ATE90096T1 - Arylsubstituierte naphthyridin- und pyridopyrazin-derivate. - Google Patents

Arylsubstituierte naphthyridin- und pyridopyrazin-derivate.

Info

Publication number: ATE90096T1
Authority: AT; Austria
Prior art keywords: aryl; disclosed; substituted naphthyridine; pyridopyrazine derivatives; substituted
Prior art date: 1986-04-11

Application number

AT87303102T

Other languages

English (en)

Inventor

David John Blythin

Marvin Ira Siegel

Ho-Jane Shue

Sidney Randall Smith

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-11

Filing date

1987-04-09

Publication date

1993-06-15

1986-10-20 Priority claimed from US06/921,288 external-priority patent/US4882332A/en

1987-04-09 Application filed by Schering Corp filed Critical Schering Corp

1993-06-15 Application granted granted Critical

1993-06-15 Publication of ATE90096T1 publication Critical patent/ATE90096T1/de

Links

150000005054 naphthyridines Chemical class 0.000 title abstract 2
YEYHFKBVNARCNE-UHFFFAOYSA-N pyrido[2,3-b]pyrazine Chemical class N1=CC=NC2=CC=CN=C21 YEYHFKBVNARCNE-UHFFFAOYSA-N 0.000 title abstract 2
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
208000008469 Peptic Ulcer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003463 hyperproliferative effect Effects 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Immunology (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT87303102T 1986-04-11 1987-04-09 Arylsubstituierte naphthyridin- und pyridopyrazin-derivate. ATE90096T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US85106886A	1986-04-11	1986-04-11
US06/921,288 US4882332A (en)	1986-10-20	1986-10-20	Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives
EP87303102A EP0241291B1 (de)	1986-04-11	1987-04-09	Arylsubstituierte Naphthyridin- und Pyridopyrazin-Derivate

Publications (1)

Publication Number	Publication Date
ATE90096T1 true ATE90096T1 (de)	1993-06-15

Family

ID=27126973

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87303102T ATE90096T1 (de)	1986-04-11	1987-04-09	Arylsubstituierte naphthyridin- und pyridopyrazin-derivate.

Country Status (16)

Country	Link
EP (1)	EP0241291B1 (de)
JP (1)	JPH0774215B2 (de)
KR (1)	KR870010049A (de)
AT (1)	ATE90096T1 (de)
AU (1)	AU609389B2 (de)
CA (1)	CA1324381C (de)
DE (1)	DE3786036T2 (de)
DK (1)	DK186487A (de)
ES (1)	ES2054665T3 (de)
FI (1)	FI88033C (de)
HU (1)	HU200768B (de)
IL (1)	IL82150A0 (de)
NO (1)	NO165923C (de)
NZ (1)	NZ219931A (de)
OA (1)	OA08583A (de)
PT (1)	PT84658B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK127086A (da) *	1985-03-25	1986-09-26	Schering Corp	Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
US5037826A (en) *	1986-10-15	1991-08-06	Schering Corporation	1-substituted naphthyridine and pyridopyrazine derivatives
ES2550101T3 (es) *	2008-12-17	2015-11-04	Merck Patent Gmbh	Inhibidores de proteína quinasa de benzonaftiridinona tricíclica modificada con anillo C y su uso

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680298A (en) *	1983-05-31	1987-07-14	Schering Corporation	Tricyclic anti-allergy and use as anti-inflammatory agents
EP0144996B1 (de) *	1983-12-14	1990-02-28	Schering Corporation	Substituierte Spiropyridinderivate, diese enthaltende pharmazeutische Zubereitungen, Verfahren zu ihrer Herstellung und Zubereitungen
DK127086A (da) *	1985-03-25	1986-09-26	Schering Corp	Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
US4596809A (en) *	1985-03-25	1986-06-24	Schering Corporation	Substituted 1,8-naphthyridinones, useful as anti-allergic agents

1987
- 1987-04-09 AT AT87303102T patent/ATE90096T1/de active
- 1987-04-09 IL IL82150A patent/IL82150A0/xx not_active IP Right Cessation
- 1987-04-09 AU AU71358/87A patent/AU609389B2/en not_active Ceased
- 1987-04-09 FI FI871568A patent/FI88033C/fi not_active IP Right Cessation
- 1987-04-09 EP EP87303102A patent/EP0241291B1/de not_active Expired - Lifetime
- 1987-04-09 ES ES87303102T patent/ES2054665T3/es not_active Expired - Lifetime
- 1987-04-09 DE DE8787303102T patent/DE3786036T2/de not_active Expired - Fee Related
- 1987-04-09 NZ NZ219931A patent/NZ219931A/xx unknown
- 1987-04-10 OA OA59104A patent/OA08583A/xx unknown
- 1987-04-10 DK DK186487A patent/DK186487A/da not_active Application Discontinuation
- 1987-04-10 JP JP62088569A patent/JPH0774215B2/ja not_active Expired - Lifetime
- 1987-04-10 CA CA000534364A patent/CA1324381C/en not_active Expired - Fee Related
- 1987-04-10 HU HU871621A patent/HU200768B/hu not_active IP Right Cessation
- 1987-04-10 NO NO871507A patent/NO165923C/no unknown
- 1987-04-10 KR KR870003429A patent/KR870010049A/ko not_active Ceased
- 1987-04-10 PT PT84658A patent/PT84658B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL82150A0 (en)	1987-10-30
FI88033C (fi)	1993-03-25
PT84658B (pt)	1989-11-30
FI871568L (fi)	1987-10-12
OA08583A (fr)	1988-09-30
EP0241291A2 (de)	1987-10-14
NO871507L (no)	1987-10-12
HU200768B (en)	1990-08-28
NO165923C (no)	1991-05-02
DK186487A (da)	1987-10-12
FI88033B (fi)	1992-12-15
NO165923B (no)	1991-01-21
DE3786036T2 (de)	1993-09-09
NO871507D0 (no)	1987-04-10
HUT43847A (en)	1987-12-28
PT84658A (en)	1987-05-01
JPS62270582A (ja)	1987-11-24
AU7135887A (en)	1987-10-15
DK186487D0 (da)	1987-04-10
DE3786036D1 (de)	1993-07-08
NZ219931A (en)	1989-10-27
KR870010049A (ko)	1987-11-30
JPH0774215B2 (ja)	1995-08-09
CA1324381C (en)	1993-11-16
EP0241291A3 (en)	1989-05-31
EP0241291B1 (de)	1993-06-02
AU609389B2 (en)	1991-05-02
FI871568A0 (fi)	1987-04-09
ES2054665T3 (es)	1994-08-16

Publication	Publication Date	Title
ATE141928T1 (de)	1996-09-15	Osteoinduktive mittel
AU588958B2 (en)	1989-09-28	Opthlamic use of quinoline and naphthyridine antibiotics
AU609389B2 (en)	1991-05-02	Aryl-substituted naphthydridine and pyridopyrazine derivatives
ATE111357T1 (de)	1994-09-15	Synergetische immunostimulierende zusammensetzung und ihre verwendung.
OA08480A (en)	1988-07-29	Polycylic quinoline, naphthyridine and pyrazinopyridine derivatives.
MY100071A (en)	1989-08-18	Aryl-substituted naphthyridine and pyridopyrazine derivatives
ATE6256T1 (de)	1984-03-15	N-(4-phenyl-2-thiazolyl)-oxamidsaeure-2ethoxyethylester, verfahren zu seiner herstellung und diesen enthaltende therapeutische mittel.
DE3775278D1 (de)	1992-01-30	Topische methotrexatzubereitung zur behandlung hyperproliferativer epithelerkrankungen.
DE3881377D1 (de)	1993-07-01	Mittel zur prophylaxe und behandlung von thrombocytopenie.
DE3887137D1 (de)	1994-02-24	Mittel zur prophylaxe und behandlung einer pankreatischen erkrannkung oder dergleichen.
ATE73645T1 (de)	1992-04-15	Mittel zur behandlung von alopezien.