ATE85758T1 - Trichotecenkonjugate. - Google Patents
Trichotecenkonjugate.Info
- Publication number
- ATE85758T1 ATE85758T1 AT86308051T AT86308051T ATE85758T1 AT E85758 T1 ATE85758 T1 AT E85758T1 AT 86308051 T AT86308051 T AT 86308051T AT 86308051 T AT86308051 T AT 86308051T AT E85758 T1 ATE85758 T1 AT E85758T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- bonds
- cells
- trichothecene
- molecules
- Prior art date
Links
- 229930013292 trichothecene Natural products 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- LZAJKCZTKKKZNT-PMNGPLLRSA-N trichothecene Chemical compound C12([C@@]3(CC[C@H]2OC2C=C(CCC23C)C)C)CO1 LZAJKCZTKKKZNT-PMNGPLLRSA-N 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000003190 augmentative effect Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 150000003327 trichothecene derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6831—Fungal toxins, e.g. alpha sarcine, mitogillin, zinniol or restrictocin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/788,325 US4744981A (en) | 1985-10-17 | 1985-10-17 | Trichothecene antibody conjugates |
| EP86308051A EP0220065B1 (de) | 1985-10-17 | 1986-10-16 | Trichotecenkonjugate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE85758T1 true ATE85758T1 (de) | 1993-03-15 |
Family
ID=25144143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86308051T ATE85758T1 (de) | 1985-10-17 | 1986-10-16 | Trichotecenkonjugate. |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US4744981A (de) |
| EP (1) | EP0220065B1 (de) |
| JP (1) | JPH072651B2 (de) |
| CN (1) | CN87104045A (de) |
| AT (1) | ATE85758T1 (de) |
| DE (1) | DE3687779T2 (de) |
| DK (1) | DK499086A (de) |
| NO (1) | NO864136L (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405966A (en) * | 1985-10-17 | 1995-04-11 | Theodore; Louis J. | Trichothecene conjugates |
| US4744981A (en) * | 1985-10-17 | 1988-05-17 | Neorx Corporation | Trichothecene antibody conjugates |
| FR2601679B1 (fr) * | 1986-07-15 | 1990-05-25 | Sanofi Sa | Immunotoxines, procede de preparation et compositions pharmaceutiques en contenant |
| FR2601680B1 (fr) * | 1986-07-15 | 1990-06-29 | Sanofi Sa | Inhibiteur de la synthese proteique, procede d'isolement, utilisation et compositions pharmaceutiques en contenant |
| US5118612A (en) * | 1987-04-28 | 1992-06-02 | Wisconsin Alumni Research Foundation | Assay for trichothecenes |
| US5030450A (en) * | 1989-11-28 | 1991-07-09 | Abbott Laboratories | Method for inhibiting nematode infection of plants with Nematostatic trichothecene compositions |
| WO1992005802A1 (en) * | 1990-09-28 | 1992-04-16 | Neorx Corporation | Polymeric carriers for release of covalently linked agents |
| JPH04334377A (ja) * | 1990-12-31 | 1992-11-20 | Akzo Nv | 酸−不安定性リンカー分子 |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| EP1447098A3 (de) | 1993-01-28 | 2005-06-29 | Boston Scientific Limited | Therapeutische Inhibitoren der glatten Gefässmuskulaturzellen |
| US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| CA2285389C (en) | 1997-03-31 | 2008-12-30 | Boston Scientific Limited | Use of cytoskeletal inhibitors for the prevention of restenosis |
| DE69838483T2 (de) | 1997-10-14 | 2008-07-03 | Darwin Molecular Corp. | Thymidinkinase mutanten und fusionproteine mit thymidinkinase und guanylatekinase aktivitäten |
| US7015244B1 (en) | 1998-08-11 | 2006-03-21 | Mark Zamoyski | Inhalable chemical debridement for COPD |
| US20040039047A1 (en) | 1998-08-11 | 2004-02-26 | Mark Zamoyski | Compositions and methods for treating lung cancers |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| DE69942782D1 (de) | 1998-11-27 | 2010-10-28 | Ucb Sa | Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung |
| US6187203B1 (en) * | 1998-12-01 | 2001-02-13 | Academia Sinica | Sample purification apparatus and method |
| US6864235B1 (en) | 1999-04-01 | 2005-03-08 | Eva A. Turley | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| US6911429B2 (en) * | 1999-04-01 | 2005-06-28 | Transition Therapeutics Inc. | Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans |
| US6355251B1 (en) | 1999-06-15 | 2002-03-12 | Mark Zamoyski | Compositions and methods for epidermal chemexfoliation |
| US6346251B1 (en) | 1999-06-15 | 2002-02-12 | Mark Zamoyski | Compositions and methods for treating psoriasis |
| US6468247B1 (en) | 2000-04-21 | 2002-10-22 | Mark Zamoyski | Perfusion device for localized drug delivery |
| US6342520B1 (en) | 2000-10-30 | 2002-01-29 | Mark Zamoyski | Locally injectable chemotherapeutics |
| US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
| EP1967525B1 (de) | 2001-05-08 | 2012-11-14 | Darwin Molecular Corporation | Verfahren zur Regulierung der Immunfunktion in Primaten unter Verwendung des foxp3-Proteins |
| EP2147679B1 (de) * | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Zusammensetzungen für den Blut-Hirn-Schrankentransport |
| US6559178B1 (en) | 2002-01-29 | 2003-05-06 | Mark Zamoyski | Compositions and methods for apoptotic chemosurgery |
| US20050026823A1 (en) * | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
| DE602005020755D1 (de) * | 2004-03-05 | 2010-06-02 | Univ Illinois | Peptidträger für die verabreichung von arzneimitteln |
| EP1991274A4 (de) | 2006-01-20 | 2009-06-10 | Women S And Children S Health | Verfahren zur behandlung, prophylaxe und diagnose von knochenerkrankungen |
| US9182398B2 (en) | 2006-04-01 | 2015-11-10 | Medical Service Consultation International, Llc | Methods and compositions for detecting fungi and mycotoxins |
| TW200913987A (en) * | 2007-09-20 | 2009-04-01 | Golden Biotechnology Corp | Extract of Myrothecium sp. mycelium used to inhibit growth of tumor cell |
| US20100068718A1 (en) | 2008-08-22 | 2010-03-18 | Hooper Dennis G | Methods and Compositions for Identifying Yeast |
| US8962251B2 (en) | 2009-10-08 | 2015-02-24 | Medical Service Consultation International, Llc | Methods and compositions for identifying sulfur and iron modifying bacteria |
| US8956821B2 (en) | 2013-02-06 | 2015-02-17 | Medical Service Consultation International, Llc | Methods and compositions for detecting Aspergillus terreus, Aspergillus niger, and mycotoxins |
| CN104098740B (zh) * | 2014-02-23 | 2016-01-20 | 江苏省农业科学院 | 一种单端孢霉烯族类毒素分子印迹聚合物 |
| KR101680183B1 (ko) | 2014-12-04 | 2016-12-06 | 고려대학교 산학협력단 | 신규한 항바이러스용 조성물 및 이를 이용한 식물바이러스의 방제 방법 |
| CN108794502B (zh) * | 2018-06-12 | 2021-02-05 | 宁波大学 | 一种单端孢霉烯类化合物及其制备方法和用途 |
| CN108822124B (zh) * | 2018-06-12 | 2020-01-24 | 河北大学 | 一种单端孢霉烯族化合物及其制备方法和应用 |
| CN110183462A (zh) * | 2019-07-03 | 2019-08-30 | 中南大学湘雅医院 | 倍半萜烯类小分子化合物在制备治疗结肠癌药物、食品或保健品中的应用 |
| CN110806476B (zh) * | 2019-11-15 | 2021-10-08 | 中国农业科学院油料作物研究所 | 检测二乙酰镳草镰刀菌烯醇污染的免疫层析试纸条、制备方法及其应用 |
| CN111007244B (zh) * | 2019-11-15 | 2021-10-08 | 中国农业科学院油料作物研究所 | 二乙酸镳草镰刀菌烯醇竞争型气压免疫传感器及检测方法 |
| CN110747172B (zh) * | 2019-11-15 | 2021-07-20 | 中国农业科学院油料作物研究所 | 杂交瘤细胞株das5g11e7及其产生的抗二乙酸镳草镰刀菌烯醇单克隆抗体 |
| AU2023208050A1 (en) | 2022-01-14 | 2024-07-04 | Regeneron Pharmaceuticals, Inc. | Verrucarin a derivatives and antibody drug conjugates thereof |
| CN120078901A (zh) * | 2023-12-01 | 2025-06-03 | 深圳碳云智肽药物科技有限公司 | 一种肽偶联t2毒素及其抗肿瘤应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044167A3 (de) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Durch einen Antikörper gerichtetes zytotoxisches Mittel |
| FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4382952A (en) * | 1981-05-19 | 1983-05-10 | Warner-Lambert Company | Antibiotic roridin L-2 and its use |
| JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
| CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| US4618585A (en) * | 1982-03-18 | 1986-10-21 | Board Of Regents, The University Of Texas System | Hybridoma cell lines producing monoclonal antibodies directed against cervical cancer cells |
| JPS59116229A (ja) * | 1982-12-24 | 1984-07-05 | Teijin Ltd | 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法 |
| US4624846A (en) * | 1983-07-29 | 1986-11-25 | Immunomedics, Inc. | Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles |
| US4744981A (en) * | 1985-10-17 | 1988-05-17 | Neorx Corporation | Trichothecene antibody conjugates |
| US5066789A (en) * | 1988-09-30 | 1991-11-19 | Neorx Corporation | Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages |
-
1985
- 1985-10-17 US US06/788,325 patent/US4744981A/en not_active Expired - Fee Related
-
1986
- 1986-10-16 EP EP86308051A patent/EP0220065B1/de not_active Expired - Lifetime
- 1986-10-16 DE DE8686308051T patent/DE3687779T2/de not_active Expired - Fee Related
- 1986-10-16 AT AT86308051T patent/ATE85758T1/de not_active IP Right Cessation
- 1986-10-16 NO NO864136A patent/NO864136L/no unknown
- 1986-10-17 JP JP61245617A patent/JPH072651B2/ja not_active Expired - Lifetime
- 1986-10-17 DK DK499086A patent/DK499086A/da not_active Application Discontinuation
-
1987
- 1987-04-28 CN CN198787104045A patent/CN87104045A/zh active Pending
-
1988
- 1988-04-28 US US07/187,113 patent/US4906452A/en not_active Expired - Fee Related
- 1988-05-16 US US07/194,642 patent/US5157104A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0220065B1 (de) | 1993-02-17 |
| DK499086D0 (da) | 1986-10-17 |
| EP0220065A3 (en) | 1988-05-25 |
| DE3687779D1 (de) | 1993-03-25 |
| CN87104045A (zh) | 1988-11-09 |
| JPH072651B2 (ja) | 1995-01-18 |
| US5157104A (en) | 1992-10-20 |
| DK499086A (da) | 1987-04-18 |
| JPS62181280A (ja) | 1987-08-08 |
| EP0220065A2 (de) | 1987-04-29 |
| NO864136D0 (no) | 1986-10-16 |
| DE3687779T2 (de) | 1993-07-01 |
| US4906452A (en) | 1990-03-06 |
| NO864136L (no) | 1987-04-21 |
| US4744981A (en) | 1988-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |