PT79207B - Process for preparing spiro-tricyclicaromatic succinimide derivatives useful as inhibitors of aldose reductase - Google Patents

Process for preparing spiro-tricyclicaromatic succinimide derivatives useful as inhibitors of aldose reductase

Info

Publication number: PT79207B
Authority: PT; Portugal
Prior art keywords: compounds; inhibitors; aldose reductase; derivatives useful; succinimide derivatives
Prior art date: 1983-09-14

Application number

PT79207A

Other languages

English (en)

Other versions

PT79207A (en

Inventor

Billie M York Jr

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-14

Filing date

1984-09-14

Publication date

1986-08-14

1984-09-14 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

1984-10-01 Publication of PT79207A publication Critical patent/PT79207A/pt

1986-08-14 Publication of PT79207B publication Critical patent/PT79207B/pt

Links

102000016912 Aldehyde Reductase Human genes 0.000 title 1
108010053754 Aldehyde reductase Proteins 0.000 title 1
229940053198 antiepileptics succinimide derivative Drugs 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical class O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
206010012601 diabetes mellitus Diseases 0.000 abstract 2
NIHNNTQXNPWCJQ-UHFFFAOYSA-N fluorene Chemical compound C1=CC=C2CC3=CC=CC=C3C2=C1 NIHNNTQXNPWCJQ-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
230000007774 longterm Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
150000003334 secondary amides Chemical class 0.000 abstract 1
125000003003 spiro group Chemical group 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D127/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers
- C09D127/02—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
- C09D127/04—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment containing chlorine atoms
- C09D127/06—Homopolymers or copolymers of vinyl chloride

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Materials Engineering (AREA)
Wood Science & Technology (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Indole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrane Compounds (AREA)

PT79207A 1983-09-14 1984-09-14 Process for preparing spiro-tricyclicaromatic succinimide derivatives useful as inhibitors of aldose reductase PT79207B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/532,168 US4537892A (en)	1983-09-14	1983-09-14	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase

Publications (2)

Publication Number	Publication Date
PT79207A PT79207A (en)	1984-10-01
PT79207B true PT79207B (en)	1986-08-14

Family

ID=24120635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT79207A PT79207B (en)	1983-09-14	1984-09-14	Process for preparing spiro-tricyclicaromatic succinimide derivatives useful as inhibitors of aldose reductase

Country Status (13)

Country	Link
US (1)	US4537892A (pt)
EP (1)	EP0137333B1 (pt)
JP (1)	JPH0825877B2 (pt)
AT (1)	ATE84026T1 (pt)
AU (1)	AU579111B2 (pt)
CA (1)	CA1269661A (pt)
DE (1)	DE3486020T2 (pt)
ES (4)	ES8900214A1 (pt)
IE (1)	IE59949B1 (pt)
IL (1)	IL72900A (pt)
NZ (1)	NZ209199A (pt)
PT (1)	PT79207B (pt)
ZA (1)	ZA847277B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5153211A (en) *	1983-09-14	1992-10-06	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase
US5070100A (en) *	1983-09-14	1991-12-03	Alcon Laboratories, Inc.	Spiro-tricyclicaromatic succinimide derivatives
US4717725A (en) *	1984-04-11	1988-01-05	Alcon Laboratories, Inc.	Ophthalmic wound healing with aldose reductase inhibitors
WO1988006887A1 (en) *	1987-03-20	1988-09-22	Alcon Laboratories, Inc.	Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus
US5091421A (en) *	1987-06-04	1992-02-25	Massachusetts Institute Of Technology	Chemical prevention or reversal of cataract by phase separation inhibitors
US5290813A (en) *	1987-06-04	1994-03-01	Massachusetts Institute Of Technology	Chemical prevention or reversal of cataract by phase separation inhibitors
US5338545A (en) *	1987-06-04	1994-08-16	Oculon Corporation	Chemical prevention or reversal of cataract by phase separation inhibitors
CA1322526C (en) *	1987-06-04	1993-09-28	John I. Clark	Chemical prevention or reversal of cataract by phase separation inhibitors
US5401880A (en) *	1987-06-04	1995-03-28	Oculon Corporation	Chemical prevention or reversal of cataract by phase separation inhibitors
US4968809A (en) *	1988-11-04	1990-11-06	Dupriest Mark T	Spirofluoreneisothiazolidinone dioxides as aldose reductase inhibitors
US5221686A (en) *	1992-08-04	1993-06-22	American Home Products Corporation	Spiro[1,2-benzisothiazole-3(2H),5'-oxazolidine]-2',4'-dione 1,1-dioxides as antihyperglycemic agents
US5760246A (en)	1996-12-17	1998-06-02	Biller; Scott A.	Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2007057889A2 (en) *	2005-11-21	2007-05-24	Mordechai Sharir	Succinimide derivatives as ocular hypotensive agents
US8853257B2 (en)	2005-11-21	2014-10-07	Mordechai Sharir	Succinimide derivatives as ocular hypotensive agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4117230A (en) *	1976-10-18	1978-09-26	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4209630A (en) *	1976-10-18	1980-06-24	Pfizer Inc.	Hydantoin derivatives as therapeutic agents
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
ATE11781T1 (de) *	1981-05-13	1985-02-15	Imperial Chemical Industries Plc	Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.
IL68314A0 (en) *	1982-04-15	1983-07-31	Alcon Lab Inc	Method and composition for inhibiting aldose reductase activity and process for preparing spirofluorofluoren and spiro-difluorofluoren compounds
DK277484A (da) *	1983-06-23	1984-12-24	Hoffmann La Roche	Thiazolidinderivater
HU198051B (en) *	1984-10-30	1989-07-28	Pfizer	Process for producing spiro square brackets open imidazolidine-4,5'(6h)-quinoline square brackets closed-2,5-dione derivatives

1983
- 1983-09-14 US US06/532,168 patent/US4537892A/en not_active Expired - Lifetime
1984
- 1984-08-13 NZ NZ209199A patent/NZ209199A/en unknown
- 1984-08-30 AU AU32547/84A patent/AU579111B2/en not_active Ceased
- 1984-09-10 ES ES535798A patent/ES8900214A1/es not_active Expired
- 1984-09-10 IL IL72900A patent/IL72900A/xx not_active IP Right Cessation
- 1984-09-11 JP JP59188994A patent/JPH0825877B2/ja not_active Expired - Lifetime
- 1984-09-12 EP EP84110855A patent/EP0137333B1/en not_active Expired - Lifetime
- 1984-09-12 AT AT84110855T patent/ATE84026T1/de not_active IP Right Cessation
- 1984-09-12 DE DE8484110855T patent/DE3486020T2/de not_active Expired - Fee Related
- 1984-09-13 IE IE233184A patent/IE59949B1/en not_active IP Right Cessation
- 1984-09-14 ZA ZA847277A patent/ZA847277B/xx unknown
- 1984-09-14 PT PT79207A patent/PT79207B/pt not_active IP Right Cessation
- 1984-09-14 CA CA000463254A patent/CA1269661A/en not_active Expired - Lifetime
1986
- 1986-01-30 ES ES551434A patent/ES8800572A1/es not_active Expired
- 1986-01-30 ES ES551436A patent/ES8800570A1/es not_active Expired
- 1986-01-30 ES ES551435A patent/ES8800915A1/es not_active Expired

Also Published As

Publication number	Publication date
AU579111B2 (en)	1988-11-17
IL72900A0 (en)	1984-12-31
ZA847277B (en)	1985-05-29
ES8800572A1 (es)	1987-11-01
EP0137333B1 (en)	1992-12-30
JPH0825877B2 (ja)	1996-03-13
IL72900A (en)	1989-01-31
CA1269661A (en)	1990-05-29
ES8800570A1 (es)	1987-11-01
ES8800915A1 (es)	1987-12-01
EP0137333A3 (en)	1986-03-05
EP0137333A2 (en)	1985-04-17
ES551436A0 (es)	1987-11-01
US4537892A (en)	1985-08-27
PT79207A (en)	1984-10-01
ES551435A0 (es)	1987-12-01
JPS6089469A (ja)	1985-05-20
ES551434A0 (es)	1987-11-01
IE842331L (en)	1985-03-14
ATE84026T1 (de)	1993-01-15
AU3254784A (en)	1985-10-03
DE3486020D1 (de)	1993-02-11
ES535798A0 (es)	1989-04-01
DE3486020T2 (de)	1993-05-19
IE59949B1 (en)	1994-05-04
ES8900214A1 (es)	1989-04-01
NZ209199A (en)	1988-04-29

Legal Events

Date

Code

Title

Description

1997-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19970228

Publication	Publication Date	Title
PT79207A (en)	1984-10-01	Process for preparing spiro-tricyclicaromatic succinimide derivatives useful as inhibitors of aldose reductase
PT79278A (en)	1984-10-01	Process for preparing 2-amino-5-hydroxy-4-methylpyrimidine derivatives
NO178858C (no)	1996-06-19	Analogifremgangsmåte for fremstilling av substituerte 4-fenyl-4-piperidinkarboksamider med både lokal anestetisk og analgetisk effekt
WO1990009993A3 (en)	1990-11-01	Method for the synthesis of huperzine a and analogs thereof and compounds useful therein
ES8600264A1 (es)	1985-05-16	Un procedimiento para la preparacion de nuevos derivados de furanona
NZ220800A (en)	1989-12-21	Tetrahydrobenzothiazoles and pharmaceutical compositions
IT1210926B (it)	1989-09-29	Derivati della 1-metil-5-nitro-imidazolina e composizioni terapeutiche che li comprendono come principio attivo.
GB1498857A (en)	1978-01-25	Antidepressant composition
IL86169A0 (en)	1988-11-15	Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation and pharmaceutical compositions containing them
JPS5285163A (en)	1977-07-15	Preparation of malenimide derivatives
JPS5251362A (en)	1977-04-25	Preparation of optically active pyrrolidine derivatives
JPS51138664A (en)	1976-11-30	Process for preparing 4-exo-hydroxy-endo-tri cyclo 95.2.2.02,6)-undeca-8-ene
JPS6463520A (en)	1989-03-09	Prolactin secretion inhibitor
JPS525782A (en)	1977-01-17	Preparation of 1-phthalazinone
JPS51139688A (en)	1976-12-02	Process for preparing new alkaloid tm-64 substance by fermentation
ES8304924A1 (es)	1983-03-16	Un procedimiento para la preparacion de nuevos derivados del acido glutamil-diaminopimelico que contiene una b-lactama.
JPS5248692A (en)	1977-04-18	Preparation of homo-pyriimidazole derivatives
ES8407035A1 (es)	1984-09-01	Un procedimiento para la preparacion de isomeros dextrogiros de derivados de 1-azabiciclo (2,2,2) octano.
JPS51122066A (en)	1976-10-25	Process for preparation of heterocyclic compounds
JPS5212185A (en)	1977-01-29	Preparation of novel antibiotics derivatives
JPS53144596A (en)	1978-12-15	Cephalosporanic acid derivatives and process for their preparation
ES8304925A1 (es)	1983-03-16	Un procedimiento para la preparacion de nuevos derivados del acido &-glutamil-diaminopimelilo.
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