ATE68346T1 - Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. - Google Patents

Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Info

Publication number: ATE68346T1
Authority: AT; Austria
Prior art keywords: weight percent; valproic acid; moisture; stable solid; production
Prior art date: 1987-07-22

Application number

AT87810611T

Other languages

English (en)

Inventor

Aracelis M Dr Ortega

Perez Pilar Martin Dr De

Margarita De

Original Assignee

Farvalsa Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-22

Filing date

1987-10-23

Publication date

1991-11-15

1987-10-23 Application filed by Farvalsa Ag filed Critical Farvalsa Ag

1991-11-15 Application granted granted Critical

1991-11-15 Publication of ATE68346T1 publication Critical patent/ATE68346T1/de

Links

NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title abstract 8
229960000604 valproic acid Drugs 0.000 title abstract 4
239000007787 solid Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229920002261 Corn starch Polymers 0.000 abstract 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
239000011230 binding agent Substances 0.000 abstract 1
239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
239000008120 corn starch Substances 0.000 abstract 1
239000007884 disintegrant Substances 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
239000000395 magnesium oxide Substances 0.000 abstract 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 1
235000019359 magnesium stearate Nutrition 0.000 abstract 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 1
229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT87810611T 1987-07-22 1987-10-23 Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung. ATE68346T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7663487A	1987-07-22	1987-07-22
EP87810611A EP0300111B1 (de)	1987-07-22	1987-10-23	Feuchtigkeitsstabile feste Valproinsäure-Zubereitung und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number	Publication Date
ATE68346T1 true ATE68346T1 (de)	1991-11-15

Family

ID=22133265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87810611T ATE68346T1 (de)	1987-07-22	1987-10-23	Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.

Country Status (6)

