DK0689449T3 - Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin - Google Patents

Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin

Info

Publication number: DK0689449T3
Authority: DK; Denmark
Prior art keywords: pct; cytokine; muramyl peptide; preparations; combining
Prior art date: 1993-03-19

Application number

DK94910445T

Other languages

English (en)

Inventor

Louis Chedid

Georges Bahr

Pierre Lefrancier

Original Assignee

Vacsyn Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-19

Filing date

1994-03-21

Publication date

2003-03-03

1993-03-19 Priority claimed from FR9303230A external-priority patent/FR2702659B1/fr

1993-03-31 Priority claimed from FR9303787A external-priority patent/FR2703251B3/fr

1994-03-21 Application filed by Vacsyn Sa filed Critical Vacsyn Sa

2003-03-03 Application granted granted Critical

2003-03-03 Publication of DK0689449T3 publication Critical patent/DK0689449T3/da

Links

108090000695 Cytokines Proteins 0.000 title abstract 2
102000004127 Cytokines Human genes 0.000 title abstract 2
125000001446 muramyl group Chemical group N[C@@H](C=O)[C@@H](O[C@@H](C(=O)*)C)[C@H](O)[C@H](O)CO 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
238000002560 therapeutic procedure Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
238000001727 in vivo Methods 0.000 abstract 2
101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 abstract 1
101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 abstract 1
102000014150 Interferons Human genes 0.000 abstract 1
108010050904 Interferons Proteins 0.000 abstract 1
108010002352 Interleukin-1 Proteins 0.000 abstract 1
102000000589 Interleukin-1 Human genes 0.000 abstract 1
102000051628 Interleukin-1 receptor antagonist Human genes 0.000 abstract 1
108090001007 Interleukin-8 Proteins 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
230000003394 haemopoietic effect Effects 0.000 abstract 1
210000000987 immune system Anatomy 0.000 abstract 1
229940079322 interferon Drugs 0.000 abstract 1
230000001737 promoting effect Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Transplantation (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Virology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK94910445T 1993-03-19 1994-03-21 Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin DK0689449T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR9303230A FR2702659B1 (fr)	1993-03-19	1993-03-19	Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine.
FR9303787A FR2703251B3 (fr)	1993-03-31	1993-03-31	Compositions pour l'application en thérapeutique humaine, caractérisées par l'association d'un muramyl-peptide à une cytokine .
PCT/FR1994/000307 WO1994021275A1 (fr)	1993-03-19	1994-03-21	Compositions pour l'application en therapeutique humaine, caracterisees par l'association d'un muramyl-peptide a une cytokine

Publications (1)

Publication Number	Publication Date
DK0689449T3 true DK0689449T3 (da)	2003-03-03

Family

ID=26230187

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94910445T DK0689449T3 (da)	1993-03-19	1994-03-21	Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin

Country Status (11)

Country	Link
US (1)	US5932208A (da)
EP (1)	EP0689449B1 (da)
JP (1)	JP3723206B2 (da)
AT (1)	ATE226828T1 (da)
AU (1)	AU6285694A (da)
CA (1)	CA2157758A1 (da)
DE (1)	DE69431620T2 (da)
DK (1)	DK0689449T3 (da)
ES (1)	ES2187520T3 (da)
PT (1)	PT689449E (da)
WO (1)	WO1994021275A1 (da)

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US6858409B1 (en)	1988-05-27	2005-02-22	Amgen Inc.	Nucleic acids encoding interleukin-1 inhibitors and processes for preparing interleukin-1 inhibitors
US5075222A (en)	1988-05-27	1991-12-24	Synergen, Inc.	Interleukin-1 inhibitors
US6159460A (en) *	1988-05-27	2000-12-12	Amgen Inc.	Method for treating interleukin-1 mediated diseases
US6267968B1 (en) *	1995-04-07	2001-07-31	Vacsyn S.A.	MDP derivatives and conjugates having haematipoietic function stimulating activity, and compositions containing same
ES2312179T3 (es)	1996-12-06	2009-02-16	Amgen Inc.	Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1.
US6294170B1 (en)	1997-08-08	2001-09-25	Amgen Inc.	Composition and method for treating inflammatory diseases
US6013253A (en) *	1997-08-15	2000-01-11	Amgen, Inc.	Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist
US8106098B2 (en)	1999-08-09	2012-01-31	The General Hospital Corporation	Protein conjugates with a water-soluble biocompatible, biodegradable polymer
CN1441676B (zh)	2000-03-31	2012-08-22	普渡研究基金会	用配体-免疫原缀合物治疗的方法
FR2809106A1 (fr) *	2000-05-17	2001-11-23	Istac	Polypeptide ro/ssa-like et ses fragments et polynucleotides codant lesdits polypeptides et applications therapeutiques
EP2295081B1 (en)	2001-06-26	2018-10-31	Amgen Inc.	Antibodies to OPGL
WO2003002187A2 (en) *	2001-06-26	2003-01-09	Photomed Technologies, Inc.	Multiple wavelength illuminator
EP2168598A1 (en) *	2001-09-28	2010-03-31	Purdue Research Foundation	Method of Treatment Using Ligand-Immunogen Conjugates
US20030097409A1 (en) *	2001-10-05	2003-05-22	Hungchou Tsai	Systems and methods for securing computers
KR101317045B1 (ko)	2002-09-06	2013-10-16	암젠 인코포레이티드	치료학적 인체 항-ｉｌ-1ｒ1 모노클로날 항체
WO2004060911A2 (en) *	2002-12-30	2004-07-22	Amgen Inc.	Combination therapy with co-stimulatory factors
US7546638B2 (en) *	2003-03-18	2009-06-09	Symantec Corporation	Automated identification and clean-up of malicious computer code
PL1708690T3 (pl)	2003-11-17	2017-01-31	Biomarin Pharmaceutical Inc.	Leczenie fenyloketonurii za pomocą BH4
KR20070084270A (ko) *	2004-11-17	2007-08-24	바이오마린 파머수티컬 인크.	안정한 정제 제형물
TW200736277A (en)	2005-11-14	2007-10-01	Amgen Inc	RANKL antibody-PTH/PTHrP chimeric molecules
US8168164B2 (en) *	2006-02-03	2012-05-01	Purdue Research Foundation	Targeted conjugates and radiation
US7767206B2 (en)	2006-10-02	2010-08-03	Amgen Inc.	Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
CN101918018B (zh)	2007-11-14	2012-12-05	再生医药有限公司	使用白介素-1受体拮抗剂作为骨髓保护剂的方法
TW201117824A (en)	2009-10-12	2011-06-01	Amgen Inc	Use of IL-17 receptor a antigen binding proteins
CN101690801B (zh)	2009-10-26	2012-08-01	上海交通大学	白细胞介素-1受体拮抗剂的用途及其药物组合物
WO2013016220A1 (en)	2011-07-22	2013-01-31	Amgen Inc.	Il-17 receptor a is required for il-17c biology
US9216178B2 (en)	2011-11-02	2015-12-22	Biomarin Pharmaceutical Inc.	Dry blend formulation of tetrahydrobiopterin
WO2015191783A2 (en)	2014-06-10	2015-12-17	Abbvie Inc.	Biomarkers for inflammatory disease and methods of using same
WO2018022982A1 (en)	2016-07-29	2018-02-01	Trustees Of Boston University	Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development
US12403181B2 (en)	2018-08-13	2025-09-02	Iltoo Pharma	Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof
WO2023222565A1 (en)	2022-05-16	2023-11-23	Institut National de la Santé et de la Recherche Médicale	Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation
EP4411592B1 (de)	2023-02-06	2025-04-02	Sick Ag	Verfahren zum lesen eines optischen codes und optoelektronischer codeleser

Family Cites Families (3)

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DK585886A (da) *	1985-12-24	1987-06-25	Takeda Chemical Industries Ltd	Immunstimulerende middel og anvendelse deraf
IL83350A0 (en) *	1986-08-13	1987-12-31	Takeda Chemical Industries Ltd	Pharmaceutical compositions comprising interleukin and intterferon active substances
GB8803365D0 (en) *	1988-02-13	1988-03-16	Ciba Geigy Ag	Antiviral combination

1994
- 1994-03-21 EP EP94910445A patent/EP0689449B1/fr not_active Expired - Lifetime
- 1994-03-21 AT AT94910445T patent/ATE226828T1/de not_active IP Right Cessation
- 1994-03-21 DE DE69431620T patent/DE69431620T2/de not_active Expired - Fee Related
- 1994-03-21 WO PCT/FR1994/000307 patent/WO1994021275A1/fr not_active Ceased
- 1994-03-21 US US08/522,342 patent/US5932208A/en not_active Expired - Fee Related
- 1994-03-21 CA CA002157758A patent/CA2157758A1/en not_active Abandoned
- 1994-03-21 PT PT94910445T patent/PT689449E/pt unknown
- 1994-03-21 DK DK94910445T patent/DK0689449T3/da active
- 1994-03-21 AU AU62856/94A patent/AU6285694A/en not_active Abandoned
- 1994-03-21 ES ES94910445T patent/ES2187520T3/es not_active Expired - Lifetime
- 1994-03-21 JP JP52072694A patent/JP3723206B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69431620T2 (de)	2003-07-03
ATE226828T1 (de)	2002-11-15
EP0689449A1 (fr)	1996-01-03
PT689449E (pt)	2003-03-31
ES2187520T3 (es)	2003-06-16
DE69431620D1 (de)	2002-12-05
CA2157758A1 (en)	1994-09-29
JPH08511235A (ja)	1996-11-26
US5932208A (en)	1999-08-03
EP0689449B1 (fr)	2002-10-30
JP3723206B2 (ja)	2005-12-07
AU6285694A (en)	1994-10-11
WO1994021275A1 (fr)	1994-09-29

Publication	Publication Date	Title
DK0689449T3 (da)	2003-03-03	Præparater til anvendelse i humanterapi, kendetegnet ved kombination af et muramylpeptid med en cytokin
CA1288694C (en)	1991-09-10	Process for treatment of diseases
IT1261949B (it)	1996-06-04	Composizione terapeutica a base di interferone umano, impiego di interferone umano in tale composizione e relativo metodo.
KR950700333A (ko)	1995-01-16	개량된 알파 인터페론 조성물 및 인간 말초혈 백혈구로부터의 제조 방법(improved alpha interferon composition and method for its production from human peripheral blood leukocytes)
DK0751992T3 (da)	2006-03-06	Karendotelvækstfaktor 2
ES2149276T3 (es)	2000-11-01	Imidazo(4,5-c)piridin-4-aminas.
EP0787802A3 (da)	1997-08-27
ATE205254T1 (de)	2001-09-15	Transformierender wachstumsfaktor alpha h1
DK0669979T3 (da)	2006-03-06	C-C CKR-1, kemokinreceptor
DE69719754D1 (de)	2003-04-17	Therapeutische verwendungen von bpi-protein produkten bei menschen mit durch trauma verursachter blutung
DK0613499T3 (da)	1998-09-23	Humame IT-4-mutantproteiner
NO964200L (no)	1996-10-03	Behandling av autoimmun sykdom ved anvendelse av oral tolerisering og/eller Th2-forsterkende cytokiner
Morhenn	1986	The etiology of lichen planus: a hypothesis
HUP0000248A2 (hu)	2000-06-28	Nagy affinitású interleukin-4 muteinek
CA2388338A1 (en)	2001-05-03	Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies
NO971378L (no)	1997-06-05	Cytokin betegnet LERK-6
ATE205531T1 (de)	2001-09-15	Lo-cd2a antikörper und dessen verwendung zur inhibition von t-zell-aktivierung und -wachstum
NZ504955A (en)	2002-11-26	The use of TH1 and TH2 cytokines for the preparation of an oromucosal medicament
ATE159172T1 (de)	1997-11-15	Peptide und deren verwendung
ATE442387T1 (de)	2009-09-15	Dimerisierter t-zell rezeptor fragment, dessen zusammensetzungen und verwendung
BR9713096A (pt)	2000-10-24	Lactação bovina associada à proteìna imunotrópica (cd14), gene codificado e aplicação na ativação de célula b
DK0862454T3 (da)	2002-12-30	CTLA-8 i kombination med G-CSF eller med G-CSF og IL-6 og anvendelse af CTLA-8 til behandling af infektioner
IT1277926B1 (it)	1997-11-12	Uso di muteine di citochine naturali come immunogeni per la preparazione di composizioni farmaceutiche per curare o prevenire
AU9743698A (en)	1999-04-05	Allelic variant of human stat3
WO2000009150A3 (en)	2000-05-11	Cytokine and cytokine receptor, agonist, antagonist and/or antibody combination for therapeutic use