ATE74512T1 - Pharmazeutische zusammensetzungen von rekombinanten interleukin-2 und herstellungsverfahren. - Google Patents
Pharmazeutische zusammensetzungen von rekombinanten interleukin-2 und herstellungsverfahren.Info
- Publication number
- ATE74512T1 ATE74512T1 AT87115694T AT87115694T ATE74512T1 AT E74512 T1 ATE74512 T1 AT E74512T1 AT 87115694 T AT87115694 T AT 87115694T AT 87115694 T AT87115694 T AT 87115694T AT E74512 T1 ATE74512 T1 AT E74512T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical compositions
- recombinant interleukin
- manufacture
- solubilizer
- stabilizers
- Prior art date
Links
- 102000000588 Interleukin-2 Human genes 0.000 title abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92338386A | 1986-10-27 | 1986-10-27 | |
| EP87115694A EP0268110B1 (de) | 1986-10-27 | 1987-10-26 | Pharmazeutische Zusammensetzungen von rekombinanten Interleukin-2 und Herstellungsverfahren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE74512T1 true ATE74512T1 (de) | 1992-04-15 |
Family
ID=25448603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87115694T ATE74512T1 (de) | 1986-10-27 | 1987-10-26 | Pharmazeutische zusammensetzungen von rekombinanten interleukin-2 und herstellungsverfahren. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0268110B1 (de) |
| JP (1) | JPS63122628A (de) |
| AT (1) | ATE74512T1 (de) |
| AU (1) | AU614066B2 (de) |
| CA (1) | CA1292686C (de) |
| DE (1) | DE3778122D1 (de) |
| ES (1) | ES2036558T3 (de) |
| GR (1) | GR3004479T3 (de) |
| IE (1) | IE60890B1 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037644A (en) * | 1986-10-27 | 1991-08-06 | Cetus Corporation | Pharmaceutical compositions of recombinant interleukin-2 and formulation processes |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
| US7307166B1 (en) | 1987-10-28 | 2007-12-11 | Wellstat Therapeutics Corporation | Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis |
| EP0401379B1 (de) * | 1988-12-06 | 1994-06-15 | Otsuka Pharmaceutical Co., Ltd. | Stabilisierte interleukin-1-beta enthaltende zusammensetzung |
| US6586222B1 (en) | 1989-08-16 | 2003-07-01 | Chiron Corporation | Recombinant PR-3 and compositions thereof |
| US5843693A (en) * | 1989-08-16 | 1998-12-01 | Chiron Corporation | Assay method for screening for inhibitors of proTNF conversion |
| US5998378A (en) * | 1989-08-16 | 1999-12-07 | Chiron Corporation | Compositions for the inhibition of TNF hormone formation and uses thereof |
| JPH0791318B2 (ja) * | 1989-09-21 | 1995-10-04 | 三井東圧化学株式会社 | 蛋白質水溶液、蛋白質水溶液の濃度増大方法および蛋白質製剤 |
| US5830452A (en) * | 1990-11-20 | 1998-11-03 | Chiron Corporation | Method for enhancing the anti-tumor therapeutic index of interleukin-2 |
| US6063764A (en) * | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| US20030171292A1 (en) | 1992-06-01 | 2003-09-11 | Creasey Abla A. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
| DE69329795T2 (de) * | 1992-10-02 | 2001-07-05 | Genetics Institute, Inc. | Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator |
| CA2147466A1 (en) * | 1992-10-20 | 1994-04-28 | Just P. J. Brakenhoff | Interleukin-6 receptor antagonists |
| SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| EP1446140A4 (de) | 2001-10-15 | 2007-03-07 | Novartis Vaccines & Diagnostic | Behandlung der schweren pneumonie durch verabreichung von tfpi (tissue factor pathway inhibitor) |
| EP1680141B8 (de) | 2003-11-04 | 2011-01-12 | Novartis Vaccines and Diagnostics, Inc. | Verfahren zur behandlung von soliden tumoren mit expression des cd40-zelloberflächen-antigens |
