ES2053729T3 - Sustituto de la sangre basado en hemoglobina, pasterizable y liofilizable. - Google Patents

Sustituto de la sangre basado en hemoglobina, pasterizable y liofilizable.

Info

Publication number
ES2053729T3
ES2053729T3 ES88304059T ES88304059T ES2053729T3 ES 2053729 T3 ES2053729 T3 ES 2053729T3 ES 88304059 T ES88304059 T ES 88304059T ES 88304059 T ES88304059 T ES 88304059T ES 2053729 T3 ES2053729 T3 ES 2053729T3
Authority
ES
Spain
Prior art keywords
hemosafe
hemoglobin
become
polymers
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88304059T
Other languages
English (en)
Inventor
Majesty The Queen In Right Her
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UK Government
Original Assignee
UK Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UK Government filed Critical UK Government
Application granted granted Critical
Publication of ES2053729T3 publication Critical patent/ES2053729T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Dental Preparations (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO EN EL QUE SE OBTIENE UN SUSTITUTO DE LA SANGRE (DESIGNADO COMO "HEMOSAFE") A PARTIR DE MONOMEROS Y POLIMEROS UNIFORMEMENTE ESTABILIZADOS DE DESOXIHENOGLOBINA DE CONFIGURACION COMPACTA (T), CON AFINIDAD HACIA EL OXIGENO SIMILAR A LA DE LA SANGRE HUMANA. SE PREODUCEN DEL TIPOS DE HEMOSAFE, UNO DERIVADO DE HEMOGLOBINA ANIMAL Y OTRO DE HEMOGLOBINA HUMANA, QUE DIFIEREN EN QUE EL ANIMAL NO TIENE POLIMEROS. PARA SU OBTENCION LAS DESOXIHEMOGLOBINAS ESTABILIZADAS SE CONVIERTEN EN SUS MONOCARBOXI-DERIVADOS (CO-HEMOSAFE) QUE SE HACEN DESPUES ESTABLES EN CONDICIONES DE PASTEURIZACION PARA CONVERTIRLOS EN LIBRES DE TRANSMISION DE ENFERMEDADES VIRICAS. LOS CO-HEMOSAFE SON ESTABLES DURANTE DOS MESES A 56 GRADOS C EN SOLUCION O LIUOFILIZADOS. PARA TRANSFUSION LOS CO-HEMOSAFE SE OXIGENAN FACILMENTE EN CONDICIONES ESTERILES, POR FOTOCONVERSION PRODUCIENDO OXI-HEMOSAFE. ADEMAS POR CONVERSION DE ESTE ULTIMO SE PUDE PREPARAR UN DERIVADO DE MET-HEMOGLOBINA PARA TRANSFUSIONES EN ELTRATAMIENTO DEL ENVENENAMIENTO POR CIANUROS.
ES88304059T 1987-05-05 1988-05-05 Sustituto de la sangre basado en hemoglobina, pasterizable y liofilizable. Expired - Lifetime ES2053729T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878710598A GB8710598D0 (en) 1987-05-05 1987-05-05 Hemoglobin based blood substitute

Publications (1)

Publication Number Publication Date
ES2053729T3 true ES2053729T3 (es) 1994-08-01

Family

ID=10616838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88304059T Expired - Lifetime ES2053729T3 (es) 1987-05-05 1988-05-05 Sustituto de la sangre basado en hemoglobina, pasterizable y liofilizable.

Country Status (15)

Country Link
US (2) US4857636A (es)
EP (1) EP0290252B1 (es)
JP (1) JPS63297330A (es)
KR (1) KR910009343B1 (es)
CN (1) CN1032471C (es)
AT (1) ATE84970T1 (es)
AU (1) AU610883B2 (es)
CA (1) CA1306583C (es)
DE (1) DE3877811T2 (es)
DK (1) DK174286B1 (es)
ES (1) ES2053729T3 (es)
GB (1) GB8710598D0 (es)
IL (1) IL86258A (es)
NZ (1) NZ224479A (es)
ZA (1) ZA883171B (es)

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JP6657070B2 (ja) 2013-03-15 2020-03-04 ウィリアム・シンドラーＷｉｌｌｉａｍ Ｓｃｈｉｎｄｌｅｒ ポリアルキレンオキシド吉草酸ヘモグロビン接合体
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CN1032471C (zh) 1996-08-07
AU1563588A (en) 1988-11-10
DK174286B1 (da) 2002-11-11
EP0290252A3 (en) 1989-01-18
ZA883171B (en) 1989-03-29
US4857636A (en) 1989-08-15
GB8710598D0 (en) 1987-06-10
KR880013571A (ko) 1988-12-21
CN1030425A (zh) 1989-01-18
CA1306583C (en) 1992-08-18
EP0290252A2 (en) 1988-11-09
DK242888D0 (da) 1988-05-04
US5364932A (en) 1994-11-15
DE3877811T2 (de) 1993-05-27
NZ224479A (en) 1991-04-26
AU610883B2 (en) 1991-05-30
EP0290252B1 (en) 1993-01-27
JPH0532372B2 (es) 1993-05-14
KR910009343B1 (ko) 1991-11-12
DE3877811D1 (es) 1993-03-11
JPS63297330A (ja) 1988-12-05
IL86258A0 (en) 1988-11-15
DK242888A (da) 1988-11-06
IL86258A (en) 1994-11-28
ATE84970T1 (de) 1993-02-15

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