ATE78042T1 - Analoge des humanen relaxins. - Google Patents

Analoge des humanen relaxins.

Info

Publication number: ATE78042T1
Authority: AT; Austria
Prior art keywords: analogues; human relaxin; shortened; consist; synthesis
Prior art date: 1982-08-12

Application number

AT88104503T

Other languages

English (en)

Inventor

Peter John Hudson

John Shine

Hugh David Niall

Geoffrey William Tregear

Original Assignee

Florey Howard Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-12

Filing date

1983-08-11

Publication date

1992-07-15

1983-08-11 Application filed by Florey Howard Inst filed Critical Florey Howard Inst

1992-07-15 Application granted granted Critical

1992-07-15 Publication of ATE78042T1 publication Critical patent/ATE78042T1/de

Links

BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical class C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT88104503T 1982-08-12 1983-08-11 Analoge des humanen relaxins. ATE78042T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPF535282		1982-08-12
EP88104503A EP0287820B1 (de)	1982-08-12	1983-08-11	Analoge des humanen Relaxins

Publications (1)

Publication Number	Publication Date
ATE78042T1 true ATE78042T1 (de)	1992-07-15

Family

ID=3769689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88104503T ATE78042T1 (de)	1982-08-12	1983-08-11	Analoge des humanen relaxins.

Country Status (14)

Country	Link
US (1)	US4871670A (de)
EP (2)	EP0101309B1 (de)
JP (3)	JP2537477B2 (de)
KR (1)	KR930003515B1 (de)
AT (1)	ATE78042T1 (de)
CA (1)	CA1340542C (de)
DE (1)	DE3382117D1 (de)
DK (2)	DK171827B1 (de)
ES (5)	ES524885A0 (de)
HU (1)	HU197350B (de)
IE (1)	IE58682B1 (de)
IL (1)	IL69469A (de)
NZ (1)	NZ205241A (de)
ZA (1)	ZA835963B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320953A (en) *	1982-08-12	1994-06-14	Howard Florey Institute Of Experimental Physiology And Medicine	Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
AU626840B2 (en) *	1988-02-26	1992-08-13	Genentech Inc.	Human relaxin formulation
CA2051375C (en) *	1989-05-04	2000-09-12	Dennis J. Henner	Process and compositions for the isolation of human relaxin
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1995000645A2 (en) *	1993-06-21	1995-01-05	Genentech, Inc.	Process for producing relaxin
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
AU2002256359A1 (en) *	2001-04-24	2002-11-05	Epigenesis Pharmaceuticals, Inc.	Antisense and anti-inflammatory based compositions to treat respiratory disorders
AU2002324727A1 (en) *	2001-08-17	2003-03-03	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian relaxin receptors
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
JP4836942B2 (ja) *	2004-04-30	2011-12-14	コーセラ，インコーポレイテッド	リラキシンの調節による胎仔の発育の制御のための方法および組成物
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US8389475B2 (en)	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
EA030886B1 (ru)	2010-08-17	2018-10-31	Амбркс, Инк.	Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
SG191186A1 (en)	2010-12-15	2013-07-31	Baxter Int	Eluate collection using conductivity gradient
EP2630964A1 (de)	2012-02-22	2013-08-28	Immundiagnostik AG	Verfahren und Medikation zur Behandlung von Patienten mit Risiko für Prädiabetes und Typ-2-Diabetes
EP3068891A1 (de)	2013-11-13	2016-09-21	Aequus Biopharma Inc.	Manipulierte glycoproteine und verwendungen davon
EP2946788A1 (de)	2014-05-23	2015-11-25	Immundiagnostik AG	Verfahren und Zusammensetzung zur Behandlung von Herzversagen mit erhaltener Austreibungsfraktion
IL263079B2 (en)	2016-05-18	2024-05-01	Modernatx Inc	Polynucleotides encoding relaxin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

1983
- 1983-08-11 EP EP83304662A patent/EP0101309B1/de not_active Expired - Lifetime
- 1983-08-11 AT AT88104503T patent/ATE78042T1/de not_active IP Right Cessation
- 1983-08-11 EP EP88104503A patent/EP0287820B1/de not_active Expired - Lifetime
- 1983-08-11 IL IL69469A patent/IL69469A/xx not_active IP Right Cessation
- 1983-08-11 ES ES524885A patent/ES524885A0/es active Granted
- 1983-08-11 DE DE8383304662T patent/DE3382117D1/de not_active Expired - Lifetime
- 1983-08-11 DK DK366483A patent/DK171827B1/da not_active IP Right Cessation
- 1983-08-12 JP JP58146766A patent/JP2537477B2/ja not_active Expired - Lifetime
- 1983-08-12 ZA ZA835963A patent/ZA835963B/xx unknown
- 1983-08-12 HU HU832842A patent/HU197350B/hu unknown
- 1983-08-12 NZ NZ205241A patent/NZ205241A/xx unknown
- 1983-08-12 KR KR1019830003783A patent/KR930003515B1/ko not_active Expired - Lifetime
- 1983-08-12 IE IE190983A patent/IE58682B1/en not_active IP Right Cessation
- 1983-08-12 CA CA000434438A patent/CA1340542C/en not_active Expired - Fee Related
1985
- 1985-03-01 ES ES540886A patent/ES8802160A1/es not_active Expired
1986
- 1986-01-16 ES ES550943A patent/ES8802394A1/es not_active Expired
- 1986-05-12 US US06/863,819 patent/US4871670A/en not_active Expired - Lifetime
1987
- 1987-04-15 ES ES557505A patent/ES8801676A1/es not_active Expired
- 1987-04-15 ES ES557506A patent/ES8801671A1/es not_active Expired
1992
- 1992-12-28 DK DK156592A patent/DK171683B1/da not_active IP Right Cessation
1993
- 1993-03-19 JP JP5060138A patent/JP2670001B2/ja not_active Expired - Lifetime
1995
- 1995-01-05 JP JP7000236A patent/JP2892596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS5985292A (ja)	1984-05-17
IE58682B1 (en)	1993-11-03
ES540886A0 (es)	1988-04-01
HU197350B (en)	1989-03-28
JP2537477B2 (ja)	1996-09-25
DK156592A (da)	1992-12-28
EP0101309A3 (en)	1984-12-27
EP0101309A2 (de)	1984-02-22
ES8801671A1 (es)	1988-02-16
ES8802394A1 (es)	1988-05-16
ZA835963B (en)	1984-04-25
JPH07215998A (ja)	1995-08-15
US4871670A (en)	1989-10-03
ES8603579A1 (es)	1985-12-16
DK156592D0 (da)	1992-12-28
DE3382117D1 (de)	1991-02-21
ES524885A0 (es)	1985-12-16
JPH0690780A (ja)	1994-04-05
EP0287820A1 (de)	1988-10-26
IL69469A (en)	1991-06-10
DK366483A (da)	1984-02-13
EP0287820B1 (de)	1992-07-08
JP2670001B2 (ja)	1997-10-29
ES557505A0 (es)	1988-02-16
IE831909L (en)	1984-02-12
JP2892596B2 (ja)	1999-05-17
ES550943A0 (es)	1988-05-16
ES8801676A1 (es)	1988-02-16
IL69469A0 (en)	1983-11-30
EP0101309B1 (de)	1991-01-16
KR840005739A (ko)	1984-11-16
DK171827B1 (da)	1997-06-23
DK366483D0 (da)	1983-08-11
CA1340542C (en)	1999-05-18
ES557506A0 (es)	1988-02-16
ES8802160A1 (es)	1988-04-01
NZ205241A (en)	1991-01-29
DK171683B1 (da)	1997-03-10
KR930003515B1 (ko)	1993-05-01

Legal Events

Date	Code	Title	Description
1993-04-15	UEP	Publication of translation of european patent specification
2003-11-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE78042T1 (de)	1992-07-15	Analoge des humanen relaxins.
DK143492D0 (da)	1992-11-30	Human-h2-praeprorelaxin, -prorelaxin og -relaxin samt polypeptid med relaxinaktivitet
NO821111L (no)	1982-10-04	Radioaktivt merkede peptider
ES548617A0 (es)	1986-12-01	Procedimiento para disociar peptidos y proteinas en el enla-ce metionilo
DE3685651D1 (de)	1992-07-16	Den antigenischen und immunogenischen determinanten von wichtigen neutralisierenden proteinen des rotavirus entsprechende peptide.
DK403384A (da)	1984-08-23	Enteralt effektivt, biologisk aktivt peptid- eller proteinmiddel ogfremgangsmaader til fremstilling deraf
AP9100296A0 (en)	1991-07-31	Peptides and analogues and mixtures thereof for detecting antibodies to HTLV-1 and HTLV11 viruses.
ES557736A0 (es)	1987-12-16	Un procedimiento para preparar un material peptidico que tiene actividad humoral timica
DE3382589D1 (de)	1992-08-13	Analoge des humanen relaxins.
ATE103339T1 (de)	1994-04-15	Lymphokin-aehnliche peptide.
ATE75255T1 (de)	1992-05-15	Peptid und dafuer kodierendes gen.
DK369888A (da)	1988-07-04	Peptidforbindelser
ATE79651T1 (de)	1992-09-15	Rekombinante materialien und verfahren zur herstellung von menschliche konnektive gewebe aktivierende peptide iii und deren analoge.
DE3485883D1 (de)	1992-09-24	Rekombinante materialien und verfahren zur herstellung von menschliche konnektive gewebe aktivierende peptide iii und deren analoge.