ATE67768T1 - Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese. - Google Patents

Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese.

Info

Publication number
ATE67768T1
ATE67768T1 AT87400739T AT87400739T ATE67768T1 AT E67768 T1 ATE67768 T1 AT E67768T1 AT 87400739 T AT87400739 T AT 87400739T AT 87400739 T AT87400739 T AT 87400739T AT E67768 T1 ATE67768 T1 AT E67768T1
Authority
AT
Austria
Prior art keywords
radical
hydrogen atom
denotes
image
nucleoside derivatives
Prior art date
Application number
AT87400739T
Other languages
English (en)
Inventor
Didier Molko
Jean-Claude Schulhof
Robert Teoule
Original Assignee
Commissariat Energie Atomique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique filed Critical Commissariat Energie Atomique
Application granted granted Critical
Publication of ATE67768T1 publication Critical patent/ATE67768T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
AT87400739T 1986-04-08 1987-04-03 Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese. ATE67768T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8604990A FR2596761B1 (fr) 1986-04-08 1986-04-08 Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
EP87400739A EP0241363B1 (de) 1986-04-08 1987-04-03 Nukleosid-Derivate und ihre Verwendung in der Oligonukleosid-Synthese

Publications (1)

Publication Number Publication Date
ATE67768T1 true ATE67768T1 (de) 1991-10-15

Family

ID=9334007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87400739T ATE67768T1 (de) 1986-04-08 1987-04-03 Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese.

Country Status (8)

Country Link
US (1) US4980460A (de)
EP (2) EP0241363B1 (de)
JP (2) JPH0631305B2 (de)
AT (1) ATE67768T1 (de)
DE (3) DE3751947T2 (de)
ES (1) ES2001000A4 (de)
FR (1) FR2596761B1 (de)
GR (1) GR880300040T1 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204456A (en) * 1986-04-08 1993-04-20 Commissariat A L'energie Atomique Derivatives of nucleosides and their use for the synthesis of oligonucleotides
FR2621591B1 (fr) * 1987-10-08 1990-01-12 Commissariat Energie Atomique Derives de nucleosides, notamment de desoxy-2' cytidine et leur utilisation pour la synthese d'oligonucleotides
GB8822228D0 (en) * 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5047524A (en) * 1988-12-21 1991-09-10 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
US5262530A (en) * 1988-12-21 1993-11-16 Applied Biosystems, Inc. Automated system for polynucleotide synthesis and purification
GB9009980D0 (en) * 1990-05-03 1990-06-27 Amersham Int Plc Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides
US5616700A (en) * 1992-04-24 1997-04-01 Beckman Instruments, Inc. Processes for synthesizing nucleotides and modified nucleotides using N.sub.
US5428148A (en) * 1992-04-24 1995-06-27 Beckman Instruments, Inc. N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
US5348868A (en) * 1992-04-24 1994-09-20 Beckman Instruments, Inc. Methods and reagents for cleaving and deprotecting oligonucleotides
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
ATE150464T1 (de) * 1993-01-08 1997-04-15 Hybridon Inc Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
US5623068A (en) * 1994-03-07 1997-04-22 Beckman Instruments, Inc. Synthesis of DNA using substituted phenylacetyl-protected nucleotides
DE4418691A1 (de) * 1994-05-28 1996-02-22 Boehringer Mannheim Gmbh 3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
US5872244A (en) * 1994-09-02 1999-02-16 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US6214987B1 (en) 1994-09-02 2001-04-10 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides
US5808045A (en) * 1994-09-02 1998-09-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US6232465B1 (en) 1994-09-02 2001-05-15 Andrew C. Hiatt Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5990300A (en) * 1994-09-02 1999-11-23 Andrew C. Hiatt Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides
US5763594A (en) * 1994-09-02 1998-06-09 Andrew C. Hiatt 3' protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
CA2332731A1 (en) 1995-06-07 1996-12-19 Sydney Brenner Oligonucleotide tags for sorting and identification
JP2000500740A (ja) * 1995-10-19 2000-01-25 プロリゴ・エルエルシー オリゴヌクレオチドの溶液相合成方法
EP0932698A1 (de) * 1996-03-26 1999-08-04 Lynx Therapeutics, Inc. Oligonukleotide zusammenstellungen zur behandlung von menschlichem melanom
US6060240A (en) * 1996-12-13 2000-05-09 Arcaris, Inc. Methods for measuring relative amounts of nucleic acids in a complex mixture and retrieval of specific sequences therefrom
US6326479B1 (en) 1998-01-27 2001-12-04 Boston Probes, Inc. Synthetic polymers and methods, kits or compositions for modulating the solubility of same
US6153411A (en) 1998-10-30 2000-11-28 American Water Works Company, Inc. Methods and kits for detection of Cryptosporidium parvum using immunomagnetic separation and amplification
US6184347B1 (en) 1998-11-19 2001-02-06 Agilent Technologies Inc. Minimization of blooming in high-density arrays by using reactive wash reagents
WO2000056749A1 (en) 1999-03-24 2000-09-28 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services N-acylphosphoramidites and their use in oligonucleotide synthesis
US6221635B1 (en) 1999-05-06 2001-04-24 The Wistar Institute Methods for solid-phase amplification of DNA template (SPADT) using multiarrays
US20070059752A1 (en) * 1999-06-09 2007-03-15 Biosearch Technologies, Inc. Fluorescence energy transfer probes with stabilized conformations
US7019129B1 (en) 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
WO2001094609A1 (en) 2000-06-07 2001-12-13 Li-Cor, Inc. Charge-switch nucleotides
EP1176151B1 (de) 2000-07-28 2014-08-20 Agilent Technologies, Inc. Synthese von Polynukleotiden unter Gebrauch von kombinierter Oxidations- und Entschützungschemie
EP1349958B1 (de) 2000-09-26 2009-06-03 Boston Probes, Inc. Sonden, sondensätzen,verfahren und kits zur nachweis, identifizierung und/oder die zählung von bakterien
US6794141B2 (en) 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
PL373962A1 (en) 2001-05-21 2005-09-19 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
US7118907B2 (en) * 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
JP4500540B2 (ja) * 2001-06-29 2010-07-14 ヴェリ‐キュー，インコーポレイテッド 化学的に合成された核酸の純度を決定し、かつ化学的に合成された核酸を精製するための方法および組成物
US7355037B2 (en) * 2001-12-03 2008-04-08 The United States Of America As Represented By The Department Of Health And Human Services Thermolabile hydroxyl protecting groups and methods of use
US7255874B1 (en) 2001-12-21 2007-08-14 Closure Medical Corporation Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
EP1485503A4 (de) * 2002-03-15 2005-12-28 Arcturus Bioscience Inc Verbesserte nukleinsäureamplifikation
US7291460B2 (en) * 2002-05-31 2007-11-06 Verenium Corporation Multiplexed systems for nucleic acid sequencing
WO2004022578A2 (en) * 2002-09-08 2004-03-18 Applera Corporation Methods, compositions and libraries pertaining pna dimer and pna oligomer synthesis
WO2004092331A2 (en) * 2003-04-08 2004-10-28 Li-Cor, Inc. Composition and method for nucleic acid sequencing
US7385050B2 (en) 2003-08-30 2008-06-10 Agilent Technologies, Inc. Cleavable linker for polynucleotide synthesis
US7193077B2 (en) 2003-08-30 2007-03-20 Agilent Technologies, Inc. Exocyclic amine triaryl methyl protecting groups in two-step polynucleotide synthesis
US7417139B2 (en) 2003-08-30 2008-08-26 Agilent Technologies, Inc. Method for polynucleotide synthesis
US7427679B2 (en) * 2003-08-30 2008-09-23 Agilent Technologies, Inc. Precursors for two-step polynucleotide synthesis
US9809824B2 (en) * 2004-12-13 2017-11-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
US7608433B2 (en) 2005-02-09 2009-10-27 Idexx Laboratories Method of detection of classical swine fever
WO2007008252A1 (en) * 2005-07-12 2007-01-18 Temple University - Of The Commonwealth Systems Of Higher Education Genetic and epigenetic alterations in the diagnosis and treatment of cancer
WO2007047408A2 (en) * 2005-10-12 2007-04-26 Pathologica, Llc. Promac signature application
EP2389452A2 (de) 2009-01-21 2011-11-30 Vertex Pharmaceuticals Incorporated Verfahren zur amplifikation von hepatitis-c-virus-nukleinsäuren
PT2658570T (pt) 2010-12-27 2019-02-08 Elanco Us Inc Composições e métodos vacinais contra o vírus da diarreia viral bovina tipo 1b
AR084358A1 (es) 2010-12-27 2013-05-08 Lilly Co Eli Composiciones y metodos para identificar y diferenciar componentes virales de vacunas multivalentes de la “fiebre de embarque” (complejo de enfermedad respiratoria bovina (brdc))
BRPI1107329A2 (pt) 2010-12-30 2019-11-19 Dow Agrosciences Llc moléculas de ácido nucléico que direcionadas à subunidade h de atpase vacuolar que conferem resistência a pragas de coleópteros, vetor de transformação de planta, célula transformada, bem como métodos para controlar uma população de praga de coleóptero, controlar uma infestação pela dita praga, melhorar o rendimento de uma safra e para produzir uma célula transgênica
WO2012092596A2 (en) 2010-12-30 2012-07-05 Dow Agrosciences Llc Nucleic acid molecules that target the rho1 small gtp-binding protein and confer resistance to coleopteran pests
CN104542694B (zh) 2010-12-30 2017-06-20 陶氏益农公司 靶向液泡atp酶c亚基并赋予对鞘翅目有害生物的抗性的核酸分子
MX345613B (es) 2010-12-30 2017-02-07 Dow Agrosciences Llc Moleculas de acido nucleico que confieren resistencia a pestes de coleopteran.
ES2683707T3 (es) 2012-05-02 2018-09-27 Ibis Biosciences, Inc. Secuenciación de ADN
US10584377B2 (en) 2012-05-02 2020-03-10 Ibis Biosciences, Inc. DNA sequencing
EP2850086B1 (de) 2012-05-18 2023-07-05 Pacific Biosciences Of California, Inc. Heteroarylcyaninfarbstoffe
WO2014063051A2 (en) 2012-10-18 2014-04-24 Idexx Laboratories, Inc. Nucleic acid amplification controls and kits and methods of use thereof
US20160046997A1 (en) 2012-10-18 2016-02-18 Oslo Universitetssykehus Hf Biomarkers for cervical cancer
BR102014031844A2 (pt) 2013-12-20 2015-10-06 Dow Agrosciences Llc ras oposto (rop) e moléculas de ácido nucleico relacionadas que conferem resistência a pragas de coleópteros e hemípteros
EP3082469B1 (de) 2013-12-20 2023-09-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Rnapii-140-nukleinsäuremoleküle zur verleihung von resistenz gegen schädlinge der art coleoptera
EP3140406B1 (de) 2014-05-07 2022-06-29 Dow AgroSciences LLC Dre4-nukleinsäuremoleküle zur verleihung von resistenz gegen coleoptera-schädlinge
US10093967B2 (en) 2014-08-12 2018-10-09 The Regents Of The University Of Michigan Detection of nucleic acids
US20160194658A1 (en) 2014-12-22 2016-07-07 Dow Agrosciences Llc Nucampholin nucleic acid molecules to control coleopteran insect pests
US20160264991A1 (en) 2015-03-13 2016-09-15 Dow Agrosciences Llc Rna polymerase i1 nucleic acid molecules to control insect pests
BR102016012010A2 (pt) 2015-05-29 2020-03-24 Dow Agrosciences Llc Molécula de ácido nucleico, de ácido ribonucleico (rna) e de ácido ribonucleico de filamento duplo (dsrna), usos de célula, planta e semente, produto primário, bem como métodos para controlar uma população de pragas coleópteras e/ou hemípteras, para melhorar o rendimento de uma cultura, e para produzir uma célula vegetal transgênica e uma planta transgênica
GB201511470D0 (en) 2015-06-30 2015-08-12 Cellcall Kft HPV detection method
WO2018089237A1 (en) 2016-11-10 2018-05-17 Dow Agrosciences Llc Cytochrome b (cytb) nucleic acid molecules that control pathogens
EP3342780A1 (de) 2016-12-30 2018-07-04 Dow AgroSciences LLC Nukleinsäuremoleküle mit prä-mrna-verarbeitungsfaktor 8 (prp8) zur kontrolle von insektenschädlingen
JP7145517B2 (ja) 2017-03-08 2022-10-03 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 分析物の検出

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500707A (en) * 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
ATE7702T1 (de) * 1980-02-29 1984-06-15 University Patents, Inc. Verfahren zum entfernen von trityl-schutzgruppen aus 5'-o-trityl-nukleosiden und oligonukleotiden.
EP0090789A1 (de) * 1982-03-26 1983-10-05 Monsanto Company Chemische DNA-Synthese
JPH0829090B2 (ja) * 1985-03-28 1996-03-27 チロン コ−ポレイシヨン ポリヌクレオチドの製造方法
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates

Also Published As

Publication number Publication date
FR2596761A1 (fr) 1987-10-09
DE3773245D1 (de) 1991-10-31
DE3751947D1 (de) 1996-12-12
US4980460A (en) 1990-12-25
FR2596761B1 (fr) 1988-05-20
JPH0694475B2 (ja) 1994-11-24
EP0241363B1 (de) 1991-09-25
EP0241363A1 (de) 1987-10-14
EP0438203A3 (en) 1991-09-25
EP0438203B1 (de) 1996-11-06
JPS62294692A (ja) 1987-12-22
JPH06199888A (ja) 1994-07-19
DE3751947T2 (de) 1997-05-07
DE241363T1 (de) 1988-06-30
JPH0631305B2 (ja) 1994-04-27
ES2001000A4 (es) 1988-04-16
EP0438203A2 (de) 1991-07-24
GR880300040T1 (en) 1988-10-18

Similar Documents

Publication Publication Date Title
DE3773245D1 (de) Nukleosid-derivate und ihre verwendung in der oligonukleosid-synthese.
AU692658B2 (en) Nucleoside derivatives with photolabile protective groups
NL300247I1 (nl) 2-Halogeen-9-(2-desoxy-2-fluor-bêta-D-arabinofuranosyl)-adeninenucleosiderivaten.
DE69109482D1 (en) Pyrimidinnucleosidderivat.
CO4520226A1 (es) Compuestos carbociclicos
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
ES8802363A1 (es) Procedimiento para la fabricacion de derivados nucleosidos
SE8902568L (sv) Antiviral komposition
DE59704973D1 (de) Nucleosid-derivate mit photolabilen schutzgruppen
GR3004855T3 (de)
ES8501416A1 (es) 5'-alquil o alquenil-fosfatos de nucleosidos.
DK163055C (da) Analogifremgangsmaade til fremstilling af 2-dipropylamino-(5 eller 7)-formylamino-6-hydroxy-1,2,3,4-tetrahydronaphthalen og farmakologisk acceptable syreadditionssalte deraf
IL89324A0 (en) Therapeutic agents for the treatment of peptic ulcer disease containing xanthine derivatives
KR900009683A (ko) 피리미딘 2 -메틸리덴 뉴클레오시드 화합물
DK37790A (da) Indolderivater, deres fremstilling og anvendelse
ATE26268T1 (de) 2-alkoxyaminosulfonylbenzolsulfonyl-harnstoffderivate.
DE3372963D1 (en) Novel aminonaphthacene derivatives and process for preparation thereof
GB2071093B (en) Benzothiopyrano(2,3-c)pyridines
JPS55167291A (en) Xanthine derivative
MX9702886A (es) Derivados de nucleosidos y proceso para preparalos.
KR960031456A (ko) 새로운 테트라하이드로피란 유도체 및 그 제조방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties