ATE82682T1 - Nichtwaessrige loesung von doxorubicinhydrochlorid. - Google Patents
Nichtwaessrige loesung von doxorubicinhydrochlorid.Info
- Publication number
- ATE82682T1 ATE82682T1 AT88111434T AT88111434T ATE82682T1 AT E82682 T1 ATE82682 T1 AT E82682T1 AT 88111434 T AT88111434 T AT 88111434T AT 88111434 T AT88111434 T AT 88111434T AT E82682 T1 ATE82682 T1 AT E82682T1
- Authority
- AT
- Austria
- Prior art keywords
- aqueous
- aqueous solution
- water
- solutions
- doxorubicin hcl
- Prior art date
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title abstract 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- 229960004679 doxorubicin Drugs 0.000 abstract 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- 229940087168 alpha tocopherol Drugs 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012457 nonaqueous media Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- UOULCEYHQNCFFH-UHFFFAOYSA-M sodium;hydroxymethanesulfonate Chemical compound [Na+].OCS([O-])(=O)=O UOULCEYHQNCFFH-UHFFFAOYSA-M 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004250 tert-Butylhydroquinone Substances 0.000 abstract 1
- 235000019281 tert-butylhydroquinone Nutrition 0.000 abstract 1
- 229960000984 tocofersolan Drugs 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 239000002076 α-tocopherol Substances 0.000 abstract 1
- 235000004835 α-tocopherol Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7418987A | 1987-07-16 | 1987-07-16 | |
| EP88111434A EP0299528B1 (de) | 1987-07-16 | 1988-07-15 | Nichtwässrige Lösung von Doxorubicinhydrochlorid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE82682T1 true ATE82682T1 (de) | 1992-12-15 |
Family
ID=22118210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88111434T ATE82682T1 (de) | 1987-07-16 | 1988-07-15 | Nichtwaessrige loesung von doxorubicinhydrochlorid. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0299528B1 (de) |
| JP (1) | JPS6438021A (de) |
| KR (1) | KR920004096B1 (de) |
| AT (1) | ATE82682T1 (de) |
| AU (1) | AU615454B2 (de) |
| DE (1) | DE3876160T2 (de) |
| DK (1) | DK396188A (de) |
| ES (1) | ES2052646T3 (de) |
| FI (1) | FI883337L (de) |
| GR (1) | GR3006383T3 (de) |
| PT (1) | PT88015B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE87210T1 (de) * | 1988-12-05 | 1993-04-15 | Bristol Myers Squibb Co | Doxorubicin-loesungen. |
| FR2690340B1 (fr) * | 1992-04-24 | 1995-02-24 | Scr Newmed | Nouveau procédé de stabilisation des préparations pharmaceutiques liquides et les compositions pharmaceutiques ainsi stabilisées en résultant. |
| RU2065307C1 (ru) * | 1994-12-13 | 1996-08-20 | Александр Васильевич Тихонов | Способ лечения первичного рака печени и набор для лечения первичного рака печени |
| US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US5946961A (en) * | 1998-05-01 | 1999-09-07 | Buhrke Industries, Inc. | Web bowing apparatus |
| US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US6071952A (en) * | 1998-12-02 | 2000-06-06 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
| RU2134589C1 (ru) * | 1998-12-22 | 1999-08-20 | Зубов Дмитрий Львович | Способ лечения первичного рака печени и набор для лечения первичного рака печени |
| CA2880855A1 (en) * | 2012-08-03 | 2014-02-06 | Mestex Ag | Resiniferatoxin solution |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU529422B2 (en) * | 1978-10-20 | 1983-06-09 | Eli Lilly And Company | Stable erythromycin solution |
| GB8519452D0 (en) * | 1985-08-02 | 1985-09-11 | Erba Farmitalia | Injectable solutions |
| DE3537761A1 (de) * | 1985-10-24 | 1987-04-30 | Bayer Ag | Infusionsloesungen der 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-chinolin-3-carbonsaeure |
-
1988
- 1988-07-13 FI FI883337A patent/FI883337L/fi not_active IP Right Cessation
- 1988-07-14 AU AU19051/88A patent/AU615454B2/en not_active Ceased
- 1988-07-14 JP JP63173843A patent/JPS6438021A/ja active Granted
- 1988-07-15 KR KR1019880008863A patent/KR920004096B1/ko not_active Expired
- 1988-07-15 DE DE8888111434T patent/DE3876160T2/de not_active Expired - Fee Related
- 1988-07-15 PT PT88015A patent/PT88015B/pt not_active IP Right Cessation
- 1988-07-15 DK DK396188A patent/DK396188A/da not_active Application Discontinuation
- 1988-07-15 EP EP88111434A patent/EP0299528B1/de not_active Expired - Lifetime
- 1988-07-15 AT AT88111434T patent/ATE82682T1/de active
- 1988-07-15 ES ES88111434T patent/ES2052646T3/es not_active Expired - Lifetime
-
1992
- 1992-11-30 GR GR920402456T patent/GR3006383T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU615454B2 (en) | 1991-10-03 |
| DE3876160T2 (de) | 1993-04-01 |
| GR3006383T3 (de) | 1993-06-21 |
| JPS6438021A (en) | 1989-02-08 |
| FI883337A7 (fi) | 1989-01-17 |
| EP0299528B1 (de) | 1992-11-25 |
| ES2052646T3 (es) | 1994-07-16 |
| PT88015B (pt) | 1995-03-01 |
| AU1905188A (en) | 1989-01-19 |
| EP0299528A1 (de) | 1989-01-18 |
| PT88015A (pt) | 1989-06-30 |
| KR920004096B1 (ko) | 1992-05-25 |
| DK396188D0 (da) | 1988-07-15 |
| FI883337A0 (fi) | 1988-07-13 |
| FI883337L (fi) | 1989-01-17 |
| DE3876160D1 (de) | 1993-01-07 |
| KR890001570A (ko) | 1989-03-27 |
| JPH0559093B2 (de) | 1993-08-30 |
| DK396188A (da) | 1989-01-17 |
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