ATE83266T1 - Verfahren zur herstellung von ribavirin unter verwendung von hohen ribose-donorkonzentrationen. - Google Patents

Verfahren zur herstellung von ribavirin unter verwendung von hohen ribose-donorkonzentrationen.

Info

Publication number: ATE83266T1
Authority: AT; Austria
Prior art keywords: ribose; production; high concentrations; ribavirin; donors
Prior art date: 1987-09-17

Application number

AT88114937T

Other languages

English (en)

Inventor

James Michael Pochodylo

Street

Original Assignee

Genencor Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-17

Filing date

1988-09-13

Publication date

1992-12-15

1988-09-13 Application filed by Genencor Int filed Critical Genencor Int

1992-12-15 Application granted granted Critical

1992-12-15 Publication of ATE83266T1 publication Critical patent/ATE83266T1/de

Links

238000000034 method Methods 0.000 title abstract 4
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 title abstract 3
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 3
IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title 1
HMFHBZSHGGEWLO-AIHAYLRMSA-N alpha-D-ribose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-AIHAYLRMSA-N 0.000 title 1
229960000329 ribavirin Drugs 0.000 title 1
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title 1
-1 1,2,4-triazole nucleoside Chemical class 0.000 abstract 2
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 2
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical group C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
241000131747 Exiguobacterium acetylicum Species 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
229940029575 guanosine Drugs 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/84—Brevibacterium

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)

AT88114937T 1987-09-17 1988-09-13 Verfahren zur herstellung von ribavirin unter verwendung von hohen ribose-donorkonzentrationen. ATE83266T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/097,767 US4840899A (en)	1987-09-17	1987-09-17	Method for the production of ribavirin using high robose donor concentrations
EP88114937A EP0307853B1 (de)	1987-09-17	1988-09-13	Verfahren zur Herstellung von Ribavirin unter Verwendung von hohen Ribose-Donor-Konzentrationen

Publications (1)

Publication Number	Publication Date
ATE83266T1 true ATE83266T1 (de)	1992-12-15

Family

ID=22265029

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88114937T ATE83266T1 (de)	1987-09-17	1988-09-13	Verfahren zur herstellung von ribavirin unter verwendung von hohen ribose-donorkonzentrationen.

Country Status (8)

Country	Link
US (1)	US4840899A (de)
EP (1)	EP0307853B1 (de)
JP (1)	JPH01102093A (de)
KR (1)	KR890005276A (de)
AT (1)	ATE83266T1 (de)
AU (1)	AU2025888A (de)
CA (1)	CA1297057C (de)
DE (1)	DE3876555T2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4840898A (en) *	1987-09-17	1989-06-20	Eastman Kodak Company	High temperature method for the production of ribavirin
DE4002066A1 (de) *	1990-01-25	1991-08-01	Basf Ag	Verfahren zur abtrennung von riboflavin aus fermentationssuspensionen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3976545A (en) *	1973-03-12	1976-08-24	Icn Pharmaceuticals, Inc.	1,2,4-Triazol E-3-carboxamides as antiviral agents
JPS57146593A (en) *	1981-03-09	1982-09-10	Ajinomoto Co Inc	Preparation of ribofuranosyltriazole derivative
US4614719A (en) *	1982-04-30	1986-09-30	Yamasa Shoyu Kabushiki Kaisha	Process for producing ribavirin
US4840898A (en) *	1987-09-17	1989-06-20	Eastman Kodak Company	High temperature method for the production of ribavirin

1987
- 1987-09-17 US US07/097,767 patent/US4840899A/en not_active Expired - Lifetime
1988
- 1988-02-09 CA CA000558442A patent/CA1297057C/en not_active Expired - Lifetime
- 1988-08-01 AU AU20258/88A patent/AU2025888A/en not_active Abandoned
- 1988-09-13 EP EP88114937A patent/EP0307853B1/de not_active Expired - Lifetime
- 1988-09-13 DE DE8888114937T patent/DE3876555T2/de not_active Expired - Fee Related
- 1988-09-13 AT AT88114937T patent/ATE83266T1/de not_active IP Right Cessation
- 1988-09-16 KR KR1019880011945A patent/KR890005276A/ko not_active Withdrawn
- 1988-09-16 JP JP63230204A patent/JPH01102093A/ja active Pending

Also Published As

Publication number	Publication date
CA1297057C (en)	1992-03-10
EP0307853A3 (en)	1990-05-02
KR890005276A (ko)	1989-05-13
EP0307853A2 (de)	1989-03-22
AU2025888A (en)	1989-03-23
EP0307853B1 (de)	1992-12-09
DE3876555D1 (de)	1993-01-21
US4840899A (en)	1989-06-20
DE3876555T2 (de)	1993-06-09
JPH01102093A (ja)	1989-04-19

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Legal Events

Date	Code	Title	Description
1993-05-15	UEP	Publication of translation of european patent specification
1996-06-15	REN	Ceased due to non-payment of the annual fee