ATE86997T1 - Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. - Google Patents

Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.

Info

Publication number: ATE86997T1
Authority: AT; Austria
Prior art keywords: preparation; intermediate products; hydroxymethyl; treating; oxabicyclo
Prior art date: 1986-06-04

Application number

AT87108128T

Other languages

English (en)

Inventor

John Kurian Thottathill

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-04

Filing date

1987-06-04

Publication date

1993-04-15

1987-06-04 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE86997T1 publication Critical patent/ATE86997T1/de

Links

239000013067 intermediate product Substances 0.000 title 2
238000000034 method Methods 0.000 title 2
239000005557 antagonist Substances 0.000 title 1
DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title 1
BSDRYXVMOKNDLY-UHFFFAOYSA-N 3-[[3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]-4-phenyl-1,3-oxazolidin-2-one Chemical compound O=C1OCC(N1CC1C2CCC(C1CO)O2)C2=CC=CC=C2 BSDRYXVMOKNDLY-UHFFFAOYSA-N 0.000 abstract 3
GGPIGKDYPGCHPK-UHFFFAOYSA-N 2-[[3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]methylamino]-2-phenylethanol Chemical compound O1C2CCC1C(CO)C2CNC(CO)C1=CC=CC=C1 GGPIGKDYPGCHPK-UHFFFAOYSA-N 0.000 abstract 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
-1 alkali metal alkoxide Chemical class 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT87108128T 1986-06-04 1987-06-04 Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. ATE86997T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US06/870,564 US4687865A (en)	1986-06-04	1986-06-04	Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
HU872539A HU201941B (en)	1986-06-04	1987-06-03	Process for producing 7-oxabicycloheptane aminoalcohol
EP87108128A EP0248435B1 (de)	1986-06-04	1987-06-04	Verfahren zur Herstellung von 7-Oxabicycloheptan-Aminoalkohol-Zwischenprodukten zur Verwendung in der Herstellung von Thromboxan-A2-Antagonisten und Zwischenprodukte in diesem Verfahren

Publications (1)

Publication Number	Publication Date
ATE86997T1 true ATE86997T1 (de)	1993-04-15

Family

ID=26317529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87108128T ATE86997T1 (de)	1986-06-04	1987-06-04	Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.

Country Status (13)

Country	Link
US (1)	US4687865A (de)
EP (1)	EP0248435B1 (de)
JP (1)	JP2525411B2 (de)
AT (1)	ATE86997T1 (de)
AU (1)	AU597373B2 (de)
CA (1)	CA1305713C (de)
DE (1)	DE3784772T2 (de)
DK (1)	DK284587A (de)
ES (1)	ES2053466T3 (de)
HU (1)	HU201941B (de)
IE (1)	IE60657B1 (de)
NZ (1)	NZ220228A (de)
ZA (1)	ZA873282B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU593316B2 (en) *	1986-02-14	1990-02-08	E.R. Squibb & Sons, Inc.	Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4749715A (en) *	1987-03-02	1988-06-07	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted amino prostaglandin analogs
US4900723A (en) *	1988-04-29	1990-02-13	E. R. Squibb & Sons, Inc.	Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
CA2006086A1 (en) *	1989-01-17	1990-07-17	A. K. Gunnar Aberg	Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
NZ233600A (en) *	1989-06-12	1992-10-28	Squibb & Sons Inc	7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US5081266A (en) *	1990-02-26	1992-01-14	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
US4978762A (en) *	1990-02-26	1990-12-18	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
EP0666840A1 (de) *	1993-08-30	1995-08-16	Otsuka Pharmaceutical Co., Ltd.	Benzylaminderivate
MY186570A (en)	2014-05-13	2021-07-27	Novartis Ag	Compounds and compositions for inducing chondrogenesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB760686A (en) *	1953-03-25	1956-11-07	Pennsylvania Salt Mfg Co	Oxygen-bridged hydrogenated derivatives of phthalamic acid
US4220594A (en) *	1977-11-04	1980-09-02	E. R. Squibb & Sons, Inc.	Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4187236A (en) *	1977-11-04	1980-02-05	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane compounds
US4254044A (en) *	1977-11-04	1981-03-03	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4143054A (en) *	1977-11-04	1979-03-06	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane- and 7-oxabicycloheptene compounds
EP0045118B1 (de) *	1979-01-05	1984-04-04	National Research Development Corporation	Zwischenprodukte für die Synthese von Bizyklo(2,2,1)heptanen und Bizyklo(2,2,1)hept-2Z-enen
US4228180A (en) *	1979-11-01	1980-10-14	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) *	1980-07-01	1983-02-23	Nat Res Dev	Prostaglandins
DE3280020D1 (en) *	1981-12-23	1989-12-21	Nat Res Dev	Prostaglandins
US4416896A (en) *	1982-05-17	1983-11-22	E. R. Squibb & Sons, Inc.	7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) *	1982-10-25	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) *	1983-01-12	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474972A (en) *	1983-03-14	1984-10-02	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane prostaglandin intermediates and method for preparing same

1986
- 1986-06-04 US US06/870,564 patent/US4687865A/en not_active Expired - Lifetime
1987
- 1987-05-07 NZ NZ220228A patent/NZ220228A/xx unknown
- 1987-05-07 ZA ZA873282A patent/ZA873282B/xx unknown
- 1987-05-07 CA CA000536604A patent/CA1305713C/en not_active Expired - Lifetime
- 1987-05-28 AU AU73488/87A patent/AU597373B2/en not_active Ceased
- 1987-05-29 IE IE141987A patent/IE60657B1/en not_active IP Right Cessation
- 1987-06-02 JP JP62139650A patent/JP2525411B2/ja not_active Expired - Fee Related
- 1987-06-03 DK DK284587A patent/DK284587A/da not_active Application Discontinuation
- 1987-06-03 HU HU872539A patent/HU201941B/hu not_active IP Right Cessation
- 1987-06-04 DE DE8787108128T patent/DE3784772T2/de not_active Expired - Lifetime
- 1987-06-04 ES ES87108128T patent/ES2053466T3/es not_active Expired - Lifetime
- 1987-06-04 AT AT87108128T patent/ATE86997T1/de not_active IP Right Cessation
- 1987-06-04 EP EP87108128A patent/EP0248435B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US4687865A (en)	1987-08-18
JPS62292786A (ja)	1987-12-19
DK284587D0 (da)	1987-06-03
DK284587A (da)	1987-12-05
ZA873282B (en)	1987-12-30
IE60657B1 (en)	1994-08-10
AU597373B2 (en)	1990-05-31
DE3784772T2 (de)	1993-06-24
DE3784772D1 (de)	1993-04-22
EP0248435A1 (de)	1987-12-09
EP0248435B1 (de)	1993-03-17
ES2053466T3 (es)	1994-08-01
JP2525411B2 (ja)	1996-08-21
HUT52776A (en)	1990-08-28
NZ220228A (en)	1989-07-27
AU7348887A (en)	1987-12-10
HU201941B (en)	1991-01-28
CA1305713C (en)	1992-07-28
IE871419L (en)	1987-12-04

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Legal Events

Date	Code	Title	Description
2006-03-15	REN	Ceased due to non-payment of the annual fee