ATE80801T1 - Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln. - Google Patents

Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln.

Info

Publication number: ATE80801T1
Authority: AT; Austria
Prior art keywords: reaction product; pharmaceutically acceptable; antitumors; penicillamin; pharmaceuticals
Prior art date: 1984-12-18

Application number

AT86900504T

Other languages

English (en)

Inventor

David Rubin

Original Assignee

Clark Pharma Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-12-18

Filing date

1985-12-16

Publication date

1992-10-15

1985-12-16 Application filed by Clark Pharma Dev filed Critical Clark Pharma Dev

1992-10-15 Application granted granted Critical

1992-10-15 Publication of ATE80801T1 publication Critical patent/ATE80801T1/de

Links

239000000203 mixture Substances 0.000 title abstract 3
239000007795 chemical reaction product Substances 0.000 title abstract 2
231100000433 cytotoxic Toxicity 0.000 title abstract 2
230000001472 cytotoxic effect Effects 0.000 title abstract 2
VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 title 1
150000001299 aldehydes Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
206010028980 Neoplasm Diseases 0.000 abstract 2
102000003425 Tyrosinase Human genes 0.000 abstract 2
108060008724 Tyrosinase Proteins 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
150000002148 esters Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 abstract 1
HRLVWWHWYVOSPG-UHFFFAOYSA-N 2-(2-hydroxyphenyl)-5,5-dimethyl-1,3-thiazolidin-3-ium-4-carboxylate Chemical compound N1C(C(O)=O)C(C)(C)SC1C1=CC=CC=C1O HRLVWWHWYVOSPG-UHFFFAOYSA-N 0.000 abstract 1
LZDQTBBSEWXLTA-UHFFFAOYSA-N 5,5-dimethyl-2-phenyl-1,3-thiazolidine-4-carboxylic acid Chemical compound N1C(C(O)=O)C(C)(C)SC1C1=CC=CC=C1 LZDQTBBSEWXLTA-UHFFFAOYSA-N 0.000 abstract 1
230000035508 accumulation Effects 0.000 abstract 1
238000009825 accumulation Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000001879 copper Chemical class 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
238000001361 intraarterial administration Methods 0.000 abstract 1
229960001639 penicillamine Drugs 0.000 abstract 1
230000002285 radioactive effect Effects 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Thiazole And Isothizaole Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT86900504T 1984-12-18 1985-12-16 Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln. ATE80801T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68299184A	1984-12-18	1984-12-18
PCT/US1985/002480 WO1986003677A1 (en)	1984-12-18	1985-12-16	Anti-tumor compositions containing the reaction product of a cytotoxic aldehyde with penicillamine and method of use thereof
EP86900504A EP0226591B1 (de)	1984-12-18	1985-12-16	Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number	Publication Date
ATE80801T1 true ATE80801T1 (de)	1992-10-15

Family

ID=24742098

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86900504T ATE80801T1 (de)	1984-12-18	1985-12-16	Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln.

Country Status (9)

Country	Link
US (1)	US5169858A (de)
EP (1)	EP0226591B1 (de)
JP (1)	JPS62501769A (de)
AT (1)	ATE80801T1 (de)
AU (1)	AU642393B2 (de)
CA (1)	CA1303505C (de)
DE (1)	DE3586683T2 (de)
WO (1)	WO1986003677A1 (de)
ZA (1)	ZA864961B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5476842A (en) *	1991-11-04	1995-12-19	Co Enzyme Technology Ltd.	Method and compositions for treating tumors having high tyrosinase activity
US5760008A (en) *	1991-11-04	1998-06-02	Co Enzyme Technology Ltd.	Method and compositions for treating malignant tumors and inhibiting metastases of malignant tumors
US6083966A (en) *	1998-08-31	2000-07-04	University Of Florida	Thiazoline acid derivatives
US6703050B1 (en) *	1998-09-04	2004-03-09	The Regents Of The University Of Michigan	Methods and compositions for the prevention or treatment of cancer
WO2000016763A2 (en) *	1998-09-21	2000-03-30	University Of Florida Research Foundation, Inc.	Antimalarial agents
US20070248689A1 (en) *	2002-05-24	2007-10-25	Regents Of The University Of Michigan	Copper lowering treatment of inflammatory and fibrotic diseases
EP1531827A4 (de) *	2002-05-24	2009-07-08	Univ Michigan	Kupfer-verringernde behandlung für entzündliche und fibrotische erkrankungen
GEP20074270B (en)	2002-07-23	2007-12-25	Univ Michigan	Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
WO2005034949A1 (en) *	2003-09-09	2005-04-21	University Of Florida	Desferrithiocin derivatives and their use as iron chelators
BRPI0610644B8 (pt)	2005-04-04	2021-05-25	Univ Florida	composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
JP5439193B2 (ja)	2007-03-15	2014-03-12	ユニバーシティーオブフロリダリサーチファンデーション，インク．	デスフェリチオシンポリエーテル類似体
JP6539046B2 (ja)	2011-12-16	2019-07-03	ユニバーシティーオブフロリダリサーチファンデーション，インク．	４’−デスフェリチオシン類似体の使用
JP6458000B2 (ja) *	2013-03-15	2019-01-23	キャンサーリサーチテクノロジーリミテッドライアビリティカンパニー	ガンマグルタミル回路調節のための方法および組成物
EP3288557A4 (de)	2015-04-27	2018-11-07	University of Florida Research Foundation, Inc.	Metabolisch programmierte metallchelatoren und verwendungen davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4384001A (en) *	1978-12-21	1983-05-17	Gosalvez Mario	Treatment of tumors with thiazolidine-4-carboxylic acid
JPS55167220A (en) *	1979-06-14	1980-12-26	Senjiyu Seiyaku Kk	Antitumor drug
JPS5633216A (en) *	1979-08-29	1981-04-03	Shimadzu Corp	Cutting method and cutter for dynamic balancing correction device
JPS57128625A (en) *	1981-01-30	1982-08-10	Rikagaku Kenkyusho	Carcinostatic

1985
- 1985-12-16 AT AT86900504T patent/ATE80801T1/de not_active IP Right Cessation
- 1985-12-16 WO PCT/US1985/002480 patent/WO1986003677A1/en not_active Ceased
- 1985-12-16 EP EP86900504A patent/EP0226591B1/de not_active Expired - Lifetime
- 1985-12-16 JP JP86500285A patent/JPS62501769A/ja active Pending
- 1985-12-16 DE DE8686900504T patent/DE3586683T2/de not_active Expired - Fee Related
- 1985-12-18 CA CA000498057A patent/CA1303505C/en not_active Expired - Fee Related
1986
- 1986-02-26 US US06/833,801 patent/US5169858A/en not_active Expired - Fee Related
- 1986-07-03 AU AU59726/86A patent/AU642393B2/en not_active Ceased
- 1986-07-03 ZA ZA864961A patent/ZA864961B/xx unknown

Also Published As

Publication number	Publication date
WO1986003677A1 (en)	1986-07-03
DE3586683T2 (de)	1993-04-08
CA1303505C (en)	1992-06-16
ZA864961B (en)	1987-02-25
US5169858A (en)	1992-12-08
DE3586683D1 (de)	1992-10-29
AU642393B2 (en)	1993-10-21
EP0226591A4 (de)	1987-06-01
AU5972686A (en)	1988-01-07
JPS62501769A (ja)	1987-07-16
EP0226591B1 (de)	1992-09-23
EP0226591A1 (de)	1987-07-01

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Legal Events

Date	Code	Title	Description
1993-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties