DK366483A - Gen, dna-transfervektor eller underenhed heraf, der koder for human preprorelaxin eller en underenhed deraf, fremgangsmaade til fremstilling af samme samt fremgangsmaade til fremstilling af human preprorelaxin eller en underenhed deraf - Google Patents

Gen, dna-transfervektor eller underenhed heraf, der koder for human preprorelaxin eller en underenhed deraf, fremgangsmaade til fremstilling af samme samt fremgangsmaade til fremstilling af human preprorelaxin eller en underenhed deraf Download PDF

Info

Publication number: DK366483A
Authority: DK; Denmark
Prior art keywords: substance; genes; codes; transfer vector; dna transfer
Prior art date: 1982-08-12

Application number

DK366483A

Other languages

English (en)

Other versions

DK171827B1 (da

DK366483D0 (da

Inventor

Peter John Hudson

John Shine

Hugh David Niall

Geoffrey William Tregear

Original Assignee

Florey Howard Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-12

Filing date

1983-08-11

Publication date

1984-02-13

1983-08-11 Application filed by Florey Howard Inst filed Critical Florey Howard Inst

1983-08-11 Publication of DK366483D0 publication Critical patent/DK366483D0/da

1984-02-13 Publication of DK366483A publication Critical patent/DK366483A/da

1997-06-23 Application granted granted Critical

1997-06-23 Publication of DK171827B1 publication Critical patent/DK171827B1/da

Links

239000000126 substance Substances 0.000 title 2
108010090955 preprorelaxin Proteins 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical class C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 abstract 1
108020004511 Recombinant DNA Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/30—Signal or leader sequence

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Veterinary Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DK366483A 1982-08-12 1983-08-11 Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle DK171827B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
AUPF535282		1982-08-12
AUPF535282		1982-08-12

Publications (3)

Publication Number	Publication Date
DK366483D0 DK366483D0 (da)	1983-08-11
DK366483A true DK366483A (da)	1984-02-13
DK171827B1 DK171827B1 (da)	1997-06-23

Family

ID=3769689

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK366483A DK171827B1 (da)	1982-08-12	1983-08-11	Dobbeltstrenget DNA-fragment, der koder for human-H1-præprorelaxin, human-H1-prorelaxin eller A- og B-kæderne i human-H1-relaxin, samt DNA-transfervektor, der indeholder en cDNA-deoxynukleotidsekvens, som svarer til et sådant DNA-fragment, celle transformeret med en sådan DNA-transfervektor, og fremgangsmåde til fremstilling af human-H1-prorelaxin eller -H1-relaxin ved dyrkning af en sådan celle
DK156592A DK171683B1 (da)	1982-08-12	1992-12-28	Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK156592A DK171683B1 (da)	1982-08-12	1992-12-28	Analogifremgangsmåde til fremstilling af human-H1-relaxinanalog

Country Status (14)

Country	Link
US (1)	US4871670A (da)
EP (2)	EP0101309B1 (da)
JP (3)	JP2537477B2 (da)
KR (1)	KR930003515B1 (da)
AT (1)	ATE78042T1 (da)
CA (1)	CA1340542C (da)
DE (1)	DE3382117D1 (da)
DK (2)	DK171827B1 (da)
ES (5)	ES524885A0 (da)
HU (1)	HU197350B (da)
IE (1)	IE58682B1 (da)
IL (1)	IL69469A (da)
NZ (1)	NZ205241A (da)
ZA (1)	ZA835963B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5320953A (en) *	1982-08-12	1994-06-14	Howard Florey Institute Of Experimental Physiology And Medicine	Process for synthesizing human H1-prorelaxin, H1-relaxin and fusion proteins thereof
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
US5023321A (en) *	1982-12-13	1991-06-11	Howard Florey Institute Of Experimental Physiology & Medicine	Molecular cloning and characterization of a further gene sequence coding for human relaxin
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
AU626840B2 (en) *	1988-02-26	1992-08-13	Genentech Inc.	Human relaxin formulation
CA2051375C (en) *	1989-05-04	2000-09-12	Dennis J. Henner	Process and compositions for the isolation of human relaxin
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
WO1995000645A2 (en) *	1993-06-21	1995-01-05	Genentech, Inc.	Process for producing relaxin
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
AU2002256359A1 (en) *	2001-04-24	2002-11-05	Epigenesis Pharmaceuticals, Inc.	Antisense and anti-inflammatory based compositions to treat respiratory disorders
AU2002324727A1 (en) *	2001-08-17	2003-03-03	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian relaxin receptors
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
JP4836942B2 (ja) *	2004-04-30	2011-12-14	コーセラ，インコーポレイテッド	リラキシンの調節による胎仔の発育の制御のための方法および組成物
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
US8389475B2 (en)	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
EA030886B1 (ru)	2010-08-17	2018-10-31	Амбркс, Инк.	Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение
SG191186A1 (en)	2010-12-15	2013-07-31	Baxter Int	Eluate collection using conductivity gradient
EP2630964A1 (en)	2012-02-22	2013-08-28	Immundiagnostik AG	Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
EP3068891A1 (en)	2013-11-13	2016-09-21	Aequus Biopharma Inc.	Engineered glycoproteins and uses thereof
EP2946788A1 (en)	2014-05-23	2015-11-25	Immundiagnostik AG	Method and composition for treating heart failure with preserved ejection fraction
IL263079B2 (en)	2016-05-18	2024-05-01	Modernatx Inc	Polynucleotides encoding relaxin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
IL70414A (en) *	1982-12-13	1991-06-10	Florey Howard Inst	Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors

1983
- 1983-08-11 EP EP83304662A patent/EP0101309B1/en not_active Expired - Lifetime
- 1983-08-11 AT AT88104503T patent/ATE78042T1/de not_active IP Right Cessation
- 1983-08-11 EP EP88104503A patent/EP0287820B1/en not_active Expired - Lifetime
- 1983-08-11 IL IL69469A patent/IL69469A/xx not_active IP Right Cessation
- 1983-08-11 ES ES524885A patent/ES524885A0/es active Granted
- 1983-08-11 DE DE8383304662T patent/DE3382117D1/de not_active Expired - Lifetime
- 1983-08-11 DK DK366483A patent/DK171827B1/da not_active IP Right Cessation
- 1983-08-12 JP JP58146766A patent/JP2537477B2/ja not_active Expired - Lifetime
- 1983-08-12 ZA ZA835963A patent/ZA835963B/xx unknown
- 1983-08-12 HU HU832842A patent/HU197350B/hu unknown
- 1983-08-12 NZ NZ205241A patent/NZ205241A/xx unknown
- 1983-08-12 KR KR1019830003783A patent/KR930003515B1/ko not_active Expired - Lifetime
- 1983-08-12 IE IE190983A patent/IE58682B1/en not_active IP Right Cessation
- 1983-08-12 CA CA000434438A patent/CA1340542C/en not_active Expired - Fee Related
1985
- 1985-03-01 ES ES540886A patent/ES8802160A1/es not_active Expired
1986
- 1986-01-16 ES ES550943A patent/ES8802394A1/es not_active Expired
- 1986-05-12 US US06/863,819 patent/US4871670A/en not_active Expired - Lifetime
1987
- 1987-04-15 ES ES557505A patent/ES8801676A1/es not_active Expired
- 1987-04-15 ES ES557506A patent/ES8801671A1/es not_active Expired
1992
- 1992-12-28 DK DK156592A patent/DK171683B1/da not_active IP Right Cessation
1993
- 1993-03-19 JP JP5060138A patent/JP2670001B2/ja not_active Expired - Lifetime
1995
- 1995-01-05 JP JP7000236A patent/JP2892596B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS5985292A (ja)	1984-05-17
IE58682B1 (en)	1993-11-03
ES540886A0 (es)	1988-04-01
HU197350B (en)	1989-03-28
JP2537477B2 (ja)	1996-09-25
DK156592A (da)	1992-12-28
EP0101309A3 (en)	1984-12-27
EP0101309A2 (en)	1984-02-22
ES8801671A1 (es)	1988-02-16
ATE78042T1 (de)	1992-07-15
ES8802394A1 (es)	1988-05-16
ZA835963B (en)	1984-04-25
JPH07215998A (ja)	1995-08-15
US4871670A (en)	1989-10-03
ES8603579A1 (es)	1985-12-16
DK156592D0 (da)	1992-12-28
DE3382117D1 (de)	1991-02-21
ES524885A0 (es)	1985-12-16
JPH0690780A (ja)	1994-04-05
EP0287820A1 (en)	1988-10-26
IL69469A (en)	1991-06-10
EP0287820B1 (en)	1992-07-08
JP2670001B2 (ja)	1997-10-29
ES557505A0 (es)	1988-02-16
IE831909L (en)	1984-02-12
JP2892596B2 (ja)	1999-05-17
ES550943A0 (es)	1988-05-16
ES8801676A1 (es)	1988-02-16
IL69469A0 (en)	1983-11-30
EP0101309B1 (en)	1991-01-16
KR840005739A (ko)	1984-11-16
DK171827B1 (da)	1997-06-23
DK366483D0 (da)	1983-08-11
CA1340542C (en)	1999-05-18
ES557506A0 (es)	1988-02-16
ES8802160A1 (es)	1988-04-01
NZ205241A (en)	1991-01-29
DK171683B1 (da)	1997-03-10
KR930003515B1 (ko)	1993-05-01

Legal Events

Date	Code	Title	Description
1997-06-23	B1	Patent granted (law 1993)
2003-09-01	PUP	Patent expired

Publication	Publication Date	Title
DK366483A (da)	1984-02-13	Gen, dna-transfervektor eller underenhed heraf, der koder for human preprorelaxin eller en underenhed deraf, fremgangsmaade til fremstilling af samme samt fremgangsmaade til fremstilling af human preprorelaxin eller en underenhed deraf
DK573783A (da)	1984-06-14	Gen, dna eller en underenhed heraf, som koder for human h2-preprorelaxin eller en underenhed deraf, fremgangsmaade til fremstilling af samme samt fremgangsmaade til fremstilling af human h2-preprorelaxin eller en underenhed deraf
DK645887A (da)	1988-06-11	Gamma-hesteinterferon, fremgangsmaade til fremstilling af, samt anvendelse af en saadan forbindelse
SE8403377D0 (sv)	1984-06-25	Nya peptider
DK185484D0 (da)	1984-04-10	Hybridvektor,der producerer humanparathyroid hormon,samt humanparathyroid hormon-gen
DK61583A (da)	1983-08-13	Gen, der koder for porcinpreprorelaxin eller dele heraf samt dna-transfervektor omfattende sekvenser svarende hertil
NO161684C (no)	1989-09-13	Endoproteinase-lyste f or utvinning av enzymet, samt anvendelse av enzymet til sekvensbestemmelse av proteiner og peptider.
NO156714C (no)	1987-11-11	Skibremse og fremgangsmaate til festing av denne.
NO902926L (no)	1990-08-30	Peptid tilsvarende hiv-env 583-599, og analoger derav, samt anvendelser av peptidene.
ES557294A0 (es)	1988-03-01	Un procedimiento para la preparacion de un transformante que comporta un vector de expresion que comprende un gen que codifica una proteina envolvente de un virus de sida