ATE71622T1 - Neue benzothiazinabkoemmlinge. - Google Patents

Neue benzothiazinabkoemmlinge.

Info

Publication number: ATE71622T1
Authority: AT; Austria
Prior art keywords: hydrogen; pct; lower alkyl; nitro; sec
Prior art date: 1985-07-29

Application number

AT86904393T

Other languages

English (en)

Inventor

Jun-Ichi Iwao

Tadashi Iso

Masayuki Oya

Original Assignee

Santen Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-29

Filing date

1986-07-21

Publication date

1992-02-15

1985-07-29 Priority claimed from PCT/JP1985/000426 external-priority patent/WO1987000837A1/ja

1986-07-21 Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd

1992-02-15 Application granted granted Critical

1992-02-15 Publication of ATE71622T1 publication Critical patent/ATE71622T1/de

Links

UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical compound C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000005194 alkoxycarbonyloxy group Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
-1 nitro, hydroxy Chemical group 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Sheets, Magazines, And Separation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)

AT86904393T 1985-07-29 1986-07-21 Neue benzothiazinabkoemmlinge. ATE71622T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
PCT/JP1985/000426 WO1987000837A1 (fr)	1985-07-29	1985-07-29	Nouveaux derives de benzothiazine
JP17353185		1985-08-06
PCT/JP1986/000379 WO1987000838A1 (fr)	1985-07-29	1986-07-21	Nouveaux derives de benzothiazine
EP86904393A EP0237573B1 (de)	1985-07-29	1986-07-21	Neue benzothiazinabkömmlinge

Publications (1)

Publication Number	Publication Date
ATE71622T1 true ATE71622T1 (de)	1992-02-15

Family

ID=15962257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86904393T ATE71622T1 (de)	1985-07-29	1986-07-21	Neue benzothiazinabkoemmlinge.

Country Status (10)

Country	Link
US (1)	US4786635A (de)
EP (1)	EP0237573B1 (de)
KR (1)	KR890004196B1 (de)
AT (1)	ATE71622T1 (de)
AU (1)	AU587057B2 (de)
DE (1)	DE3683483D1 (de)
DK (1)	DK158087D0 (de)
FI (1)	FI87352C (de)
NO (1)	NO170082C (de)
WO (1)	WO1987000838A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3614363A1 (de) *	1986-04-28	1987-10-29	Hoechst Ag	Benzothiazinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
AT389113B (de) *	1987-10-08	1989-10-25	Hoechst Ag	Neue benzothiazinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
AT389112B (de) *	1987-10-08	1989-10-25	Hoechst Ag	Benzothiazinon-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
EP0429676B1 (de) *	1989-06-16	1996-09-18	Santen Pharmaceutical Co., Ltd	Arzneimittel für bessere gehirnwirkung
DE69117030T2 (de)	1990-11-29	1996-07-18	Daiichi Seiyaku Co	Therapeutisches Mittel gegen Glaukom, das 2-Phenyl-3-oxo-2H-1,4-Benzothiazinderivate enthält
PL343317A1 (en)	1998-03-31	2001-08-13	Warner Lambert Co	Benzoxazinones/benzothiazinones as serine protease inhibitors
AU2003250483A1 (en)	2002-08-19	2004-03-11	Pfizer Products Inc.	Combination therapy for hyperproliferative diseases
JP2008507585A (ja) *	2004-07-26	2008-03-13	コセリックスインク	微粒子製剤を用いて吸入したイロプロストによる肺高血圧症の治療
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
WO2007050783A2 (en) *	2005-10-26	2007-05-03	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (de)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US20090069413A1 (en) *	2007-09-09	2009-03-12	Protia, Llc	Deuterium-enriched olopatadine
WO2012037665A1 (en)	2010-09-24	2012-03-29	Oral Delivery Technology Ltd.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
EP2986599A1 (de)	2013-04-17	2016-02-24	Pfizer Inc.	N-piperidin-3-ylbenzamid-derivate zur behandlung von herz-kreislauf-erkrankungen
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5651465A (en) *	1979-10-02	1981-05-09	Yoshitomi Pharmaceut Ind Ltd	Benzothiazine derivative
JPS59148771A (ja) *	1983-02-09	1984-08-25	Santen Pharmaceut Co Ltd	ベンゾチアジン誘導体
JPS59144775A (ja) *	1983-02-07	1984-08-18	Santen Pharmaceut Co Ltd	ヒドロキシフエニルベンゾチアジン誘導体およびその製造法
US4584300A (en) *	1983-02-07	1986-04-22	Santen Pharmaceutical Co., Ltd.	Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
DE3347173A1 (de) *	1983-12-27	1985-07-04	Hoechst Ag, 6230 Frankfurt	Neue benzothiazin-derivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung
JPS60166674A (ja) *	1984-02-09	1985-08-29	Santen Pharmaceut Co Ltd	ベンゾチアジン誘導体
AU5511986A (en) *	1985-03-19	1986-10-13	Santen Pharmaceutical Co. Ltd.	2-arylbenzothiazine derivatives
AU4673285A (en) *	1985-07-29	1987-03-05	Santen Pharmaceutical Co. Ltd.	Novel benzothiazine derivatives

1986
- 1986-07-21 KR KR1019870700275A patent/KR890004196B1/ko not_active Expired
- 1986-07-21 AU AU61371/86A patent/AU587057B2/en not_active Ceased
- 1986-07-21 US US07/034,164 patent/US4786635A/en not_active Expired - Fee Related
- 1986-07-21 DE DE8686904393T patent/DE3683483D1/de not_active Expired - Lifetime
- 1986-07-21 EP EP86904393A patent/EP0237573B1/de not_active Expired - Lifetime
- 1986-07-21 WO PCT/JP1986/000379 patent/WO1987000838A1/ja not_active Ceased
- 1986-07-21 AT AT86904393T patent/ATE71622T1/de not_active IP Right Cessation
1987
- 1987-03-26 FI FI871322A patent/FI87352C/fi not_active IP Right Cessation
- 1987-03-27 DK DK158087A patent/DK158087D0/da unknown
- 1987-03-27 NO NO871314A patent/NO170082C/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI87352C (fi)	1992-12-28
AU6137186A (en)	1987-03-05
KR890004196B1 (ko)	1989-10-27
FI871322A0 (fi)	1987-03-26
DE3683483D1 (de)	1992-02-27
DK158087A (da)	1987-03-27
NO170082C (no)	1992-09-09
FI87352B (fi)	1992-09-15
EP0237573A1 (de)	1987-09-23
WO1987000838A1 (fr)	1987-02-12
EP0237573B1 (de)	1992-01-15
KR870700613A (ko)	1987-12-30
NO871314D0 (no)	1987-03-27
FI871322A7 (fi)	1987-03-26
AU587057B2 (en)	1989-08-03
US4786635A (en)	1988-11-22
EP0237573A4 (de)	1987-10-26
DK158087D0 (da)	1987-03-27
NO170082B (no)	1992-06-01

Legal Events

Date	Code	Title	Description
1992-09-15	UEP	Publication of translation of european patent specification
2001-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE71622T1 (de)	1992-02-15	Neue benzothiazinabkoemmlinge.
IL104305A0 (en)	1993-05-13	Piperazine derivatives,their preparation and pharmaceutical compositions containing them
ES8802521A1 (es)	1988-07-16	Un procedimiento para la obtencion de 1,3-dihidro-2h-imidazo (4,5-b)-quinolin-2-onas
ES8604128A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
AU3022484A (en)	1985-01-17	Triazolo(3,4-a)phthalazine and their use as anti-anxiety agents
GR3002051T3 (en)	1992-12-30	3-oxadiazolyl and 3-carboxylic-acid beta-carboline derivatives, their preparation and their use as medicaments
ATE53032T1 (de)	1990-06-15	2-thiazolylimidazo(1,2-a)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
ES2012648A6 (es)	1990-04-01	Procedimiento para la preparacion de nuevos derivados de 1,4-benzoxazina y 1,4-benzotiazina.
GB2115815B (en)	1985-06-19	Benzothiazoline compounds
DE3375784D1 (en)	1988-04-07	1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino (2,1-alpha) isoquinolines useful as intermediates and pharmaceutical compounds and methods of preparation
ATE52776T1 (de)	1990-06-15	1-phenyl-3-benzazepine.
NO872874L (no)	1987-07-10	Amid-derivater.
ES8401952A1 (es)	1984-01-01	Un procedimiento para preparar nuevos derivados de 1,4-benzotiazina.
ES8705405A1 (es)	1987-05-16	Procedimiento de preparar nuevos derivados morfolinicos
NZ218918A (en)	1989-04-26	4-oxo-1,4-dihydro-quinoline 3-carboxamides,their preparation and pharmaceutical compositions containing them
ES8707939A1 (es)	1987-09-01	Procedimiento para preparar derivados de n-carboxialquil-2--oxo-3-diaril-5,6-triazinas
DE3160719D1 (en)	1983-09-08	Benzothiopyrano(2,3-c) pyridines and their acid addition salts, their preparation, their use as medicaments and compositions containing them
NO842825L (no)	1985-01-14	Pyridazino(4,3-c) isokinolinderivater og fremgangsmaate for deres fremstilling
AU579416B2 (en)	1988-11-24	3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
DE3782229D1 (de)	1992-11-19	Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.