| EP1844815B1 (de) | 2003-11-04 | 2011-09-14 | Novartis Vaccines and Diagnostics, Inc. | Kombinationstherapie von anti-CD20 und anti-CD40 Antikörpern zur Behandlung von B-Zell-bedingtem Krebs |
| PT1694360E (pt) | 2003-11-04 | 2010-12-13 | Novartis Vaccines & Diagnostic | Utilização de anticorpos monoclonais antagonistas anti-cd40 para o tratamento de doenças auto-imunes e inflamatórias e da rejeição ao transplante de orgãos |
| CA2544951A1 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Use of antagonist anti-cd40 monoclonal antibodies for treatment of multiple myeloma |
| ATE474598T1 (de) | 2003-11-04 | 2010-08-15 | Novartis Vaccines & Diagnostic | Verwendung von antagonisten-anti-cd40-antikörpern zur behandlung von chronisch lymphozytischer leukämie |
| GB0404586D0 (en) * | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| KR100624013B1 (ko) | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
| JP5518608B2 (ja) * | 2010-07-09 | 2014-06-11 | ロート製薬株式会社 | 粘膜適用液状組成物 |
| AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
| WO2012075111A1 (en) | 2010-11-30 | 2012-06-07 | Novartis Ag | Uses of anti-cd40 antibodies in combination therapy for b cell-related cancers |
| US9550811B2 (en) | 2010-12-02 | 2017-01-24 | Bionor Immuno As | Peptide scaffold design |
| US9493514B2 (en) | 2011-01-06 | 2016-11-15 | Bionor Immuno As | Dimeric scaffold proteins comprising HIV-1 GP120 and GP41 epitopes |
| DE102012101864A1 (de) * | 2012-03-06 | 2013-09-12 | Gramme-Revit Gmbh | Mittel zur Behandlung von Allergien und anderen Erkrankungen |
| JP6310909B2 (ja) | 2012-06-06 | 2018-04-11 | ビオノール イミュノ エーエスＢｉｏｎｏｒ Ｉｍｍｕｎｏ Ａｓ | 免疫原及び投薬反応物として使用するためのウイルスタンパク質に由来するペプチド |
| UA105278C2 (ru) | 2012-09-06 | 2014-04-25 | Інститут Біології Клітини Нан України | Способ получения каталитически активных антител (абзимов) с сиалидазной активностью |
| WO2014176375A2 (en) | 2013-04-23 | 2014-10-30 | Cedars-Sinai Medical Center | Systems and methods for recording simultaneously visible light image and infrared light image from fluorophores |
| EP3096773B1 (de) | 2014-01-17 | 2020-07-01 | Cedars-Sinai Medical Center | Auf einen rezeptor abzielende konstrukte und verwendungen davon |
| CA2937035A1 (en) | 2014-02-05 | 2015-08-13 | Cedars-Sinai Medical Center | Methods and compositions for treating cancer and infectious diseases |
| CN106794175B (zh) | 2014-06-12 | 2020-06-09 | 西达-赛奈医疗中心 | 用于治疗癌症的组合物 |
| EP3173074A4 (de) | 2014-07-22 | 2018-03-07 | Lemonex Inc. | Zusammensetzung zur verabreichung von bioaktivem material oder protein und verwendung davon |
| CN107106669A (zh) | 2014-11-04 | 2017-08-29 | 南加利福尼亚大学 | 用于治疗过度表达HIF‑1α的癌症的组合物和方法 |
| WO2016179326A1 (en) | 2015-05-05 | 2016-11-10 | The Regents Of The University Of California | H3.3 ctl peptides and uses thereof |
| US10441644B2 (en) | 2015-05-05 | 2019-10-15 | The Regents Of The University Of California | H3.3 CTL peptides and uses thereof |
| AU2016315752B2 (en) | 2015-08-31 | 2021-08-05 | Cedars-Sinai Medical Center | Novel blood cell biomarker for late onset Alzheimer's disease |
| KR101843985B1 (ko) | 2016-02-09 | 2018-03-30 | 오토텔릭 엘엘씨 | 암을 치료하기 위한 조성물과 방법 |
| KR20180103816A (ko) | 2016-02-09 | 2018-09-19 | 오토텔릭 엘엘씨 | 췌장암을 치료하기 위한 조성물과 방법 |
| US10927070B2 (en) | 2016-06-09 | 2021-02-23 | Cedars-Sinai Medical Center | Compositions and methods for treating cancer |
| KR20180091768A (ko) | 2017-02-06 | 2018-08-16 | 주식회사 레모넥스 | 생리활성물질 전달체 |
| WO2018143787A1 (ko) | 2017-02-06 | 2018-08-09 | 주식회사 레모넥스 | 생리활성물질 전달체 |
| US20210121493A1 (en) | 2017-07-25 | 2021-04-29 | Cedars-Sinai Medical Center | Methods for treating liver diseases |
| US11529338B2 (en) | 2017-08-22 | 2022-12-20 | Cedars-Sinai Medical Center | Compositions and methods for treating cancer |
| KR102152348B1 (ko) | 2017-09-05 | 2020-09-08 | 주식회사 레모넥스 | 세포 운명 조절용 조성물 |
| KR102753455B1 (ko) | 2018-08-08 | 2025-01-10 | 세다르스-신나이 메디칼 센터 | 암 및 자가면역 질환을 치료하기 위한 조성물 및 방법 |
| JP2022512937A (ja) | 2018-11-08 | 2022-02-07 | セダーズ－シナイ メディカル センター | Ｈｌａ感作患者を脱感作し患者における腎移植を改善するためのクラザキズマブの使用 |
| US20220073605A1 (en) | 2018-12-20 | 2022-03-10 | Cedars-Sinai Medical Center | Clazakizumab in the treatment of chronic antibody-mediated rejection of organ transplant |
| AU2020401371A1 (en) * | 2019-12-13 | 2022-07-21 | Synthekine, Inc. | IL-2 orthologs and methods of use |
| EP4098238A4 (de) * | 2020-01-28 | 2024-02-28 | Zeon Corporation | Vorgefüllte arzneimittelverpackung und verfahren zur herstellung einer vorgefüllten arzneimittelverpackung |
| US20230109142A1 (en) | 2020-02-14 | 2023-04-06 | Immunor As | Corona virus vaccine |
| AU2021270745A1 (en) * | 2020-05-11 | 2022-12-15 | Mural Oncology, Inc. | IL-2 fusion polypeptide compositions and methods of making and using the same |
| CN116234912A (zh) * | 2020-11-13 | 2023-06-06 | 江苏恒瑞医药股份有限公司 | 一种包含人白细胞介素2变体或其衍生物的药物组合物及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2652636A1 (de) * | 1976-11-19 | 1978-05-24 | Hans Uwe Dr Rer Nat Wolf | Verfahren zur stabilisierung von proteinen und verwandten verbindungen waehrend ihrer reinigung, isolierung und lagerung |
| US4457916A (en) * | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
| EP0211835B1 (de) * | 1984-03-28 | 1990-01-03 | Cetus Corporation | Pharmazeutische zusammensetzungen von mikrobenerzeugtem interleukin-2 |
| DE3583880D1 (de) * | 1984-04-09 | 1991-10-02 | Takeda Chemical Industries Ltd | Stabile interleukin-2-zusammensetzung. |
| CA1297003C (en) * | 1985-09-20 | 1992-03-10 | Jack H. Nunberg | Composition and method for treating animals |
| US4822605A (en) * | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
-
1987
- 1987-10-16 CA CA000549488A patent/CA1292686C/en not_active Expired - Lifetime
- 1987-10-22 IE IE284487A patent/IE60890B1/en not_active IP Right Cessation
- 1987-10-26 DE DE8787115694T patent/DE3778122D1/de not_active Expired - Lifetime
- 1987-10-26 ES ES198787115694T patent/ES2036558T3/es not_active Expired - Lifetime
- 1987-10-26 EP EP87115694A patent/EP0268110B1/de not_active Expired - Lifetime
- 1987-10-26 AT AT87115694T patent/ATE74512T1/de not_active IP Right Cessation
- 1987-10-27 AU AU80181/87A patent/AU614066B2/en not_active Expired - Fee Related
- 1987-10-27 JP JP62271603A patent/JPS63122628A/ja active Pending
-
1992
- 1992-05-04 GR GR920400417T patent/GR3004479T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE872844L (en) | 1988-04-27 |
| ES2036558T3 (es) | 1993-06-01 |
| AU614066B2 (en) | 1991-08-22 |
| IE60890B1 (en) | 1994-08-24 |
| CA1292686C (en) | 1991-12-03 |
| GR3004479T3 (de) | 1993-03-31 |
| EP0268110A1 (de) | 1988-05-25 |
| EP0268110B1 (de) | 1992-04-08 |
| AU8018187A (en) | 1988-04-28 |
| JPS63122628A (ja) | 1988-05-26 |
| DE3778122D1 (de) | 1992-05-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEFA | Change of the company name | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |