ATE84026T1 - Spirotricycloaromatische succinimidderivate als aldose-reduktase-inhibitoren. - Google Patents

Spirotricycloaromatische succinimidderivate als aldose-reduktase-inhibitoren.

Info

Publication number: ATE84026T1
Authority: AT; Austria
Prior art keywords: compounds; spirotricycloaromatic; reductase inhibitors; aldose reductase; treatment
Prior art date: 1983-09-14

Application number

AT84110855T

Other languages

English (en)

Inventor

Billie M York Jr

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-14

Filing date

1984-09-12

Publication date

1993-01-15

1984-09-12 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

1993-01-15 Application granted granted Critical

1993-01-15 Publication of ATE84026T1 publication Critical patent/ATE84026T1/de

Links

239000003288 aldose reductase inhibitor Substances 0.000 title 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
229940053198 antiepileptics succinimide derivative Drugs 0.000 title 1
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
206010012601 diabetes mellitus Diseases 0.000 abstract 2
NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
230000007774 longterm Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003334 secondary amides Chemical class 0.000 abstract 1
125000003003 spiro group Chemical group 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D127/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers
- C09D127/02—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
- C09D127/04—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C09D127/06—Homopolymers or copolymers of vinyl chloride

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Ophthalmology & Optometry (AREA)
Materials Engineering (AREA)
Diabetes (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pyrane Compounds (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT84110855T 1983-09-14 1984-09-12 Spirotricycloaromatische succinimidderivate als aldose-reduktase-inhibitoren. ATE84026T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/532,168 US4537892A (en)	1983-09-14	1983-09-14	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
EP84110855A EP0137333B1 (de)	1983-09-14	1984-09-12	Spirotricycloaromatische Succinimidderivate als Aldose-Reduktase-Inhibitoren

Publications (1)

Publication Number	Publication Date
ATE84026T1 true ATE84026T1 (de)	1993-01-15

Family

ID=24120635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84110855T ATE84026T1 (de)	1983-09-14	1984-09-12	Spirotricycloaromatische succinimidderivate als aldose-reduktase-inhibitoren.

Country Status (13)

Country	Link
US (1)	US4537892A (de)
EP (1)	EP0137333B1 (de)
JP (1)	JPH0825877B2 (de)
AT (1)	ATE84026T1 (de)
AU (1)	AU579111B2 (de)
CA (1)	CA1269661A (de)
DE (1)	DE3486020T2 (de)
ES (4)	ES8900214A1 (de)
IE (1)	IE59949B1 (de)
IL (1)	IL72900A (de)
NZ (1)	NZ209199A (de)
PT (1)	PT79207B (de)
ZA (1)	ZA847277B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5070100A (en) *	1983-09-14	1991-12-03	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US5153211A (en) *	1983-09-14	1992-10-06	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US4717725A (en) *	1984-04-11	1988-01-05	Alcon Laboratories, Inc.	Ophthalmic wound healing with aldose reductase inhibitors
WO1988006887A1 (en) *	1987-03-20	1988-09-22	Alcon Laboratories, Inc.	Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US5290813A (en) *	1987-06-04	1994-03-01	Massachusetts Institute Of Technology	Chemical prevention or reversal of cataract by phase separation inhibitors
US5091421A (en) *	1987-06-04	1992-02-25	Massachusetts Institute Of Technology	Chemical prevention or reversal of cataract by phase separation inhibitors
US5338545A (en) *	1987-06-04	1994-08-16	Oculon Corporation	Chemical prevention or reversal of cataract by phase separation inhibitors
US5401880A (en) *	1987-06-04	1995-03-28	Oculon Corporation	Chemical prevention or reversal of cataract by phase separation inhibitors
WO1988009660A2 (en) *	1987-06-04	1988-12-15	Massachusetts Institute Of Technology	Chemical prevention or reversal of cataract by phase separation inhibitors
US4968809A (en) *	1988-11-04	1990-11-06	Dupriest Mark T	Spirofluoreneisothiazolidinone dioxides as aldose reductase inhibitors
US5221686A (en) *	1992-08-04	1993-06-22	American Home Products Corporation	Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
US5760246A (en)	1996-12-17	1998-06-02	Biller; Scott A.	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
US8853257B2 (en)	2005-11-21	2014-10-07	Mordechai Sharir	Succinimide derivatives as ocular hypotensive agents
WO2007057889A2 (en) *	2005-11-21	2007-05-24	Mordechai Sharir	Succinimide derivatives as ocular hypotensive agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4209630A (en) *	1976-10-18	1980-06-24	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
IL68314A0 (en) *	1982-04-15	1983-07-31	Alcon Lab Inc	Method and composition for inhibiting aldose reductase activity and process for preparing spirofluorofluoren and spiro-difluorofluoren compounds
DK277484A (da) *	1983-06-23	1984-12-24	Hoffmann La Roche	Thiazolidinderivater
WO1986002647A1 (en) *	1984-10-30	1986-05-09	Pfizer Inc.	Spiro-heteroazolones for treatment of diabetes complications

1983
- 1983-09-14 US US06/532,168 patent/US4537892A/en not_active Expired - Lifetime
1984
- 1984-08-13 NZ NZ209199A patent/NZ209199A/en unknown
- 1984-08-30 AU AU32547/84A patent/AU579111B2/en not_active Ceased
- 1984-09-10 IL IL72900A patent/IL72900A/xx not_active IP Right Cessation
- 1984-09-10 ES ES535798A patent/ES8900214A1/es not_active Expired
- 1984-09-11 JP JP59188994A patent/JPH0825877B2/ja not_active Expired - Lifetime
- 1984-09-12 DE DE8484110855T patent/DE3486020T2/de not_active Expired - Fee Related
- 1984-09-12 EP EP84110855A patent/EP0137333B1/de not_active Expired - Lifetime
- 1984-09-12 AT AT84110855T patent/ATE84026T1/de not_active IP Right Cessation
- 1984-09-13 IE IE233184A patent/IE59949B1/en not_active IP Right Cessation
- 1984-09-14 ZA ZA847277A patent/ZA847277B/xx unknown
- 1984-09-14 CA CA000463254A patent/CA1269661A/en not_active Expired - Lifetime
- 1984-09-14 PT PT79207A patent/PT79207B/pt not_active IP Right Cessation
1986
- 1986-01-30 ES ES551435A patent/ES8800915A1/es not_active Expired
- 1986-01-30 ES ES551434A patent/ES8800572A1/es not_active Expired
- 1986-01-30 ES ES551436A patent/ES8800570A1/es not_active Expired

Also Published As

Publication number	Publication date
ES8800570A1 (es)	1987-11-01
CA1269661A (en)	1990-05-29
IE59949B1 (en)	1994-05-04
US4537892A (en)	1985-08-27
PT79207B (en)	1986-08-14
DE3486020D1 (de)	1993-02-11
AU3254784A (en)	1985-10-03
ZA847277B (en)	1985-05-29
ES8800915A1 (es)	1987-12-01
NZ209199A (en)	1988-04-29
EP0137333A3 (en)	1986-03-05
IE842331L (en)	1985-03-14
ES8800572A1 (es)	1987-11-01
IL72900A0 (en)	1984-12-31
ES551435A0 (es)	1987-12-01
ES551434A0 (es)	1987-11-01
ES535798A0 (es)	1989-04-01
IL72900A (en)	1989-01-31
DE3486020T2 (de)	1993-05-19
PT79207A (en)	1984-10-01
ES551436A0 (es)	1987-11-01
JPS6089469A (ja)	1985-05-20
EP0137333B1 (de)	1992-12-30
EP0137333A2 (de)	1985-04-17
AU579111B2 (en)	1988-11-17
ES8900214A1 (es)	1989-04-01
JPH0825877B2 (ja)	1996-03-13

Legal Events

Date	Code	Title	Description
1993-06-15	UEP	Publication of translation of european patent specification
1997-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE84026T1 (de)	1993-01-15	Spirotricycloaromatische succinimidderivate als aldose-reduktase-inhibitoren.
SE8700499D0 (sv)	1987-02-10	Novel pharmacologically active compounds
AU548268B2 (en)	1985-12-05	2-ammo-5-hydroxy-4-methylpyrimidinme derivatives
AU560436B2 (en)	1987-04-09	5-substituted 1,2,4,-oxadiazole derivatives
DK0506778T3 (da)	1996-10-07	Substituerede 4-phenyl-4-piperidincarboxamider med både lokal anæstetisk og analgetisk virkning samt fremgangsmåder til deres fremstilling
EA199800701A1 (ru)	1999-02-25	БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5a-РЕДУКТАЗ
ES2046528T3 (es)	1994-02-01	Derivados heterotetraciclicos de lactamas, proceso para su preparacion y composiciones farmaceuticas a base de los mismos.
DE3374005D1 (en)	1987-11-12	1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
NZ220800A (en)	1989-12-21	Tetrahydrobenzothiazoles and pharmaceutical compositions
GB1433103A (en)	1976-04-22	Pharmacologically active pyrrolodiazepines
GB1498857A (en)	1978-01-25	Antidepressant composition
JPS5251362A (en)	1977-04-25	Preparation of optically active pyrrolidine derivatives
JPS52111576A (en)	1977-09-19	Synthesis of 5,7,8-trimethyl-3,4-dehydrotocotrienol
JPS5285163A (en)	1977-07-15	Preparation of malenimide derivatives
YU12191A (sh)	1994-01-20	Kristalni hidrohlorid novog beta-laktamskog antibiotika i postupak za njegovo dobijanje
SE8107470L (sv)	1982-10-17	Imidazolderivat
SE8104675L (sv)	1982-02-06	Farmacevtisk komposition med antiflogistisk, antipyretisk och analgetisk verkan
NO961061L (no)	1996-03-15	Terapeutisk aktive antracyclin-disakkarider
JPS527956A (en)	1977-01-21	Succinimide derivatives and its preparation
JPS57159711A (en)	1982-10-01	Low oxygen cell sensitizer for radiation
GB931019A (en)	1963-07-10	Pharmaceutical compositions containing quinazolone compounds
FR2379505A1 (fr)	1978-09-01	Nouveaux produits doues notamment de proprietes therapeutiques, leurs procedes de preparation, et medicaments a base de ces produits
JPS5253830A (en)	1977-04-30	Preparation of optically active benzyl alcohol derivatives
JPS5210252A (en)	1977-01-26	Preparation of tetracyclo(7,3,1,02,5,05, 10) tridecan-3-ones
JPS52116481A (en)	1977-09-29	Novel lactol derivatives and preparation of the same