BRPI0610644B8 - composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. - Google Patents

composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.

Info

Publication number
BRPI0610644B8
BRPI0610644B8 BRPI0610644A BRPI0610644A BRPI0610644B8 BR PI0610644 B8 BRPI0610644 B8 BR PI0610644B8 BR PI0610644 A BRPI0610644 A BR PI0610644A BR PI0610644 A BRPI0610644 A BR PI0610644A BR PI0610644 B8 BRPI0610644 B8 BR PI0610644B8
Authority
BR
Brazil
Prior art keywords
compound
diluent
pharmaceutically acceptable
pharmaceutical composition
acceptable carrier
Prior art date
Application number
BRPI0610644A
Other languages
English (en)
Inventor
J Bergeron Raymond
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36676582&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0610644(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida filed Critical Univ Florida
Publication of BRPI0610644A2 publication Critical patent/BRPI0610644A2/pt
Publication of BRPI0610644B1 publication Critical patent/BRPI0610644B1/pt
Publication of BRPI0610644B8 publication Critical patent/BRPI0610644B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

composto, composição farmacêutica que compreende um carreador ou diluente farmaceuticamente aceitável e o composto, método de tratamento de uma condição patológica, método para reduzir estresse oxidante, método de tratamento de um paciente que padece de enfermidade neoplástica ou uma condição pré-neoplástica. compostos representados pela fórmula estrutural descrita neste contexto, tal como a fórmula estrutural (i), são de utilidade no tratamento de condições tais como sobrecarga de metal, estresse oxidante, e condições neoplásticas e pré-neoplásticas.
BRPI0610644A 2005-04-04 2006-03-22 composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. BRPI0610644B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66804505P 2005-04-04 2005-04-04
US60/668,05 2005-04-04
US60/668,045 2005-04-04
PCT/US2006/010945 WO2006107626A1 (en) 2005-04-04 2006-03-22 Desferrithiocin polyether analogues

Publications (3)

Publication Number Publication Date
BRPI0610644A2 BRPI0610644A2 (pt) 2010-07-13
BRPI0610644B1 BRPI0610644B1 (pt) 2020-09-29
BRPI0610644B8 true BRPI0610644B8 (pt) 2021-05-25

Family

ID=36676582

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0610644A BRPI0610644B8 (pt) 2005-04-04 2006-03-22 composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.

Country Status (14)

Country Link
US (6) US8278458B2 (pt)
EP (2) EP3190106B1 (pt)
JP (3) JP5202299B2 (pt)
CN (1) CN101189216B (pt)
AU (1) AU2006232929B9 (pt)
BR (1) BRPI0610644B8 (pt)
CA (1) CA2603385C (pt)
CY (1) CY1119002T1 (pt)
DK (2) DK3190106T3 (pt)
ES (2) ES2732625T3 (pt)
MX (1) MX2007012226A (pt)
PL (2) PL1866296T3 (pt)
TR (1) TR201910900T4 (pt)
WO (1) WO2006107626A1 (pt)

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AU2003270473A1 (en) 2003-09-09 2005-04-27 University Of Florida Desferrithiocin derivatives and their use as iron chelators
ES2732625T3 (es) * 2005-04-04 2019-11-25 Univ Florida Análogos de poliéter de desferritiocina
US20100137346A1 (en) * 2006-12-12 2010-06-03 University Of Florida Research Foundation, Inc. Desferrithiocin analogue actinide decorporation agents
CN104003955A (zh) * 2007-03-15 2014-08-27 佛罗里达大学研究基金公司 去铁硫辛聚醚类似物
CN102149700A (zh) * 2008-07-14 2011-08-10 法罗肯生物科学公司 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的新型盐和多晶型物
BR112012001761A2 (pt) * 2009-07-27 2017-05-09 Ferrokin Bioscience Inc composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo
CA2772212A1 (en) * 2009-08-25 2011-03-10 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof
EP2566854A4 (en) 2010-05-04 2013-11-06 Shire Llc DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS
CA2857990A1 (en) 2011-12-09 2013-06-13 Ferrokin Biosciences, Inc. Oral formulations for treating metal overload
BR112014014544A2 (pt) * 2011-12-16 2017-06-13 Univ Florida usos de análogos de 4'-desferritiocina
HK1220194A1 (zh) 2013-03-15 2017-04-28 Ferrokin Biosciences, Inc. 去氮杂去铁硫代霉素(desazadesferrithiocin)类似物的多晶型形式
US10010535B2 (en) 2013-11-22 2018-07-03 University Of Florida Research Foundation, Incorporated Desferrithiocin analogs and uses thereof
US20170203364A1 (en) * 2014-07-18 2017-07-20 Applied Materials, Inc. Additive manufacturing with laser and plasma
WO2016176343A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
US10982136B2 (en) 2016-02-26 2021-04-20 The Regents Of The University Of California Ligand-sensitized lanthanide nanocrystals as ultraviolet downconverters
KR102480882B1 (ko) 2016-08-05 2022-12-26 아브페로 파마슈티칼스, 인크. 금속-매개 상태를 치료하기 위한 투여 요법
WO2018044812A2 (en) 2016-08-29 2018-03-08 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
US11684614B2 (en) 2016-09-06 2023-06-27 The Regents Of The University Of California Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
JP7323737B2 (ja) 2016-09-29 2023-08-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 液－液抽出による金属イオンの分離
CA3038670A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Chelating molecules

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BR112012001761A2 (pt) 2009-07-27 2017-05-09 Ferrokin Bioscience Inc composto de formula i, composto farmacêutica e método de tratamento de uma condição mediada por metal em um indivduo
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US20130030028A1 (en) 2013-01-31
US20170217912A1 (en) 2017-08-03
PL1866296T3 (pl) 2017-05-31
AU2006232929A1 (en) 2006-10-12
EP1866296A1 (en) 2007-12-19
CA2603385C (en) 2014-07-15
TR201910900T4 (tr) 2019-08-21
US20180290990A1 (en) 2018-10-11
JP2015145403A (ja) 2015-08-13
MX2007012226A (es) 2007-12-10
WO2006107626A1 (en) 2006-10-12
JP2012131814A (ja) 2012-07-12
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US8278458B2 (en) 2012-10-02
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US8722899B2 (en) 2014-05-13
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US9994535B2 (en) 2018-06-12
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