|
US5047533A
(en)
*
|
1983-05-24 |
1991-09-10 |
Sri International |
Acyclic purine phosphonate nucleotide analogs
|
|
US4845084A
(en)
*
|
1984-01-26 |
1989-07-04 |
Merck & Co., Inc. |
Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
|
|
CS264222B1
(en)
*
|
1986-07-18 |
1989-06-13 |
Holy Antonin |
N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
|
|
AU613592B2
(en)
*
|
1986-11-18 |
1991-08-08 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
|
|
US5650510A
(en)
*
|
1986-11-18 |
1997-07-22 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
|
|
US5247085A
(en)
*
|
1987-11-30 |
1993-09-21 |
Beecham Group P.L.C. |
Antiviral purine compounds
|
|
DK663588A
(da)
*
|
1987-11-30 |
1989-05-31 |
Beecham Group Plc |
Purinderivater
|
|
EP0339161A1
(en)
*
|
1988-04-01 |
1989-11-02 |
Merrell Dow Pharmaceuticals Inc. |
Novel fluorophosphonate nucleotide derivatives
|
|
EP0335770B1
(en)
*
|
1988-04-01 |
1997-01-15 |
Merrell Pharmaceuticals Inc. |
Novel fluorophosphonate nucleotide derivatives
|
|
US5284837A
(en)
*
|
1988-05-06 |
1994-02-08 |
Medivir Ab |
Derivatives of purine, process for their preparation and a pharmaceutical preparation
|
|
EP0353955A3
(en)
*
|
1988-08-02 |
1991-08-14 |
Beecham Group Plc |
Novel compounds
|
|
US5744600A
(en)
*
|
1988-11-14 |
1998-04-28 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Phosphonomethoxy carbocyclic nucleosides and nucleotides
|
|
US4966895A
(en)
*
|
1989-02-02 |
1990-10-30 |
Merck & Co. Inc. |
Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
|
|
US5688778A
(en)
*
|
1989-05-15 |
1997-11-18 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Nucleoside analogs
|
|
GB8912043D0
(en)
*
|
1989-05-25 |
1989-07-12 |
Beecham Group Plc |
Novel compounds
|
|
US5302585A
(en)
*
|
1990-04-20 |
1994-04-12 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
|
|
CS276072B6
(en)
*
|
1990-08-06 |
1992-03-18 |
Ustav Organicke Chemie A Bioch |
(2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
|
|
JP3116079B2
(ja)
*
|
1990-08-10 |
2000-12-11 |
インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック |
ヌクレオチドの新規な製法
|
|
EP0481214B1
(en)
*
|
1990-09-14 |
1998-06-24 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Prodrugs of phosphonates
|
|
US5208221A
(en)
*
|
1990-11-29 |
1993-05-04 |
Bristol-Myers Squibb Company |
Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
|
|
US6057305A
(en)
*
|
1992-08-05 |
2000-05-02 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
Antiretroviral enantiomeric nucleotide analogs
|
|
US5514798A
(en)
*
|
1993-06-02 |
1996-05-07 |
Gilead Sciences, Inc. |
Method and cyclic carbonates for nucleotide analogues
|
|
US5798340A
(en)
*
|
1993-09-17 |
1998-08-25 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
WO1995007919A1
(en)
*
|
1993-09-17 |
1995-03-23 |
Gilead Sciences, Inc. |
Method for dosing therapeutic compounds
|
|
US5656745A
(en)
*
|
1993-09-17 |
1997-08-12 |
Gilead Sciences, Inc. |
Nucleotide analogs
|
|
DE4408534A1
(de)
*
|
1994-03-14 |
1995-09-28 |
Hoechst Ag |
Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
|
|
US6465650B1
(en)
|
1995-03-13 |
2002-10-15 |
Aventis Pharma Deutschland Gmbh |
Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
|
|
US5977061A
(en)
*
|
1995-04-21 |
1999-11-02 |
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic |
N6 - substituted nucleotide analagues and their use
|
|
US5877166A
(en)
*
|
1996-04-29 |
1999-03-02 |
Sri International |
Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
|
|
US5733788A
(en)
*
|
1996-07-26 |
1998-03-31 |
Gilead Sciences, Inc. |
PMPA preparation
|
|
PT915894E
(pt)
*
|
1996-07-26 |
2003-10-31 |
Gilead Sciences Inc |
Analogos de nucleotidos
|
|
ATE305009T1
(de)
*
|
1997-07-25 |
2005-10-15 |
Gilead Sciences Inc |
Nukleotid-analog zusamensetzung und synthese verfahren
|
|
US5935946A
(en)
*
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
AU2645199A
(en)
*
|
1998-11-18 |
2000-06-05 |
Viktor Veniaminovich Tets |
Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methy lphosphonates
|
|
US7205404B1
(en)
*
|
1999-03-05 |
2007-04-17 |
Metabasis Therapeutics, Inc. |
Phosphorus-containing prodrugs
|
|
CN1291994C
(zh)
|
2000-07-21 |
2006-12-27 |
吉里德科学公司 |
核苷酸膦酸酯类似物前药及其筛选和制备方法
|
|
MXPA04000138A
(es)
|
2001-06-29 |
2005-06-06 |
Acad Of Science Czech Republic |
Compuestos novedosos y metodos de trabajo.
|
|
US20050033051A1
(en)
*
|
2001-11-14 |
2005-02-10 |
Babu Yarlagadda S |
Nucleosides preparation thereof and use as inhibitors of rna viral polymerases
|
|
US7388002B2
(en)
|
2001-11-14 |
2008-06-17 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
|
AU2003235501A1
(en)
|
2002-05-13 |
2003-11-11 |
Metabasis Therapeutics, Inc. |
PMEA and PMPA cyclic producing synthesis
|
|
NZ536328A
(en)
*
|
2002-05-13 |
2007-11-30 |
Metabasis Therapeutics Inc |
Novel phosphonic acid based prodrugs of PMEA and its analogues
|
|
KR20050086519A
(ko)
*
|
2002-11-12 |
2005-08-30 |
티안진 킨슬리 파마슈티컬 컴퍼니 리미티드 |
새로운 결정 형태를 가진 아데포비어 디피복실 및 그조성물
|
|
EA015145B1
(ru)
|
2003-01-14 |
2011-06-30 |
Джилид Сайэнс, Инк. |
Фармацевтическая композиция и пероральная фармацевтическая дозированная форма (варианты), проявляющие активность в отношении вич-инфекций, лечебный набор и таблетка и способ лечения или предотвращения симптомов или эффектов вич-инфекции
|
|
AU2004247305B2
(en)
*
|
2003-06-16 |
2010-02-18 |
Institute Of Organic Chemistry And Biochemistry, Academy Of Sciences Of The Czech Republic |
Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
|
|
EP1656387A2
(en)
*
|
2003-07-30 |
2006-05-17 |
Gilead Sciences, Inc. |
Nucleobase phosphonate analogs for antiviral treatment
|
|
MXPA06014013A
(es)
*
|
2004-06-08 |
2007-03-15 |
Metabasis Therapeutics Inc |
Sintesis mediada por acidos de lewis de esteres ciclicos.
|
|
CN100338080C
(zh)
*
|
2004-06-16 |
2007-09-19 |
山东中科泰斗化学有限公司 |
9-[2-(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
|
|
UA93354C2
(ru)
|
2004-07-09 |
2011-02-10 |
Гилиад Сайенсиз, Инк. |
Местный противовирусный препарат
|
|
ES2401285T3
(es)
|
2004-12-16 |
2013-04-18 |
The Regents Of The University Of California |
Fármacos con el pulmón como diana
|
|
US20090156545A1
(en)
*
|
2005-04-01 |
2009-06-18 |
Hostetler Karl Y |
Substituted Phosphate Esters of Nucleoside Phosphonates
|
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
|
JP5249028B2
(ja)
|
2005-07-25 |
2013-07-31 |
インターミューン・インコーポレーテッド |
C型肝炎ウイルス複製の新規大環状阻害剤
|
|
WO2007013085A1
(en)
*
|
2005-07-26 |
2007-02-01 |
Hetero Drugs Limited |
Novel process for acyclic phosphonate nucleotide analogs
|
|
GEP20104956B
(en)
*
|
2005-10-11 |
2010-04-12 |
Array Biopharma Inc |
Compounds for inhibiting hepatitis c viral replication and use thereof
|
|
US20080317852A1
(en)
*
|
2005-12-14 |
2008-12-25 |
Amar Lulla |
Pharmaceutical Combination
|
|
FR2908133B1
(fr)
*
|
2006-11-08 |
2012-12-14 |
Centre Nat Rech Scient |
Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
|
|
AU2008265397C1
(en)
|
2007-06-18 |
2013-08-29 |
Sunshine Lake Pharma Co., Ltd. |
Bromo-phenyl substituted thiazolyl dihydropyrimidines
|
|
TWI444384B
(zh)
|
2008-02-20 |
2014-07-11 |
Gilead Sciences Inc |
核苷酸類似物及其在治療惡性腫瘤上的用途
|
|
US20110059921A1
(en)
*
|
2008-03-27 |
2011-03-10 |
Ektar Therapeutics |
Oligomer-Nitrogenous Base Conjugates
|
|
US7935817B2
(en)
*
|
2008-03-31 |
2011-05-03 |
Apotex Pharmachem Inc. |
Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
|
|
KR20110005869A
(ko)
*
|
2008-04-15 |
2011-01-19 |
인터뮨, 인크. |
C형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제
|
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
|
TW201010692A
(en)
|
2008-06-19 |
2010-03-16 |
Public Univ Corp Nagoya City Univ |
Pharmaceutical composition for treatment or prevention of hbv infection
|
|
CN102216321A
(zh)
*
|
2008-10-15 |
2011-10-12 |
因特蒙公司 |
治疗性抗病毒肽
|
|
CL2009002206A1
(es)
|
2008-12-23 |
2011-08-26 |
Gilead Pharmasset Llc |
Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
|
|
JP6104504B2
(ja)
|
2008-12-23 |
2017-03-29 |
ギリアド ファーマセット エルエルシー |
ヌクレオシド類似体
|
|
TW201026715A
(en)
|
2008-12-23 |
2010-07-16 |
Pharmasset Inc |
Nucleoside phosphoramidates
|
|
US9169257B2
(en)
|
2009-03-26 |
2015-10-27 |
Daewoong Pharmaceutical Co., Ltd. |
Crystal forms of adefovir dipivoxil and processes for preparing the same
|
|
WO2011038293A1
(en)
*
|
2009-09-28 |
2011-03-31 |
Intermune, Inc. |
Cyclic peptide inhibitors of hepatitis c virus replication
|
|
WO2011041551A1
(en)
*
|
2009-10-01 |
2011-04-07 |
Intermune, Inc. |
Therapeutic antiviral peptides
|
|
CL2011000716A1
(es)
|
2010-03-31 |
2012-04-20 |
Gilead Pharmasset Llc |
Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c.
|
|
CN104203275A
(zh)
|
2010-06-09 |
2014-12-10 |
疫苗技术股份有限公司 |
用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫
|
|
EP2579871B1
(en)
|
2010-06-11 |
2015-08-26 |
Gilead Sciences, Inc. |
Topical antiviral formulations for prevention of transmission of hsv-2
|
|
RU2606845C2
(ru)
|
2010-12-10 |
2017-01-10 |
СИГМАФАРМ ЛЭБОРЭТОРИЗ, ЭлЭлСи |
Высокостабильные композиции перорально активных аналогов нуклеотидов или перорально активных пролекарств аналогов нуклеотидов
|
|
WO2012154698A2
(en)
*
|
2011-05-06 |
2012-11-15 |
Mckenna Charles E |
Method to improve antiviral activity of nucleotide analogue drugs
|
|
CN103665043B
(zh)
|
2012-08-30 |
2017-11-10 |
江苏豪森药业集团有限公司 |
一种替诺福韦前药及其在医药上的应用
|
|
WO2014068265A1
(en)
|
2012-10-29 |
2014-05-08 |
Cipla Limited |
Antiviral phosphonate analogues and process for preparation thereof
|
|
SMT201800538T1
(it)
|
2013-03-15 |
2019-01-11 |
Univ California |
Diesteri di fosfonato nucleosidico aciclico
|
|
US10449210B2
(en)
|
2014-02-13 |
2019-10-22 |
Ligand Pharmaceuticals Inc. |
Prodrug compounds and their uses
|
|
US10167302B2
(en)
*
|
2014-05-23 |
2019-01-01 |
University College Cork |
Phosphonate nucleosides useful in the treatment of viral diseases
|
|
CN106687118A
(zh)
|
2014-07-02 |
2017-05-17 |
配体药物公司 |
前药化合物及其用途
|
|
HRP20220651T1
(hr)
|
2014-09-15 |
2022-08-19 |
The Regents Of The University Of California |
Nukleotidni analozi
|
|
US10377782B2
(en)
|
2015-09-15 |
2019-08-13 |
The Regents Of The University Of California |
Nucleotide analogs
|
|
EP3372227A1
(en)
|
2017-03-06 |
2018-09-12 |
MH10 Spolka z ograniczona odpowiedzialnoscia |
Tablet formulation of adefovir dipivoxil
|
|
CN111788196A
(zh)
|
2018-01-09 |
2020-10-16 |
配体药物公司 |
缩醛化合物及其治疗用途
|
|
JP2025526212A
(ja)
|
2022-07-21 |
2025-08-13 |
アンティバ バイオサイエンシズ インコーポレイテッド |
Hpv感染症及びhpv誘発性新生物の治療用の組成物及び剤形
|