NO20002440L - Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitet - Google Patents
Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitetInfo
- Publication number
- NO20002440L NO20002440L NO20002440A NO20002440A NO20002440L NO 20002440 L NO20002440 L NO 20002440L NO 20002440 A NO20002440 A NO 20002440A NO 20002440 A NO20002440 A NO 20002440A NO 20002440 L NO20002440 L NO 20002440L
- Authority
- NO
- Norway
- Prior art keywords
- mmp
- inhibitory activity
- hydroxamic
- carboxylic acid
- acid derivatives
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/04—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Transplantation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9723906.5A GB9723906D0 (en) | 1997-11-12 | 1997-11-12 | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activiy |
| GBGB9802618.0A GB9802618D0 (en) | 1998-02-06 | 1998-02-06 | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| GBGB9813933.0A GB9813933D0 (en) | 1998-06-26 | 1998-06-26 | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| PCT/GB1998/003395 WO1999024399A1 (en) | 1997-11-12 | 1998-11-12 | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002440D0 NO20002440D0 (no) | 2000-05-11 |
| NO20002440L true NO20002440L (no) | 2000-05-11 |
Family
ID=27269088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002440A NO20002440L (no) | 1997-11-12 | 2000-05-11 | Hydroksam- og karboksylsyrederivater med MMP- og TNF- inhiberende aktivitet |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1030836B1 (no) |
| JP (1) | JP2001522832A (no) |
| KR (1) | KR100609926B1 (no) |
| CN (1) | CN1283183A (no) |
| AT (1) | ATE231837T1 (no) |
| AU (1) | AU748843B2 (no) |
| BR (1) | BR9814147A (no) |
| CA (1) | CA2308359A1 (no) |
| DE (1) | DE69811111T2 (no) |
| DK (1) | DK1030836T3 (no) |
| ES (1) | ES2190115T3 (no) |
| HU (1) | HUP0100152A3 (no) |
| IL (1) | IL135921A (no) |
| NO (1) | NO20002440L (no) |
| NZ (1) | NZ504387A (no) |
| PL (1) | PL340551A1 (no) |
| RU (1) | RU2210567C2 (no) |
| WO (1) | WO1999024399A1 (no) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU721748B2 (en) * | 1997-02-03 | 2000-07-13 | Pfizer Products Inc. | Arylsulfonylamino hydroxamic acid derivatives |
| GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
| US6479502B1 (en) | 1998-08-29 | 2002-11-12 | British Biotech Pharmaceuticals | Hydroxamic acid derivatives as proteinase inhibitors |
| US6706719B1 (en) | 1998-11-12 | 2004-03-16 | Darwin Discovery, Ltd. | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity |
| AP2001002240A0 (en) * | 1999-02-08 | 2001-09-30 | Searle & Co | Sufamato hydroxamic acid metalloprotease inhibitor. |
| US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
| GB9929527D0 (en) * | 1999-12-14 | 2000-02-09 | Smithkline Beecham Plc | Novel compounds |
| EP1286994A1 (en) * | 2000-05-15 | 2003-03-05 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives having mmp and tnf inhibitory activity |
| JP2003533513A (ja) | 2000-05-15 | 2003-11-11 | ダーウィン・ディスカバリー・リミテッド | Ｍｍｐおよびｔｎｆ阻害活性を有するヒドロキサム酸およびカルボン酸誘導体 |
| WO2001087870A1 (en) * | 2000-05-15 | 2001-11-22 | Darwin Discovery Limited | Hydroxamic acid derivatives |
| JP4975941B2 (ja) | 2000-09-29 | 2012-07-11 | トポターゲット ユーケー リミテッド | （ｅ）−ｎ−ヒドロキシ−３−（３−スルファモイル−フェニル）アクリルアミド化合物及びその治療用途 |
| WO2002026696A1 (en) | 2000-09-29 | 2002-04-04 | Prolifix Limited | Carbamic acid compounds comprising an amide linkage as hdac inhibitors |
| JP2004527511A (ja) * | 2001-03-15 | 2004-09-09 | アストラゼネカ・アクチエボラーグ | メタロプロテイナーゼ阻害剤 |
| SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
| GB0119396D0 (en) * | 2001-08-09 | 2001-10-03 | Celltech R&D Ltd | Hydroxamic acid derivatives |
| SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| BR0308908A (pt) | 2002-04-03 | 2005-01-04 | Topotarget Uk Ltd | Composto, composição, uso de um composto, e, métodos para inibir a hdac em uma célula, para o tratamento de uma condição mediada pela hdac, de um condição proliferativa, de câncer e de psorìase |
| BR0309671A (pt) | 2002-04-25 | 2005-05-03 | Pharmacia Corp | ácidos de piperidinil- e piperazinil-sulfonilmetil hidroxâmicos e seu uso como inibidores de protease |
| GB0216383D0 (en) * | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Compounds |
| GB0216382D0 (en) * | 2002-07-13 | 2002-08-21 | Astrazeneca Ab | Compounds |
| SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
| AU2004205372B2 (en) | 2003-01-17 | 2011-02-24 | Topotarget Uk Limited | Hydroxamic acid compounds comprising an ester or ketone linkage as HDAC inhibitors |
| US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
| SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
| RU2277418C1 (ru) * | 2004-12-08 | 2006-06-10 | Государственное научное учреждение (ГНУ) Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии (ВНИВИПФиТ) | Препарат для лечения бронхопневмонии у телят |
| SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
| SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
| RU2286141C1 (ru) * | 2005-03-03 | 2006-10-27 | Общество с ограниченной ответственностью "Фарм-Лад" | Мазь для наружного применения |
| WO2008008398A2 (en) * | 2006-07-14 | 2008-01-17 | Shionogi & Co., Ltd. | Oxime compounds and the use thereof |
| ES2422603T3 (es) | 2007-05-31 | 2013-09-12 | Shionogi & Co | Compuestos oxiimino y el uso de estos |
| WO2009151152A1 (en) | 2008-06-11 | 2009-12-17 | Shionogi & Co., Ltd. | Oxycarbamoyl compounds and the use thereof |
| KR20220164216A (ko) * | 2021-06-04 | 2022-12-13 | 에스티팜 주식회사 | 신규한 에르고스텐올 유도체 및 이의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1067965A (en) * | 1965-01-22 | 1967-05-10 | Beecham Group Ltd | Penicillins, esters, amides and salts thereof |
| US5239079A (en) * | 1988-05-12 | 1993-08-24 | Eisai Co., Ltd. | Pyridinium salt and pharmacological composition containing the same |
| ATE225343T1 (de) * | 1995-12-20 | 2002-10-15 | Hoffmann La Roche | Matrix-metalloprotease inhibitoren |
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1998
- 1998-11-12 KR KR1020007005163A patent/KR100609926B1/ko not_active Expired - Fee Related
- 1998-11-12 ES ES98952927T patent/ES2190115T3/es not_active Expired - Lifetime
- 1998-11-12 JP JP2000520413A patent/JP2001522832A/ja active Pending
- 1998-11-12 AU AU10469/99A patent/AU748843B2/en not_active Ceased
- 1998-11-12 BR BR9814147-3A patent/BR9814147A/pt not_active IP Right Cessation
- 1998-11-12 WO PCT/GB1998/003395 patent/WO1999024399A1/en not_active Ceased
- 1998-11-12 CN CN98812677A patent/CN1283183A/zh active Pending
- 1998-11-12 PL PL98340551A patent/PL340551A1/xx not_active Application Discontinuation
- 1998-11-12 DE DE69811111T patent/DE69811111T2/de not_active Expired - Fee Related
- 1998-11-12 CA CA002308359A patent/CA2308359A1/en not_active Abandoned
- 1998-11-12 RU RU2000114881/04A patent/RU2210567C2/ru not_active IP Right Cessation
- 1998-11-12 HU HU0100152A patent/HUP0100152A3/hu unknown
- 1998-11-12 IL IL13592198A patent/IL135921A/xx not_active IP Right Cessation
- 1998-11-12 NZ NZ504387A patent/NZ504387A/xx unknown
- 1998-11-12 AT AT98952927T patent/ATE231837T1/de not_active IP Right Cessation
- 1998-11-12 DK DK98952927T patent/DK1030836T3/da active
- 1998-11-12 EP EP98952927A patent/EP1030836B1/en not_active Expired - Lifetime
-
2000
- 2000-05-11 NO NO20002440A patent/NO20002440L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL340551A1 (en) | 2001-02-12 |
| KR100609926B1 (ko) | 2006-08-04 |
| CN1283183A (zh) | 2001-02-07 |
| EP1030836A1 (en) | 2000-08-30 |
| HUP0100152A2 (hu) | 2002-02-28 |
| ATE231837T1 (de) | 2003-02-15 |
| DK1030836T3 (da) | 2003-05-26 |
| IL135921A (en) | 2005-08-31 |
| IL135921A0 (en) | 2001-05-20 |
| HUP0100152A3 (en) | 2002-07-29 |
| ES2190115T3 (es) | 2003-07-16 |
| KR20010032042A (ko) | 2001-04-16 |
| JP2001522832A (ja) | 2001-11-20 |
| NO20002440D0 (no) | 2000-05-11 |
| DE69811111T2 (de) | 2003-07-24 |
| EP1030836B1 (en) | 2003-01-29 |
| AU1046999A (en) | 1999-05-31 |
| BR9814147A (pt) | 2000-10-03 |
| DE69811111D1 (de) | 2003-03-06 |
| CA2308359A1 (en) | 1999-05-20 |
| NZ504387A (en) | 2002-10-25 |
| RU2210567C2 (ru) | 2003-08-20 |
| AU748843B2 (en) | 2002-06-13 |
| WO1999024399A1 (en) | 1999-05-20 |
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