ATE84304T1 - Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin dmetaboliten. - Google Patents

Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin dmetaboliten.

Info

Publication number
ATE84304T1
ATE84304T1 AT89401262T AT89401262T ATE84304T1 AT E84304 T1 ATE84304 T1 AT E84304T1 AT 89401262 T AT89401262 T AT 89401262T AT 89401262 T AT89401262 T AT 89401262T AT E84304 T1 ATE84304 T1 AT E84304T1
Authority
AT
Austria
Prior art keywords
derivatives
vitamin
group
denotes
ether
Prior art date
Application number
AT89401262T
Other languages
English (en)
Inventor
Roger Bouillon
Clercq Pierre Jean De
Pierre Eliard
Mauritz Vandewalle
Original Assignee
Medgenix Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medgenix Diagnostic filed Critical Medgenix Diagnostic
Application granted granted Critical
Publication of ATE84304T1 publication Critical patent/ATE84304T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C07C49/733—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Steroid Compounds (AREA)
AT89401262T 1988-05-04 1989-05-03 Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin dmetaboliten. ATE84304T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8805985A FR2631025B1 (fr) 1988-05-04 1988-05-04 Nouveaux derives de la vitamine d3 et application aux dosages des metabolites de la vitamine d3
EP89401262A EP0341158B1 (de) 1988-05-04 1989-05-03 Vitamin D-Derivate : Anwendung in der Therapie und zur quantitativen Bestimmung der Vitamin D-Metaboliten

Publications (1)

Publication Number Publication Date
ATE84304T1 true ATE84304T1 (de) 1993-01-15

Family

ID=9365980

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89401262T ATE84304T1 (de) 1988-05-04 1989-05-03 Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin dmetaboliten.

Country Status (7)

Country Link
US (1) US5093519A (de)
EP (1) EP0341158B1 (de)
JP (1) JPH02262555A (de)
AT (1) ATE84304T1 (de)
DE (1) DE68904235T2 (de)
ES (1) ES2045484T3 (de)
FR (1) FR2631025B1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5258559A (en) * 1990-11-27 1993-11-02 Hoffmann-La Roche Inc. Process for the preparation of [1R-(1β(R*), 3aα, 4β, 7aβ)] octahydro-1-(5-hydroxy-1,5-dimethylhexyl)-7a-methyl-4H-inden-4-one
US6166000A (en) * 1991-01-08 2000-12-26 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-Dihydroxy vitamin . D.sub2
US20040009958A1 (en) * 1991-01-08 2004-01-15 Bone Care International, Inc. Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
AU650751B2 (en) * 1991-05-28 1994-06-30 Wisconsin Alumni Research Foundation Novel synthesis of 19-nor vitamin D compounds
GB9226877D0 (en) * 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
US5354872A (en) * 1993-05-28 1994-10-11 Alcon Laboratories, Inc. Process for preparation of calcitriol lactone and related intermediates
GB9623569D0 (en) * 1996-11-13 1997-01-08 Immunodiagnostic Systems Ltd Vitamin D immumoassay systems
WO2000053578A1 (en) * 1999-03-11 2000-09-14 Kuraray Co., Ltd. Vitamin d derivatives and process for the preparation thereof
JP4803939B2 (ja) * 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンｄ誘導体
JP2002069003A (ja) * 2000-08-23 2002-03-08 Teijin Ltd ビタミンｄ誘導体を含有する骨吸収抑制剤
US20040019024A1 (en) * 2000-08-23 2004-01-29 Seiichi Ishizuka Use of vitamin d derivatives as bone resorption inhibitors
JP4887503B2 (ja) * 2005-03-04 2012-02-29 国立大学法人 東京医科歯科大学 ９−置換−１９−ノルビタミンｄ誘導体
US8785603B2 (en) 2011-05-20 2014-07-22 Siemens Healthcare Diagnostics Inc. Antibodies to 25-hydroxyvitamin D2 and D3 and uses thereof
MX349035B (es) * 2012-05-17 2017-07-07 Extend Biosciences Inc Portadores para el suministro mejorado de farmaco.
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
US9618523B2 (en) 2013-02-28 2017-04-11 Siemens Healthcare Diagnostics Inc. Methods and reagents for determining isomeric analytes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2407672A (en) * 1941-06-20 1946-09-17 Research Corp Process for the synthesis of 1-alkyl-8-methyl hexahydroindanone-4
DE2440406A1 (de) * 1974-08-23 1976-03-04 Basf Ag Bicyclische ketone und verfahren zu deren herstellung
GB1592170A (en) * 1977-01-07 1981-07-01 Hoffmann La Roche 1a-hydroxycholecalciferol-25-hydroxy esters and their use in radioimmunoassay
GB1589921A (en) * 1977-01-07 1981-05-20 Hoffmann La Roche Radioimmunoassay for the determination of cholecalciferol
EP0092004B1 (de) * 1982-04-20 1985-10-30 Teijin Limited Vitamin-D3-Derivate, Verfahren zu ihrer Herstellung und die diese Derivate enthaltenden Antigene die für die Herstellung von Antikörpern zu immunochemischen Testverfahren gebraucht werden und die daraus bereiteten Antikörper
JPS58193463A (ja) * 1982-05-07 1983-11-11 Teijin Ltd ビタミンｄ３類からなる免疫化学的測定用抗体作製のための抗原
WO1987000834A1 (en) * 1985-08-02 1987-02-12 Leo Pharmaceutical Products Ltd. A/S Novel vitamin d analogues
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
JPH02274A (ja) * 1987-10-14 1990-01-05 Toyo Jozo Co Ltd 新規な２５−ヒドロキシビタミンｄ↓３誘導体およびその製造法およびそれを用いた定量法
US5206229A (en) * 1988-04-21 1993-04-27 Leo Pharmaceutical Products Ltd Vitamin d analogues

Also Published As

Publication number Publication date
EP0341158B1 (de) 1993-01-07
DE68904235D1 (de) 1993-02-18
ES2045484T3 (es) 1994-01-16
JPH02262555A (ja) 1990-10-25
US5093519A (en) 1992-03-03
EP0341158A2 (de) 1989-11-08
DE68904235T2 (de) 1993-07-29
EP0341158A3 (en) 1990-04-04
FR2631025A1 (fr) 1989-11-10
FR2631025B1 (fr) 1991-04-12

Similar Documents

Publication Publication Date Title
DE68904235D1 (de) Vitamin d-derivate : anwendung in der therapie und zur quantitativen bestimmung der vitamin d-metaboliten.
ATE180484T1 (de) Morphinderivate sowie deren konjugate und labels mit proteinen und polypeptiden
ATE64396T1 (de) Konjugierte vinblastin-verbindungen und ihre derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
CY1105701T1 (el) Μεθοδος δια την παρασκευη ενος ενεσιμου φαρμακευτικου σκευασματος
BR9807734A (pt) Composto para imunodiagnose de câncer de próstata e métodos para o uso dos memos
LU91411I2 (fr) Panitumumab et ses dérivés pharmaceutiquement acceptables (VECTIBIX)
JPH0625071B2 (ja) 細胞供給剤
DE19981132D2 (de) Funktionelle Vitamin-D-Derivate und Verfahren zur Bestimmung von 25-Hydroxy- und 1alpha,25-Dihydroxy-Vitamin-D
DK97987A (da) Solubilisering af proteiner til farmaceutiske sam mensaetninger under anvendelse af polymerkonjugation
DE69329538D1 (de) Chlorophyll- und Bakteriochlorophyll-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen
ATE267255T1 (de) Ob proteinderivate mit verlängerter halbwertzeit
DK499086A (da) Konjugater af trichothecen og anvendelse af samme som terapeutisk substans
JP2019163276A (ja) 抱合方法
ATE9475T1 (de) Aminosaeure- und peptid-n-(vinblastinoyl-23)derivate und ihre herstellung.
Pearson et al. Affinity labeling of a novel cholecystokinin-binding protein in rat pancreatic plasmalemma using new short probes for the receptor.
Baldwin et al. Identification of a gastrin binding protein in porcine gastric mucosal membranes by covalent cross-linking with iodinated gastrin.
PT97423A (pt) Processo para a preparacao de composicoes farmaceuticas contendo conjugados de anticorpos para o tratamento de neoplasias
Matsumoto et al. Gastrin receptor characterization: affinity cross-linking of the gastrin receptor on canine gastric parietal cells
CY1105683T1 (el) Ενεργο συζυγες ακανθοχοιρικης πρωτεϊνης, μεθοδος για την παρασκευη και χρηση αυτου
ES508633A0 (es) Un procedimiento para la preparacion de nuevos conjugados de inmunoglobulina utiles como agentes anticancerosas.
ATE164838T1 (de) Neue propoxyphenderivate sowie deren protein-und polypeptidlabels und-konjugate
Kato et al. A novel method of conjugation of daunomycin with antibody with a poly (L-glutamic acid) derivative as intermediate drug carrier. An anti-. alpha.-fetoprotein antibody-daunomycin conjugate
ATE193534T1 (de) Benzodiazepin-derivate sowie deren konjugate mit proteinen und polypeptiden
Paik et al. Interposition of different chemical linkages between antibody and 111In-DTPA to accelerate clearance from non-target organs and blood
Hudecz et al. The influence of synthetic conditions on the stability of methotrexate‐monoclonal antibody conjugates determined by reversed phase high performance liquid chromatography

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties