DK284587A - Fremgangsmaade til fremstilling af 7-oxabicyclohexan-aminoalkohol-mellemprodukter til femstilling af thromboxan a2-antagonister og saaledes fremstillede mellemprodukter - Google Patents

Fremgangsmaade til fremstilling af 7-oxabicyclohexan-aminoalkohol-mellemprodukter til femstilling af thromboxan a2-antagonister og saaledes fremstillede mellemprodukter

Info

Publication number: DK284587A
Authority: DK; Denmark
Prior art keywords: intermediates; hydroxymethyl; treating; oxabicyclohexan; fibrication
Prior art date: 1986-06-04

Application number

DK284587A

Other languages

English (en)

Other versions

DK284587D0 (da

Inventor

John Kurian Thottathil

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-04

Filing date

1987-06-03

Publication date

1987-12-05

1987-06-03 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1987-06-03 Publication of DK284587D0 publication Critical patent/DK284587D0/da

1987-12-05 Publication of DK284587A publication Critical patent/DK284587A/da

Links

239000000543 intermediate Substances 0.000 title 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
BSDRYXVMOKNDLY-UHFFFAOYSA-N 3-[[3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]methyl]-4-phenyl-1,3-oxazolidin-2-one Chemical compound O=C1OCC(N1CC1C2CCC(C1CO)O2)C2=CC=CC=C2 BSDRYXVMOKNDLY-UHFFFAOYSA-N 0.000 abstract 3
GGPIGKDYPGCHPK-UHFFFAOYSA-N 2-[[3-(hydroxymethyl)-7-oxabicyclo[2.2.1]heptan-2-yl]methylamino]-2-phenylethanol Chemical compound O1C2CCC1C(CO)C2CNC(CO)C1=CC=CC=C1 GGPIGKDYPGCHPK-UHFFFAOYSA-N 0.000 abstract 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
229910052783 alkali metal Inorganic materials 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
-1 alkali metal alkoxide Chemical class 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK284587A 1986-06-04 1987-06-03 Fremgangsmaade til fremstilling af 7-oxabicyclohexan-aminoalkohol-mellemprodukter til femstilling af thromboxan a2-antagonister og saaledes fremstillede mellemprodukter DK284587A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/870,564 US4687865A (en)	1986-06-04	1986-06-04	Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
HU872539A HU201941B (en)	1986-06-04	1987-06-03	Process for producing 7-oxabicycloheptane aminoalcohol

Publications (2)

Publication Number	Publication Date
DK284587D0 DK284587D0 (da)	1987-06-03
DK284587A true DK284587A (da)	1987-12-05

Family

ID=26317529

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK284587A DK284587A (da)	1986-06-04	1987-06-03	Fremgangsmaade til fremstilling af 7-oxabicyclohexan-aminoalkohol-mellemprodukter til femstilling af thromboxan a2-antagonister og saaledes fremstillede mellemprodukter

Country Status (13)

Country	Link
US (1)	US4687865A (da)
EP (1)	EP0248435B1 (da)
JP (1)	JP2525411B2 (da)
AT (1)	ATE86997T1 (da)
AU (1)	AU597373B2 (da)
CA (1)	CA1305713C (da)
DE (1)	DE3784772T2 (da)
DK (1)	DK284587A (da)
ES (1)	ES2053466T3 (da)
HU (1)	HU201941B (da)
IE (1)	IE60657B1 (da)
NZ (1)	NZ220228A (da)
ZA (1)	ZA873282B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU593316B2 (en) *	1986-02-14	1990-02-08	E.R. Squibb & Sons, Inc.	Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4749715A (en) *	1987-03-02	1988-06-07	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane substituted amino prostaglandin analogs
US4900723A (en) *	1988-04-29	1990-02-13	E. R. Squibb & Sons, Inc.	Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
CA2006086A1 (en) *	1989-01-17	1990-07-17	A. K. Gunnar Aberg	Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
NZ233600A (en) *	1989-06-12	1992-10-28	Squibb & Sons Inc	7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US4978762A (en) *	1990-02-26	1990-12-18	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
US5081266A (en) *	1990-02-26	1992-01-14	E. R. Squibb & Sons, Inc.	Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
WO1995006630A1 (en) *	1993-08-30	1995-03-09	Otsuka Pharmaceutical Co., Ltd.	Benzylamine derivatives
DK3143026T3 (da)	2014-05-13	2024-09-30	Novartis Ag	Forbindelser og sammensætninger til induktion af chondrogenese

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB760686A (en) *	1953-03-25	1956-11-07	Pennsylvania Salt Mfg Co	Oxygen-bridged hydrogenated derivatives of phthalamic acid
US4143054A (en) *	1977-11-04	1979-03-06	E. R. Squibb & Sons, Inc.	7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) *	1977-11-04	1980-02-05	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane compounds
US4254044A (en) *	1977-11-04	1981-03-03	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) *	1977-11-04	1980-09-02	E. R. Squibb & Sons, Inc.	Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
EP0045118B1 (en) *	1979-01-05	1984-04-04	National Research Development Corporation	Intermediates for the synthesis of bicyclo (2,2,1) heptanes and bicyclo (2,2,1) hept-2z-enes
US4228180A (en) *	1979-11-01	1980-10-14	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) *	1980-07-01	1983-02-23	Nat Res Dev	Prostaglandins
DE3280020D1 (en) *	1981-12-23	1989-12-21	Nat Res Dev	Prostaglandins
US4416896A (en) *	1982-05-17	1983-11-22	E. R. Squibb & Sons, Inc.	7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) *	1982-10-25	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) *	1983-01-12	1984-06-26	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474972A (en) *	1983-03-14	1984-10-02	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane prostaglandin intermediates and method for preparing same

1986
- 1986-06-04 US US06/870,564 patent/US4687865A/en not_active Expired - Lifetime
1987
- 1987-05-07 ZA ZA873282A patent/ZA873282B/xx unknown
- 1987-05-07 NZ NZ220228A patent/NZ220228A/xx unknown
- 1987-05-07 CA CA000536604A patent/CA1305713C/en not_active Expired - Lifetime
- 1987-05-28 AU AU73488/87A patent/AU597373B2/en not_active Ceased
- 1987-05-29 IE IE141987A patent/IE60657B1/en not_active IP Right Cessation
- 1987-06-02 JP JP62139650A patent/JP2525411B2/ja not_active Expired - Fee Related
- 1987-06-03 HU HU872539A patent/HU201941B/hu not_active IP Right Cessation
- 1987-06-03 DK DK284587A patent/DK284587A/da not_active Application Discontinuation
- 1987-06-04 DE DE8787108128T patent/DE3784772T2/de not_active Expired - Lifetime
- 1987-06-04 ES ES87108128T patent/ES2053466T3/es not_active Expired - Lifetime
- 1987-06-04 EP EP87108128A patent/EP0248435B1/en not_active Expired - Lifetime
- 1987-06-04 AT AT87108128T patent/ATE86997T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA873282B (en)	1987-12-30
ATE86997T1 (de)	1993-04-15
AU7348887A (en)	1987-12-10
JP2525411B2 (ja)	1996-08-21
EP0248435A1 (en)	1987-12-09
HUT52776A (en)	1990-08-28
DK284587D0 (da)	1987-06-03
DE3784772D1 (de)	1993-04-22
EP0248435B1 (en)	1993-03-17
IE871419L (en)	1987-12-04
HU201941B (en)	1991-01-28
CA1305713C (en)	1992-07-28
NZ220228A (en)	1989-07-27
DE3784772T2 (de)	1993-06-24
ES2053466T3 (es)	1994-08-01
JPS62292786A (ja)	1987-12-19
IE60657B1 (en)	1994-08-10
AU597373B2 (en)	1990-05-31
US4687865A (en)	1987-08-18

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Legal Events

Date	Code	Title	Description
1996-08-05	AHS	Application shelved for other reasons than non-payment