ATE66613T1 - Immunstimulierende mittel. - Google Patents

Immunstimulierende mittel.

Info

Publication number: ATE66613T1
Authority: AT; Austria
Prior art keywords: immune stimulants; muramyldipeptide; exhibits; stimulants; immune
Prior art date: 1985-12-24

Application number

AT86309526T

Other languages

English (en)

Inventor

Koichiro Ootsu

Giichi Goto

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-12-24

Filing date

1986-12-08

Publication date

1991-09-15

1986-12-08 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1991-09-15 Application granted granted Critical

1991-09-15 Publication of ATE66613T1 publication Critical patent/ATE66613T1/de

Links

229960001438 immunostimulant agent Drugs 0.000 title 1
108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
230000003308 immunostimulating effect Effects 0.000 abstract 1
BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/141—Interleukin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
External Artificial Organs (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT86309526T 1985-12-24 1986-12-08 Immunstimulierende mittel. ATE66613T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP29147185		1985-12-24
EP19860309526 EP0228833B1 (de)	1985-12-24	1986-12-08	Immunstimulierende Mittel

Publications (1)

Publication Number	Publication Date
ATE66613T1 true ATE66613T1 (de)	1991-09-15

Family

ID=17769299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86309526T ATE66613T1 (de)	1985-12-24	1986-12-08	Immunstimulierende mittel.

Country Status (10)

Country	Link
US (1)	US4780313A (de)
EP (1)	EP0228833B1 (de)
JP (1)	JPS62228026A (de)
AT (1)	ATE66613T1 (de)
AU (1)	AU601957B2 (de)
CA (1)	CA1285479C (de)
DE (1)	DE3681145D1 (de)
DK (1)	DK585886A (de)
IL (1)	IL80927A0 (de)
PH (1)	PH25112A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5503841A (en) *	1985-09-20	1996-04-02	Cetus Oncology Corporation	Human IL-2 as a vaccine adjuvant
US5643565A (en) *	1985-09-20	1997-07-01	Chiron Corporation	Human IL-2 as a vaccine adjuvant
IL83350A0 (en) *	1986-08-13	1987-12-31	Takeda Chemical Industries Ltd	Pharmaceutical compositions comprising interleukin and intterferon active substances
AU603820B2 (en) *	1986-08-13	1990-11-29	Takeda Chemical Industries Ltd.	Antitumor agent
US4938956A (en) *	1987-04-01	1990-07-03	International Minerals & Chemical Corp.	Synergistic immunostimulating composition and method
AU609524B2 (en) *	1987-09-02	1991-05-02	Daiichi Pharmaceutical Co., Ltd.	Method for preventing or treating thrombocytopenia
US4895835A (en) *	1987-11-20	1990-01-23	Nisshin Oil Mills, Ltd.	Muramyl peptide derivatives and use thereof
US4950647A (en) *	1988-10-04	1990-08-21	Nucleic Acid Research Institute	T cell immunopotentiator
DE3902021A1 (de) *	1989-01-20	1990-07-26	Entec	Verwendung von antipeptidergen mitteln, gegebenenfalls in kombination mit anti-androgenen mitteln zur behandlung des humanen prostatakarzinoms
JPH0832638B2 (ja) *	1989-05-25	1996-03-29	カイロンコーポレイション	サブミクロン油滴乳剤を含んで成るアジュバント製剤
DK0494224T3 (da) *	1989-09-25	2000-08-07	Univ Utah Res Found	Anvendelse af steroidhormoner i sammensætninger til induktion af T-cellelymfokinproduktion
US5250296A (en) *	1990-11-29	1993-10-05	Takeda Chemical Industries, Ltd.	Immunostimulant agent containing interleukin-2 and 5'-deoxy-5-fluorouridine
FR2684878B1 (fr) *	1991-12-12	1994-02-11	Roussel Uclaf	Composition pharmaceutique stabilisee d'il2 humaine recombinante non glycosylee sous forme reduite et son procede de preparation.
US5258407A (en) *	1991-12-31	1993-11-02	Sterling Winthrop Inc.	3,4-disubstituted phenols-immunomodulating agents
US5449691A (en) *	1991-12-31	1995-09-12	Sterling Winthrop Inc.	3,4-disubstituted anilines-immunomodulating agents
FR2702659B1 (fr) *	1993-03-19	1995-08-25	Vacsyn Sa	Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine.
EP0689449B1 (de) *	1993-03-19	2002-10-30	Vacsyn S.A.	Zusammensetzungen für die anwendung in menschlicher therapie, charakterisiert durch die assoziation eines muramylpeptids mit einem cytokin
CA2163652A1 (en) *	1993-05-27	1994-12-08	Carol A. Nacy	Compositions and methods for treating cancer and hyperproliferative disorders
US6551618B2 (en)	1994-03-15	2003-04-22	University Of Birmingham	Compositions and methods for delivery of agents for neuronal regeneration and survival
US6008319A (en)	1996-12-23	1999-12-28	University Of Southern California	Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof
US20030166147A1 (en) *	2001-12-14	2003-09-04	Lee Chichang	Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
US20040152170A1 (en) *	2001-12-14	2004-08-05	Lee Chichang	Clonal myeloma cell lines useful for manufacturing proteins in chemically defined media
EP1490481A4 (de) *	2001-12-14	2005-12-07	Centocor Inc	Zur herstellung von proteinen in chemisch definierten medien geeignete klonale myelomzellinien

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1563561A (en) *	1976-06-23	1980-03-26	Daiichi Seiyaku Co	Muramyldipeptide derivatives and process for the preparation thereof
FR2446292A1 (fr) *	1979-01-12	1980-08-08	Anvar	Muramyl-peptides fixes sur polymeres peptidiques et medicaments les contenant
JPS55111499A (en) *	1979-02-21	1980-08-28	Takeda Chem Ind Ltd	Glucosamine derivative and its preparation
FR2522967B1 (fr) *	1982-03-15	1986-03-07	Anvar	Conjugues d'haptenes et de muramyl-peptides, doues d'activite immunogene et compositions les contenant
JPH0751511B2 (ja) *	1982-03-15	1995-06-05	味の素株式会社	インターロイキン２を含有してなる癌治療剤
US4518584A (en) *	1983-04-15	1985-05-21	Cetus Corporation	Human recombinant interleukin-2 muteins
JPS60115528A (ja) *	1983-11-28	1985-06-22	Takeda Chem Ind Ltd	ヒトインタ―ロイキン―２蛋白質を含有する抗腫瘍用または免疫機能低下疾患治療用組成物
IL76360A0 (en) *	1984-09-26	1986-01-31	Takeda Chemical Industries Ltd	Mutual separation of proteins

1986
- 1986-12-05 DK DK585886A patent/DK585886A/da not_active Application Discontinuation
- 1986-12-08 EP EP19860309526 patent/EP0228833B1/de not_active Expired - Lifetime
- 1986-12-08 AT AT86309526T patent/ATE66613T1/de active
- 1986-12-08 DE DE8686309526T patent/DE3681145D1/de not_active Expired - Fee Related
- 1986-12-08 AU AU66189/86A patent/AU601957B2/en not_active Ceased
- 1986-12-10 IL IL80927A patent/IL80927A0/xx unknown
- 1986-12-15 CA CA000525278A patent/CA1285479C/en not_active Expired - Lifetime
- 1986-12-18 US US06/943,924 patent/US4780313A/en not_active Expired - Fee Related
- 1986-12-22 JP JP61307382A patent/JPS62228026A/ja active Pending
- 1986-12-22 PH PH34636A patent/PH25112A/en unknown

Also Published As

Publication number	Publication date
IL80927A0 (en)	1987-03-31
AU601957B2 (en)	1990-09-27
CA1285479C (en)	1991-07-02
EP0228833A2 (de)	1987-07-15
DK585886A (da)	1987-06-25
DK585886D0 (da)	1986-12-05
PH25112A (en)	1991-02-19
AU6618986A (en)	1987-06-25
JPS62228026A (ja)	1987-10-06
DE3681145D1 (de)	1991-10-02
US4780313A (en)	1988-10-25
EP0228833B1 (de)	1991-08-28
EP0228833A3 (en)	1988-12-14

Publication	Publication Date	Title
ATE66613T1 (de)	1991-09-15	Immunstimulierende mittel.
GR890100838A (el)	1991-03-15	Νέα ?εραπευτικώς δραστική ένωσις και μέ?οδος για την παραγωγή της.
DE3880593D1 (de)	1993-06-03	Arzneizubereitungen mit retardierter wirkstofffreisetzung.
DE3650082D1 (de)	1994-11-03	Orale impfstoffe.
DE3671372D1 (de)	1990-06-28	Etoposid-praeparate.
DE68903192D1 (de)	1992-11-19	Orale praeparate.
ES554125A0 (es)	1987-10-16	Procedimiento de preparar hidroxamatos farmaceuticamente activos.
DK224687D0 (da)	1987-05-01	Aktive forbindelser
NL970029I1 (nl)	1997-10-01	Benzimidazoolderivaten, bereiding en therapeutische toepassing.
NO861517L (no)	1986-10-20	Stabilt smakstoffholdig tannpleiemiddel.
FI88825C (fi)	1993-07-12	Aktivt pansar
DE3682960D1 (de)	1992-01-30	Pharmazeutische praeparate.
NO870533D0 (no)	1987-02-11	Terapeutisk aktive 3-alkoksy-2-aminopropylaminer.
NO874193D0 (no)	1987-10-06	Farmasoeytiske preparater.
FI861193L (fi)	1986-09-26	Stabilt gammainterferonpreparat.
FI862444L (fi)	1987-01-09	Medicinhoelje.
DE3675679D1 (de)	1991-01-03	Menschliche bauchspeichelelastase.
FI861253L (fi)	1986-09-28	Revolverkolvstruktur.
EP0257890A3 (de)	1989-03-15	Antikrebsmittel
IT8520591A0 (it)	1985-05-06	Formulazione farmaceutica.
DK674187A (da)	1988-06-23	Aktive forbindelser
FI864235A7 (fi)	1987-04-23	Interleukiini-2-johdos, sen valmistus ja käyttö.
NO864764D0 (no)	1986-11-26	Vaksine.
FI860761L (fi)	1986-08-27	Hopfaellbar stol.
IT8522712A0 (it)	1985-11-04	Preparazioni farmacetuche per uso anticataratta.