ATE79404T1 - Verfahren zur herstellung von hepatitis-b-virus- innenkoerperantigen (hbcag) in hefe. - Google Patents

Verfahren zur herstellung von hepatitis-b-virus- innenkoerperantigen (hbcag) in hefe.

Info

Publication number: ATE79404T1
Authority: AT; Austria
Prior art keywords: hepatitis; hbcag; yeast; production; internal body
Prior art date: 1986-05-23

Application number

AT87304314T

Other languages

English (en)

Inventor

Ronald W Ellis

Arpi Hagopian

Peter J Kniskern

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-23

Filing date

1987-05-15

Publication date

1992-08-15

1987-05-15 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1992-08-15 Application granted granted Critical

1992-08-15 Publication of ATE79404T1 publication Critical patent/ATE79404T1/de

Links

241000700721 Hepatitis B virus Species 0.000 title abstract 3
240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 2
239000000427 antigen Substances 0.000 title 1
102000036639 antigens Human genes 0.000 title 1
108091007433 antigens Proteins 0.000 title 1
101710132601 Capsid protein Proteins 0.000 abstract 3
239000002245 particle Substances 0.000 abstract 2
108010058643 Fungal Proteins Proteins 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
229960005486 vaccine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Mycology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)

AT87304314T 1986-05-23 1987-05-15 Verfahren zur herstellung von hepatitis-b-virus- innenkoerperantigen (hbcag) in hefe. ATE79404T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86655886A	1986-05-23	1986-05-23
EP87304314A EP0251460B1 (de)	1986-05-23	1987-05-15	Verfahren zur Herstellung von Hepatitis-B-Virus-Innenkörperantigen (HBcAg) in Hefe

Publications (1)

Publication Number	Publication Date
ATE79404T1 true ATE79404T1 (de)	1992-08-15

Family

ID=25347871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87304314T ATE79404T1 (de)	1986-05-23	1987-05-15	Verfahren zur herstellung von hepatitis-b-virus- innenkoerperantigen (hbcag) in hefe.

Country Status (6)

Country	Link
EP (1)	EP0251460B1 (de)
JP (1)	JPS6332491A (de)
AT (1)	ATE79404T1 (de)
DE (1)	DE3781049T2 (de)
DK (1)	DK257887A (de)
IE (1)	IE59389B1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3856496T2 (de) *	1987-06-22	2002-06-27	Medeva Holdings B.V., Amsterdam	Hepatitis-B-Oberflächenantigen enthaltendes Peptid
US4963483A (en) *	1987-10-13	1990-10-16	Merck & Co., Inc.	Method for producing hepatitis B virus proteins in yeast
EP0491077A1 (de) *	1990-12-19	1992-06-24	Medeva Holdings B.V.	Zusammensetzung verwendbar als therapeutisches Mittel gegen chronische virale Leberkrankheiten
RU2216590C1 (ru) *	2002-02-26	2003-11-20	Государственный научный центр вирусологии и биотехнологии "Вектор"	Рекомбинантный аттенуированный штамм бактерий salmonella typhimurium t10/pkhbc - продуцент корового антигена вируса гепатита в
JP4895281B2 (ja) *	2006-10-16	2012-03-14	日本電産リード株式会社	コネクタ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0105149B1 (de) *	1982-08-16	1990-05-16	Science and Technology Agency, Minister's Secretariat, Director of Finance Division	Hepatitis-B-Virus-Gen enthaltendes rekombinantes Plasmid, mit diesem rekombinanten Plasmid transformierte Hefe und Herstellung von Hepatitis-B-Virus-Oberflächenantigen
EP0174444B1 (de) *	1984-06-18	1992-03-11	Chiron Corporation	Hepatitisoberflächenantigenpartikelvakzin

1987
- 1987-05-11 IE IE122487A patent/IE59389B1/en not_active IP Right Cessation
- 1987-05-15 DE DE8787304314T patent/DE3781049T2/de not_active Expired - Fee Related
- 1987-05-15 AT AT87304314T patent/ATE79404T1/de not_active IP Right Cessation
- 1987-05-15 EP EP87304314A patent/EP0251460B1/de not_active Expired - Lifetime
- 1987-05-21 DK DK257887A patent/DK257887A/da not_active Application Discontinuation
- 1987-05-23 JP JP62125046A patent/JPS6332491A/ja active Pending

Also Published As

Publication number	Publication date
DK257887D0 (da)	1987-05-21
DE3781049D1 (de)	1992-09-17
IE59389B1 (en)	1994-12-23
EP0251460B1 (de)	1992-08-12
EP0251460A2 (de)	1988-01-07
DK257887A (da)	1987-11-24
IE871224L (en)	1987-11-23
EP0251460A3 (en)	1988-07-20
JPS6332491A (ja)	1988-02-12
DE3781049T2 (de)	1993-03-04

Similar Documents

Publication	Publication Date	Title
ATE99330T1 (de)	1994-01-15	Rekombinantes viren-ueberzugsprotein assoziiert mit ''acquired immune deficiency syndrome'' (aids) und verfahren zur testung von aids.
Mogensen et al.	1975	Raising antibodies to human leukocyte interferon
PT101052A (pt)	1994-01-31	Proteinas hibridas uteis na preparacao de vacinas
PT97159A (pt)	1991-12-31	Processo para a preparacao de uma proteina do antigenio de superficie da hepatite b ou de um seu fragmento e processo para a preparacao de uma vacina
DE3588254D1 (de)	2007-10-25	Gag-Antigen und dessen Verwendung zum Nachweis von LAV-Infektion, sowie in immunogenen Zusammensetzungen
DK532184A (da)	1984-11-08	Antigene aminosyresekvenser
AU697743C (en)	2007-06-14	Papillomavirus vaccines
FI101381B1 (fi)	1998-06-15	Nukleotidisekvenssi ja menetelmä polypeptidin HSA(1-387) tuottamiseksi
ES2013346A6 (es)	1990-05-01	Metodos para producir secuencias y moleculas de adn recombinante, asi como proteinas t4 solubles.
CA2116348A1 (en)	1993-03-04	Sirs vaccine and diagnosis method
ATE149202T1 (de)	1997-03-15	Gentechnologisch veränderte bakteriophagen und sie enthaltende impfstoffe
MX26715A (es)	1993-10-01	Procedimiento para la preparacion de particulas antigenicas del virus de la hepatitis b en levaduras metilotroficas.
BR9510520A (pt)	1998-07-14	Proteína de capsídeo de vírus papiloma isolada e purificada capsídeos partículas semelhantes a vírus processo de produzir a proteína purificada proteína do vírus papilona recombinante vacina composições farmacêuticas processo de tratamento ou de prevenção contra a infecção por vírus papilona kit para a detecção de vírus papiloma ou de anticorpos a vírus papiloma processos para a produção de uma proteína de capsídeo de vírus papilona recombinante para induzir uma resposta imunológica em um animalvertebrado sistema sintetico processos de obtenção de partículas semelhantes a vírus de obtenção da capsideos prificados capsideos de virus papilona
ATE79404T1 (de)	1992-08-15	Verfahren zur herstellung von hepatitis-b-virus- innenkoerperantigen (hbcag) in hefe.
IE870507L (en)	1987-09-07	Bovine virus diarrhea and hog cholera vaccines
EP0344864A3 (de)	1990-09-12	Verfahren zur Herstellung von nicht-hyperglycosylierten Hepatitis B Virusproteinen
Cresta et al.	1980	Biological properties of junin virus proteins: I. identification of the immunogenic glycoprotein
NO912942L (no)	1991-09-26	Vaksine for preventiv behandling av infeksjon av leverikte hos droevtyggere.
HU9200583D0 (en)	1992-05-28	Method for producing el peptides of rubeola
PT91316A (pt)	1990-02-08	Processo para a preparacao de vectores recombinantes e de particulas hbsag recombinantes hibridas tendo as caracteristicas morfologicas do antigenio hbsag contendo uma sequencia imunogenica que induz anticorpos neutralizantes dirigidos contra hiv ou susceptivel de ser reconhecida por tais anticorpos
DE2965191D1 (en)	1983-05-19	Herpes virus vaccine and its preparation
ATE7267T1 (de)	1984-05-15	Impfstoff und verfahren zu seiner herstellung.
NZ230996A (en)	1991-09-25	Immunogenic recombinant polypeptides and their use in the production of neutralising antibodies against viral haemorrhagic septicaemia virus
ATE2392T1 (de)	1983-03-15	Verfahren zur herstellung eines rhesusantigens, arzneimittel und pharmazeutische zusammensetzungen, die das antigen enthalten, und verabreichungsformen.
EP0503252A3 (en)	1992-12-09	Recombinant proteins having the immunoreactivity of hepatitis b virus e antigens (hbeag), method for their production and their application in immunoassays and as vaccines

Legal Events

Date	Code	Title	Description
1993-01-15	UEP	Publication of translation of european patent specification
1996-02-15	REN	Ceased due to non-payment of the annual fee