ATE76410T1 - Cryptate von seltenen erden, verfahren und zwischenprodukte zu ihrer herstellung und verwendung als fluoreszierende markierungen. - Google Patents

Cryptate von seltenen erden, verfahren und zwischenprodukte zu ihrer herstellung und verwendung als fluoreszierende markierungen.

Info

Publication number
ATE76410T1
ATE76410T1 AT88403210T AT88403210T ATE76410T1 AT E76410 T1 ATE76410 T1 AT E76410T1 AT 88403210 T AT88403210 T AT 88403210T AT 88403210 T AT88403210 T AT 88403210T AT E76410 T1 ATE76410 T1 AT E76410T1
Authority
AT
Austria
Prior art keywords
group
groups
macrocycle
rare earth
possibly
Prior art date
Application number
AT88403210T
Other languages
English (en)
Inventor
Jean-Marie Lehn
Gerard Mathis
Beatrice Alpha
Robert Deschenaux
Etienne Jolu
Original Assignee
Cis Bio Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cis Bio Int filed Critical Cis Bio Int
Application granted granted Critical
Publication of ATE76410T1 publication Critical patent/ATE76410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Luminescent Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AT88403210T 1987-12-18 1988-12-16 Cryptate von seltenen erden, verfahren und zwischenprodukte zu ihrer herstellung und verwendung als fluoreszierende markierungen. ATE76410T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8717765A FR2624862B1 (fr) 1987-12-18 1987-12-18 Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents
EP88403210A EP0321353B1 (de) 1987-12-18 1988-12-16 Cryptate von Seltenen Erden, Verfahren und Zwischenprodukte zu ihrer Herstellung und Verwendung als fluoreszierende Markierungen

Publications (1)

Publication Number Publication Date
ATE76410T1 true ATE76410T1 (de) 1992-06-15

Family

ID=9358067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88403210T ATE76410T1 (de) 1987-12-18 1988-12-16 Cryptate von seltenen erden, verfahren und zwischenprodukte zu ihrer herstellung und verwendung als fluoreszierende markierungen.

Country Status (12)

Country Link
EP (1) EP0321353B1 (de)
JP (1) JP2866419B2 (de)
KR (1) KR0133732B1 (de)
AT (1) ATE76410T1 (de)
AU (1) AU2908889A (de)
CA (1) CA1334026C (de)
DE (1) DE3871353D1 (de)
ES (1) ES2043874T3 (de)
FI (1) FI92698C (de)
FR (1) FR2624862B1 (de)
RU (1) RU2074859C1 (de)
WO (1) WO1989005813A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664702B1 (fr) * 1990-07-13 1993-08-06 Cis Bio Int Procede de reduction d'interferences dans un dosage par fluorescence.
FR2664699B1 (fr) * 1990-07-13 1995-08-18 Cis Bio Int Procede d'amplification du signal d'emission d'un compose luminescent.
WO1993011433A1 (en) * 1991-12-05 1993-06-10 Wallac Oy Luminescent lanthanide chelates
FR2769315B1 (fr) * 1997-10-03 2001-06-08 Cis Bio Int Conjugues fluorescents de nucleosides ou de nucleotides, leur procede de preparation et leur utilisation
US6689574B1 (en) 1997-10-07 2004-02-10 Merck & Co., Inc. Assays for nuclear receptor agonists and antagonists using fluorescence resonance energy transfer
FR2778744B1 (fr) 1998-05-14 2000-06-23 Cis Bio Int Dosage immunologique de la chromogranine a humaine (cga) anticorps, reactifs et trousses utilisables pour ce dosage
US6488097B1 (en) 1999-01-08 2002-12-03 Pnm, Inc. Fire protection sprinkler head support
FR2791141B1 (fr) * 1999-03-15 2001-06-01 Cis Bio Int Procede de reduction de l'extinction de fluorescence due au milieu de mesure
FR2792072A1 (fr) * 1999-04-08 2000-10-13 Cis Bio Int Methode homogene de detection ou de determination d'une interaction chimique ou physicochimique
FR2809817B1 (fr) 2000-06-02 2003-08-15 Cis Bio Int Procede de detection de presence d'un liquide dans un melange
FR2810406B1 (fr) * 2000-06-15 2002-09-20 Cis Bio Int Nouveaux cryptates de terre rare peu sensibles a l'extinction de fluorescence
DE102004034517A1 (de) * 2004-07-16 2006-02-16 Covion Organic Semiconductors Gmbh Metallkomplexe
FR2878850B1 (fr) 2004-12-02 2008-10-31 Cis Bio Internat Sa Derives de l'inositol-1-phosphate
FR2890446B1 (fr) 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
US7845599B2 (en) 2007-03-22 2010-12-07 The Viking Corporation Mounting coupling for sprinkler support system
CN101720328A (zh) * 2007-06-20 2010-06-02 通用电气健康护理有限公司 标记方法
FR2934684B1 (fr) 2008-07-31 2012-11-16 Cis Bio Int Methode de detection de l'internalisation de proteines membranaires.
FR2940286B1 (fr) 2008-12-19 2011-04-08 Cis Bio Int Nouveaux cryptates de terres rares comportant un motif tetraazatriphenylene
CA2759885A1 (fr) 2009-04-30 2010-11-04 Etienne Doumazane Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft
FR2949156B1 (fr) 2009-08-13 2016-04-15 Cis-Bio Int Methode de determination de la liaison d'un compose donne a un recepteur membranaire
FR2977674B1 (fr) 2011-07-06 2015-08-14 Cisbio Bioassays Methode amelioree de detection et/ou de quantification d'un analyte present a la surface d'une cellule
FR2978149B1 (fr) 2011-07-18 2014-01-10 Cisbio Bioassays Nouveaux agents complexants et complexes de lanthanide correspondant, et leur utilisation comme marqueurs luminescents
FR2980271B1 (fr) 2011-09-16 2013-10-11 Cisbio Bioassays Procede de determination de la glycosylation d'un anticorps
EP2817614A1 (de) 2012-02-22 2014-12-31 Cisbio Bioassays Verfahren zur normalisierung der von einem messmedium emittierten lumineszenz
FR2988174B1 (fr) 2012-03-19 2014-04-25 Cisbio Bioassays Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre
FR3000960B1 (fr) * 2013-01-16 2015-03-06 Cisbio Bioassays Nouveaux agents complexants hydrosolubles et complexes de lanthanide correspondants
FR3004189B1 (fr) 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
FR3032797B1 (fr) 2015-02-13 2017-03-03 Cisbio Bioassays Procede de quantification d'une proteine d'interet presente dans un echantillon biologique
FR3045053B1 (fr) 2015-12-09 2018-01-05 Cisbio Bioassays Agents complexants hydrosolubles a base de triazapyridinophane et complexes de lanthanide fluorescents correspondants
US9834808B2 (en) 2016-01-21 2017-12-05 SeLux Diagnostics, Inc. Methods for rapid antibiotic susceptibility testing
ES2862345T3 (es) 2016-01-21 2021-10-07 Selux Diagnostics Inc Métodos rápidos para probar la susceptibilidad antimicrobiana
CN106432070A (zh) * 2016-09-20 2017-02-22 上海应用技术大学 一种6,6’‑二溴甲基‑2,2’‑联吡啶‑4,4’‑二甲酸二甲酯的制备方法
BR112018016717A2 (pt) 2016-12-16 2018-12-26 H Lundbeck As agentes, usos e métodos
RU2647578C1 (ru) * 2016-12-20 2018-03-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) N,n’-диэтил- n,n’-ди(2-бром-4-r-фенил)диамиды 2,2’-бипиридил-6,6’-дикарбоновой кислоты и способ их получения, циклизация полученных амидов с образованием 6,6’-диэтил-9,9’-диr-дибензо[f]-1,7-нафтиридин-5,5’(6н,6’h)-дионов
JP7146765B2 (ja) 2016-12-23 2022-10-04 セルックス・ダイアグノスティクス・インコーポレイテッド 改善された迅速な抗菌薬感受性試験のための方法
FR3067349B1 (fr) 2017-06-12 2020-12-04 Cisbio Bioassays Nouveaux agents mono et di-antennes complexants hydrosolubles et complexes de lanthanide correspondants
FR3067712B1 (fr) 2017-06-14 2019-08-02 Cisbio Bioassays Nouveaux agents complexants de type trimethoxyphenyl pyridine hydrosolubles et complexes de lanthanide correspondants
FR3069644B1 (fr) 2017-07-28 2024-07-12 Cisbio Bioassays Methode pour mesurer la modulation de l'activation d'un recepteur couple a une proteine g
US20200309796A1 (en) 2017-12-21 2020-10-01 H. Lundbeck A/S Assay, method and treatment of alpha-synucleinopathies
FR3084365B1 (fr) 2018-07-27 2020-10-23 Cisbio Bioassays Anticorps a domaine unique qui se lient a la proteine g alpha
CN109456309B (zh) * 2018-11-22 2020-11-27 北京工业大学 一种多吡唑含氮杂环化合物及其制备和应用
FR3092172B1 (fr) 2019-01-30 2021-02-12 Cisbio Bioassays Méthode pour mesurer la modulation de l’activation d’un récepteur couplé à une protéine G avec des analogues du GTP
CN111848621B (zh) * 2020-06-29 2022-05-27 中国科学院苏州生物医学工程技术研究所 一种镧系笼状化合物及其制备方法与用途
WO2022208269A2 (en) * 2021-03-29 2022-10-06 Arbutus Biopharma Corporation Substituted 1-aryl-1'-heteroaryl compounds, substituted 1,1'-biheteroaryl compounds, and methods using same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2570703B1 (fr) * 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents

Also Published As

Publication number Publication date
FI902981A0 (fi) 1990-06-14
KR0133732B1 (ko) 1998-04-21
JPH03502575A (ja) 1991-06-13
RU2074859C1 (ru) 1997-03-10
FI92698B (fi) 1994-09-15
KR900700489A (ko) 1990-08-13
CA1334026C (fr) 1995-01-17
DE3871353D1 (de) 1992-06-25
EP0321353A1 (de) 1989-06-21
WO1989005813A1 (fr) 1989-06-29
FR2624862B1 (fr) 1990-06-08
FI92698C (fi) 1994-12-27
EP0321353B1 (de) 1992-05-20
AU2908889A (en) 1989-07-19
JP2866419B2 (ja) 1999-03-08
ES2043874T3 (es) 1994-01-01
FR2624862A1 (fr) 1989-06-23

Similar Documents

Publication Publication Date Title
ATE76410T1 (de) Cryptate von seltenen erden, verfahren und zwischenprodukte zu ihrer herstellung und verwendung als fluoreszierende markierungen.
ES8604090A1 (es) Procedimiento para la preparacion de acidos a,w -dicarboxi- licos
DK24389A (da) (cycloalkylamino)methylenbis(phosphonsyre) og farmaceutiske praeparater indeholdende forbindelsen
ES2036551T3 (es) Compuestos heterociclicos.
EP1219626A4 (de) Verbdindungen zur floureszenz-kennzeichnung
DE3853051D1 (de) Verfahren zur Herstellung von Polyphenylensulfid-Zusammensetzungen.
KR910007704A (ko) 피브리노겐 수용체 길항제
DE3760532D1 (en) Benzoûb¨thiophene and benzoûb¨furancarboxamide derivatives, processes for their preparation and therapeutical agents containing them
ES2072981T3 (es) Composicion suavizante de tejidos.
DE69026851D1 (de) Verfahren zur Erhöhung von Chemilumineszenz
DE69226815D1 (de) 1-Methyl-carbapenemderivate, deren Herstellung und Verwendung als Antibiotika
ES8505518A1 (es) Procedimiento para preparar derivados de aminoacidos
ATE118769T1 (de) Benzotriazol-derivate und diese enthaltende fluoreszierende reagenzien.
KR880008980A (ko) 안트라퀴논 화합물 및 이를 함유하는 편광 필름
KR840006482A (ko) 디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법
ATE38675T1 (de) Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
ATE55134T1 (de) Salze von amino-beta-lactamsaeuren und verfahren zu ihrer herstellung.
DE69119714D1 (de) Verfahren zur Herstellung von Benzylphthalazinonderivaten und von deren Salzen
DE3752124D1 (de) Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
KR910011287A (ko) 외과용 필라멘트
GR900100356A (el) Νέα παράγωγα 9α-υδροξυ-3-οξο4,24(25)-στιγμασταδιέν-26-οϊκού οξέος και μέ?οδος για την παρασκευή τους.
IT1237805B (it) Composto fotocromatico, metodo per la sua preparazione e articoli che lo contengono
DE68928558D1 (de) Verfahren zur Herstellung von heterocyclischen Derivaten
DE58901277D1 (de) Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
KR880007502A (ko) 신규의 아미노알카노일-디벤조[d, g][1,3,6]디옥사조신 및 그의 제조방법

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties