ATE87469T1 - Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung. - Google Patents

Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.

Info

Publication number
ATE87469T1
ATE87469T1 AT86117946T AT86117946T ATE87469T1 AT E87469 T1 ATE87469 T1 AT E87469T1 AT 86117946 T AT86117946 T AT 86117946T AT 86117946 T AT86117946 T AT 86117946T AT E87469 T1 ATE87469 T1 AT E87469T1
Authority
AT
Austria
Prior art keywords
mixture
gelatin
collagen
release formulation
preparing
Prior art date
Application number
AT86117946T
Other languages
English (en)
Inventor
Keiji Fujioka
Shigeji Sato
Yoshio Sasaki
Teruo Miyata
Masayasu Furuse
Hiromi Naito
Original Assignee
Sumitomo Pharma
Koken Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP29459785A external-priority patent/JPS62152816A/ja
Priority claimed from JP29129886A external-priority patent/JPH0759522B2/ja
Application filed by Sumitomo Pharma, Koken Kk filed Critical Sumitomo Pharma
Application granted granted Critical
Publication of ATE87469T1 publication Critical patent/ATE87469T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
AT86117946T 1985-12-27 1986-12-23 Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung. ATE87469T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP29459785A JPS62152816A (ja) 1985-12-27 1985-12-27 ゲル状高分子の成形方法
JP29459685 1985-12-27
JP29129886A JPH0759522B2 (ja) 1985-12-27 1986-12-05 徐放性製剤の製造法
EP86117946A EP0230647B1 (de) 1985-12-27 1986-12-23 Verfahren zur Herstellung einer Formulierung mit verzögerter Freisetzung

Publications (1)

Publication Number Publication Date
ATE87469T1 true ATE87469T1 (de) 1993-04-15

Family

ID=27337645

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86117946T ATE87469T1 (de) 1985-12-27 1986-12-23 Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.

Country Status (6)

Country Link
US (1) US4849141A (de)
EP (1) EP0230647B1 (de)
AT (1) ATE87469T1 (de)
CA (1) CA1277601C (de)
DE (1) DE3688188T2 (de)
ES (1) ES2054613T3 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556620A (en) * 1985-02-05 1996-09-17 Cetus Oncology Corporation Use of recombinant colony stimulating factor-1 to enhance wound healing
JPH0720483B2 (ja) * 1987-05-29 1995-03-08 住友製薬株式会社 高粘度糊状組成物成形体の乾燥法
ES2054815T3 (es) * 1987-09-08 1994-08-16 Takeda Chemical Industries Ltd Citoquinas insolubilizadas en agua.
CA1338839C (en) * 1988-01-29 1997-01-14 Yoshio Sasaki Controlled release formulation
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5162114A (en) * 1989-02-23 1992-11-10 Stryker Corporation Bone collagen matrix for xenogenic implants
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5023080A (en) * 1988-06-17 1991-06-11 Basic Bio Systems, Inc. Time release protein
US5447966A (en) * 1988-07-19 1995-09-05 United States Surgical Corporation Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin
US5298243A (en) * 1988-10-20 1994-03-29 Denki Kagaku Kogyo Kabushiki Kaisha Colony stimulating factor-gelatin conjugate
US4992220A (en) * 1989-06-23 1991-02-12 Neri Michael A Method for producing biodegradable packaging material
JP2719671B2 (ja) * 1989-07-11 1998-02-25 日本ゼオン株式会社 創傷被覆材
JP3187410B2 (ja) * 1989-08-10 2001-07-11 住友製薬株式会社 脳内投与用徐放性製剤
WO1991005802A1 (en) * 1989-10-17 1991-05-02 Creative Biomolecules, Inc. Osteogenic devices
US5645591A (en) 1990-05-29 1997-07-08 Stryker Corporation Synthetic bone matrix
US5128136A (en) * 1990-07-16 1992-07-07 The Oregon Health Sciences University Wound healing kit comprised of gelable collagen
US5081106A (en) * 1990-07-16 1992-01-14 The Oregon Health Sciences University Wound dressing protocol utilizing collagen gelatin formed with iodine
US5139152A (en) * 1990-07-18 1992-08-18 Rhone-Poulenc Ag Company Water dispersible gel formulations
WO1992013547A1 (en) * 1991-02-07 1992-08-20 Alexander Mellon Eaton Drug delivery composition and method of using the same
BR9205864A (pt) * 1991-04-08 1994-06-28 Sumitomo Pharma Formulações sólidas porosas contendo substâncias proteináceas fisiologicamente ativas.
CA2071137A1 (en) * 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
US5658593A (en) * 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
US5876754A (en) * 1992-01-17 1999-03-02 Alfatec-Pharma Gmbh Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies
EP0621775B1 (de) * 1992-01-17 1997-08-06 ALFATEC-PHARMA GmbH Peptidarzneistoffe enthaltende pellets und ihre herstellung sowie deren verwendung
JP2616252B2 (ja) * 1992-10-16 1997-06-04 日本新薬株式会社 ワックスマトリックスの製法
CN1040840C (zh) * 1993-02-22 1998-11-25 唐山市骨科医院 抗生素植入剂及生产方法
US6015844A (en) * 1993-03-22 2000-01-18 Johnson & Johnson Medical, Inc. Composite surgical material
GB2280850B (en) * 1993-07-28 1997-07-30 Johnson & Johnson Medical Absorbable composite materials for use in the treatment of periodontal disease
US6001895A (en) * 1993-03-22 1999-12-14 Johnson & Johnson Medical, Inc. Composite surgical material
GB2281861B (en) * 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
US5693085A (en) 1994-04-29 1997-12-02 Scimed Life Systems, Inc. Stent with collagen
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US6998268B2 (en) 1995-07-03 2006-02-14 Dainippon Sumitomo Pharma Co. Ltd. Gene preparations
US6090915A (en) * 1996-10-18 2000-07-18 Hormel Foods Corporation Collagen or gelatin crumble composition and uses
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
DE19739031A1 (de) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung
US6432442B1 (en) 1998-02-23 2002-08-13 Mcneil-Ppc, Inc. Chewable product
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20010046968A1 (en) * 2000-03-23 2001-11-29 Zagon Ian S. Opioid growth factor modulates angiogenesis
US20030003157A1 (en) * 2001-06-06 2003-01-02 University Of Medicine & Dentistry Of New Jersey Collagen compositions and methods for making and using the same
JP2003119156A (ja) * 2001-08-06 2003-04-23 Kikuji Yamashita コラーゲンを含有する口腔用剤、医薬品および医薬部外品
CN1638732A (zh) * 2002-03-04 2005-07-13 研究及应用科学协会股份有限公司 含载体肽的缓释药物制剂
CA2483778A1 (en) * 2002-04-29 2003-11-13 Gel-Del Technologies, Inc. Biomatrix structural containment and fixation systems and methods of use thereof
US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
WO2005034852A2 (en) 2003-08-26 2005-04-21 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
WO2005055945A2 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
US8283312B2 (en) 2005-02-04 2012-10-09 The Research Foundation Of State University Of New York Compositions and methods for modulating body weight and treating obesity-related disorders
DE102007051059B4 (de) * 2007-10-18 2014-04-03 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen
CA2711001A1 (en) * 2007-12-26 2009-07-09 Gel-Del Technologies, Inc. Biocompatible protein-based particles and methods thereof
US10016534B2 (en) 2008-11-17 2018-07-10 Gel-Del Technologies, Inc. Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB642385A (en) * 1947-06-03 1950-08-30 Wyeth Corp Improvements in therapeutic products
US2518510A (en) * 1947-08-25 1950-08-15 Weich Henry Stable injectable oil-pectin therapeutic compositions
US3016895A (en) * 1958-08-01 1962-01-16 Pan American Lab Inc Injector for subcutaneous implantation of solids
US3143475A (en) * 1961-01-23 1964-08-04 Hoffmann La Roche Vitamin-containing gelatin beadlets and the process of preparing them
US3857932A (en) * 1970-09-09 1974-12-31 F Gould Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants
US4193813A (en) * 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
US4181731A (en) * 1976-09-07 1980-01-01 Sumitomo Chemical Company, Limited Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole
US4294241A (en) * 1977-06-09 1981-10-13 Teruo Miyata Collagen skin dressing
US4164559A (en) * 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4245635A (en) * 1979-01-29 1981-01-20 Jelco Laboratories Catheter assembly for intermittent intravenous use
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4279812A (en) * 1979-09-12 1981-07-21 Seton Company Process for preparing macromolecular biologically active collagen
US4374121A (en) * 1979-09-12 1983-02-15 Seton Company Macromolecular biologically active collagen articles
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
IN151913B (de) * 1980-01-11 1983-09-03 Boots Co Ltd
JPS56122317A (en) * 1980-02-29 1981-09-25 Koken:Kk Drug transporting material and its preparation
GB2075458B (en) * 1980-04-21 1983-06-02 Nicholas Pty Ltd Encapsulation of indomethacin
US4440680A (en) * 1980-09-24 1984-04-03 Seton Company Macromolecular biologically active collagen articles
GB2091554B (en) * 1981-01-13 1984-09-12 Mitsui Toatsu Chemicals Rod like moulded drug
US4483807A (en) * 1981-01-27 1984-11-20 Japan Atomic Energy Research Institute Process for producing a slow release composite
US4357312A (en) * 1981-07-16 1982-11-02 The Children's Hospital Medical Center Method of making prolonged release body
DE3134479C2 (de) * 1981-09-01 1988-12-22 Josef A. 7144 Asperg Blach Vorrichtung zum kontinuierlichen Aufschmelzen und Mischen von Kunststoffen
US4409332A (en) * 1982-01-12 1983-10-11 Jefferies Steven R Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same
DE3360633D1 (en) * 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
EP0094157B1 (de) * 1982-04-30 1987-07-29 Takeda Chemical Industries, Ltd. Pharmazeutische Zusammensetzung und ihre Verwendung
DE3380726D1 (en) * 1982-06-24 1989-11-23 Japan Chem Res Long-acting composition
JPS597684A (ja) * 1982-07-05 1984-01-14 株式会社日立製作所 エスカレ−タ−
JPS5919925A (ja) * 1982-07-27 1984-02-01 Stanley Electric Co Ltd ２層式液晶セルの製造方法
ZA836030B (en) * 1983-08-16 1985-02-27 Verex Lab Constant order release solid dosage indomethacin formulation and method of treating arthritis and other inflammatory conditions
EP0139286B1 (de) * 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Verlängerte Präparate mit verzögerter Abgabe
US4774091A (en) * 1983-10-14 1988-09-27 Sumitomo Pharmaceuticals Company, Ltd. Long-term sustained-release preparation
EP0140255B1 (de) * 1983-10-14 1991-05-15 Sumitomo Pharmaceuticals Company, Limited Injektionen mit verzögerter Abgabe
EP0138216B1 (de) * 1983-10-14 1993-01-07 Sumitomo Pharmaceuticals Company, Limited IFN-Präparat mit verzögerter Abgabe für parentale Verabreichung
DE3429038A1 (de) * 1984-08-07 1986-02-20 B. Braun Melsungen Ag, 3508 Melsungen Wirkstoff-depot

Also Published As

Publication number Publication date
CA1277601C (en) 1990-12-11
US4849141A (en) 1989-07-18
EP0230647A2 (de) 1987-08-05
EP0230647A3 (en) 1988-12-14
DE3688188T2 (de) 1993-10-14
ES2054613T3 (es) 1994-08-16
EP0230647B1 (de) 1993-03-31
DE3688188D1 (de) 1993-05-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee