ATE87921T1 - Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen. - Google Patents

Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.

Info

Publication number: ATE87921T1
Authority: AT; Austria
Prior art keywords: alkyl; substituted; cycloalkylamides; 8beta; ergolines
Prior art date: 1987-06-15

Application number

AT88305408T

Other languages

English (en)

Inventor

Mark M Foreman

William L Garbrecht

Gifford P Marzoni

Kathleen R Whitten

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-06-15

Filing date

1988-06-14

Publication date

1993-04-15

1988-06-14 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1993-04-15 Application granted granted Critical

1993-04-15 Publication of ATE87921T1 publication Critical patent/ATE87921T1/de

Links

RHGUXDUPXYFCTE-ZWNOBZJWSA-N ergoline Chemical compound C1=CC([C@@H]2[C@H](NCCC2)C2)=C3C2=CNC3=C1 RHGUXDUPXYFCTE-ZWNOBZJWSA-N 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
108091005479 5-HT2 receptors Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT88305408T 1987-06-15 1988-06-14 Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen. ATE87921T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US6228587A	1987-06-15	1987-06-15
EP88305408A EP0296748B1 (de)	1987-06-15	1988-06-14	Cycloalkylamide von (8beta)-1-Alkyl-6-(substituierten) Ergolinen

Publications (1)

Publication Number	Publication Date
ATE87921T1 true ATE87921T1 (de)	1993-04-15

Family

ID=22041482

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88305408T ATE87921T1 (de)	1987-06-15	1988-06-14	Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.

Country Status (22)

Country	Link
EP (1)	EP0296748B1 (de)
JP (1)	JP2653835B2 (de)
KR (1)	KR960010454B1 (de)
CN (1)	CN1019451B (de)
AT (1)	ATE87921T1 (de)
AU (1)	AU613641B2 (de)
CA (1)	CA1339661C (de)
DE (1)	DE3880022T2 (de)
DK (1)	DK322588A (de)
EG (1)	EG18586A (de)
ES (1)	ES2054806T3 (de)
HK (1)	HK77693A (de)
HU (2)	HU203344B (de)
IE (1)	IE61884B1 (de)
IL (1)	IL86725A (de)
MX (1)	MX11866A (de)
NZ (1)	NZ225022A (de)
PH (1)	PH24309A (de)
PT (1)	PT87716B (de)
SU (1)	SU1597103A3 (de)
UA (1)	UA6022A1 (de)
ZA (1)	ZA884222B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4902691A (en) *	1988-12-19	1990-02-20	Eli Lilly And Company	Heteroalkylamides of (8-β)-1-alkyl-6-(substituted)ergolines useful for blocking 5HT2 receptors
IT1232692B (it) *	1989-08-04	1992-03-04	Poli Ind Chimica Spa	Derivati ergolinici con attivita' dopaminergica
US5141944A (en) *	1990-04-11	1992-08-25	Eli Lilly And Company	N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
US5043341A (en) *	1990-04-11	1991-08-27	Eli Lilly And Company	N-(2-hydroxycyclopentyl)-1-isopropyl-6-methylergoline-8-carboxamides
JPH11503757A (ja) *	1995-04-18	1999-03-30	イーライ・リリー・アンド・カンパニー	５−ｈｔ▲下７▼レセプターにおいて生理学的および病理学的機能を生じるエルゴリン化合物の使用方法
US5880134A (en) *	1996-03-20	1999-03-09	Eli Lilly And Company	Method for using ergoline compounds to effect physiological and pathological functions at the 5-HT7 receptor
EP0961148B1 (de)	1998-05-26	2010-07-21	Canon Kabushiki Kaisha	Kamera mit Fokussierungsdetektor
EP2515654A4 (de)	2009-12-23	2013-04-24	Map Pharmaceuticals Inc	Neue ergolinanaloga
CN102775402B (zh) *	2011-05-13	2015-08-26	上海现代制药股份有限公司	一种制备二氢麦角酸的中间体及其制备方法
EP2723735A4 (de)	2011-06-23	2015-02-18	Map Pharmaceuticals Inc	Neue fluorergolin-analoga
AU2012355982A1 (en)	2011-12-19	2014-07-10	Map Pharmaceuticals, Inc.	Novel iso-ergoline derivatives
US8946420B2 (en)	2011-12-21	2015-02-03	Map Pharmaceuticals, Inc.	Neuromodulatory compounds
US9012640B2 (en)	2012-06-22	2015-04-21	Map Pharmaceuticals, Inc.	Cabergoline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH386441A (de) *	1961-02-17	1965-01-15	Sandoz Ag	Verfahren zur Herstellung von am Indolstickstoff substituierten Derivaten der Lysergsäure-Reihe
GB982737A (en) *	1961-05-08	1965-02-10	Westminster Bank Ltd	Improvements in or relating to lysergic acid compounds
GB996062A (en) *	1961-07-13	1965-06-23	Westminster Bank Ltd	Improvements in or relating to lysergic acid compounds

1988
- 1988-06-13 IL IL86725A patent/IL86725A/xx not_active IP Right Cessation
- 1988-06-13 EG EG332/88A patent/EG18586A/xx active
- 1988-06-13 MX MX1186688A patent/MX11866A/es unknown
- 1988-06-13 PH PH37059A patent/PH24309A/en unknown
- 1988-06-13 ZA ZA884222A patent/ZA884222B/xx unknown
- 1988-06-13 CA CA000569291A patent/CA1339661C/en not_active Expired - Fee Related
- 1988-06-14 AT AT88305408T patent/ATE87921T1/de not_active IP Right Cessation
- 1988-06-14 NZ NZ225022A patent/NZ225022A/xx unknown
- 1988-06-14 SU SU884355904A patent/SU1597103A3/ru active
- 1988-06-14 EP EP88305408A patent/EP0296748B1/de not_active Expired - Lifetime
- 1988-06-14 IE IE178888A patent/IE61884B1/en unknown
- 1988-06-14 JP JP63146689A patent/JP2653835B2/ja not_active Expired - Lifetime
- 1988-06-14 DK DK322588A patent/DK322588A/da not_active Application Discontinuation
- 1988-06-14 UA UA4355904A patent/UA6022A1/uk unknown
- 1988-06-14 DE DE8888305408T patent/DE3880022T2/de not_active Expired - Fee Related
- 1988-06-14 KR KR1019880007099A patent/KR960010454B1/ko not_active Expired - Fee Related
- 1988-06-14 ES ES88305408T patent/ES2054806T3/es not_active Expired - Lifetime
- 1988-06-14 CN CN88103627A patent/CN1019451B/zh not_active Expired
- 1988-06-14 PT PT87716A patent/PT87716B/pt not_active IP Right Cessation
- 1988-06-14 HU HU883047A patent/HU203344B/hu not_active IP Right Cessation
- 1988-06-14 AU AU17652/88A patent/AU613641B2/en not_active Ceased
1993
- 1993-08-05 HK HK776/93A patent/HK77693A/en not_active IP Right Cessation
1995
- 1995-06-22 HU HU95P/P00405P patent/HU211235A9/hu unknown

Also Published As

Publication number	Publication date
SU1597103A3 (ru)	1990-09-30
HK77693A (en)	1993-08-13
KR960010454B1 (ko)	1996-08-01
HU211235A9 (en)	1995-11-28
IL86725A0 (en)	1988-11-30
AU613641B2 (en)	1991-08-08
PH24309A (en)	1990-05-29
CA1339661C (en)	1998-02-10
EP0296748B1 (de)	1993-04-07
EG18586A (en)	1993-08-30
DK322588A (da)	1989-02-01
HUT47271A (en)	1989-02-28
ES2054806T3 (es)	1994-08-16
ZA884222B (en)	1990-02-28
AU1765288A (en)	1988-12-15
JP2653835B2 (ja)	1997-09-17
HU203344B (en)	1991-07-29
CN1030586A (zh)	1989-01-25
DE3880022T2 (de)	1993-08-19
IE881788L (en)	1988-12-15
JPS6416781A (en)	1989-01-20
UA6022A1 (uk)	1994-12-29
CN1019451B (zh)	1992-12-16
NZ225022A (en)	1990-07-26
KR890000482A (ko)	1989-03-14
IL86725A (en)	1993-01-14
DE3880022D1 (de)	1993-05-13
IE61884B1 (en)	1994-11-30
PT87716B (pt)	1992-10-30
PT87716A (pt)	1988-07-01
EP0296748A1 (de)	1988-12-28
DK322588D0 (da)	1988-06-14
MX11866A (es)	1993-12-01

Legal Events

Date	Code	Title	Description
1993-10-15	UEP	Publication of translation of european patent specification
2002-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DK0378518T3 (da)	1994-10-24	Adenosinderivater med farmaceutisk aktivitet som antihypertensiva
ES538418A0 (es)	1986-02-01	Un derivado de indol-3-carboxamida
DE3880022D1 (de)	1993-05-13	Cycloalkylamide von (8beta)-1-alkyl-6-(substituierten) ergolinen.
DE3572170D1 (de)	1989-09-14	Quinolonecarboxylic acid derivatives
PT93687A (pt)	1990-11-20	Processo para a preparacao de antagonistas de serotonina de tetra-hidrobenz,d}indole
PH27444A (en)	1993-07-02	Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes
ATE86860T1 (de)	1993-04-15	Praeparat gegen ulcus.
GB8706662D0 (en)	1987-04-23	Anti-arrhythmia agents
TW221429B (de)	1994-03-01
GR3005444T3 (de)	1993-05-24
DK0420224T3 (da)	1993-04-05	Anthihepatopatisk middel
FI901277A0 (fi)	1990-03-14	2,5,6,7-tetranor-4,8-inter-m-fenylen pg1z-derivativ.
NO872874D0 (no)	1987-07-10	Amid-derivater.
ATE189813T1 (de)	2000-03-15	Prostaglandin-i-analoga
FR2598914B1 (fr)	1991-10-25	Composition prophylactique et curative pour l'arteriosclerose