ATE90340T1 - Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen. - Google Patents
Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen.Info
- Publication number
- ATE90340T1 ATE90340T1 AT89105547T AT89105547T ATE90340T1 AT E90340 T1 ATE90340 T1 AT E90340T1 AT 89105547 T AT89105547 T AT 89105547T AT 89105547 T AT89105547 T AT 89105547T AT E90340 T1 ATE90340 T1 AT E90340T1
- Authority
- AT
- Austria
- Prior art keywords
- antihyperlipidemic
- compositions
- compounds
- antiatherosclerotic
- antiatherosclerotic compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 230000001315 anti-hyperlipaemic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/90—Xanthenes with hydrocarbon radicals, substituted by amino radicals, directly attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/176,080 US4868210A (en) | 1988-03-30 | 1988-03-30 | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| EP89105547A EP0335375B1 (de) | 1988-03-30 | 1989-03-29 | Antihyperlipidemische und antiatherosclerotische Verbindungen und Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE90340T1 true ATE90340T1 (de) | 1993-06-15 |
Family
ID=22642893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89105547T ATE90340T1 (de) | 1988-03-30 | 1989-03-29 | Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4868210A (de) |
| EP (1) | EP0335375B1 (de) |
| JP (1) | JPH0688957B2 (de) |
| AT (1) | ATE90340T1 (de) |
| DE (1) | DE68906940T2 (de) |
| ES (1) | ES2055754T3 (de) |
| HK (1) | HK148295A (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5030653A (en) * | 1988-03-30 | 1991-07-09 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US4948806A (en) * | 1988-03-30 | 1990-08-14 | Warner-Lambert Company | Antihyperlipidemic and antiatherosclerotic compounds and compositions |
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| US5155127A (en) * | 1989-02-09 | 1992-10-13 | Warner-Lambert Company | N-(substituted aryl)-n'-(substituted alkoxy)-ureas and thioureas as antihypercholesterolemic and antiatherosclerotic agents |
| JPH0395153A (ja) * | 1989-06-15 | 1991-04-19 | Mitsubishi Kasei Corp | ジフェニル尿素誘導体 |
| CA2022346A1 (en) * | 1989-08-04 | 1991-02-05 | Mitsubishi Chemical Corporation | 1-phenylalkyl-3-phenylurea derivatives |
| JPH05310678A (ja) * | 1990-01-22 | 1993-11-22 | Mitsubishi Kasei Corp | １−フェニルアルキル−３−フェニル尿素誘導体 |
| EP0447116B1 (de) * | 1990-03-12 | 1994-12-14 | Yamanouchi Pharmaceutical Co. Ltd. | Harnstoffderivate, deren Herstellung sowie diese enthaltende pharmazeutische Zusammensetzungen |
| US5177104A (en) * | 1990-04-03 | 1993-01-05 | E. R. Squibb & Sons, Inc. | 6-α-hydroxy derivatives of mevinic acids |
| EP0481383B1 (de) * | 1990-10-16 | 1995-06-28 | Takeda Chemical Industries, Ltd. | Heterozyklische Aminderivate, deren Herstellung und deren Verwendung |
| JPH0694464B2 (ja) * | 1991-01-23 | 1994-11-24 | 協和醗酵工業株式会社 | 三環式化合物およびその中間体 |
| IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them |
| FR2673629B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives du benzopyrane leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| TW209868B (de) * | 1991-04-04 | 1993-07-21 | Yoshitomi Pharmaceutical | |
| US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
| US5310748A (en) * | 1992-05-11 | 1994-05-10 | The Du Pont Merck Pharmaceutical Company | Imidazoles for the treatment of atherosclerosis |
| WO1993024458A1 (en) * | 1992-05-28 | 1993-12-09 | Pfizer Inc. | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat) |
| AU675961B2 (en) * | 1992-08-19 | 1997-02-27 | Merrell Dow Pharmaceuticals Inc. | Antiangiogenic oligomers |
| CA2106103A1 (en) * | 1992-09-16 | 1994-03-17 | Masashi Yanase | Tricyclic compounds |
| US5679703A (en) * | 1992-09-16 | 1997-10-21 | Kyowa Hakko Kogyo, Co., Ltd. | Tricyclic compounds having ACAT inhibiting activity |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| DE4401893A1 (de) * | 1994-01-24 | 1995-07-27 | Bayer Ag | Substituierte Arylharnstoffe |
| US5491152A (en) * | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| EP0742208A1 (de) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamid-Derivate |
| WO1997046549A1 (en) * | 1996-06-05 | 1997-12-11 | Novartis Ag | Anti-neurodegeneratively effective xanthene derivatives |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| MXPA02002578A (es) | 1999-09-08 | 2002-10-23 | Guilford Pharm Inc | Compuestos de union a ciclofilina no peptidicos, y su uso. |
| EE200200429A (et) | 2000-02-02 | 2003-12-15 | Warner-Lambert Company | Kolesteroolestri ja vahaestri sünteesi duaalsed inhibiitorid rasunäärme häirete jaoks |
| EP1308438B9 (de) * | 2000-08-10 | 2012-03-28 | Mitsubishi Tanabe Pharma Corporation | 3-substituierte harnstoffderivate und deren medizinische verwendung |
| EP1360173A2 (de) | 2001-01-25 | 2003-11-12 | Guilford Pharmaceuticals Inc. | Trisubstituierte karbozyklische zyklophilin bindende verbindungen und deren verwendung |
| US6984647B2 (en) * | 2002-05-17 | 2006-01-10 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid VR1 receptor |
| US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
| GB2393958A (en) | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2055608A (en) * | 1934-11-03 | 1936-09-29 | Du Pont | Ar. tetrahydro-naphthyl thioureas |
| DE1810191C3 (de) * | 1967-12-15 | 1973-10-18 | L'oreal, Paris | Färbemittel für Keratinfasern und menschliche Haare, darin enthaltene Phenylharnstoffe bzw. Phenylthioharnstoffe und Verfahren zum Färben menschlicher Haare |
| US3636104A (en) * | 1968-10-29 | 1972-01-18 | Olin Mathieson | Process for preparing n n'-diarylthioureas |
| US3734961A (en) * | 1969-06-25 | 1973-05-22 | Exxon Co | Herbicidal fluorinated phenyl ureas and thioureas |
| CH649078A5 (de) * | 1980-01-25 | 1985-04-30 | Reanal Finomvegyszergyar | Verfahren zur herstellung von n-mono- oder disubstituierten n-aryl-harnstoff-derivaten. |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| US4387105A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
| US4387106A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Method of treating atherosclerosis with di(aralkyl)ureas and di(aralkyl)thioureas |
| US4473579A (en) * | 1982-01-26 | 1984-09-25 | American Cyanamid Company | Antiatherosclerotic tetrasubstituted ureas and thioureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| JPS58222063A (ja) * | 1982-06-17 | 1983-12-23 | Nippon Tokushu Noyaku Seizo Kk | ベンジルウレア誘導体、その製法及び農園芸用殺菌剤 |
| IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
-
1988
- 1988-03-30 US US07/176,080 patent/US4868210A/en not_active Expired - Lifetime
-
1989
- 1989-03-29 ES ES89105547T patent/ES2055754T3/es not_active Expired - Lifetime
- 1989-03-29 JP JP1075245A patent/JPH0688957B2/ja not_active Expired - Fee Related
- 1989-03-29 DE DE89105547T patent/DE68906940T2/de not_active Expired - Fee Related
- 1989-03-29 AT AT89105547T patent/ATE90340T1/de not_active IP Right Cessation
- 1989-03-29 EP EP89105547A patent/EP0335375B1/de not_active Expired - Lifetime
-
1995
- 1995-09-14 HK HK148295A patent/HK148295A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0335375A3 (de) | 1991-04-17 |
| EP0335375A2 (de) | 1989-10-04 |
| JPH026457A (ja) | 1990-01-10 |
| US4868210A (en) | 1989-09-19 |
| EP0335375B1 (de) | 1993-06-09 |
| DE68906940T2 (de) | 1993-10-28 |
| ES2055754T3 (es) | 1994-09-01 |
| JPH0688957B2 (ja) | 1994-11-09 |
| HK148295A (en) | 1995-09-22 |
| DE68906940D1 (de) | 1993-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |