ATE88182T1 - Antidepressive n-substitierte nikotinamidverbindungen. - Google Patents

Antidepressive n-substitierte nikotinamidverbindungen.

Info

Publication number
ATE88182T1
ATE88182T1 AT89308481T AT89308481T ATE88182T1 AT E88182 T1 ATE88182 T1 AT E88182T1 AT 89308481 T AT89308481 T AT 89308481T AT 89308481 T AT89308481 T AT 89308481T AT E88182 T1 ATE88182 T1 AT E88182T1
Authority
AT
Austria
Prior art keywords
fluoro
chloro
antidepressive
nicotinamide compounds
methoxy
Prior art date
Application number
AT89308481T
Other languages
English (en)
Inventor
Nicholas Alex Saccomano
Fredric James Vinick
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE88182T1 publication Critical patent/ATE88182T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Saccharide Compounds (AREA)
AT89308481T 1988-08-31 1989-08-22 Antidepressive n-substitierte nikotinamidverbindungen. ATE88182T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/238,951 US4861891A (en) 1988-08-31 1988-08-31 Antidepressant N-substituted nicotinamide compounds
EP89308481A EP0357316B1 (de) 1988-08-31 1989-08-22 Antidepressive N-substitierte Nikotinamid-Verbindungen

Publications (1)

Publication Number Publication Date
ATE88182T1 true ATE88182T1 (de) 1993-04-15

Family

ID=22899998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308481T ATE88182T1 (de) 1988-08-31 1989-08-22 Antidepressive n-substitierte nikotinamidverbindungen.

Country Status (18)

Country Link
US (1) US4861891A (de)
EP (1) EP0357316B1 (de)
JP (1) JPH02115168A (de)
KR (1) KR920000760B1 (de)
AT (1) ATE88182T1 (de)
AU (1) AU609329B2 (de)
CA (1) CA1329605C (de)
DE (1) DE68905979T2 (de)
DK (1) DK426889A (de)
FI (1) FI894066A7 (de)
HU (1) HU208120B (de)
IE (1) IE892775L (de)
IL (1) IL91417A0 (de)
MY (1) MY104179A (de)
NO (1) NO893471L (de)
NZ (1) NZ230493A (de)
PT (1) PT91580B (de)
ZA (1) ZA896626B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973597A (en) * 1989-06-30 1990-11-27 Eli Lilly And Company Anticonvulsant agents
US5395935A (en) * 1992-05-08 1995-03-07 Pfizer Inc. Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
SK132899A3 (en) * 1997-04-04 2000-09-12 Pfizer Prod Inc NICOTINAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONì (54) COMPRISING THEM
GB9715584D0 (en) * 1997-07-23 1997-10-01 Eisai Co Ltd Compounds
CZ20022410A3 (cs) * 2000-01-31 2003-08-13 Pfizer Products Inc. Benzoanelované heterocyklylové deriváty nikotinamidu užitečné jako selektivní inhibitory isozymů PDE4
AU2700301A (en) * 2000-01-31 2001-08-14 Pfizer Products Inc. Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
KR100661081B1 (ko) * 2000-06-10 2006-12-26 동화약품공업주식회사 항바이러스제로 유용한 6-메틸니코틴아미드 유도체
OA12542A (en) * 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
KR20030070150A (ko) 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Ｐｄｅ4 이소자임 억제제로서 유용한 에테르 유도체
JP2004520386A (ja) * 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Ｐｄｅ４アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
US7250518B2 (en) * 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
GB0317472D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
JP2008503446A (ja) 2004-05-06 2008-02-07 プレキシコン，インコーポレーテッド Ｐｄｅ４ｂ阻害剤及びその使用
EP1786813A2 (de) * 2004-09-03 2007-05-23 Plexxikon, Inc. Bizyklische heteroaryl-pde4b-inhibitoren
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
RS55192B1 (sr) * 2005-11-24 2017-01-31 Dompé Farm S P A Derivati (r)-arilkilamina i farmaceutske kompozicije koje ih sadrže
EP1987004A2 (de) * 2006-02-16 2008-11-05 Boehringer Ingelheim International GmbH Substituierte pyridinamid-verbindungen als lösliche epoxid-hydrolase-hemmer
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2068872A1 (de) 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
DE102007057089B4 (de) * 2006-12-22 2010-04-29 Lg Display Co., Ltd. Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben
WO2008112164A2 (en) 2007-03-08 2008-09-18 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
EP2337563B1 (de) 2008-09-08 2014-04-09 The Board of Trustees of The Leland Stanford Junior University Modulatoren der aldehyddehydrogenase-aktivität und anwendungsverfahren für diese
JP2012506856A (ja) 2008-10-28 2012-03-22 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ アルデヒドデヒドロゲナーゼのモジュレーターおよびその使用方法
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
EP2804603A1 (de) 2012-01-10 2014-11-26 President and Fellows of Harvard College Betazellen-replikation für promoterverbindungen und verwendungsverfahren dafür
WO2014160185A2 (en) * 2013-03-14 2014-10-02 The Board Of Trustees Of The Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251263A (en) * 1979-09-04 1981-02-17 Stauffer Chemical Company N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof
US4270946A (en) * 1979-10-01 1981-06-02 Stauffer Chemical Company N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof
IL64220A (en) * 1980-11-21 1985-06-30 May & Baker Ltd Nicotinamide derivatives,their preparation and their use as herbicides
US4692185A (en) * 1986-01-13 1987-09-08 Stauffer Chemical Company N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides

Also Published As

Publication number Publication date
NZ230493A (en) 1991-03-26
CA1329605C (en) 1994-05-17
KR920000760B1 (ko) 1992-01-21
HUT52058A (en) 1990-06-28
IL91417A0 (en) 1990-04-29
EP0357316A1 (de) 1990-03-07
NO893471D0 (no) 1989-08-30
US4861891A (en) 1989-08-29
DK426889D0 (da) 1989-08-30
IE892775L (en) 1990-02-28
ZA896626B (en) 1991-04-24
JPH02115168A (ja) 1990-04-27
HU208120B (en) 1993-08-30
AU4091389A (en) 1990-06-28
NO893471L (no) 1990-03-01
PT91580A (pt) 1990-03-08
KR900003154A (ko) 1990-03-23
FI894066L (fi) 1990-03-01
AU609329B2 (en) 1991-04-26
DK426889A (da) 1990-03-01
DE68905979T2 (de) 1993-07-22
FI894066A0 (fi) 1989-08-30
EP0357316B1 (de) 1993-04-14
FI894066A7 (fi) 1990-03-01
MY104179A (en) 1994-02-28
PT91580B (pt) 1995-05-04
DE68905979D1 (de) 1993-05-19

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