NO933376L - Morfinan-derivater og medisinsk anvendelse derav - Google Patents
Morfinan-derivater og medisinsk anvendelse deravInfo
- Publication number
- NO933376L NO933376L NO93933376A NO933376A NO933376L NO 933376 L NO933376 L NO 933376L NO 93933376 A NO93933376 A NO 93933376A NO 933376 A NO933376 A NO 933376A NO 933376 L NO933376 L NO 933376L
- Authority
- NO
- Norway
- Prior art keywords
- medical applications
- morphinan derivatives
- nch3
- morphinan
- xso2
- Prior art date
Links
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 title abstract 2
- 229940051807 opiod analgesics morphinan derivative Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Fertilizers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1011592 | 1992-01-23 | ||
| JP29430892 | 1992-11-02 | ||
| PCT/JP1993/000080 WO1993015081A1 (en) | 1992-01-23 | 1993-01-22 | Morphinan derivative and medicinal use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO933376D0 NO933376D0 (no) | 1993-09-22 |
| NO933376L true NO933376L (no) | 1993-09-23 |
| NO302755B1 NO302755B1 (no) | 1998-04-20 |
Family
ID=26345314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933376A NO302755B1 (no) | 1992-01-23 | 1993-09-22 | Morfinan-derivater |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6323212B1 (no) |
| EP (2) | EP0577847B1 (no) |
| JP (1) | JP2525552B2 (no) |
| KR (1) | KR970011390B1 (no) |
| AT (1) | ATE172201T1 (no) |
| AU (2) | AU666702B2 (no) |
| CA (1) | CA2105072C (no) |
| DE (1) | DE69321525T2 (no) |
| DK (1) | DK0577847T3 (no) |
| ES (1) | ES2121988T3 (no) |
| FI (1) | FI106126B (no) |
| NO (1) | NO302755B1 (no) |
| NZ (1) | NZ246687A (no) |
| TW (1) | TW332814B (no) |
| WO (1) | WO1993015081A1 (no) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970011390B1 (ko) * | 1992-01-23 | 1997-07-10 | 도레이 가부시키가이샤 | 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물 |
| EP0657163B1 (en) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussive |
| KR100341950B1 (ko) * | 1993-07-19 | 2002-11-29 | 도레이 가부시끼가이샤 | 뇌세포보호제 |
| AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| SE9401727D0 (sv) * | 1994-05-18 | 1994-05-18 | Astra Ab | New compounds I |
| DE19602971A1 (de) * | 1995-12-20 | 1997-07-31 | Nycomed Arzneimittel Gmbh | Neue 7,8-Dihydromorphinderivate, Verfahren zu deren Herstellung und deren Verwendung |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| US6239154B1 (en) | 1996-03-08 | 2001-05-29 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| EP0829481A1 (en) * | 1996-09-16 | 1998-03-18 | Pfizer Inc. | Morphinan hydroxamic acid compounds |
| ES2236630T3 (es) * | 1996-11-25 | 2005-07-16 | Toray Industries, Inc. | Agente antipruritico. |
| US6187782B1 (en) | 1997-03-27 | 2001-02-13 | Toray Industries, Inc. | Morphinane derivatives and medicinal use thereof |
| KR100514963B1 (ko) * | 1997-07-11 | 2005-09-15 | 도레이 가부시끼가이샤 | 4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물 |
| US5760023A (en) * | 1997-07-14 | 1998-06-02 | Adolor Corporation | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith |
| MXPA99011298A (es) * | 1997-07-14 | 2004-10-28 | Adolor Corp | Formulaciones farmaceuticas antiprurito de agonista kappa y metodo para tratar prurito con las mismas. |
| AU6117298A (en) * | 1997-07-25 | 1999-02-16 | Toray Industries, Inc. | Hyponatremia remedies |
| US6583151B2 (en) | 1997-09-02 | 2003-06-24 | Toray Industries, Inc. | Remedies for drug addiction |
| US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
| TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| CN1204139C (zh) * | 1999-08-24 | 2005-06-01 | 东丽株式会社 | 神经性疼痛治疗剂 |
| US6688746B2 (en) * | 1999-12-03 | 2004-02-10 | Iouri Malov | Field testing using spread spectrum technique |
| WO2001074819A1 (en) * | 2000-04-03 | 2001-10-11 | Toray Industries, Inc. | Analgesics containing morphinan n-oxide derivatives as the active ingredient |
| US8338442B2 (en) * | 2001-03-30 | 2012-12-25 | Toray Industries, Inc. | Remedies for psychoneurosis |
| WO2002080918A1 (en) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Remedial or prophylactic agent for frequent urination or urinary incontinence |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2987788A1 (en) | 2002-05-17 | 2016-02-24 | Taiwanj Pharmaceuticals Co., Ltd. | Opioid and opioid-like compounds and uses thereof |
| HK1079786B (zh) | 2002-10-09 | 2010-03-12 | 东丽株式会社 | 尿频或尿失禁的治疗或预防剂以及具有含氮环状取代基的吗啡烷衍生物 |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7279579B2 (en) * | 2003-06-04 | 2007-10-09 | Alkermes, Inc. | Polymorphic forms of naltrexone |
| JP5266492B2 (ja) * | 2004-05-28 | 2013-08-21 | ヒューマン バイオモレキュラル リサーチ インスティテュート | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
| AR053098A1 (es) * | 2004-11-04 | 2007-04-25 | Toray Industries | Analgesico derivado de morfinano |
| WO2006109671A1 (ja) * | 2005-04-06 | 2006-10-19 | Toray Industries, Inc. | モルヒナン誘導体の結晶及びその製造法 |
| ES2307352B1 (es) * | 2005-04-12 | 2009-09-18 | Bti, I+D, S.L. | Implante dental y piezas destinadas a ser conectadas a un implante dental, y la conexion interna entre el implante dental y cada pieza. |
| KR101421747B1 (ko) | 2006-04-21 | 2014-07-30 | 넥타르 테라퓨틱스 | 모르피논의 입체선택적 환원 |
| ES2418104T3 (es) | 2007-04-24 | 2013-08-12 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la discinesia |
| MX2009011554A (es) | 2007-04-26 | 2010-01-25 | Toray Industries | Preparacion solida estable conteniendo un derivado de 4,5-epoximorfinano. |
| JP5343848B2 (ja) | 2007-06-22 | 2013-11-13 | 東レ株式会社 | 統合失調症の治療または予防剤 |
| CN101848714B (zh) | 2007-10-05 | 2014-08-20 | 东丽株式会社 | 以吗啡喃衍生物或其药理学上允许的酸加成盐为有效成分的皮肤性状改善治疗药 |
| WO2009103004A1 (en) * | 2008-02-14 | 2009-08-20 | Alkermes, Inc. | Selective opioid compounds |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| US8829019B2 (en) | 2008-10-24 | 2014-09-09 | Toray Industries, Inc. | Stable tablet containing 4,5-epoxymorphinan derivative |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| CN102325777B (zh) * | 2009-02-23 | 2015-08-12 | 马林克罗特公司 | (+)-吗啡喃*n-氧化物及其制备方法 |
| US8436174B2 (en) * | 2009-02-23 | 2013-05-07 | Mallinckrodt Llc | (+)-morphinanium quaternary salts and processes for their production |
| EP2398807A1 (en) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| PL2440562T3 (pl) * | 2009-06-11 | 2017-07-31 | Mallinckrodt Llc | Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru |
| EP2440561B1 (en) * | 2009-06-11 | 2014-04-30 | Mallinckrodt LLC | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| AU2011211223B2 (en) | 2010-01-29 | 2014-10-23 | Toray Industries, Inc. | Therapeutic or prophylactic agent for biliary diseases |
| AU2011263416B2 (en) | 2010-06-11 | 2014-04-10 | Rhodes Technologies | Process for N-dealkylation of tertiary amines |
| CA2802295C (en) | 2010-06-11 | 2016-09-20 | Rhodes Technologies | Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof |
| WO2012008984A1 (en) * | 2010-07-16 | 2012-01-19 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| EP2630150B1 (en) * | 2010-10-19 | 2017-04-12 | Memorial Sloan-Kettering Cancer Center | 6-amido derivatives of 4,5a-epoxymorphinans for treatment of pain |
| ES2586655T3 (es) | 2011-01-31 | 2016-10-18 | Toray Industries, Inc. | (-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer |
| EP2718294B1 (en) | 2011-06-09 | 2018-09-05 | SpecGx LLC | Reductive amination of 6-keto morphinans by catalytic hydrogen transfer |
| CN103917543A (zh) | 2011-09-08 | 2014-07-09 | 马林克罗特有限公司 | 在不分离中间体的情况下制备生物碱 |
| EP2884978B1 (en) | 2012-08-16 | 2019-07-17 | The Scripps Research Institute | Novel kappa opioid ligands |
| TWI449704B (zh) * | 2013-04-26 | 2014-08-21 | Everlight Chem Ind Corp | 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物 |
| WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
| JP2015166331A (ja) * | 2014-05-14 | 2015-09-24 | 遼東化学工業株式会社 | ナルフラフィンの結晶およびその製造方法 |
| WO2016152953A1 (ja) * | 2015-03-24 | 2016-09-29 | 東レ株式会社 | モルヒナン誘導体及びその医薬用途 |
| US11046692B2 (en) | 2015-04-30 | 2021-06-29 | Memorial Sloan-Kettering Cancer Center | Mitragynine analogs and uses thereof |
| SG11201803191VA (en) | 2015-10-29 | 2018-05-30 | Univ Tsukuba | Morphinan derivative and medical usage thereof |
| AU2017238208B2 (en) | 2016-03-22 | 2022-01-06 | Regents Of The University Of Minnesota | Combination for treating pain |
| EP3458061B1 (en) * | 2016-05-19 | 2023-01-18 | Virginia Commonwealth University | Potent and selective mu opioid receptor modulators |
| JP6814470B2 (ja) | 2017-02-10 | 2021-01-20 | 国立大学法人 筑波大学 | モルヒナン誘導体 |
| JP2021515038A (ja) * | 2018-02-27 | 2021-06-17 | デルポー・インコーポレイテッドＤｅｌｐｏｒ， Ｉｎｃ． | 小分子治療剤化合物のための組成物 |
| US20210015813A1 (en) | 2018-03-08 | 2021-01-21 | Victoria Link Ltd. | Treatment of demyelinating diseases |
| WO2020205735A1 (en) * | 2019-03-29 | 2020-10-08 | Humanwell Pharmaceutical US | Novel morphinans useful for treating medical disorders |
| EP3997092A4 (en) * | 2019-07-08 | 2023-09-06 | University of Health Sciences & Pharmacy in St. Louis | G-PROTEIN INFLUENCED OPIOID RECEPTOR AGONIST/ANALGESICS WITH REDUCED ARRESTIN RECRUITMENT |
| KR20220071223A (ko) | 2019-09-30 | 2022-05-31 | 닛뽕 케미파 가부시키가이샤 | 아제판 유도체 |
| BR112022005457A2 (pt) | 2019-10-24 | 2022-06-21 | Toray Industries | Agente terapêutico ou profilático para caquexia |
| CA3187797A1 (en) | 2020-06-30 | 2022-01-06 | Toray Industries, Inc. | Ameliorating agent or prophylactic agent for muscle weakness symptom in disease or syndrome associated with metabolic disorder |
| CN115181109B (zh) * | 2021-04-02 | 2024-06-04 | 南京正大天晴制药有限公司 | 吗啡喃衍生物的晶体及其制备方法 |
| WO2022225045A1 (ja) | 2021-04-23 | 2022-10-27 | 東レ株式会社 | グレリン抵抗性を伴う悪液質の治療剤又は予防剤 |
| WO2022265993A1 (en) | 2021-06-14 | 2022-12-22 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
| CN115960108B (zh) * | 2021-10-09 | 2026-02-03 | 山东新时代药业有限公司 | 一种无定型盐酸纳呋拉啡及其制备方法 |
| JPWO2023190665A1 (no) * | 2022-03-29 | 2023-10-05 |
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|---|---|---|---|---|
| NL290054A (no) * | ||||
| US3236851A (en) * | 1966-02-22 | Unsaturated morphinan derivatives | ||
| DE622231C (de) * | 1934-03-09 | 1935-11-23 | Hermann Fischer Dr | Verfahren zur Herstellung von Diacetylmorphin |
| GB864107A (en) * | 1958-09-10 | 1961-03-29 | Albert Boehringer | Morphine derivatives |
| GB919311A (en) * | 1958-10-29 | 1963-02-20 | T & H Smith Ltd | Derivatives of 14-hydroxycodeine and their preparation |
| DE2254298A1 (de) * | 1972-11-06 | 1974-05-16 | Boehringer Sohn Ingelheim | Neue (heteroarylmethyl)-normorphine, deren saeureadditionssalze, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
| GB1593191A (en) * | 1977-03-23 | 1981-07-15 | Reckitt & Colmann Prod Ltd | Derivatives of morphine |
| GB1587831A (en) * | 1977-03-23 | 1981-04-08 | Reckitt & Colmann Prod Ltd | Morphine derivatives |
| US4362870A (en) * | 1980-01-16 | 1982-12-07 | Regents Of The University Of Minnesota | Selective opioid receptor alkylating agents |
| JPS574991A (en) * | 1980-06-10 | 1982-01-11 | Sankyo Co Ltd | Cyclopropylmethylnormorphine-6-sulfuric ester |
| US4401672A (en) | 1981-10-13 | 1983-08-30 | Regents Of The University Of Minnesota | Non-addictive narcotic antitussive preparation |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| US4767718A (en) * | 1984-06-18 | 1988-08-30 | Southern Illinois University Foundation | Fluorescent opioid reagents and methods of use thereof in the detection of opioid receptors |
| IN163125B (no) * | 1985-01-08 | 1988-08-13 | Alkaloida Vegyeszeti Gyar | |
| HU196376B (en) * | 1985-05-23 | 1988-11-28 | Sandoz Ag | Process for preparing morphinane derivatives and pharmaceutical compositions containing such compounds |
| DE3617182A1 (de) | 1985-05-23 | 1986-11-27 | Sandoz-Patent-GmbH, 79539 Lörrach | Morphinan-derivate |
| US4730048A (en) | 1985-12-12 | 1988-03-08 | Regents Of The University Of Minnesota | Gut-selective opiates |
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| US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
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| CA2006311A1 (en) * | 1988-12-21 | 1990-06-21 | Ken Kanematsu | Morphine derivative |
| US5258386A (en) * | 1991-06-05 | 1993-11-02 | The United States Of America As Represented By The Secretary Of The Army | (+)-3-substituted-N alkylmorphinans, synthesis and use as anticonvulsant and neuroprotective agents |
| KR970011390B1 (ko) * | 1992-01-23 | 1997-07-10 | 도레이 가부시키가이샤 | 모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물 |
| EP0657163B1 (en) * | 1993-06-30 | 1998-10-14 | Toray Industries, Inc. | Antitussive |
-
1993
- 1993-01-22 KR KR1019930702860A patent/KR970011390B1/ko not_active Expired - Lifetime
- 1993-01-22 US US08/108,643 patent/US6323212B1/en not_active Expired - Lifetime
- 1993-01-22 ES ES93902520T patent/ES2121988T3/es not_active Expired - Lifetime
- 1993-01-22 AU AU33671/93A patent/AU666702B2/en not_active Expired
- 1993-01-22 DE DE69321525T patent/DE69321525T2/de not_active Expired - Lifetime
- 1993-01-22 CA CA002105072A patent/CA2105072C/en not_active Expired - Lifetime
- 1993-01-22 DK DK93902520T patent/DK0577847T3/da active
- 1993-01-22 EP EP93902520A patent/EP0577847B1/en not_active Expired - Lifetime
- 1993-01-22 JP JP5509616A patent/JP2525552B2/ja not_active Expired - Lifetime
- 1993-01-22 AT AT93902520T patent/ATE172201T1/de active
- 1993-01-22 NZ NZ246687A patent/NZ246687A/en not_active IP Right Cessation
- 1993-01-22 WO PCT/JP1993/000080 patent/WO1993015081A1/ja not_active Ceased
- 1993-01-22 EP EP98100805A patent/EP0846694A1/en not_active Withdrawn
- 1993-01-30 TW TW082100590A patent/TW332814B/zh not_active IP Right Cessation
- 1993-09-22 FI FI934144A patent/FI106126B/fi not_active IP Right Cessation
- 1993-09-22 NO NO933376A patent/NO302755B1/no not_active IP Right Cessation
-
1995
- 1995-12-22 AU AU40671/95A patent/AU686483B2/en not_active Expired
-
2000
- 2000-03-31 US US09/541,793 patent/US6277859B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI934144L (fi) | 1993-09-22 |
| US6277859B1 (en) | 2001-08-21 |
| FI934144A0 (fi) | 1993-09-22 |
| DE69321525T2 (de) | 1999-03-04 |
| ES2121988T3 (es) | 1998-12-16 |
| NZ246687A (en) | 1996-12-20 |
| DK0577847T3 (da) | 1999-06-23 |
| US6323212B1 (en) | 2001-11-27 |
| CA2105072C (en) | 1998-07-28 |
| AU3367193A (en) | 1993-09-01 |
| EP0577847B1 (en) | 1998-10-14 |
| FI106126B (fi) | 2000-11-30 |
| EP0846694A1 (en) | 1998-06-10 |
| NO933376D0 (no) | 1993-09-22 |
| TW332814B (en) | 1998-06-01 |
| AU4067195A (en) | 1996-03-07 |
| AU686483B2 (en) | 1998-02-05 |
| ATE172201T1 (de) | 1998-10-15 |
| KR970011390B1 (ko) | 1997-07-10 |
| NO302755B1 (no) | 1998-04-20 |
| EP0577847A1 (en) | 1994-01-12 |
| AU666702B2 (en) | 1996-02-22 |
| DE69321525D1 (de) | 1998-11-19 |
| JPH08502275A (ja) | 1996-03-12 |
| CA2105072A1 (en) | 1993-07-24 |
| JP2525552B2 (ja) | 1996-08-21 |
| WO1993015081A1 (en) | 1993-08-05 |
| EP0577847A4 (en) | 1994-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |