ATE86991T1 - Analgetische carbonsaeureamid-derivate. - Google Patents
Analgetische carbonsaeureamid-derivate.Info
- Publication number
- ATE86991T1 ATE86991T1 AT89308639T AT89308639T ATE86991T1 AT E86991 T1 ATE86991 T1 AT E86991T1 AT 89308639 T AT89308639 T AT 89308639T AT 89308639 T AT89308639 T AT 89308639T AT E86991 T1 ATE86991 T1 AT E86991T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- group
- hydrogen
- analgesic
- acid derivatives
- Prior art date
Links
- 230000000202 analgesic effect Effects 0.000 title abstract 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 239000001301 oxygen Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- DBTDEFJAFBUGPP-UHFFFAOYSA-N Methanethial Chemical group S=C DBTDEFJAFBUGPP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21007488 | 1988-08-24 | ||
| EP89308639A EP0356247B1 (de) | 1988-08-24 | 1989-08-24 | Analgetische Carbonsäureamid-Derivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE86991T1 true ATE86991T1 (de) | 1993-04-15 |
Family
ID=16583388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89308639T ATE86991T1 (de) | 1988-08-24 | 1989-08-24 | Analgetische carbonsaeureamid-derivate. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5021413B1 (de) |
| EP (1) | EP0356247B1 (de) |
| KR (2) | KR0145704B1 (de) |
| CN (4) | CN1022185C (de) |
| AT (1) | ATE86991T1 (de) |
| CA (1) | CA1340541C (de) |
| DE (1) | DE68905407T2 (de) |
| ES (1) | ES2055077T3 (de) |
| HK (1) | HK1003002A1 (de) |
| HU (1) | HU211471A9 (de) |
| IE (1) | IE63873B1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2081351A1 (en) * | 1990-04-28 | 1991-10-29 | Vittorio Vecchietti | 1-(2h-1-oxo-3, 4-dihydronaphtyl-6) -acetyl-piperidines, process for their preparation and therapeutic use |
| GB9011656D0 (en) * | 1990-05-24 | 1990-07-11 | Zambeletti Spa L | Novel compounds |
| JPH06122677A (ja) * | 1992-08-28 | 1994-05-06 | Sankyo Co Ltd | 光学活性なカルボン酸アミド誘導体 |
| CN1054379C (zh) * | 1994-01-31 | 2000-07-12 | 三共株式会社 | 止痛化合物,它们的制备及其应用 |
| IT1273751B (it) * | 1994-02-11 | 1997-07-10 | Smithkline Beecham Farma | Derivati azaciclici |
| ATE213415T1 (de) | 1995-12-28 | 2002-03-15 | N T Predpr Sligands Obschestvo | Substituierte 6-h-1,3,4,-thiadiazin-2-amine, deren verwendung als anaesthetisierende, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung |
| DE69523346T2 (de) * | 1995-12-28 | 2002-08-29 | Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju), Ekaterinburg | Substituierte 6-h-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetisierende cardiovaskulare und hypometabole mittel, und eine sie enthaltende pharmazeutische zubereitung |
| EP0877026B1 (de) * | 1995-12-28 | 2001-10-31 | The Procter & Gamble Company | Substituierte 6-r-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetische, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung |
| RU2157210C2 (ru) * | 1995-12-28 | 2000-10-10 | Проктер энд Гэмбл Компани | Замещенные 6h-1,3,4-тиадиазин-2-амины, их применение в качестве анестезирующих, сердечно-сосудистых и гипометаболических средств и содержащие их фармацевтические композиции |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US5834487A (en) * | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
| CN1535687A (zh) * | 1996-11-25 | 2004-10-13 | ������������ʽ���� | 止痒药物 |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| JP2003526594A (ja) * | 1997-07-14 | 2003-09-09 | アドラー コーポレーション | カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法 |
| EP4786458A1 (de) * | 2023-09-28 | 2026-08-05 | West China Hospital, Sichuan University | Analgetische verbindung, herstellungsverfahren dafür und verwendung davon |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3917617A (en) * | 1973-10-01 | 1975-11-04 | Sharps Ass | 1-{8 2,6-Dihydroxy-4-hydrocarbyl-benzoyl{9 polymethyleneimines and derivatives |
| US4339576A (en) * | 1980-11-19 | 1982-07-13 | Sterling Drug Inc. | Anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory 1-[(benzoylphenyl)-lower-alkyl]piperidines and analogs thereof |
| DE3670080D1 (de) * | 1985-12-23 | 1990-05-10 | Zambeletti Spa L | Azacyclische verbindungen, verfahren zur ihrer herstellung und ihre verwendung als pharmazeutika. |
| DE3767527D1 (de) * | 1986-03-29 | 1991-02-28 | Suntory Ltd | Derivate vom benzoquinonylphenylalkansaeure-amid. |
| DE3767816D1 (de) * | 1986-09-02 | 1991-03-07 | Zambeletti Spa L | 1-acylsubstituierte piperidinderivate. |
-
1989
- 1989-08-22 US US07397105 patent/US5021413B1/en not_active Expired - Fee Related
- 1989-08-23 CA CA000609076A patent/CA1340541C/en not_active Expired - Fee Related
- 1989-08-23 IE IE271089A patent/IE63873B1/en not_active IP Right Cessation
- 1989-08-24 EP EP89308639A patent/EP0356247B1/de not_active Expired - Lifetime
- 1989-08-24 CN CN89107759A patent/CN1022185C/zh not_active Expired - Fee Related
- 1989-08-24 AT AT89308639T patent/ATE86991T1/de active
- 1989-08-24 DE DE8989308639T patent/DE68905407T2/de not_active Expired - Fee Related
- 1989-08-24 KR KR1019890012074A patent/KR0145704B1/ko not_active Expired - Fee Related
- 1989-08-24 ES ES89308639T patent/ES2055077T3/es not_active Expired - Lifetime
-
1993
- 1993-04-08 CN CN93103737A patent/CN1030450C/zh not_active Expired - Fee Related
- 1993-04-08 CN CN93103740A patent/CN1034731C/zh not_active Expired - Fee Related
- 1993-04-08 CN CN93103803A patent/CN1036004C/zh not_active Expired - Fee Related
-
1995
- 1995-06-29 HU HU95P/P00548P patent/HU211471A9/hu unknown
-
1998
- 1998-03-13 HK HK98102106A patent/HK1003002A1/en not_active IP Right Cessation
- 1998-03-20 KR KR1019980009754A patent/KR0182220B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0356247A1 (de) | 1990-02-28 |
| KR900003156A (ko) | 1990-03-23 |
| KR0145704B1 (ko) | 1998-08-17 |
| US5021413A (en) | 1991-06-04 |
| KR0182220B1 (ko) | 1999-10-01 |
| EP0356247B1 (de) | 1993-03-17 |
| IE892710L (en) | 1990-02-24 |
| DE68905407T2 (de) | 1993-09-23 |
| CN1030450C (zh) | 1995-12-06 |
| CN1036004C (zh) | 1997-10-01 |
| DE68905407D1 (de) | 1993-04-22 |
| ES2055077T3 (es) | 1994-08-16 |
| CN1040791A (zh) | 1990-03-28 |
| CN1034731C (zh) | 1997-04-30 |
| HU211471A9 (en) | 1995-11-28 |
| HK1003002A1 (en) | 1998-09-30 |
| CA1340541C (en) | 1999-05-11 |
| CN1078461A (zh) | 1993-11-17 |
| IE63873B1 (en) | 1995-06-14 |
| CN1022185C (zh) | 1993-09-22 |
| CN1079740A (zh) | 1993-12-22 |
| US5021413B1 (en) | 1994-12-13 |
| CN1079741A (zh) | 1993-12-22 |
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