ATE80295T1 - Fettsaeure und cyclosporin enthaltende zusammensetzung mit ermaessigter nephrotoxizitaet. - Google Patents

Fettsaeure und cyclosporin enthaltende zusammensetzung mit ermaessigter nephrotoxizitaet.

Info

Publication number: ATE80295T1
Authority: AT; Austria
Prior art keywords: fatty acid; cyclosporine; compositions; acceptable salt; methods
Prior art date: 1986-05-02

Application number

AT87903559T

Other languages

English (en)

Inventor

Vicki E Kelley

William M Bennett

Original Assignee

Brigham & Womens Hospital

Univ Oregon Health Sciences

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-02

Filing date

1987-05-04

Publication date

1992-09-15

1987-05-04 Application filed by Brigham & Womens Hospital, Univ Oregon Health Sciences filed Critical Brigham & Womens Hospital

1992-09-15 Application granted granted Critical

1992-09-15 Publication of ATE80295T1 publication Critical patent/ATE80295T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 6
108010036949 Cyclosporine Proteins 0.000 title abstract 6
229960001265 ciclosporin Drugs 0.000 title abstract 6
229930182912 cyclosporin Natural products 0.000 title abstract 6
235000014113 dietary fatty acids Nutrition 0.000 title abstract 4
229930195729 fatty acid Natural products 0.000 title abstract 4
239000000194 fatty acid Substances 0.000 title abstract 4
150000004665 fatty acids Chemical class 0.000 title abstract 4
239000000203 mixture Substances 0.000 title abstract 3
229930105110 Cyclosporin A Natural products 0.000 title 1
206010029155 Nephropathy toxic Diseases 0.000 title 1
230000007694 nephrotoxicity Effects 0.000 title 1
231100000417 nephrotoxicity Toxicity 0.000 title 1
235000020660 omega-3 fatty acid Nutrition 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
241001465754 Metazoa Species 0.000 abstract 1
JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 abstract 1
MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 1
235000020673 eicosapentaenoic acid Nutrition 0.000 abstract 1
229960005135 eicosapentaenoic acid Drugs 0.000 abstract 1
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 1
230000003589 nefrotoxic effect Effects 0.000 abstract 1
229940012843 omega-3 fatty acid Drugs 0.000 abstract 1
239000006014 omega-3 oil Substances 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
150000003180 prostaglandins Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/60—Fish, e.g. seahorses; Fish eggs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Marine Sciences & Fisheries (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT87903559T 1986-05-02 1987-05-04 Fettsaeure und cyclosporin enthaltende zusammensetzung mit ermaessigter nephrotoxizitaet. ATE80295T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US85900286A	1986-05-02	1986-05-02
EP87903559A EP0305400B1 (de)	1986-05-02	1987-05-04	Fettsäure und cyclosporin enthaltende zusammensetzung mit ermässigter nephrotoxizität
PCT/US1987/001024 WO1987006463A1 (en)	1986-05-02	1987-05-04	A composition having reduced nephrotoxicity comprising a fatty acid containing component and cyclosporine

Publications (1)

Publication Number	Publication Date
ATE80295T1 true ATE80295T1 (de)	1992-09-15

Family

ID=25329727

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87903559T ATE80295T1 (de)	1986-05-02	1987-05-04	Fettsaeure und cyclosporin enthaltende zusammensetzung mit ermaessigter nephrotoxizitaet.

Country Status (7)

Country	Link
EP (1)	EP0305400B1 (de)
JP (1)	JP2574354B2 (de)
AT (1)	ATE80295T1 (de)
AU (1)	AU588695B2 (de)
CA (1)	CA1302879C (de)
DE (1)	DE3781686T2 (de)
WO (1)	WO1987006463A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0300675A3 (de) *	1987-07-21	1990-04-11	Merck Frosst Canada Inc.	Methode zur Verbesserung der Cyclosporintherapie
GB8729153D0 (en) *	1987-12-14	1988-01-27	Efamol Ltd	Fatty acid compositions
CH679119A5 (de) *	1988-05-13	1991-12-31	Sandoz Ag
GB8823621D0 (en) *	1988-10-07	1988-11-16	Madhok R	Compositions containing cyclosporins
US5516801A (en) *	1992-08-21	1996-05-14	Scotia Holdings Plc	Fatty acid treatment for ectopic calcium deposition
GB9217781D0 (en) *	1992-08-21	1992-10-07	Efamol Holdings	Fatty acid treatment
CZ278863B6 (en) *	1992-09-07	1994-07-13	Galena	Medicinal preparations with n-methylated cyclic undecapeptides
CN1077800C (zh) *	1993-07-01	2002-01-16	韩美药品工业株式会社	环孢菌素软胶囊组合物
KR100587551B1 (ko) *	1997-12-10	2006-06-08	싸이클로스포린 테라퓨틱스 리미티드	오메가-3 지방산 오일을 함유하는 약학 조성물
US9000040B2 (en)	2004-09-28	2015-04-07	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
EP1811933B1 (de)	2004-09-28	2016-03-23	Atrium Medical Corporation	Barriereschicht
US9012506B2 (en)	2004-09-28	2015-04-21	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
US9278161B2 (en)	2005-09-28	2016-03-08	Atrium Medical Corporation	Tissue-separating fatty acid adhesion barrier
US9427423B2 (en)	2009-03-10	2016-08-30	Atrium Medical Corporation	Fatty-acid based particles
US20110038910A1 (en)	2009-08-11	2011-02-17	Atrium Medical Corporation	Anti-infective antimicrobial-containing biomaterials
EP2593141B1 (de)	2010-07-16	2018-07-04	Atrium Medical Corporation	Zusammensetzung und verfahren zur veränderung der geschwindigkeit einer hydrolyse ausgehärteter materialien auf ölbasis
US9867880B2 (en)	2012-06-13	2018-01-16	Atrium Medical Corporation	Cured oil-hydrogel biomaterial compositions for controlled drug delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1506563A (en) *	1974-04-25	1978-04-05	Williams J	Immunosuppressive agents
FI65914C (fi) *	1978-03-07	1984-08-10	Sandoz Ag	Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
EP0087865B1 (de) *	1982-03-01	1986-10-01	Efamol Limited	Pharmazeutische Zusammensetzung

1987
- 1987-05-04 AT AT87903559T patent/ATE80295T1/de active
- 1987-05-04 WO PCT/US1987/001024 patent/WO1987006463A1/en not_active Ceased
- 1987-05-04 EP EP87903559A patent/EP0305400B1/de not_active Expired - Lifetime
- 1987-05-04 AU AU74382/87A patent/AU588695B2/en not_active Ceased
- 1987-05-04 DE DE8787903559T patent/DE3781686T2/de not_active Expired - Fee Related
- 1987-05-04 JP JP62503174A patent/JP2574354B2/ja not_active Expired - Fee Related
- 1987-05-04 CA CA000536328A patent/CA1302879C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA1302879C (en)	1992-06-09
AU588695B2 (en)	1989-09-21
JPH01503296A (ja)	1989-11-09
WO1987006463A1 (en)	1987-11-05
DE3781686T2 (de)	1993-03-11
DE3781686D1 (de)	1992-10-15
EP0305400A4 (de)	1989-11-07
AU7438287A (en)	1987-11-24
JP2574354B2 (ja)	1997-01-22
EP0305400B1 (de)	1992-09-09
EP0305400A1 (de)	1989-03-08

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