NL8901431A - Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan. - Google Patents

Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan. Download PDF

Info

Publication number: NL8901431A
Authority: NL; Netherlands
Prior art keywords: cyclophosphamide; freeze; preparation; monohydrate; powdered
Prior art date: 1989-06-06

Application number

NL8901431A

Other languages

English (en)

Dutch (nl)

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-06

Filing date

1989-06-06

Publication date

1991-01-02

1989-06-06 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

1989-06-06 Priority to NL8901431A priority Critical patent/NL8901431A/nl

1990-05-28 Priority to EP90201352A priority patent/EP0401894B1/de

1990-05-28 Priority to AT90201352T priority patent/ATE81777T1/de

1990-05-28 Priority to DE9090201352T priority patent/DE69000412D1/de

1991-01-02 Publication of NL8901431A publication Critical patent/NL8901431A/nl

Links

229960004397 cyclophosphamide Drugs 0.000 title claims abstract description 17
CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 title claims abstract description 16
238000002360 preparation method Methods 0.000 title claims description 12
238000000034 method Methods 0.000 title claims description 4
PWOQRKCAHTVFLB-UHFFFAOYSA-N cyclophosphamide hydrate Chemical compound O.ClCCN(CCCl)P1(=O)NCCCO1 PWOQRKCAHTVFLB-UHFFFAOYSA-N 0.000 claims abstract description 10
150000004682 monohydrates Chemical class 0.000 claims abstract description 9
150000001408 amides Chemical class 0.000 claims description 3
238000004108 freeze drying Methods 0.000 abstract description 6
239000000203 mixture Substances 0.000 abstract description 5
238000004519 manufacturing process Methods 0.000 abstract 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
-1 cyclophosphamide amide Chemical class 0.000 description 1
238000009472 formulation Methods 0.000 description 1
238000007710 freezing Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

NL8901431A 1989-06-06 1989-06-06 Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan. NL8901431A (nl)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
NL8901431A NL8901431A (nl)	1989-06-06	1989-06-06	Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan.
EP90201352A EP0401894B1 (de)	1989-06-06	1990-05-28	Gefriergetrocknete pulverförmige Cyclophosphamidzusammensetzung sowie Verfahren zu deren Herstellung
AT90201352T ATE81777T1 (de)	1989-06-06	1990-05-28	Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung.
DE9090201352T DE69000412D1 (de)	1989-06-06	1990-05-28	Gefriergetrocknete pulverfoermige cyclophosphamidzusammensetzung sowie verfahren zu deren herstellung.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8901431		1989-06-06
NL8901431A NL8901431A (nl)	1989-06-06	1989-06-06	Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan.

Publications (1)

Publication Number	Publication Date
NL8901431A true NL8901431A (nl)	1991-01-02

Family

ID=19854783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8901431A NL8901431A (nl)	1989-06-06	1989-06-06	Gevriesdroogd, poedervormig cyclofosfamidepreparaat, alsmede werkwijze ter bereiding daarvan.

Country Status (4)

Country	Link
EP (1)	EP0401894B1 (de)
AT (1)	ATE81777T1 (de)
DE (1)	DE69000412D1 (de)
NL (1)	NL8901431A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2001552C (en) *	1988-11-14	1997-07-22	The Upjohn Company	Cyclophosphamide - sodium bicarbonate lyophilizates
US5418223A (en) *	1993-05-20	1995-05-23	Erbamont, Inc.	Method for lyophilization of cyclophosphamide and product
US6613927B1 (en) *	2002-02-08	2003-09-02	American Pharmaceutical Partners, Inc.	Sterile lyophilized ifosfamide and associated methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4537883A (en) *	1982-11-12	1985-08-27	Mead Johnson & Company	Lyophilized cyclophosphamide
US4659699A (en) *	1983-08-22	1987-04-21	Cetus-Ben Venue Therapeutics	Process for freeze drying cyclophosphamide

1989
- 1989-06-06 NL NL8901431A patent/NL8901431A/nl not_active Application Discontinuation
1990
- 1990-05-28 DE DE9090201352T patent/DE69000412D1/de not_active Expired - Lifetime
- 1990-05-28 EP EP90201352A patent/EP0401894B1/de not_active Expired - Lifetime
- 1990-05-28 AT AT90201352T patent/ATE81777T1/de active

Also Published As

Publication number	Publication date
EP0401894A1 (de)	1990-12-12
EP0401894B1 (de)	1992-10-28
ATE81777T1 (de)	1992-11-15
DE69000412D1 (de)	1992-12-03

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Legal Events

Date	Code	Title	Description
1991-01-02	A1B	A search report has been drawn up
1992-02-03	BV	The patent application has lapsed