IT1206341B - Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. - Google Patents

Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.

Info

Publication number: IT1206341B
Authority: IT; Italy
Prior art keywords: treatment; ischhemia; pharmaceutical composition; acute myocardium; acute
Prior art date: 1984-02-16

Application number

IT8419645A

Other languages

English (en)

Other versions

IT8419645A0 (it

Inventor

Giuseppe Primo

Marisa Mantovani

Riccardo Niada

Original Assignee

Crinos Industria Farmaco

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-02-16

Filing date

1984-02-16

Publication date

1989-04-14

1984-02-16 Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco

1984-02-16 Publication of IT8419645A0 publication Critical patent/IT8419645A0/it

1984-02-16 Priority to IT8419645A priority Critical patent/IT1206341B/it

1985-02-11 Priority to EP85200159A priority patent/EP0152148B1/en

1985-02-11 Priority to AT85200159T priority patent/ATE76296T1/de

1985-02-14 Priority to BE0/214518A priority patent/BE901737A/fr

1985-02-14 Priority to US06/701,695 priority patent/US4693995A/en

1985-02-15 Priority to AU38787/85A priority patent/AU585495B2/en

1985-02-15 Priority to CH722/85A priority patent/CH662509A5/it

1985-02-15 Priority to JP60029218A priority patent/JPH0649651B2/ja

1985-02-15 Priority to DE3505359A priority patent/DE3505359C2/de

1989-04-14 Application granted granted Critical

1989-04-14 Publication of IT1206341B publication Critical patent/IT1206341B/it

Links

230000001154 acute effect Effects 0.000 title abstract 2
210000004165 myocardium Anatomy 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
210000001557 animal structure Anatomy 0.000 abstract 1
229960004120 defibrotide Drugs 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
208000031225 myocardial ischemia Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

IT8419645A 1984-02-16 1984-02-16 Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio. IT1206341B (it)

Priority Applications (9)

Application Number	Priority Date	Filing Date	Title
IT8419645A IT1206341B (it)	1984-02-16	1984-02-16	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
EP85200159A EP0152148B1 (en)	1984-02-16	1985-02-11	Pharmaceutica composition for the treatment of acute myocardial ischemia
AT85200159T ATE76296T1 (de)	1984-02-16	1985-02-11	Pharmazeutische zusammensetzung zur behandlung von akuter myocardischer ischaemie.
US06/701,695 US4693995A (en)	1984-02-16	1985-02-14	Pharmaceutical composition for the treatment of acute myocardial ischemia
BE0/214518A BE901737A (fr)	1984-02-16	1985-02-14	Composition pharmaceutique pour le traitement de l'ischemie myocardique aigue.
AU38787/85A AU585495B2 (en)	1984-02-16	1985-02-15	Pharmaceutical composition for the treatment of acute myocardial ischemia
CH722/85A CH662509A5 (it)	1984-02-16	1985-02-15	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
JP60029218A JPH0649651B2 (ja)	1984-02-16	1985-02-15	心筋虚血治療用医薬組成物
DE3505359A DE3505359C2 (de)	1984-02-16	1985-02-15	Verwendung von Defibrotid zur Behandlung von akuter myocardialer Ischämie

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8419645A IT1206341B (it)	1984-02-16	1984-02-16	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.

Publications (2)

Publication Number	Publication Date
IT8419645A0 IT8419645A0 (it)	1984-02-16
IT1206341B true IT1206341B (it)	1989-04-14

Family

ID=11160049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT8419645A IT1206341B (it)	1984-02-16	1984-02-16	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.

Country Status (9)

Country	Link
US (1)	US4693995A (it)
EP (1)	EP0152148B1 (it)
JP (1)	JPH0649651B2 (it)
AT (1)	ATE76296T1 (it)
AU (1)	AU585495B2 (it)
BE (1)	BE901737A (it)
CH (1)	CH662509A5 (it)
DE (1)	DE3505359C2 (it)
IT (1)	IT1206341B (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1170214B (it) *	1983-09-12	1987-06-03	Crinos Industria Farmaco	Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1190313B (it) *	1986-04-17	1988-02-16	Crinos Industria Farmaco	Procedimento per l'ottenimento di polidesossiribonucleotidi chimicamente definiti e riproducibili e prodotto farmacologicamente attivo risultante
JP2930589B2 (ja) *	1986-10-06	1999-08-03	ザユニバーシィティオブバージニアアルミニパテンツファンデーション	外科手術中における改善された心臓保護のためのアデノシン，ヒポキサンチン及びリボース含有溶液の使用
IT1223322B (it) *	1987-10-23	1990-09-19	Crinos Industria Farmaco	Metodo per prevenire la formazione di coaguli sanguigni nel circuito extracorporeo di apparecchi di dialisi a composizione utile per esso
IT1231509B (it) *	1989-09-07	1991-12-07	Crinos Industria Farmaco	Composizione farmceutica ad uso topico per la terapia della fragilita' capillare.
US5977083A (en) *	1991-08-21	1999-11-02	Burcoglu; Arsinur	Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
US5624912A (en) *	1991-08-21	1997-04-29	Burcoglu; Arsinur	Method of treating HIV infection and related secondary infections with defibrotide
US6699985B2 (en) *	1991-08-21	2004-03-02	Arsinur Burcoglu	Method of treating HIV infection and related secondary infections thereof
IT1252174B (it) *	1991-12-09	1995-06-05	Crinos Industria Farmaco	Oligodesossimibonucleotidi ad attivita' antiischemica e procedimenti per il loro ottenimento
EP0678029A1 (en) *	1993-01-13	1995-10-25	BURCOGLU, Arsinur	Method for using polynucleotides, oligonucleotides and derivatives thereof to treat various disease states
CA2146242A1 (en) *	1993-08-25	1995-03-02	Otsuka Pharmaceutical Factory, Inc.	Heart function restorative
US5852000A (en) *	1993-08-25	1998-12-22	Otsuka Pharmaceutical Factory, Inc.	Cardiac rehabilitation agent
HK1044896A1 (zh) *	1997-04-28	2002-11-08	Burcoglu Arsinur	治疗hiv感染和与之有关的继发感染的方法
US7252818B2 (en) *	1998-07-24	2007-08-07	Cardiovascular Biotherapeutics, Inc.	Method of producing biologically active human acidic fibroblast growth factor and its use in promoting angiogenesis
EP1147777A1 (en)	2000-04-18	2001-10-24	Crinos Industria Farmacobiologica S.p.A.	Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors
EP1325962A1 (en) *	2001-12-17	2003-07-09	Gentium S.p.A.	A method for determining the biological activity of defibrotide
EP1495702A1 (fr)	2003-07-10	2005-01-12	Nestec S.A.	Dispositif pour l'extraction d'une capsule
ITMI20031714A1 (it) *	2003-09-05	2005-03-06	Gentium Spa	Formazioni ad azione antitumorale.
WO2006094916A1 (en) *	2005-03-03	2006-09-14	Gentium Spa	Defibrotide and/or oligodeoxyribonucleotides for treating angiogenesis-dependent tumors
EP1872787A1 (en) *	2006-06-27	2008-01-02	Gentium S.p.A.	Use of defibrotide for the inhibition of heparanase
EP1982722A1 (en) *	2007-04-16	2008-10-22	Gentium S.p.A.	Use of oligotide for the treatment of renal diseases
EP2103689A1 (en)	2008-03-19	2009-09-23	Gentium S.p.A.	Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
IT1406068B1 (it)	2010-07-22	2014-02-06	Medestea Int Spa	Polidesossiribonucleotidi (pdrn) per l'impiego nel trattamento di condizioni di acidosi e composizioni a base di polidesossiribonucleotidi per il suddetto impiego
DE102010039631A1 (de)	2010-08-22	2012-02-23	Ulrich Schubert	Pharmazeutische Zusammensetzungen mit immunmodulatorischen Eigenschaften
AU2010363814B2 (en)	2010-11-12	2016-05-19	Gentium S.R.L.	Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
CN110079580B (zh)	2012-06-22	2022-12-06	真蒂奥姆责任有限公司	用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法
EP3026122A1 (en)	2014-11-27	2016-06-01	Gentium S.p.A.	Cellular-based method for determining the potency of defibrotide
JP2020530004A (ja)	2017-08-03	2020-10-15	ジャズファーマシューティカルズアイルランドリミテッド	核酸を高濃度で含む製剤
CN112236149A (zh)	2018-04-12	2021-01-15	贾兹制药公司	用于预防和治疗细胞因子释放综合征和与免疫耗竭相关的神经毒性的去纤苷
WO2020118165A1 (en)	2018-12-07	2020-06-11	Jazz Pharmaceuticals Ireland Limited	Subcutaneous delivery of high concentration formulations
EP4110287A1 (en)	2020-02-28	2023-01-04	Jazz Pharmaceuticals Ireland Limited	Delivery of low viscosity formulations
US20230086833A1 (en)	2020-04-17	2023-03-23	Jazz Pharmaceuticals Ireland Limited	Defibrotide treatment for the prevention of organ rejection and injury
TW202308659A (zh)	2021-05-06	2023-03-01	愛爾蘭商爵士製藥愛爾蘭有限責任公司	用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3899481A (en) *	1970-11-03	1975-08-12	Crinos Industria Farmaco	Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
IT1043823B (it) *	1970-11-03	1980-02-29	Prephar	Procedimento per l estrazione di acidi nucleici da organi animali
DE2154279A1 (de) *	1970-11-03	1972-05-25	Crinos Industria Farmaco	Medikamente für das fibrinolytische System

1984
- 1984-02-16 IT IT8419645A patent/IT1206341B/it active
1985
- 1985-02-11 AT AT85200159T patent/ATE76296T1/de active
- 1985-02-11 EP EP85200159A patent/EP0152148B1/en not_active Expired - Lifetime
- 1985-02-14 US US06/701,695 patent/US4693995A/en not_active Expired - Fee Related
- 1985-02-14 BE BE0/214518A patent/BE901737A/fr not_active IP Right Cessation
- 1985-02-15 DE DE3505359A patent/DE3505359C2/de not_active Expired - Fee Related
- 1985-02-15 CH CH722/85A patent/CH662509A5/it not_active IP Right Cessation
- 1985-02-15 AU AU38787/85A patent/AU585495B2/en not_active Ceased
- 1985-02-15 JP JP60029218A patent/JPH0649651B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPS60188323A (ja)	1985-09-25
CH662509A5 (it)	1987-10-15
BE901737A (fr)	1985-05-29
EP0152148A2 (en)	1985-08-21
US4693995A (en)	1987-09-15
AU585495B2 (en)	1989-06-22
ATE76296T1 (de)	1992-06-15
DE3505359C2 (de)	1994-01-20
AU3878785A (en)	1985-08-22
IT8419645A0 (it)	1984-02-16
JPH0649651B2 (ja)	1994-06-29
DE3505359A1 (de)	1985-08-22
EP0152148A3 (en)	1987-04-29
EP0152148B1 (en)	1992-05-20

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19950404

Publication	Publication Date	Title
IT1206341B (it)	1989-04-14	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.
ES2058411T3 (es)	1994-11-01	Sustancia fr 901228 y su preparacion.
EP0444196A4 (en)	1991-11-27	Agent for treatment and prophylaxis of ischemic disease of heart or brain
ATE89547T1 (de)	1993-06-15	Dopamin-vorlaeufer.
MX9305248A (es)	1995-01-31	Compuestos de diarilpiperazinoacetamida.
ES2045182T3 (es)	1994-01-16	Substancias fisiologicamente activas, un proceso para la preparacion de las mismas y composiciones farmaceuticas que las contienen.
KR970705553A (ko)	1997-10-09	디히드로벤조푸란, 및 항염증 약물로서 유용한 관련 화합물(dihydrobenzofuran and related compounds useful as anti-inflammatory agents)
IT1190824B (it)	1988-02-24	Composizione farmaceutica contenente 24,25-diidrossicolecalciferolo come ingrediente attivo
DE19475001I2 (de)	2004-07-01	Anthelminthische Wirkstoffkombinationen.
ES478967A1 (es)	1980-08-16	Un procedimiento para preparar compuestos de acido 3-cefem-4-carboxilico disustituido en las posiciones 3 y 7.
FR2405657A1 (fr)	1979-05-11	Agent favorisant la croissance des animaux
ES511962A0 (es)	1983-06-01	"procedimiento para la preparacion de composiciones de ferormonas aldehidicas de lenta liberacion del compuesto activo".
MX9203361A (es)	1992-07-01	Composiciones farmaceuticas que contienen cloruro de galio.
FR2420344A1 (fr)	1979-10-19	Nouveaux oxime-ethers, leur preparation et leur application therapeutique.
ES472864A1 (es)	1979-10-16	Un procedimiento para la preparacion de derivados de picro- podofilona
IT8026233A0 (it)	1980-11-26	Derivato della n-acetil-cisteina ad attivita' terapeutica, procedimento per la sua preparazione e relative composizioni farmaceutiche.
FR2387952A1 (fr)	1978-11-17	Derives de composes du type inter-phenylene-prostaglandine et compositions pharmaceutiques en contenant
FR2392966A1 (fr)	1978-12-29	Nouveaux acides uree-bis(naphtalene-sulfoniques et naphtalene-carboxyliques), leurs sels pharmaceutiquement acceptables, et leur utilisation therapeutique
IT8521528A0 (it)	1985-07-11	Composizioni farmaceutiche e cosmetiche contenenti come ingrediente attivo diidrossi-1,8fenil-10 antrone-9, e procedimentodi preparazione dell'ingrediente attivo.
FR2403032A1 (fr)	1979-04-13	Nouveau compose favorisant la croissance des animaux
ES465578A1 (es)	1979-01-01	Procedimiento para la obtencion de preparados farmaceuticos diureticos, antihipertensivos y cardiales
FR2391208A1 (fr)	1978-12-15	Thiophenes substitues et compositions pharmaceutiques en contenant
ES2072005T3 (es)	1995-07-01	Utilizacion de analogos de 20(r)-22-oxa-vitamina d en la preparacion de un medicamento para el tratamiento del envejecimiento de la piel.
ES2039436T3 (es)	1993-10-01	Un procedimiento para preparar una composicion farmaceutica.
ATE49958T1 (de)	1990-02-15	Pharmazeutische zusammensetzungen mit immunodepressivwirkung.