Country	Link
US (1)	US5049586A (de)
EP (1)	EP0300111B1 (de)
AT (1)	ATE68346T1 (de)
DE (1)	DE3773926D1 (de)
ES (1)	ES2026198T3 (de)
GR (1)	GR3003187T3 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR1002098B (en) *	1989-06-08	1995-12-28	Squibb & Sons Inc	Pharmaceutical composition having good stability
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
MY110880A (en) *	1991-01-30	1999-06-30	The Wellcome Foundation Ltd	Water-dispersible tablets
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
US20040191314A1 (en) *	1994-04-28	2004-09-30	Frank Jao	Antiepileptic dosage form and process for protecting antiepileptic drug
ZA953078B (en) *	1994-04-28	1996-01-05	Alza Corp	Effective therapy for epilepsies
US5681854A (en) *	1995-11-22	1997-10-28	Alcon Laboratories, Inc.	Use of aliphatic carboxylic acid derivatives in ophthalmic disorders
CN1063971C (zh) *	1997-09-24	2001-04-04	中国兽药监察所	一种动物用冻干活疫苗制造方法
US6300328B1 (en)	1999-08-06	2001-10-09	Alcon Universal Ltd.	Selective inhibitors of adenosine monophosphate deaminase for the treatment of optic nerve and retinal damage
BR0016415A (pt) *	1999-12-16	2002-12-24	Alcon Inc	Inibidores de adenosina cinase para o tratamento de dano retinal e de nervo ótico
US20020143058A1 (en)	2001-01-24	2002-10-03	Taro Pharmaceutical Inductries Ltd.	Process for preparing non-hygroscopic sodium valproate composition
US6610326B2 (en) *	2001-02-16	2003-08-26	Andrx Corporation	Divalproex sodium tablets
US20040105886A1 (en) *	2001-02-16	2004-06-03	Chih-Ming Chen	Divalproex sodium tablets
NZ540288A (en)	2002-11-22	2009-06-26	Univ Johns Hopkins	Target for therapy of cognitive impairment
MXPA05005937A (es)	2002-12-06	2005-08-18	Alcon Inc	Imitaciones de superoxido de dismutasa para el tratamiento de trastornos y enfermedades oculares.
US20040176463A1 (en) *	2003-02-05	2004-09-09	Daniella Licht	Immediate release formulation of n-(2-propylpentanoyl)glycinamide
MXPA06006187A (es) *	2003-12-11	2006-08-25	Alcon Inc	Imitadores de super oxido dismutasa para el tratamiento de dano retinal y de nervio optico.
US20050276849A1 (en) *	2004-06-15	2005-12-15	Nilobon Podhipleux	Sustained release dosage forms
US7713550B2 (en) *	2004-06-15	2010-05-11	Andrx Corporation	Controlled release sodium valproate formulation
US20070048379A1 (en) *	2005-08-29	2007-03-01	Mintong Guo	Valproate tablet
JP2009525953A (ja) *	2006-01-11	2009-07-16	テバファーマシューティカルインダストリーズリミティド	ジバルプロ酸及びその誘導体の徐放性製剤
DE602006003848D1 (de) *	2006-01-11	2009-01-08	Teva Pharma	Formulierung zur verzögerten Freisetzung von Valproinsäure und deren Derivate
US20070160667A1 (en) *	2006-01-11	2007-07-12	Nava Shterman	Controlled release formulation of divalproex sodium
US7625927B2 (en) *	2006-02-27	2009-12-01	Alcon Research, Ltd.	Method of treating glaucoma
WO2008001151A1 (en) *	2006-06-29	2008-01-03	Wockhardt Limited	Controlled release compositions of divalproex sodium
US20110203586A1 (en) *	2008-02-20	2011-08-25	Boehringer Ingelheim International Gmbh	Powder Inhalers
US20090235929A1 (en) *	2008-03-19	2009-09-24	Marc Egen	Powder inhalers
ES2865504T3 (es)	2008-10-16	2021-10-15	Univ Johns Hopkins	Procedimientos y composiciones para la mejora de la función cognitiva
AU2011215870B2 (en) *	2010-02-09	2016-01-28	The Johns Hopkins University	Methods and compositions for improving cognitive function
DK2683371T3 (da) *	2011-03-09	2021-01-18	Cereno Scient Ab	Forbindelser og fremgangsmåder til forbedring af forringet endogen fibrinolyse ved anvendelse af histondeacetylasehæmmere
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
WO2014144663A1 (en)	2013-03-15	2014-09-18	The Johns Hopkins University	Methods and compositions for improving cognitive function
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
GB201417828D0 (en)	2014-10-08	2014-11-19	Cereno Scient Ab	New methods and compositions
WO2016191288A1 (en)	2015-05-22	2016-12-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
CA3018043A1 (en)	2016-04-08	2017-10-12	Cereno Scientific Ab	Delayed release pharmaceutical formulations comprising valproic acid, and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL32673A (en) *	1968-08-05	1973-11-28	Ciba Geigy Ag	A granular material containing oily or liquid therapeutically usable furanosides and a process for its manufacture
US4301176A (en) *	1980-08-18	1981-11-17	Warner-Lambert Company	Method of administering calcium valproate
NL8600050A (nl) *	1986-01-13	1987-08-03	Sanico Nv	Farmaceutisch preparaat met vertraagde afgifte van het werkzame bestanddeel en werkwijze voor de bereiding er van.

1987
- 1987-10-23 AT AT87810611T patent/ATE68346T1/de not_active IP Right Cessation
- 1987-10-23 DE DE8787810611T patent/DE3773926D1/de not_active Expired - Fee Related
- 1987-10-23 ES ES198787810611T patent/ES2026198T3/es not_active Expired - Lifetime
- 1987-10-23 EP EP87810611A patent/EP0300111B1/de not_active Expired
1990
- 1990-05-02 US US07/517,620 patent/US5049586A/en not_active Expired - Fee Related
1991
- 1991-11-25 GR GR91401648T patent/GR3003187T3/el unknown

Also Published As

Publication number	Publication date
ES2026198T3 (es)	1992-04-16
GR3003187T3 (en)	1993-02-17
EP0300111B1 (de)	1991-10-16
EP0300111A1 (de)	1989-01-25
US5049586A (en)	1991-09-17
DE3773926D1 (de)	1991-11-21

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Legal Events

Date	Code	Title	Description
1992-06-15	UEP	Publication of translation of european patent specification
1995-07-15	REN	Ceased due to non-payment of the annual fee