ATE84970T1 - Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis. - Google Patents
Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis.Info
- Publication number
- ATE84970T1 ATE84970T1 AT88304059T AT88304059T ATE84970T1 AT E84970 T1 ATE84970 T1 AT E84970T1 AT 88304059 T AT88304059 T AT 88304059T AT 88304059 T AT88304059 T AT 88304059T AT E84970 T1 ATE84970 T1 AT E84970T1
- Authority
- AT
- Austria
- Prior art keywords
- hemosafe
- hemoglobin
- derived
- human
- hemosafes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
- A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2103/00—Materials or objects being the target of disinfection or sterilisation
- A61L2103/05—Living organisms or biological materials
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878710598A GB8710598D0 (en) | 1987-05-05 | 1987-05-05 | Hemoglobin based blood substitute |
| EP88304059A EP0290252B1 (de) | 1987-05-05 | 1988-05-05 | Pasteurisierbares, lyophilisierbares Blutsurrogat auf Hämoglobinbasis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE84970T1 true ATE84970T1 (de) | 1993-02-15 |
Family
ID=10616838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88304059T ATE84970T1 (de) | 1987-05-05 | 1988-05-05 | Pasteurisierbares, lyophilisierbares blutsurrogat auf haemoglobinbasis. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US4857636A (de) |
| EP (1) | EP0290252B1 (de) |
| JP (1) | JPS63297330A (de) |
| KR (1) | KR910009343B1 (de) |
| CN (1) | CN1032471C (de) |
| AT (1) | ATE84970T1 (de) |
| AU (1) | AU610883B2 (de) |
| CA (1) | CA1306583C (de) |
| DE (1) | DE3877811T2 (de) |
| DK (1) | DK174286B1 (de) |
| ES (1) | ES2053729T3 (de) |
| GB (1) | GB8710598D0 (de) |
| IL (1) | IL86258A (de) |
| NZ (1) | NZ224479A (de) |
| ZA (1) | ZA883171B (de) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464814A (en) * | 1986-06-20 | 1995-11-07 | Northfield Laboratories, Inc. | Acellular red blood cell substitute |
| US5753616A (en) * | 1986-11-10 | 1998-05-19 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
| DE3778006D1 (de) * | 1986-11-10 | 1992-05-07 | Biopure Corp | Hochreines, halbsynthetisches blutsurrogat. |
| US5955581A (en) * | 1986-11-10 | 1999-09-21 | Biopure Corporation | Method for producing a stable polymerized hemoglobin blood-substitute |
| US5854209A (en) * | 1995-03-23 | 1998-12-29 | Biopure Corporation | Method for oxygenating tissue having reduced red blood cell flow |
| US5189146A (en) * | 1987-05-05 | 1993-02-23 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Pasteurizable, freeze-driable hemoglobin-based blood substitute |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
| US5844090A (en) * | 1994-05-09 | 1998-12-01 | Somatogen, Inc. | Modified hemoglobin-like compounds |
| US5386014A (en) * | 1989-11-22 | 1995-01-31 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute |
| US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
| US5439882A (en) * | 1989-12-29 | 1995-08-08 | Texas Tech University Health Sciences Center | Blood substitute |
| DE69026513T2 (de) * | 1989-12-29 | 1996-09-12 | Texas Tech University Health Sciences Centre, Lubbock, Tex. | Polyhämoglobin durch purinderivate und glutathion stabilisiert |
| AU658821B2 (en) * | 1990-03-14 | 1995-05-04 | University Of Toronto Innovations Foundation, The | Acyl phosphate esters and modification of proteins therewith |
| US5248766A (en) * | 1990-08-17 | 1993-09-28 | Baxter International Inc. | Oxirane-modified hemoglobin based composition |
| WO1992008478A1 (en) * | 1990-11-20 | 1992-05-29 | Enzon, Inc. | Method of enhancing long-term storage stability of hemoglobin products |
| SK54993A3 (en) * | 1990-11-29 | 1993-10-06 | Upjohn Co | Imidoester cross-linked hemoglobin compositions |
| ATE173273T1 (de) * | 1991-02-12 | 1998-11-15 | Univ Texas Tech | Verbesserter blutersatz |
| US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
| GB9617611D0 (en) * | 1996-08-22 | 1996-10-02 | Vasogen Inc | Treatment of autoimmune disease |
| US6669965B2 (en) | 1992-02-07 | 2003-12-30 | Vasogen Ireland Limited | Method of treating atherosclerosis |
| US5591457A (en) * | 1992-02-07 | 1997-01-07 | Vasogen Inc | Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human |
| US5980954A (en) | 1992-02-07 | 1999-11-09 | Vasogen Ireland Limited | Treatment of autoimmune diseases |
| US5646252A (en) * | 1992-02-10 | 1997-07-08 | Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid | Hemoglobin composition and preparation thereof |
| US5399671A (en) * | 1992-11-18 | 1995-03-21 | Kluger; Ronald | Specifically crosslinked hemoglobin with free functionality |
| ES2095751T3 (es) * | 1993-03-16 | 1997-02-16 | Hemosol Inc | Regulacion selectiva de hemoglobinas mediante sacaridos de anillo abierto oxidados. |
| AU6523194A (en) * | 1993-03-26 | 1994-10-24 | Biorelease Technologies, Inc. | Compositions including heme-containing proteins and methods relating thereto |
| US5578564A (en) * | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
| US5840851A (en) * | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
| US5767089A (en) * | 1993-08-16 | 1998-06-16 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5807831A (en) * | 1993-08-16 | 1998-09-15 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| TW381022B (en) * | 1993-08-16 | 2000-02-01 | Hsia Jen Chang | Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute |
| US5840701A (en) * | 1993-08-16 | 1998-11-24 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5725839A (en) * | 1993-08-16 | 1998-03-10 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI |
| US5804561A (en) * | 1993-08-16 | 1998-09-08 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5741893A (en) * | 1993-08-16 | 1998-04-21 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5824781A (en) * | 1993-08-16 | 1998-10-20 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5817632A (en) * | 1993-08-16 | 1998-10-06 | Hsia; Jen-Chang | Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules |
| US5631219A (en) * | 1994-03-08 | 1997-05-20 | Somatogen, Inc. | Method of stimulating hematopoiesis with hemoglobin |
| US6242417B1 (en) | 1994-03-08 | 2001-06-05 | Somatogen, Inc. | Stabilized compositions containing hemoglobin |
| CA2135739C (en) * | 1994-11-14 | 1997-10-21 | Felice D'agnillo | Hemoglobin-enzyme complexes |
| US6288027B1 (en) | 1995-03-23 | 2001-09-11 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
| US5895810A (en) * | 1995-03-23 | 1999-04-20 | Biopure Corporation | Stable polymerized hemoglobin and use thereof |
| US5691452A (en) * | 1995-03-23 | 1997-11-25 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| US6610832B1 (en) | 1995-03-23 | 2003-08-26 | Biopure Corporation | Preserving a hemoglobin blood substitute with a transparent overwrap |
| US6271351B1 (en) | 1995-03-23 | 2001-08-07 | Biopure Corporation | Method for preserving a hemoglobin blood substitute |
| US5952470A (en) * | 1995-06-07 | 1999-09-14 | Biopure Corporation | Method for separating unmodified hemoglobin from cross-linked hemoglobin |
| US5691453A (en) * | 1995-06-07 | 1997-11-25 | Biopure Corporation | Separation of polymerized hemoglobin from unpolymerized hemoglobin on hydroxyapatite using HPLC |
| US5865784A (en) * | 1995-06-07 | 1999-02-02 | Alliance Pharmaceutical Corp. | Method of hemodilution facilitated by monitoring oxygenation status |
| WO1997010268A1 (en) * | 1995-09-11 | 1997-03-20 | Staat Der Nederlanden, De Minister Van Defensie, Voor Deze: Het Hoofd Van De Afdeling Militair Geneeskundig Beleid | Spray-drying haemoglobin |
| US5741894A (en) * | 1995-09-22 | 1998-04-21 | Baxter International, Inc. | Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form |
| AU1946397A (en) * | 1996-03-15 | 1997-10-01 | Staat Der Nederlanden, De Minister Van Defensie | Methods for producing hemoglobin preparations and preparations obtainable thereby |
| US5917020A (en) * | 1997-01-15 | 1999-06-29 | Kluger; Ronald H. | Bis-tetrameric hemoglobin and reagents for its production |
| US6436705B1 (en) | 1997-02-18 | 2002-08-20 | The United States Of America As Represented By The Secretary Of The Navy | Shape stabilized erythrocytes |
| US6358678B1 (en) | 1998-02-11 | 2002-03-19 | The United States Of America As Represented By The Secretary Of The Navy | Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes |
| US5814601A (en) * | 1997-02-28 | 1998-09-29 | The Regents Of The University Of California | Methods and compositions for optimization of oxygen transport by cell-free systems |
| AU735799C (en) * | 1997-02-28 | 2005-04-28 | Regents Of The University Of California, The | Methods and compositions for optimisation of oxygen transport by cell-free systems |
| CA2233725A1 (en) * | 1998-03-31 | 1999-09-30 | Hemosol Inc. | Hemoglobin-hydroxyethyl starch complexes |
| DE10031744A1 (de) * | 2000-06-29 | 2002-01-17 | Sanguibio Tech Ag | Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung |
| DE10031740A1 (de) * | 2000-06-29 | 2002-02-14 | Sanguibio Tech Ag | Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung |
| DE10031741A1 (de) * | 2000-06-29 | 2002-01-17 | Sanguibio Tech Ag | Einen Sauerstoffträger, ausgewählt aus Hämoglobin oder Hämoglobin- und Myoglobin-enthaltende Zubereitung als Externum zur natürlichen Regeneration der Haut bei Sauerstoff-Mangel |
| DE10031742A1 (de) * | 2000-06-29 | 2002-01-17 | Sanguibio Tech Ag | Verfahren zur Herstellung künstlicher Sauerstoffträger aus kovalent vernetzten Hämoglobinen mit verbesserten funktionellen Eigenschaften durch Vernetzung in Anwesenheit chemisch nicht reagierender Effektoren der Sauerstoffaffinität der Hämoglobine |
| CA2319966A1 (en) * | 2000-09-19 | 2002-03-19 | Dextro-Sang Corporation | Improved dextran-hemoglobin conjugate as potential blood substitute |
| US6747132B2 (en) | 2000-11-29 | 2004-06-08 | Apex Biosciences, Inc. | Methods for the synthesis of a modified hemoglobin solution |
| US6518010B2 (en) * | 2001-02-28 | 2003-02-11 | Biopure Corporation | Use of defibrinated blood for manufacture of a hemoglobin-based oxygen carrier |
| US6884228B2 (en) * | 2001-03-06 | 2005-04-26 | Baxter International Inc. | Automated system adaptable for use with different fluid circuits |
| US6808503B2 (en) * | 2001-03-06 | 2004-10-26 | Baxter International Inc. | Automated system and method for pre-surgical blood donation and fluid replacement |
| CA2444590C (en) * | 2001-04-18 | 2009-12-01 | Robert L. Mcginnis | Stabilized hemoglobin solutions |
| JP4416356B2 (ja) * | 2001-07-10 | 2010-02-17 | 克博 山本 | 食肉・食肉加工品退色防止方法 |
| SI1465643T1 (sl) | 2002-01-11 | 2008-06-30 | Sangart Inc | Postopki in sestavki za transport kisika z visokoafiniteto za kisik |
| US20030153491A1 (en) | 2002-01-11 | 2003-08-14 | Winslow Robert M. | Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| WO2003059286A2 (en) * | 2002-01-11 | 2003-07-24 | Sangart, Inc. | Methods and compositions for oxygen transport comprising modified hemoglobin in plasma |
| WO2003059287A2 (en) * | 2002-01-11 | 2003-07-24 | Sangart, Inc. | Methods and compositions for oxygen transport comprising an oxygen carrier and a crystalloid in hypertonic solution |
| US20050164915A1 (en) | 2002-04-01 | 2005-07-28 | Sangart, Inc. | Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin |
| US7001715B2 (en) * | 2002-02-28 | 2006-02-21 | Biopure Corporation | Purification of red blood cells by separation and diafiltration |
| IL149611A (en) * | 2002-05-13 | 2011-07-31 | Safetin Ltd | Method for extended storage of viable and pathogen-safe blood and blood components using carbon monoxide |
| JP3912206B2 (ja) * | 2002-07-05 | 2007-05-09 | 株式会社日立製作所 | 筒内直接燃料噴射装置用燃料ポンプ |
| US20040072729A1 (en) * | 2002-10-10 | 2004-04-15 | Sunbio Inc. | High oxygen affinity PEG-hemoglobin as treatment for brain stroke |
| NZ541340A (en) * | 2003-01-29 | 2008-04-30 | Northfield Lab | Polymerized hemoglobin solutions having reduced amount of tetramer and method for preparing |
| AU2005279780B2 (en) * | 2004-08-31 | 2011-02-03 | Sangart, Inc. | Methods to enhance hemodynamic stability using oxygen carrying compositions |
| JP2009524436A (ja) * | 2006-01-24 | 2009-07-02 | ノースフィールド ラボラトリーズ、インコーポレイテッド | 重合したヘモグロビンの培地、並びに島細胞の単離及び移植におけるその使用 |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| US7759306B2 (en) * | 2006-05-16 | 2010-07-20 | Simoni Jan S | Methods of treating acute blood loss |
| US10172950B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| US10172949B2 (en) | 2009-06-09 | 2019-01-08 | Prolong Pharmaceuticals, LLC | Hemoglobin compositions |
| KR102170375B1 (ko) * | 2009-06-09 | 2020-10-27 | 프로롱 파마슈티컬스, 엘엘씨 | 헤모글로빈 조성물 |
| US8273857B2 (en) * | 2009-09-22 | 2012-09-25 | Jen-Chang Hsia | Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine |
| US20110319858A1 (en) * | 2010-06-23 | 2011-12-29 | Bing Lou Wong | Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical compositions and the use thereof |
| ES2432075T3 (es) * | 2011-07-23 | 2013-11-29 | Sastomed Gmbh | Espray para heridas |
| CN104411807B (zh) | 2012-04-03 | 2018-10-02 | 桑加特公司 | 琥珀酰亚胺活化型硝酰化合物及其用于蛋白质硝酰化的使用方法 |
| CN105188761B (zh) | 2013-03-15 | 2020-05-15 | 桑加特公司 | 聚环氧烷戊酸酯血红蛋白缀合物 |
| WO2014179793A1 (en) | 2013-05-03 | 2014-11-06 | Washington University | Blood substitute composition and method of use |
| CN103387613B (zh) * | 2013-08-02 | 2016-12-28 | 西北大学 | 一种血红蛋白及血红蛋白氧载体病毒灭活的方法 |
| US10973883B2 (en) * | 2016-05-19 | 2021-04-13 | University of Pittsburgh—of the Commonwealth System of Higher Education | Reduced oxygen carriers and their use for the treatment of carboxyhemoglobinemia |
| EP4041193A1 (de) * | 2019-10-11 | 2022-08-17 | Medical Technology Associates II, Inc. | Stabilisierte hämoglobinzusammensetzungen und pharmazeutische formulierungen davon |
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| US4049673A (en) * | 1971-06-08 | 1977-09-20 | Israel Herbert Scheinberg | Preparation of ferrous hemoglobin and enzymatic digestion products thereof active for absorption of carbon monoxide |
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| AU2965284A (en) * | 1983-05-04 | 1984-11-19 | Tye, R.W. | Modified crosslinked stroma-free tetrameric hemoglobin |
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| DE3330770A1 (de) * | 1983-08-26 | 1985-03-14 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von humanplasma |
| JPS60258126A (ja) * | 1984-06-02 | 1985-12-20 | Teruo Tomota | 重合化ヘモグロビンの製造方法 |
| US4600531A (en) * | 1984-06-27 | 1986-07-15 | University Of Iowa Research Foundation | Production of alpha-alpha cross-linked hemoglobins in high yield |
| NL8403425A (nl) * | 1984-11-09 | 1986-06-02 | Stichting Gastransport | Stromavrije hemoglobine-oplossing, werkwijze voor de bereiding daarvan en toepassing daarvan. |
| US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
| US4863964A (en) * | 1985-07-02 | 1989-09-05 | Biomedical Frontiers, Inc. | Method for the stabilization of deferoxamine to chelate free ions in physiological fluid |
| DE3778006D1 (de) * | 1986-11-10 | 1992-05-07 | Biopure Corp | Hochreines, halbsynthetisches blutsurrogat. |
| GB8710598D0 (en) * | 1987-05-05 | 1987-06-10 | Star Medical Diagnostics Ltd | Hemoglobin based blood substitute |
| US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
-
1987
- 1987-05-05 GB GB878710598A patent/GB8710598D0/en active Pending
-
1988
- 1988-04-29 CA CA000565563A patent/CA1306583C/en not_active Expired - Lifetime
- 1988-04-29 US US07/187,721 patent/US4857636A/en not_active Expired - Lifetime
- 1988-05-03 IL IL8625888A patent/IL86258A/en not_active IP Right Cessation
- 1988-05-03 NZ NZ224479A patent/NZ224479A/en unknown
- 1988-05-04 DK DK198802428A patent/DK174286B1/da not_active IP Right Cessation
- 1988-05-04 ZA ZA883171A patent/ZA883171B/xx unknown
- 1988-05-04 KR KR1019880005223A patent/KR910009343B1/ko not_active Expired
- 1988-05-05 AT AT88304059T patent/ATE84970T1/de not_active IP Right Cessation
- 1988-05-05 DE DE8888304059T patent/DE3877811T2/de not_active Expired - Lifetime
- 1988-05-05 EP EP88304059A patent/EP0290252B1/de not_active Expired - Lifetime
- 1988-05-05 CN CN88103596A patent/CN1032471C/zh not_active Expired - Lifetime
- 1988-05-05 AU AU15635/88A patent/AU610883B2/en not_active Expired
- 1988-05-05 ES ES88304059T patent/ES2053729T3/es not_active Expired - Lifetime
- 1988-05-06 JP JP63109257A patent/JPS63297330A/ja active Granted
-
1992
- 1992-07-27 US US07/918,610 patent/US5364932A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL86258A0 (en) | 1988-11-15 |
| AU1563588A (en) | 1988-11-10 |
| CN1032471C (zh) | 1996-08-07 |
| EP0290252B1 (de) | 1993-01-27 |
| GB8710598D0 (en) | 1987-06-10 |
| CA1306583C (en) | 1992-08-18 |
| IL86258A (en) | 1994-11-28 |
| ES2053729T3 (es) | 1994-08-01 |
| DK174286B1 (da) | 2002-11-11 |
| DK242888D0 (da) | 1988-05-04 |
| KR910009343B1 (ko) | 1991-11-12 |
| KR880013571A (ko) | 1988-12-21 |
| JPS63297330A (ja) | 1988-12-05 |
| ZA883171B (en) | 1989-03-29 |
| EP0290252A3 (en) | 1989-01-18 |
| US4857636A (en) | 1989-08-15 |
| EP0290252A2 (de) | 1988-11-09 |
| AU610883B2 (en) | 1991-05-30 |
| JPH0532372B2 (de) | 1993-05-14 |
| DE3877811D1 (de) | 1993-03-11 |
| DE3877811T2 (de) | 1993-05-27 |
| US5364932A (en) | 1994-11-15 |
| NZ224479A (en) | 1991-04-26 |
| DK242888A (da) | 1988-11-06 |
| CN1030425A (zh) | 1989-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |