ATE90108T1 - Vasokonstriktor-peptid. - Google Patents

Vasokonstriktor-peptid.

Info

Publication number: ATE90108T1
Authority: AT; Austria
Prior art keywords: vasoconstrictor; endothelin; present; vasoconstrictor peptide; serum
Prior art date: 1987-10-09

Application number

AT88115674T

Other languages

English (en)

Inventor

Tomoh Masaki

Katsutoshi Goto

Sadao Kimura

Youji Mitsui

Yoshio Yazaki

Masashi Yanagisawa

Hiroki Kurihara

Original Assignee

Takeda Chemical Industries Ltd

Agency Ind Science Techn

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-09

Filing date

1988-09-23

Publication date

1993-06-15

1988-09-23 Application filed by Takeda Chemical Industries Ltd, Agency Ind Science Techn filed Critical Takeda Chemical Industries Ltd

1993-06-15 Application granted granted Critical

1993-06-15 Publication of ATE90108T1 publication Critical patent/ATE90108T1/de

Links

239000005526 vasoconstrictor agent Substances 0.000 title abstract 5
108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
102000002045 Endothelin Human genes 0.000 abstract 2
108050009340 Endothelin Proteins 0.000 abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 2
208000001953 Hypotension Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
210000002889 endothelial cell Anatomy 0.000 abstract 1
230000036543 hypotension Effects 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
239000012679 serum free medium Substances 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1
230000002792 vascular Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT88115674T 1987-10-09 1988-09-23 Vasokonstriktor-peptid. ATE90108T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP25538187		1987-10-09
EP88115674A EP0310887B1 (de)	1987-10-09	1988-09-23	Vasokonstriktor-Peptid

Publications (1)

Publication Number	Publication Date
ATE90108T1 true ATE90108T1 (de)	1993-06-15

Family

ID=17277972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88115674T ATE90108T1 (de)	1987-10-09	1988-09-23	Vasokonstriktor-peptid.

Country Status (4)

Country	Link
US (1)	US4981950A (de)
EP (1)	EP0310887B1 (de)
AT (1)	ATE90108T1 (de)
DE (1)	DE3881467T2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5231166A (en) *	1988-10-25	1993-07-27	Takeda Chemical Industries, Ltd.	Endothelin
CA2032559C (en) *	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
WO1992002237A1 (en) *	1990-08-08	1992-02-20	The Rockefeller University	Analogs of endothelin
FR2669339B1 (fr) *	1990-11-21	1995-03-03	Roussel Uclaf	Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.
EP0569487A1 (de) *	1991-01-31	1993-11-18	Abbott Laboratories	Endothelin konvertierende enzyminhibitoren
EP0574530A4 (en) *	1991-03-08	1996-04-03	Res Corp Technologies Inc	Endothelin antagonists
US5382569A (en) *	1991-05-16	1995-01-17	Warner-Lambert Company	Endotherlin antagonists
US5260276A (en) *	1991-06-14	1993-11-09	Warner-Lambert Company	Linear and monocyclic endothelin antagonists
HUT67665A (en) *	1991-11-05	1995-04-28	Smithkline Beckman Corp	Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
TW299333B (de) *	1992-12-29	1997-03-01	Takeda Pharm Industry Co Ltd
PT1355940E (pt) *	2000-10-20	2007-11-08	Sod Conseils Rech Applic	Agonistas e antagonistas da urotensina-ii
AU2007230887A1 (en) *	2006-03-23	2007-10-04	Amylin Pharmaceuticals, Inc.	Endothelin and endothelin receptor agonists in the treatment of metabolic diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4496544A (en) *	1983-11-10	1985-01-29	Washington University	Atrial Peptides
US4557864A (en) *	1984-01-10	1985-12-10	Washington University	Atrial peptides
US4618600A (en) *	1984-04-19	1986-10-21	Biotechnology Research Associates, J.V.	Novel polypeptide diuretic/vasodilators
US4716147A (en) *	1986-03-27	1987-12-29	Monsanto Company	Synthetic airial peptides

1988
- 1988-09-23 DE DE88115674T patent/DE3881467T2/de not_active Expired - Lifetime
- 1988-09-23 EP EP88115674A patent/EP0310887B1/de not_active Expired - Lifetime
- 1988-09-23 AT AT88115674T patent/ATE90108T1/de not_active IP Right Cessation
- 1988-09-26 US US07/249,429 patent/US4981950A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3881467T2 (de)	1993-10-21
US4981950A (en)	1991-01-01
EP0310887A3 (en)	1990-07-18
DE3881467D1 (de)	1993-07-08
EP0310887A2 (de)	1989-04-12
EP0310887B1 (de)	1993-06-02

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Legal Events

Date	Code	Title	Description
1993-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties