin

Publications (1)

Publication Number	Publication Date
ATE66229T1 true ATE66229T1 (de)	1991-08-15

Family

ID=26348109

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86100944T ATE66229T1 (de)	1985-01-28	1986-01-24	Verfahren zur herstellung von (6r)-tetrahydro-l- biopterin.

Country Status (6)

Country	Link
US (1)	US4713454A (de)
EP (1)	EP0191335B1 (de)
AT (1)	ATE66229T1 (de)
AU (1)	AU581052B2 (de)
CA (1)	CA1262347A (de)
DE (1)	DE3680800D1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4550109A (en) *	1984-05-31	1985-10-29	The Board Of Regents, The University Of Texas System	Lipoidal biopterin compounds
CA1334654C (en) *	1987-11-30	1995-03-07	Masayasu Kurono	Intermediates for synthesizing bh _and its derivatives
US7442372B2 (en)	2003-08-29	2008-10-28	Biomarin Pharmaceutical Inc.	Delivery of therapeutic compounds to the brain and other tissues
CN1894251B (zh)	2003-11-17	2011-06-29	默克和西伊公司	(6r)-l-赤型-四氢生物蝶呤二盐酸盐的晶型
AU2012200512C1 (en) *	2003-11-17	2020-04-30	Merck & Cie	Crystalline forms of (6R) -L-erythro-tetrahydrobiopterin dihydrochloride
KR20070005550A (ko)	2003-11-17	2007-01-10	바이오마린 파머수티컬 인크.	대사 장애 치료를 위한 조성물 및 방법
BRPI0517088A (pt)	2004-11-17	2008-09-30	Biomarin Pharm Inc	formulação de comprimido estável
EP1819340A2 (de) *	2004-12-08	2007-08-22	Biomarin Pharmaceutical Inc.	Verfahren und zusammensetzungen zur behandlung von lungenhypertonie bei neugeborenen
ATE415403T1 (de) *	2005-04-14	2008-12-15	Shiratori Pharm	Verfahren zur herstellung von alphaformkristallen von sapropterinhydrochlorid
AU2006321942A1 (en) *	2005-12-05	2007-06-14	Biomarin Pharmaceutical Inc.	Methods and compositions for the treatment of disease
WO2008089148A1 (en) *	2007-01-12	2008-07-24	Biomarin Pharmaceutical Inc.	Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug
JP2010515747A (ja) *	2007-01-12	2010-05-13	ビオマリンプハルマセウトイカルインコーポレイテッド	テトラヒドロビオプテリンプロドラッグ
SI3461503T1 (sl)	2007-04-11	2022-04-29	Biomarin Pharmaceutical Inc.	Postopki za dajanje tetrahidrobiopterina, povezani sestavki in postopki merjenja
WO2009088530A1 (en)	2008-01-03	2009-07-16	Biomarin Pharmaceutical Inc.	Pterin analog for treating bh4 responsive condition
WO2009088979A1 (en) *	2008-01-07	2009-07-16	Biomarin Pharmaceutical Inc.	Method of synthesizing tetrahydrobiopterin
IT1400964B1 (it)	2010-06-15	2013-07-05	Dipharma Francis Srl	Procedimento per la preparazione di derivati pteridinici
CN102443006B (zh) *	2010-10-13	2016-02-24	因华生技制药股份有限公司	(6r)-四氢生物喋呤盐酸盐的制备方法
TWI481612B (zh) *	2010-10-15	2015-04-21	Innopharmax Inc	（６ｒ）－四氫生物喋呤鹽酸鹽的製備方法
JP5972911B2 (ja)	2011-02-18	2016-08-17	アレクシオンファーマインターナショナルエスアーアールエル	モリブドプテリン前駆体ｚ誘導体を合成するための方法
US9216178B2 (en)	2011-11-02	2015-12-22	Biomarin Pharmaceutical Inc.	Dry blend formulation of tetrahydrobiopterin
CN102627644B (zh) *	2012-04-10	2014-04-16	凯莱英医药集团（天津）股份有限公司	一种通过直接手性合成方法制备二盐酸沙丙蝶呤的方法
CN102633799B (zh)	2012-04-10	2014-06-25	凯莱英医药集团（天津）股份有限公司	一种从消旋体中间体拆分路线合成二盐酸沙丙蝶呤的方法
ES2681345T3 (es)	2012-05-07	2018-09-12	Shiratori Pharmaceutical Co., Ltd.	Método para producir sepiapterina y tetrahidrolactoilpterina
WO2016189542A1 (en)	2015-05-28	2016-12-01	Natco Pharma Ltd	Novel process for the preparation of sapropterin dihydrochloride and its key intermediate, l-biopterin
ES2805031T3 (es)	2016-02-10	2021-02-10	Sumitomo Chemical Co	Método de producción de 1-metilpirrolidin-3-ol
WO2019175332A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
WO2019175328A1 (en)	2018-03-14	2019-09-19	Imba - Institut Für Molekulare Biotechnologie Gmbh	Bh4pathwayactivationandusethereoffortreatingcancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60178887A (ja) *	1984-02-23	1985-09-12	Kanegafuchi Chem Ind Co Ltd	５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法

1986
- 1986-01-23 CA CA000500218A patent/CA1262347A/en not_active Expired
- 1986-01-23 US US06/824,288 patent/US4713454A/en not_active Expired - Lifetime
- 1986-01-24 AU AU52720/86A patent/AU581052B2/en not_active Expired
- 1986-01-24 AT AT86100944T patent/ATE66229T1/de not_active IP Right Cessation
- 1986-01-24 EP EP86100944A patent/EP0191335B1/de not_active Expired
- 1986-01-24 DE DE8686100944T patent/DE3680800D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0191335A2 (de)	1986-08-20
DE3680800D1 (de)	1991-09-19
CA1262347A (en)	1989-10-17
US4713454A (en)	1987-12-15
EP0191335A3 (en)	1988-02-10
EP0191335B1 (de)	1991-08-14
AU5272086A (en)	1986-07-31
AU581052B2 (en)	1989-02-09

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Legal Events

Date	Code	Title	Description
1992-11-15	UEP	Publication of translation of european patent specification
2006-04-15	EELA	Cancelled due to lapse of time