ATE84798T1 - Transformierender wachstumsfaktor-beta. - Google Patents

Transformierender wachstumsfaktor-beta.

Info

Publication number: ATE84798T1
Authority: AT; Austria
Prior art keywords: growth factor; beta; factor beta; tgf; factor
Prior art date: 1987-01-30

Application number

AT88902000T

Other languages

English (en)

Inventor

Roger C Lucas

James A Weatherbee

Monica L-S Tsang

Original Assignee

Techne Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-30

Filing date

1988-01-29

Publication date

1993-02-15

1988-01-29 Application filed by Techne Inc filed Critical Techne Inc

1993-02-15 Application granted granted Critical

1993-02-15 Publication of ATE84798T1 publication Critical patent/ATE84798T1/de

Links

239000003102 growth factor Substances 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
102000009618 Transforming Growth Factors Human genes 0.000 abstract 1
108010009583 Transforming Growth Factors Proteins 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
239000000833 heterodimer Substances 0.000 abstract 1
238000004007 reversed phase HPLC Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Orthopedic Medicine & Surgery (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT88902000T 1987-01-30 1988-01-29 Transformierender wachstumsfaktor-beta. ATE84798T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/008,808 US4931548A (en)	1987-01-30	1987-01-30	Heterodimer form of transforming growth factor-beta
PCT/US1988/000272 WO1988005788A1 (en)	1987-01-30	1988-01-29	Tranforming growth factor-beta
EP88902000A EP0359739B1 (de)	1987-01-30	1988-01-29	Transformierender wachstumsfaktor-beta

Publications (1)

Publication Number	Publication Date
ATE84798T1 true ATE84798T1 (de)	1993-02-15

Family

ID=21733793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88902000T ATE84798T1 (de)	1987-01-30	1988-01-29	Transformierender wachstumsfaktor-beta.

Country Status (8)

Country	Link
US (1)	US4931548A (de)
EP (1)	EP0359739B1 (de)
JP (1)	JPH02502008A (de)
AT (1)	ATE84798T1 (de)
AU (1)	AU1299088A (de)
CA (1)	CA1338077C (de)
DE (1)	DE3877753T2 (de)
WO (1)	WO1988005788A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5284763A (en) *	1985-03-22	1994-02-08	Genentech, Inc.	Nucleic acid encoding TGF-β and its uses
US4886747A (en) *	1985-03-22	1989-12-12	Genentech, Inc.	Nucleic acid encoding TGF-β and its uses
US6559123B1 (en) *	1985-04-19	2003-05-06	Osi Pharmaceuticals, Inc.	Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
US5221734A (en) *	1987-10-01	1993-06-22	Ciba-Geigy Corporation	Process for preparing a polypeptide growth factor for milk
IL87877A0 (en) *	1987-10-06	1989-03-31	Oncogen	Cloning and expression of transforming growth factor beta2
US5268455A (en) *	1989-05-25	1993-12-07	Genentech, Inc.	Process for making biologically active polypeptides based on transforming growth factor-βsequences
US5061786A (en) *	1989-05-25	1991-10-29	Genentech, Inc.	Biologically active polypeptides based on transforming growth factor-β
US5043431A (en) *	1989-09-11	1991-08-27	Codon	Method and apparatus for the production of TGF-β
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5824297A (en) *	1990-06-25	1998-10-20	Oncogene Science, Inc.	Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
WO1992000318A1 (en) *	1990-06-25	1992-01-09	Oncogene Science, Inc.	Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof
DE69132275T2 (de) *	1990-11-16	2001-01-25	Celtrix Pharmaceuticals, Inc.	Beta-type ähnlicher transformierender wachstumfaktor
US5206023A (en) *	1991-01-31	1993-04-27	Robert F. Shaw	Method and compositions for the treatment and repair of defects or lesions in cartilage
GB9106678D0 (en) *	1991-03-28	1991-05-15	Ferguson Mark W J	Wound healing
US5270300A (en) *	1991-09-06	1993-12-14	Robert Francis Shaw	Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5280109A (en) *	1992-01-27	1994-01-18	Ludwig Institute For Cancer Research	Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
US5684136A (en) *	1992-05-18	1997-11-04	Genentech, Inc.	Chimeric hepatocyte growth factor (HGF) ligand variants
EP0642585B1 (de) *	1992-05-18	2005-12-28	Genentech, Inc.	Aktivierung von Rezeptoren fähig zur Oligomerisierung durch Verwendung von fusionierten Rezeptor Liganden
TW517059B (en)	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
US6521227B1 (en)	1999-11-18	2003-02-18	Peter L. Hudson	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US5994102A (en) *	1994-12-15	1999-11-30	Human Genome Sciences, Inc.	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
JP3159105B2 (ja) *	1997-02-21	2001-04-23	日本電気株式会社	不揮発性半導体記憶装置及びその書込方法
WO1999036441A2 (en) *	1998-01-17	1999-07-22	Telistar International	Haemopoietic stem cell inhibitor(s)
JP2001218840A (ja) *	2000-02-14	2001-08-14	Kanegafuchi Chem Ind Co Ltd	トランスフォーミング増殖因子βの吸着材、吸着除去方法および吸着器
WO2003039232A2 (en) *	2001-10-26	2003-05-15	Large Scale Biology Corporation	Endothelial cell derived hemotopoietic growth factor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3382562D1 (de) *	1982-09-24	1992-06-25	Us Health	Wiederherstellung von gewebe bei tieren.
US4434094A (en) *	1983-04-12	1984-02-28	Collagen Corporation	Partially purified osteogenic factor and process for preparing same from demineralized bone
IE57724B1 (en) *	1983-05-09	1993-03-24	Todaro George Joseph	Biologically active polypeptides
US4627982A (en) *	1984-07-16	1986-12-09	Collagen Corporation	Partially purified bone-inducing factor
DE3588058T3 (de) *	1984-07-16	2005-04-07	Celtrix Pharmaceuticals, Inc., Palo Alto	Knorpel-induzierende Polypeptid-Faktoren aus Knochen
US4563350A (en) *	1984-10-24	1986-01-07	Collagen Corporation	Inductive collagen based bone repair preparations
IL78197A (en) *	1985-03-22	1991-07-18	Genentech Inc	Nucleic acid encoding tgf-beta and its uses
US4806523A (en) *	1985-08-06	1989-02-21	Collagen Corporation	Method of treating inflammation
US4816442A (en) *	1986-11-07	1989-03-28	Collagen Corporation	Method of inhibiting tumor growth sensitive to CIF-βtreatment

1987
- 1987-01-30 US US07/008,808 patent/US4931548A/en not_active Expired - Fee Related
1988
- 1988-01-29 WO PCT/US1988/000272 patent/WO1988005788A1/en not_active Ceased
- 1988-01-29 JP JP63501900A patent/JPH02502008A/ja active Pending
- 1988-01-29 EP EP88902000A patent/EP0359739B1/de not_active Expired - Lifetime
- 1988-01-29 AT AT88902000T patent/ATE84798T1/de not_active IP Right Cessation
- 1988-01-29 AU AU12990/88A patent/AU1299088A/en not_active Abandoned
- 1988-01-29 CA CA000557717A patent/CA1338077C/en not_active Expired - Fee Related
- 1988-01-29 DE DE8888902000T patent/DE3877753T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA1338077C (en)	1996-02-20
WO1988005788A1 (en)	1988-08-11
EP0359739A1 (de)	1990-03-28
AU1299088A (en)	1988-08-24
JPH02502008A (ja)	1990-07-05
US4931548A (en)	1990-06-05
DE3877753D1 (de)	1993-03-04
EP0359739A4 (de)	1990-04-10
DE3877753T2 (de)	1993-05-13
EP0359739B1 (de)	1993-01-20

Legal Events

Date	Code	Title	Description
1993-07-15	UEP	Publication of translation of european patent specification
1998-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE84798T1 (de)	1993-02-15	Transformierender wachstumsfaktor-beta.
DE69033710D1 (de)	2001-04-12	Sekretion vom mit Gamma-Interferon Signalpeptid gebundenen humänen Protein
DE69634726D1 (de)	2005-06-16	Menschliche ctla-8 und verwendung von ctla-8 ähnlichen proteinen
AU5649586A (en)	1987-10-29	Partially purified bone-inducing factor
IT8619338A0 (it)	1986-02-07	Peptide sintetico ad attivita'interleukina 1 umana.
DE3882593D1 (de)	1993-09-02	Polypeptid und dessen herstellung.
ATE145241T1 (de)	1996-11-15	Polypeptid, das zur interaktion mit thrombin fähig ist
NZ220526A (en)	1989-08-29	Peptide which inhibits binding of von willebrand factor to heparin, platelets and collagen
ES2043609T3 (es)	1994-01-01	Composiciones de interleucina-2.
MX9203767A (es)	1992-09-01	Peptidos que inhiben la union del factor de von willebrand al receptor gpib de las plaquetas.
DK489187A (da)	1988-03-19	Protein med antikoagulerende og antimetastatiske egenskaber
DK551287A (da)	1988-04-24	Polypeptid
AU2560588A (en)	1989-05-18	Proteolytic fragments and synthetic peptides that block the binding of von willebrand factor to the platelet membrane glycoprotein Ib.
DE68906566D1 (de)	1993-06-24	Dimerisierung von niedrigen alpha-olefinen.
DK354389D0 (da)	1989-07-18	Polypeptid
MX9206960A (es)	1993-12-01	Alboagreginas:agonistas de las plaquetas que se ligan a la glicoproteina ib de la membrana de las plaquetas
DK288789D0 (da)	1989-06-13	Peptider og syreadditionssalte deraf, deres fremstilling og anvendelse
DE69226448D1 (de)	1998-09-03	Glykoprotein komplexe und glykoproteine
DE3886517D1 (de)	1994-02-03	Menschlicher Prourokinase ähnliches Polypeptid.
NO894880L (no)	1990-06-08	Fremgangsmaate for fremstilling av antikoagulerende peptider.
DE68918479D1 (de)	1994-11-03	Menschlicher Hitzeschock-Faktor.
FI882741A7 (fi)	1989-04-10	Rekombinantti-HTLV-III-proteiineja ja niiden käyttötapoja.
FI885301A7 (fi)	1989-05-18	Tekijä VIII:n puhdistuksessa käyttökelpoisia peptidejä
ATE143974T1 (de)	1996-10-15	Peptide des hiv-gag proteins, ihre herstellung und verwendung
IL91771A0 (en)	1990-06-10	Increased expression of small molecular weight recombinant proteins