ATE87212T1 - Megakaryozyt-stimulationsfaktor. - Google Patents

Megakaryozyt-stimulationsfaktor.

Info

Publication number: ATE87212T1
Authority: AT; Austria
Prior art keywords: msf; protein; homogeneity; column; megakaryocyte
Prior art date: 1986-09-17

Application number

AT87308118T

Other languages

English (en)

Inventor

Robert D Rosenberg

Original Assignee

Massachusetts Inst Technology

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-17

Filing date

1987-09-15

Publication date

1993-04-15

1987-09-15 Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87212T1 publication Critical patent/ATE87212T1/de

Links

210000003593 megakaryocyte Anatomy 0.000 title abstract 3
230000000638 stimulation Effects 0.000 title 1
210000004027 cell Anatomy 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
101800000263 Acidic protein Proteins 0.000 abstract 1
229920002101 Chitin Polymers 0.000 abstract 1
229920002684 Sepharose Polymers 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 abstract 1
229910052921 ammonium sulfate Inorganic materials 0.000 abstract 1
235000011130 ammonium sulphate Nutrition 0.000 abstract 1
230000004071 biological effect Effects 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
239000003636 conditioned culture medium Substances 0.000 abstract 1
230000007717 exclusion Effects 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
230000002607 hemopoietic effect Effects 0.000 abstract 1
238000004128 high performance liquid chromatography Methods 0.000 abstract 1
238000001155 isoelectric focusing Methods 0.000 abstract 1
210000003734 kidney Anatomy 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
229920001542 oligosaccharide Polymers 0.000 abstract 1
150000002482 oligosaccharides Chemical class 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
238000001243 protein synthesis Methods 0.000 abstract 1
238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
230000004936 stimulating effect Effects 0.000 abstract 1
230000003582 thrombocytopenic effect Effects 0.000 abstract 1
230000014616 translation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/834—Urine; urinary system
- Y10S530/835—Kidney

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Fodder In General (AREA)

AT87308118T 1986-09-17 1987-09-15 Megakaryozyt-stimulationsfaktor. ATE87212T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/908,183 US4894440A (en)	1986-09-17	1986-09-17	Method of isolating megakaryocyte stimulatory factor
EP87308118A EP0260918B1 (de)	1986-09-17	1987-09-15	Megakaryozyt-Stimulationsfaktor

Publications (1)

Publication Number	Publication Date
ATE87212T1 true ATE87212T1 (de)	1993-04-15

Family

ID=25425332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87308118T ATE87212T1 (de)	1986-09-17	1987-09-15	Megakaryozyt-stimulationsfaktor.

Country Status (9)

Country	Link
US (1)	US4894440A (de)
EP (1)	EP0260918B1 (de)
JP (1)	JPS63239298A (de)
AT (1)	ATE87212T1 (de)
AU (1)	AU598297B2 (de)
DE (1)	DE3784992D1 (de)
DK (1)	DK485287A (de)
PT (1)	PT85730B (de)
ZA (1)	ZA876860B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL90719A0 (en) *	1988-06-28	1990-01-18	Yissum Res Dev Co	Novel nuclei acids and polypeptides encoded thereby
IL88831A0 (en) *	1988-12-29	1989-07-31	Yeda Res & Dev	Blood assay
US5032396A (en) *	1989-02-17	1991-07-16	Immunex Corporation	IL-7 to stimulate platelet production
US5260417A (en) *	1989-04-03	1993-11-09	Genetics Institute, Inc.	Megakaryocyte growth promoting activity protein
US6433142B1 (en) *	1989-08-08	2002-08-13	Genetics Institute, Llc	Megakaryocyte stimulating factors
US5326558A (en) *	1989-08-08	1994-07-05	Genetics Institute, Inc.	Megakaryocytopoietic factor
CA2086248A1 (en) *	1990-07-02	1992-01-03	Martin J. Murphy	Human meg-csf protein and methods
EP0504361A4 (en) *	1990-10-05	1994-08-17	Systemix Inc	Megakaryocyte and platelet growth, production and composition
CA2071479A1 (en) *	1990-10-12	1992-04-13	Pamela Hunt	Megakaryocyte maturation factors
AU646530B2 (en) *	1990-12-28	1994-02-24	Asahi Kasei Kogyo Kabushiki Kaisha	Novel megakaryocyte amplifier and production thereof
JPH04295500A (ja) *	1991-03-26	1992-10-20	Asahi Chem Ind Co Ltd	新規な巨核球増幅因子とその製法
US5482924A (en) *	1991-05-06	1996-01-09	Centre National De La Recherche	Proteinaceous compositions having an activity on erythropoiesis
CA2112492A1 (en) *	1991-06-28	1993-01-07	Hava Avraham	A differentiated megakaryocyte line producing novel megakaryocyte differentiation factors
AU4190893A (en) *	1992-07-17	1994-01-20	Suntory Limited	Megakaryocyte differentiation factor
US8357513B1 (en)	1994-01-03	2013-01-22	Genentech, Inc.	Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US8147844B1 (en)	1994-01-03	2012-04-03	Genentech, Inc.	Mpl ligand (thrombopoietin), nucleic acids encoding such, and methods of treatment using mpl ligand
US8192955B1 (en)	1994-01-03	2012-06-05	Genentech, Inc.	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
IL139335A (en) *	1994-01-03	2005-08-31	Genentech Inc	Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia
US8241900B1 (en)	1994-01-03	2012-08-14	Genentech, Inc.	mpl ligand
US6660256B1 (en) *	1994-01-03	2003-12-09	Genetech, Inc.	Porcine mpl ligand
US8278099B1 (en)	1994-02-15	2012-10-02	Genentech, Inc.	Monoclonal antibody to human thrombopoietin
US5795569A (en) *	1994-03-31	1998-08-18	Amgen Inc.	Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
DE69503849T2 (de) *	1994-03-31	1999-04-01	Amgen Inc., Thousand Oaks, Calif.	Zusammensetzungen und Verfahren zur Anregung des Wachstums und der Differenzierung von Megakaryozyten
US5593666A (en) *	1994-08-16	1997-01-14	The University Of Tennessee Research Corp.	Methods and compositions for treating thrombocytopenia
US6013067A (en) *	1995-06-07	2000-01-11	Zymogenetics, Inc.	Methods for increasing hematopoietic cells
JPH09143199A (ja) *	1995-11-17	1997-06-03	Nippon Chem Res Kk	血小板第４因子の製造方法
US20030180948A1 (en) *	2000-12-29	2003-09-25	Hutchins Jeff T.	Superficial zone protein and methods of making and using same
US20040028661A1 (en) *	2002-08-07	2004-02-12	Bartelmez Stephen H.	Expansion of cells using thrombopoietin and anti-transforming growth factor-beta

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN150740B (de) *	1978-11-24	1982-12-04	Hoffmann La Roche

1986
- 1986-09-17 US US06/908,183 patent/US4894440A/en not_active Expired - Lifetime
1987
- 1987-09-10 AU AU78244/87A patent/AU598297B2/en not_active Ceased
- 1987-09-14 ZA ZA876860A patent/ZA876860B/xx unknown
- 1987-09-15 DE DE8787308118T patent/DE3784992D1/de not_active Expired - Lifetime
- 1987-09-15 EP EP87308118A patent/EP0260918B1/de not_active Expired - Lifetime
- 1987-09-15 AT AT87308118T patent/ATE87212T1/de not_active IP Right Cessation
- 1987-09-16 PT PT85730A patent/PT85730B/pt not_active IP Right Cessation
- 1987-09-16 DK DK485287A patent/DK485287A/da not_active Application Discontinuation
- 1987-09-17 JP JP62233621A patent/JPS63239298A/ja active Pending

Also Published As

Publication number	Publication date
EP0260918A2 (de)	1988-03-23
US4894440A (en)	1990-01-16
EP0260918A3 (en)	1989-03-22
ZA876860B (en)	1988-08-31
PT85730B (pt)	1990-08-31
DK485287A (da)	1988-03-18
AU598297B2 (en)	1990-06-21
AU7824487A (en)	1988-05-19
PT85730A (en)	1987-10-01
DE3784992D1 (de)	1993-04-29
EP0260918B1 (de)	1993-03-24
DK485287D0 (da)	1987-09-16
JPS63239298A (ja)	1988-10-05

Legal Events

Date	Code	Title	Description
1993-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE3784992D1 (de)	1993-04-29	Megakaryozyt-stimulationsfaktor.
ATE142255T1 (de)	1996-09-15	Verfahren zur herstellung eines aktivierten faktor vii-konzentrates mit einer hohen reinheit
DE3684078D1 (de)	1992-04-09	Reinigung und aktivierung von proteinen aus unloeslichen einschlusskoerpern.
Tayrien et al.	1987	Purification and properties of a megakaryocyte stimulatory factor present both in the serum-free conditioned medium of human embryonic kidney cells and in thrombocytopenic plasma.
NO960111D0 (no)	1996-01-10	Preparater og metoder for stimulering av vekst og differensiering av megakaryocytter
GB2253397A (en)	1992-09-09	Purified cdw52-specific antibodies
DE59309332D1 (de)	1999-03-04	Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält
EP0239565A3 (en)	1989-07-26	Method of and apparatus for separating proteins
IL79972A0 (en)	1986-12-31	Protein recovery
GB1534812A (en)	1978-12-06	Method for the purification of interferon
Jaffé et al.	1959	Purification of a toxic phytohaemagglutinin from black beans (Phaseolus vulgaris)
SE8104482L (sv)	1982-02-28	Forfarande for framstellning av ett faktor viii (ahf)-hogkoncentrat
KR960009052B1 (en)	1996-07-10	Simultaneous preparation process of useful proteins from human urine
JPS57193494A (en)	1982-11-27	Method of purifying or concentrating biologically active protein and drug therefor
DE3788170D1 (de)	1993-12-23	Methode zur Reinigung und Isolierung von zwei ionischen Formen von Somatomedin.
Donnelly	1977	Chromatography of milk proteins on hydroxyapatite
ES8507000A1 (es)	1985-08-16	Metodo para la preparacion y purificacion de concentrados de factor viii antihemofilia de la sangre
Greenstein et al.	1987	[25] Purification of rat insulin-like growth factor II
FUNATSU et al.	1971	Structure and Toxic Function of Ricin I Purification Procedures of Ricin D
Healy et al.	1970	Growth-active globulins from calf serum tested on cultures of newly isolated mouse embryo cells
DE3687246T2 (de)	1993-06-24	Antitumor-polypeptid und dessen methode zur herstellung.
DE3249215T1 (de)	1983-11-17	Verfahren zur herstellung von humanem (gamma)-interferon
Schlunk et al.	1983	Preparative purification of human placental colony-stimulating factors
Schofield et al.	1977	Synthesis of procollagen by matrix-free cells from embryonic-chick arteries
JPS55100321A (en)	1980-07-31	Production of glycoprotein