ATE81778T1 - Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe. - Google Patents

Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.

Info

Publication number: ATE81778T1
Authority: AT; Austria
Prior art keywords: hypoxanthine; ribose; adenosin; protect; heart during
Prior art date: 1986-10-06

Application number

AT87906894T

Other languages

English (en)

Inventor

Robert M Mentzer Jr

Stephen W Ely

Robert M Berne

Robert D Lasley

Original Assignee

Univ Virginia

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-06

Filing date

1987-10-05

Publication date

1992-11-15

1987-10-05 Application filed by Univ Virginia filed Critical Univ Virginia

1992-11-15 Application granted granted Critical

1992-11-15 Publication of ATE81778T1 publication Critical patent/ATE81778T1/de

Links

OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title abstract 4
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 title abstract 4
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 title abstract 2
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 title abstract 2
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 title abstract 2
HMFHBZSHGGEWLO-AIHAYLRMSA-N alpha-D-ribose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-AIHAYLRMSA-N 0.000 title 1
238000001356 surgical procedure Methods 0.000 title 1
239000008148 cardioplegic solution Substances 0.000 abstract 2
239000002126 C01EB10 - Adenosine Substances 0.000 abstract 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
229960005305 adenosine Drugs 0.000 abstract 1
239000003792 electrolyte Substances 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT87906894T 1986-10-06 1987-10-05 Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe. ATE81778T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US91555786A	1986-10-06	1986-10-06
PCT/US1987/002524 WO1988002258A1 (en)	1986-10-06	1987-10-05	Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
EP87906894A EP0290496B2 (de)	1986-10-06	1987-10-05	Verwendung einer adenosin, hypoxanthin und ribose enthaltender lösung zur schonung des herzens während chirurgischer eingriffe

Publications (1)

Publication Number	Publication Date
ATE81778T1 true ATE81778T1 (de)	1992-11-15

Family

ID=25435935

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87906894T ATE81778T1 (de)	1986-10-06	1987-10-05	Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.

Country Status (10)

Country	Link
US (1)	US4880783A (de)
EP (1)	EP0290496B2 (de)
JP (1)	JP2930589B2 (de)
AT (1)	ATE81778T1 (de)
AU (1)	AU618723B2 (de)
CA (1)	CA1317225C (de)
DE (1)	DE3782427T2 (de)
DK (1)	DK173372B1 (de)
NZ (1)	NZ222051A (de)
WO (1)	WO1988002258A1 (de)

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US5679650A (en) *	1993-11-24	1997-10-21	Fukunaga; Atsuo F.	Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine
US6180616B1 (en)	1990-05-10	2001-01-30	Atsuo F. Fukunaga	Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function
US5677290A (en) *	1990-05-10	1997-10-14	Fukunaga; Atsuo F.	Therapeutic use of adenosine compounds as surgical anesthetics
US6004945A (en) *	1990-05-10	1999-12-21	Fukunaga; Atsuo F.	Use of adenosine compounds to relieve pain
US5320846A (en) *	1991-04-17	1994-06-14	New England Deaconess Hospital Corp.	Method and composition for testing patients with metabolic depleting diseases
IT1252174B (it) *	1991-12-09	1995-06-05	Crinos Industria Farmaco	Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
US5466680A (en) *	1992-03-26	1995-11-14	Cytologics, Inc.	Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5852000A (en) *	1993-08-25	1998-12-22	Otsuka Pharmaceutical Factory, Inc.	Cardiac rehabilitation agent
US5629298A (en) *	1995-03-13	1997-05-13	University Of Massachusetts Medical Center	Adenosine as a positive inotrop in the compromised heart
GB9814039D0 (en) *	1998-06-29	1998-08-26	Univ London	Materials and methods relating to the prevention or treatment of ischaemia-reperfusion injury
US20030166605A1 (en) *	1999-04-27	2003-09-04	Edward Leung	Method of minimizing damage to heart tissue during cardiac surgery and cardiac transplantation
AU2001228325A1 (en) *	2000-02-01	2001-08-14	Novo-Nordisk A/S	Use of compounds for the regulation of food intake
US20010020012A1 (en) *	2000-02-01	2001-09-06	Andersen Maibritt Bansholm	Use of compounds for the regulation of food intake
CA2439043A1 (en)	2001-02-26	2002-09-06	Ben-Ami Ballin	Syringe for use in blood analysis
US20040111079A1 (en) *	2002-12-03	2004-06-10	Richard Hayes	Targeted sanguinous drug solution delivery to a targeted organ
CA2464175A1 (en) *	2003-04-14	2004-10-14	Queen's University At Kingston	Methods and compositions for modulating proteins modified in preconditioning against ischemia/hypoxia
IT1391588B1 (it) *	2008-10-15	2012-01-11	Giellepi Chemicals S P A	Composizione sinergica per il recupero e la riduzione del danno ischemico lieve
US20210219542A1 (en) *	2018-05-15	2021-07-22	The Regents Of The University Of Colorado, A Body Corporate	Compositions and methods for storage of red blood cells
CN121818659A (zh) *	2024-10-10	2026-04-10	四川大学华西医院	一种天然衍生物在制备治疗心肌病和/或心肌纤维化药物中的应用

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US3992531A (en) *	1973-12-26	1976-11-16	Abbott Laboratories	2-Substituted adenosine-5'-carboxylates in the treatment of anginal pain
GB1523865A (en) *	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
EP0011399A1 (de) *	1978-11-11	1980-05-28	FISONS plc	N-Substituierte Theophylline, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4338319A (en) *	1979-11-27	1982-07-06	Aktiebolaget Draco	Method for the treatment of chronic obstructive airway or cardiac diseases
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DE3019322A1 (de) *	1980-05-21	1981-12-03	Merck Patent Gmbh, 6100 Darmstadt	Psychopharmakon sowie verwendung von adenosinderivaten
US4388308A (en) *	1980-06-09	1983-06-14	G.D. Searle & Co.	N6 -[(2-Hydroxypropyl)aryl]adenosines
US4546095A (en) *	1980-07-21	1985-10-08	Markov Angel K	Use of fructose-1,6-diphosphate for treating myocardial infarction
US4673563A (en) *	1980-10-14	1987-06-16	The University Of Virginia Alumni Patents Foundation	Adenosine in the treatment of supraventricular tachycardia
EP0054635B1 (de) *	1980-12-23	1985-02-13	Dr. Franz Köhler Chemie GmbH	Protektive Lösung für Herz und Niere und Verfahren zu deren Herstellung
US4514405A (en) *	1981-09-17	1985-04-30	Merck Patent Gesellschaft Mit Beschrankter Haftung	Use of adenosine derivatives as anticonvulsants
SE8200252L (sv) *	1982-01-18	1983-07-19	Pharmacia Ab	Farmaceutisk komposition
IT1200944B (it) *	1982-08-10	1989-01-27	Malesci Sas	Derivati xantinici,procedimento per la loro preparazione,composizione farmaceutiche che il contengono e loro impiego terapeutico
US4473571A (en) *	1983-01-17	1984-09-25	Sterling Drug Inc.	8-Substituted-2-(4-pyridinyl)-9H-purin-6-amines and their cardiotonic use
US4501735A (en) *	1983-12-05	1985-02-26	Warner-Lambert Company	N6-(1- and 2-benzocycloalkyl) adenosines
IT1206341B (it) *	1984-02-16	1989-04-14	Crinos Industria Farmaco	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
US4593019A (en) *	1984-10-26	1986-06-03	Warner-Lambert Company	N6 -tricyclic adenosines
US4614732A (en) *	1984-10-26	1986-09-30	Warner-Lambert Company	N6 -acenaphthyl adenosines and analogs thereof
US4605644A (en) *	1985-02-07	1986-08-12	Regents Of The University Of Minnesota	Method for stimulating recovery from ischemia employing ribose and adenine
EP0506205B1 (de) *	1985-09-24	1999-01-27	Item Development Ab	Verwendung von Adenosin zur Herstellung eines Arzneimittels für kontinuierliche Intravenöse Infusion an menschlichen Patienten
US4693996A (en) *	1985-12-23	1987-09-15	Warner-Lambert Company	Method of treating heart failure and medicaments therefor

1987
- 1987-10-05 EP EP87906894A patent/EP0290496B2/de not_active Expired - Lifetime
- 1987-10-05 CA CA000548637A patent/CA1317225C/en not_active Expired - Fee Related
- 1987-10-05 AT AT87906894T patent/ATE81778T1/de not_active IP Right Cessation
- 1987-10-05 AU AU80789/87A patent/AU618723B2/en not_active Ceased
- 1987-10-05 NZ NZ222051A patent/NZ222051A/xx unknown
- 1987-10-05 DE DE3782427T patent/DE3782427T2/de not_active Expired - Fee Related
- 1987-10-05 JP JP62506227A patent/JP2930589B2/ja not_active Expired - Fee Related
- 1987-10-05 WO PCT/US1987/002524 patent/WO1988002258A1/en not_active Ceased
1988
- 1988-06-03 DK DK198803057A patent/DK173372B1/da active IP Right Grant
- 1988-09-29 US US07/252,027 patent/US4880783A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3782427T2 (de)	1996-07-18
CA1317225C (en)	1993-05-04
AU618723B2 (en)	1992-01-09
EP0290496B2 (de)	1995-12-20
JP2930589B2 (ja)	1999-08-03
DK305788A (da)	1988-06-03
US4880783A (en)	1989-11-14
WO1988002258A1 (en)	1988-04-07
EP0290496A4 (de)	1989-11-29
EP0290496B1 (de)	1992-10-28
EP0290496A1 (de)	1988-11-17
DK173372B1 (da)	2000-09-11
NZ222051A (en)	1990-07-26
JPH01501311A (ja)	1989-05-11
DE3782427D1 (de)	1992-12-03
DK305788D0 (da)	1988-06-03
AU8078987A (en)	1988-04-21

Legal Events

Date	Code	Title	Description
2007-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3782427D1 (de)	1992-12-03	Verwendung einer adenosin, hypoxanthin und ribose enthaltender loesung zur schonung des herzens waehrend chirurgischer eingriffe.
DE3780924D1 (de)	1992-09-10	Vorrichtung zur untersuchung von thermischen beanspruchungen.
FI891463A7 (fi)	1989-03-28	Menetelmät solunulkoisen adenosiinin kartuttamiseksi ja syöttösolujen stabiloimiseksi
ATE84667T1 (de)	1993-02-15	Hautpenetration verbessernde zusammensetzungen.
IT1075527B (it)	1985-04-22	Procedimento per la determinazione di substrati oppure di attivita' enzimatiche
DE3782825D1 (de)	1993-01-07	Vorrichtung zur mechanischen fuehrung von kathetern waehrend der untersuchung von herz- und blutgefaessen.
DK273587D0 (da)	1987-05-27	1,5-diaryl-3-substituerede pyrazoler samt fremgangsmaade til fremstilling deraf
FI880349A7 (fi)	1988-01-26	Kiinnitysjärjestelmä katetrien, kanyylien tai vastaavien kiinnittämiseksi ihon pintaan
DK427485A (da)	1986-03-22	Blodkoagulationshaemmende proteiner, fremgangsmaade til deres fremstilling samt deres anvendelse
NO790509L (no)	1980-02-15	Kirurgisk sutur eller ligatur.
NO893637D0 (no)	1989-09-11	Fremgangsmaate for aa stabilisere blodkoagulasjonsfaktorer.
JPS6470415A (en)	1989-03-15	Skin permeable remedy system
BG35465A3 (en)	1984-04-15	Method for preparing derivatives of 1-(cyclohexyl)-4-aryl-4- piperidine carbonic acid
DK436387D0 (da)	1987-08-21	Triazol- eller imidazolgruppeholdige 2,5-dihydrofuran-derivater, fremgangsmaade til fremstilling deraf, mellemprodukter til brug ved fremstilling samt anvendelse af saadanne derivater som fungicider
DK317088A (da)	1989-01-06	Substituerede triazolinoner, fremgangsmaader til deres fremstilling samt deres anvendelse
NO875263D0 (no)	1987-12-16	2,3-disubstituerte isoksazolidiner, fremgangsmaate til deres fremstilling, midler inneholdende disse og deres anvendelse.
DK303887D0 (da)	1987-06-15	Dopamin-beta-hydroxylaseinhibitorer og fremgangsmaade til fremstilling deraf
DK162839C (da)	1992-05-04	N,3-diacyl-2-oxindol-1-carboxamid-forbindelser og 3-acyl-2-oxindol-forbindelser til anvendelse som mellemprodukter ved deres fremstilling
FI874697A7 (fi)	1988-04-30	Kromin poistaminen sähkökemiallisesti kloraattiliuoksesta.
IT8521950A0 (it)	1985-08-20	Procedimenti per trattare pellami ed apparecchiatura per attuare il procedimento.
DK474081A (da)	1982-04-29	Fremgangsmaade til stabilisering af en vandig hydrogenperoxidoploesning saaledes stabiliseret vandig hydrogenperoxidoploesning og fremgangsmaade til udnyttelse af denne oploesnings oxiderende egenskaber
DK203784D0 (da)	1984-04-18	1-(4-(4-(fluoralkylmethylthio-eller-sulfinyl-eller-sulfonyl-)-phenoxy)phenyl)-1,3,5-triazin-2,4,6(1h,3h,5h)trioner,fremgangsmaade til fremstilling deraf og deres anvendelse som coccidiosemidler
DE3785812D1 (de)	1993-06-17	Verfahren zur zuechtung von safranstigmageweben.
NO870346D0 (no)	1987-01-28	1-(3-(2-hydroksy-3-alkylaminopropoksy)-2-tienyl)3-fenyl-1-propanon og dets syreaddisjonssalter samt fremgangsmaate ved fremstilling derav.
DK532688A (da)	1989-03-29	Straalingshaerdelige harpikser til anvendelse ved elektronik, og fremgangsmaade til fremstilling af saadanne harpikser