ATE88891T1 - Verfahren zur verbesserung des gedaechnisses oder zur beseitigung des gedaechnis-mangels mit arylamido-(und arylthioamido)-azabicycloalkanen. - Google Patents
Verfahren zur verbesserung des gedaechnisses oder zur beseitigung des gedaechnis-mangels mit arylamido-(und arylthioamido)-azabicycloalkanen.Info
- Publication number
- ATE88891T1 ATE88891T1 AT86300747T AT86300747T ATE88891T1 AT E88891 T1 ATE88891 T1 AT E88891T1 AT 86300747 T AT86300747 T AT 86300747T AT 86300747 T AT86300747 T AT 86300747T AT E88891 T1 ATE88891 T1 AT E88891T1
- Authority
- AT
- Austria
- Prior art keywords
- memory
- arylthioamido
- azabicycloalkanes
- arylamido
- deficiency
- Prior art date
Links
- 230000007812 deficiency Effects 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- -1 methoxy- indolinyl Chemical group 0.000 abstract 2
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/697,944 US4605652A (en) | 1985-02-04 | 1985-02-04 | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| EP86300747A EP0190920B1 (de) | 1985-02-04 | 1986-02-04 | Verfahren zur Verbesserung des Gedächnisses oder zur Beseitigung des Gedächnis-Mangels mit Arylamido-(und Arylthioamido)-Azabicycloalkanen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE88891T1 true ATE88891T1 (de) | 1993-05-15 |
Family
ID=24803233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86300747T ATE88891T1 (de) | 1985-02-04 | 1986-02-04 | Verfahren zur verbesserung des gedaechnisses oder zur beseitigung des gedaechnis-mangels mit arylamido-(und arylthioamido)-azabicycloalkanen. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4605652A (de) |
| EP (1) | EP0190920B1 (de) |
| JP (1) | JPH0662414B2 (de) |
| AT (1) | ATE88891T1 (de) |
| AU (1) | AU589155B2 (de) |
| CA (1) | CA1273297A (de) |
| DE (1) | DE3688377T2 (de) |
| PH (1) | PH22646A (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4820715A (en) * | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| US5231170A (en) * | 1986-08-27 | 1993-07-27 | Paul Averback | Antibodies to dense microspheres |
| US4816416A (en) * | 1986-08-27 | 1989-03-28 | Paul Averback | Microspheric bodies for use in screening therapies for Azheimer's disease and related conditions |
| EP0272052B1 (de) * | 1986-12-16 | 1992-07-08 | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) | Angstlösende N-(1-Azabicyclo[2.2.2)oct-3-yl)benzamide und -thiobenzamide |
| DE3752062T2 (de) * | 1986-12-17 | 1997-09-11 | Glaxo Group Ltd | Verwendung von heterozyklischen Derivaten zur Herstellung von Arzneimitteln |
| US5244909A (en) * | 1986-12-17 | 1993-09-14 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
| US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
| JP2608078B2 (ja) * | 1986-12-17 | 1997-05-07 | グラクソ、グループ、リミテッド | 医 薬 |
| US5246941A (en) * | 1986-12-17 | 1993-09-21 | Glaxo Group Limited | Method for the treatment of depression |
| US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
| GB8720805D0 (en) * | 1987-09-04 | 1987-10-14 | Naylor R J | 2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides |
| EP0311724A1 (de) * | 1987-10-16 | 1989-04-19 | Synthelabo | Anxiolytische R-N-(1-Azabicyclo[2.2.2]oct-3-yl)-benzamide und -thiobenzamide |
| US4863919A (en) * | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
| EP0353371A1 (de) * | 1988-08-04 | 1990-02-07 | Synthelabo | Steigerung der Gedächtnisleistung durch R-N-(1-azabicyclo[2.2.2]oct-3-yl)Benzamide und Thiobenzamide |
| US5229407A (en) * | 1988-09-01 | 1993-07-20 | Glaxo Group Limited | Medicaments |
| GB8820651D0 (en) * | 1988-09-01 | 1988-10-05 | Glaxo Group Ltd | Medicaments |
| DE4009565A1 (de) * | 1990-03-24 | 1991-09-26 | Merck Patent Gmbh | Indolderivate |
| EP0492020A1 (de) * | 1990-12-21 | 1992-07-01 | Merrell Dow Pharmaceuticals Inc. | Verwendung von bestimmten Estern von Hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-on und verwandter Verbindungen zur Behandlung von kognitiven Erkrankungen |
| ZA92278B (en) * | 1991-02-01 | 1992-10-28 | Akzo Nv | 3-quinuclidine derivatives |
| AU654013B2 (en) * | 1991-03-13 | 1994-10-20 | Regents Of The University Of Minnesota | 2-hydroxy-3(4-iodophenyl)-1-(4-phenylpiperidinyl) propane |
| IT1250629B (it) * | 1991-07-04 | 1995-04-21 | Boehringer Ingelheim Italia | Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico. |
| US5723103A (en) * | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
| SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| WO2002016357A2 (en) | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
| US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
| JP2004506735A (ja) | 2000-08-18 | 2004-03-04 | ファルマシア・アンド・アップジョン・カンパニー | 疾患治療用キヌクリジン置換アリール化合物 |
| WO2002017358A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists) |
| WO2002015662A2 (en) | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists |
| PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
| AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
| JP2005504058A (ja) | 2001-08-24 | 2005-02-10 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | 疾患の治療のための置換ヘテロアリール−7−アザ[2.2.1]ビシクロヘプタン |
| US20030069296A1 (en) * | 2001-08-24 | 2003-04-10 | Wishka Donn G. | Substituted-aryl 7-aza[2.2.1]bicycloheptanes for the treatment of disease |
| BR0212477A (pt) * | 2001-09-12 | 2004-08-24 | Upjohn Co | 7-aza[2.2.1] bicicloheptanos substituìdos para o tratamento de doenças |
| EA007429B1 (ru) | 2001-10-02 | 2006-10-27 | Фармация Энд Апджон Компани | Азабициклические замещённые конденсированные гетероарильные соединения |
| WO2003032897A2 (en) * | 2001-10-16 | 2003-04-24 | Astrazeneca Ab | Azabicyclic compounds for the treatment of fibromyalgia syndrome |
| MXPA04003986A (es) * | 2001-10-26 | 2004-07-23 | Upjohn Co | Carboxamidas hetero-biciclicas n-azabiciclico sustituidas como agonistas nachr. |
| US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
| US6919359B2 (en) * | 2001-11-08 | 2005-07-19 | Pfizer Inc | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease |
| WO2003042210A1 (en) | 2001-11-09 | 2003-05-22 | Pharmacia & Upjohn Company | Azabicyclic-phenyl-fused-heterocyclic compounds and their use as alpha7 nachr ligands |
| DE10162375A1 (de) | 2001-12-19 | 2003-07-10 | Bayer Ag | Bicyclische N-Aryl-amide |
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| US6852716B2 (en) | 2002-02-15 | 2005-02-08 | Pfizer Inc | Substituted-aryl compounds for treatment of disease |
| EP1476448A2 (de) * | 2002-02-19 | 2004-11-17 | PHARMACIA & UPJOHN COMPANY | Azabicyclische verbindungen zur behandlung von erkrankungen |
| BR0307735A (pt) * | 2002-02-19 | 2005-01-25 | Upjohn Co | Carboxamidas heteroaromáticas com ligação-n em ponte biciclìcas fundidas para o tratamento de doença |
| US7001900B2 (en) * | 2002-02-20 | 2006-02-21 | Pfizer Inc. | Azabicyclic compounds for the treatment of disease |
| DE10234424A1 (de) | 2002-07-29 | 2004-02-12 | Bayer Ag | Benzothiophen-, Benzofuran- und Indolharnstoffe |
| AU2003253686A1 (en) | 2002-08-01 | 2004-02-23 | Pharmacia & Upjohn Company Llc | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| ES2405594T3 (es) * | 2002-09-25 | 2013-05-31 | Memory Pharmaceuticals Corporation | Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos |
| CA2503786A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases |
| WO2005063767A2 (en) | 2003-12-22 | 2005-07-14 | Memory Pharmaceuticals Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof |
| RU2417225C2 (ru) * | 2004-03-25 | 2011-04-27 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение |
| CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| JP2007538011A (ja) * | 2004-05-07 | 2007-12-27 | メモリー・ファーマシューティカルズ・コーポレイション | 1h−インダゾール、ベンゾチアゾール、1,2−ベンゾイソキサゾール、1,2−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用 |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| JP2008525464A (ja) | 2004-12-22 | 2008-07-17 | メモリー・ファーマシューティカルズ・コーポレイション | α−7ニコチン性受容体リガンド並びにその製造及び使用 |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| US20080242688A1 (en) * | 2007-03-19 | 2008-10-02 | Astrazeneca Ab | Method 741 |
| EP2344636B1 (de) * | 2008-10-09 | 2017-12-06 | Howard Hughes Medical Institute | Neue chimäre ligandgesteuerte ionenkanäle und anwendungsverfahren dafür |
| SI2540297T1 (sl) | 2008-11-19 | 2015-08-31 | Forum Pharmaceuticals Inc. | Zdravljenje kognitivne motnje z (R)-7-Kloro-N-(kinuklidin-3-il)benzo(b)tiofen-2-karboksamid in farmacevtsko nje sprejemljivih soli |
| CN102802620A (zh) * | 2009-05-11 | 2012-11-28 | 英维沃医药有限公司 | 使用某种α-7烟酸受体与乙酰胆碱酯酶抑制剂结合治疗认知障碍 |
| NZ603625A (en) | 2010-05-17 | 2014-10-31 | Envivo Pharmaceuticals Inc | A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate |
| WO2013010679A1 (en) | 2011-07-15 | 2013-01-24 | Novartis Ag | Salts of aza-bicyclic di-aryl ethers and methods to make them or their precursors |
| EP3666272A1 (de) | 2012-05-08 | 2020-06-17 | Forum Pharmaceuticals Inc. | Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit |
| WO2017060287A1 (en) * | 2015-10-05 | 2017-04-13 | Sandoz Ag | Process for the preparation of encenicline from 7-chloro-benzo[b]thiophene-2-carboxylic acid chloride and (r)-quinuclidin-3-amine in the presence of imidazole |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1293446A (en) * | 1970-07-23 | 1972-10-18 | Rech S Et D Applic Scient Soge | Quinuclidine derivatives, the preparation thereof and pharmaceutical compositions containing them |
| GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
| FR2531083B1 (fr) * | 1982-06-29 | 1986-11-28 | Sandoz Sa | Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments |
| FR2529548A1 (fr) * | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| US4593034A (en) * | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
| US4661500A (en) * | 1985-08-29 | 1987-04-28 | Roman Rozencwaig | Method of medical treatment with serotonin antagonists |
-
1985
- 1985-02-04 US US06/697,944 patent/US4605652A/en not_active Expired - Lifetime
-
1986
- 1986-01-23 AU AU52672/86A patent/AU589155B2/en not_active Ceased
- 1986-02-03 CA CA000500990A patent/CA1273297A/en not_active Expired - Fee Related
- 1986-02-03 PH PH33375A patent/PH22646A/en unknown
- 1986-02-04 DE DE86300747T patent/DE3688377T2/de not_active Expired - Fee Related
- 1986-02-04 EP EP86300747A patent/EP0190920B1/de not_active Expired - Lifetime
- 1986-02-04 AT AT86300747T patent/ATE88891T1/de not_active IP Right Cessation
- 1986-02-04 JP JP61022819A patent/JPH0662414B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0190920B1 (de) | 1993-05-05 |
| EP0190920A2 (de) | 1986-08-13 |
| AU5267286A (en) | 1986-08-07 |
| CA1273297A (en) | 1990-08-28 |
| EP0190920A3 (en) | 1990-04-18 |
| PH22646A (en) | 1988-10-28 |
| JPS61183223A (ja) | 1986-08-15 |
| DE3688377T2 (de) | 1993-10-21 |
| AU589155B2 (en) | 1989-10-05 |
| DE3688377D1 (de) | 1993-06-09 |
| US4605652A (en) | 1986-08-12 |
| JPH0662414B2 (ja) | 1994-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |