ATE81777T1 - Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung. - Google Patents

Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung.

Info

Publication number: ATE81777T1
Authority: AT; Austria
Prior art keywords: freeze; cyclophosphamide; dried powder; powder composition; same manufacture
Prior art date: 1989-06-06

Application number

AT90201352T

Other languages

English (en)

Inventor

Alfred James Nijkerk

Johanna Maria Pieterne Vermeer

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-06

Filing date

1990-05-28

Publication date

1992-11-15

1990-05-28 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

1992-11-15 Application granted granted Critical

1992-11-15 Publication of ATE81777T1 publication Critical patent/ATE81777T1/de

Links

CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical group ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title abstract 3
229960004397 cyclophosphamide Drugs 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
239000000843 powder Substances 0.000 title 1
238000004108 freeze drying Methods 0.000 abstract 2
PWOQRKCAHTVFLB-UHFFFAOYSA-N cyclophosphamide hydrate Chemical compound O.ClCCN(CCCl)P1(=O)NCCCO1 PWOQRKCAHTVFLB-UHFFFAOYSA-N 0.000 abstract 1
150000004682 monohydrates Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

AT90201352T 1989-06-06 1990-05-28 Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung. ATE81777T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8901431A NL8901431A (nl)	1989-06-06	1989-06-06	Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan.
EP90201352A EP0401894B1 (de)	1989-06-06	1990-05-28	Gefriergetrocknete pulverförmige Cyclophosphamidzusammensetzung sowie Verfahren zu deren Herstellung

Publications (1)

Publication Number	Publication Date
ATE81777T1 true ATE81777T1 (de)	1992-11-15

Family

ID=19854783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90201352T ATE81777T1 (de)	1989-06-06	1990-05-28	Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung.

Country Status (4)

Country	Link
EP (1)	EP0401894B1 (de)
AT (1)	ATE81777T1 (de)
DE (1)	DE69000412D1 (de)
NL (1)	NL8901431A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2001552C (en) *	1988-11-14	1997-07-22	The Upjohn Company	Cyclophosphamide - sodium bicarbonate lyophilizates
US5418223A (en) *	1993-05-20	1995-05-23	Erbamont, Inc.	Method for lyophilization of cyclophosphamide and product
US6613927B1 (en) *	2002-02-08	2003-09-02	American Pharmaceutical Partners, Inc.	Sterile lyophilized ifosfamide and associated methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4537883A (en) *	1982-11-12	1985-08-27	Mead Johnson & Company	Lyophilized cyclophosphamide
US4659699A (en) *	1983-08-22	1987-04-21	Cetus-Ben Venue Therapeutics	Process for freeze drying cyclophosphamide

1989
- 1989-06-06 NL NL8901431A patent/NL8901431A/nl not_active Application Discontinuation
1990
- 1990-05-28 AT AT90201352T patent/ATE81777T1/de active
- 1990-05-28 EP EP90201352A patent/EP0401894B1/de not_active Expired - Lifetime
- 1990-05-28 DE DE9090201352T patent/DE69000412D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69000412D1 (de)	1992-12-03
EP0401894B1 (de)	1992-10-28
NL8901431A (nl)	1991-01-02
EP0401894A1 (de)	1990-12-12

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