DK426889A - N-substituerede 2-(phenyl eller bicyclo (2.2.1)hept-2-yl)oxynicotinamid-forbindelser, saadanne forbindelser til terapeutisk anvendelse og deres anvendelse til fremstilling af laegemidler til behandling af depression - Google Patents
N-substituerede 2-(phenyl eller bicyclo (2.2.1)hept-2-yl)oxynicotinamid-forbindelser, saadanne forbindelser til terapeutisk anvendelse og deres anvendelse til fremstilling af laegemidler til behandling af depressionInfo
- Publication number
- DK426889A DK426889A DK426889A DK426889A DK426889A DK 426889 A DK426889 A DK 426889A DK 426889 A DK426889 A DK 426889A DK 426889 A DK426889 A DK 426889A DK 426889 A DK426889 A DK 426889A
- Authority
- DK
- Denmark
- Prior art keywords
- medicinal products
- substituted
- hept
- bicyclo
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/238,951 US4861891A (en) | 1988-08-31 | 1988-08-31 | Antidepressant N-substituted nicotinamide compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK426889D0 DK426889D0 (da) | 1989-08-30 |
| DK426889A true DK426889A (da) | 1990-03-01 |
Family
ID=22899998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK426889A DK426889A (da) | 1988-08-31 | 1989-08-30 | N-substituerede 2-(phenyl eller bicyclo (2.2.1)hept-2-yl)oxynicotinamid-forbindelser, saadanne forbindelser til terapeutisk anvendelse og deres anvendelse til fremstilling af laegemidler til behandling af depression |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4861891A (da) |
| EP (1) | EP0357316B1 (da) |
| JP (1) | JPH02115168A (da) |
| KR (1) | KR920000760B1 (da) |
| AT (1) | ATE88182T1 (da) |
| AU (1) | AU609329B2 (da) |
| CA (1) | CA1329605C (da) |
| DE (1) | DE68905979T2 (da) |
| DK (1) | DK426889A (da) |
| FI (1) | FI894066L (da) |
| HU (1) | HU208120B (da) |
| IE (1) | IE892775L (da) |
| IL (1) | IL91417A0 (da) |
| MY (1) | MY104179A (da) |
| NO (1) | NO893471L (da) |
| NZ (1) | NZ230493A (da) |
| PT (1) | PT91580B (da) |
| ZA (1) | ZA896626B (da) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4973597A (en) * | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| US5395935A (en) * | 1992-05-08 | 1995-03-07 | Pfizer Inc. | Endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents |
| TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
| GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
| TR199902432T2 (xx) * | 1997-04-04 | 2000-01-21 | Prizer Products Inc. | Nikotinamid t�revleri. |
| GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
| PL357555A1 (en) * | 2000-01-31 | 2004-07-26 | Pfizer Products Inc. | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes |
| BR0107964A (pt) * | 2000-01-31 | 2002-10-29 | Pfizer Prod Inc | Derivados de nicotinamida benzofundida com heterociclica úteis como inibidores seletivos de isozimas pde4 |
| KR100661081B1 (ko) * | 2000-06-10 | 2006-12-26 | 동화약품공업주식회사 | 항바이러스제로 유용한 6-메틸니코틴아미드 유도체 |
| CN1527830A (zh) | 2001-01-31 | 2004-09-08 | �Ʒ� | 用作pde4同工酶的抑制剂的醚衍生物 |
| BR0116850A (pt) * | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4 |
| PL364135A1 (en) * | 2001-01-31 | 2004-12-13 | Pfizer Products Inc. | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
| US7250518B2 (en) * | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| GB0317472D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| CA2565965A1 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
| EP1786813A2 (en) * | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| HRP20161260T1 (hr) * | 2005-11-24 | 2016-11-18 | Dompé Farmaceutici S.P.A. | Derivati (r)-arilkilamina i farmaceutski pripravci koji ih sadrže |
| WO2007098352A2 (en) * | 2006-02-16 | 2007-08-30 | Boehringer Ingelheim International Gmbh | Substituted pyridineamide compounds useful as soluble epoxide hydrolase inhibitors |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| DE102007057089B4 (de) * | 2006-12-22 | 2010-04-29 | Lg Display Co., Ltd. | Flüssigkristallanzeige mit Photosensor und Herstellungsverfahren derselben |
| EP2126574B1 (en) | 2007-03-08 | 2015-12-23 | The Board of Trustees of the Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
| WO2010028175A1 (en) | 2008-09-08 | 2010-03-11 | The Board Of Trustees Of The Leland Stanford Junior University | Modulators of aldehyde dehydrogenase activity and methods of use thereof |
| EP2349279A4 (en) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | MODIFIERS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2012149106A1 (en) | 2011-04-29 | 2012-11-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251263A (en) * | 1979-09-04 | 1981-02-17 | Stauffer Chemical Company | N-substituted, 2-phenoxynicotinamide compounds and the herbicidal use thereof |
| US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
| IL64220A (en) * | 1980-11-21 | 1985-06-30 | May & Baker Ltd | Nicotinamide derivatives,their preparation and their use as herbicides |
| US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
-
1988
- 1988-08-31 US US07/238,951 patent/US4861891A/en not_active Expired - Fee Related
-
1989
- 1989-08-22 EP EP89308481A patent/EP0357316B1/en not_active Expired - Lifetime
- 1989-08-22 AT AT89308481T patent/ATE88182T1/de active
- 1989-08-22 DE DE8989308481T patent/DE68905979T2/de not_active Expired - Fee Related
- 1989-08-24 IL IL91417A patent/IL91417A0/xx unknown
- 1989-08-25 MY MYPI89001168A patent/MY104179A/en unknown
- 1989-08-29 CA CA000609655A patent/CA1329605C/en not_active Expired - Fee Related
- 1989-08-30 KR KR1019890012412A patent/KR920000760B1/ko not_active Expired
- 1989-08-30 JP JP1224342A patent/JPH02115168A/ja active Pending
- 1989-08-30 NO NO89893471A patent/NO893471L/no unknown
- 1989-08-30 AU AU40913/89A patent/AU609329B2/en not_active Ceased
- 1989-08-30 PT PT91580A patent/PT91580B/pt not_active IP Right Cessation
- 1989-08-30 NZ NZ230493A patent/NZ230493A/en unknown
- 1989-08-30 DK DK426889A patent/DK426889A/da not_active Application Discontinuation
- 1989-08-30 HU HU894507A patent/HU208120B/hu not_active IP Right Cessation
- 1989-08-30 ZA ZA896626A patent/ZA896626B/xx unknown
- 1989-08-30 IE IE892775A patent/IE892775L/xx unknown
- 1989-08-30 FI FI894066A patent/FI894066L/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE68905979T2 (de) | 1993-07-22 |
| FI894066A0 (fi) | 1989-08-30 |
| HU208120B (en) | 1993-08-30 |
| AU609329B2 (en) | 1991-04-26 |
| EP0357316A1 (en) | 1990-03-07 |
| ATE88182T1 (de) | 1993-04-15 |
| ZA896626B (en) | 1991-04-24 |
| MY104179A (en) | 1994-02-28 |
| DK426889D0 (da) | 1989-08-30 |
| NZ230493A (en) | 1991-03-26 |
| KR900003154A (ko) | 1990-03-23 |
| US4861891A (en) | 1989-08-29 |
| PT91580A (pt) | 1990-03-08 |
| HUT52058A (en) | 1990-06-28 |
| PT91580B (pt) | 1995-05-04 |
| AU4091389A (en) | 1990-06-28 |
| FI894066A7 (fi) | 1990-03-01 |
| NO893471L (no) | 1990-03-01 |
| KR920000760B1 (ko) | 1992-01-21 |
| DE68905979D1 (de) | 1993-05-19 |
| FI894066L (fi) | 1990-03-01 |
| CA1329605C (en) | 1994-05-17 |
| IE892775L (en) | 1990-02-28 |
| IL91417A0 (en) | 1990-04-29 |
| EP0357316B1 (en) | 1993-04-14 |
| NO893471D0 (no) | 1989-08-30 |
| JPH02115168A (ja) | 1990-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment |