ATE91712T1 - Enzymstabilisierung. - Google Patents

Enzymstabilisierung.

Info

Publication number
ATE91712T1
ATE91712T1 AT89202954T AT89202954T ATE91712T1 AT E91712 T1 ATE91712 T1 AT E91712T1 AT 89202954 T AT89202954 T AT 89202954T AT 89202954 T AT89202954 T AT 89202954T AT E91712 T1 ATE91712 T1 AT E91712T1
Authority
AT
Austria
Prior art keywords
enzyme stabilization
polyelectolyte
cationic
protein
comprises mixing
Prior art date
Application number
AT89202954T
Other languages
English (en)
Inventor
Timothy David Gibson
John Robert Woodward
Original Assignee
Cranfield Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10646706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE91712(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cranfield Biotech Ltd filed Critical Cranfield Biotech Ltd
Application granted granted Critical
Publication of ATE91712T1 publication Critical patent/ATE91712T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
AT89202954T 1988-11-11 1989-11-13 Enzymstabilisierung. ATE91712T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888826429A GB8826429D0 (en) 1988-11-11 1988-11-11 Enzyme stabilisation systems
EP89202954A EP0376361B2 (de) 1988-11-11 1989-11-13 Enzymstabilisierung

Publications (1)

Publication Number Publication Date
ATE91712T1 true ATE91712T1 (de) 1993-08-15

Family

ID=10646706

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89202954T ATE91712T1 (de) 1988-11-11 1989-11-13 Enzymstabilisierung.

Country Status (8)

Country Link
US (1) US5240843A (de)
EP (2) EP0444111A1 (de)
JP (1) JPH04502105A (de)
AT (1) ATE91712T1 (de)
AU (1) AU637776B2 (de)
DE (1) DE68907707T3 (de)
GB (1) GB8826429D0 (de)
WO (1) WO1990005182A1 (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8903593D0 (en) 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
USRE38385E1 (en) 1989-02-16 2004-01-13 Nektar Therapeutics Storage of materials
US5621094A (en) * 1990-05-14 1997-04-15 Quadrant Holdings Cambridge Limited Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
US5192657A (en) * 1990-12-18 1993-03-09 Ortho Diagnostic Systems, Inc. Stabilized proteolytic solution and reagent kit
JP2562085B2 (ja) * 1991-02-21 1996-12-11 天野製薬株式会社 酵素の安定化方法
AU659645B2 (en) 1991-06-26 1995-05-25 Inhale Therapeutic Systems Storage of materials
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE69332105T2 (de) 1992-09-29 2003-03-06 Inhale Therapeutic Systems, San Carlos Pulmonale abgabe von aktiven fragmenten des parathormons
JP3470973B2 (ja) * 1993-08-31 2003-11-25 ロシュ ダイアグノスティックス コーポレーション 試薬及びその使用方法
GB9320782D0 (en) * 1993-10-08 1993-12-01 Univ Leeds Innovations Ltd Stabilising of proteins on solution
EP0748213B1 (de) 1994-03-07 2004-04-14 Nektar Therapeutics Verfahren und mittel zur verabreichung von insulin über die lunge
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
US5593824A (en) * 1994-09-02 1997-01-14 Pharmacia Biotech, Inc. Biological reagent spheres
US5565318A (en) * 1994-09-02 1996-10-15 Pharmacia Biotech, Inc. Room temperature stable reagent semi-spheres
US5556771A (en) * 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
US6309671B1 (en) 1995-04-14 2001-10-30 Inhale Therapeutic Systems Stable glassy state powder formulations
GB9508691D0 (en) 1995-04-28 1995-06-14 Pafra Ltd Stable compositions
US6689265B2 (en) 1995-10-11 2004-02-10 Therasense, Inc. Electrochemical analyte sensors using thermostable soybean peroxidase
US5876992A (en) * 1996-07-03 1999-03-02 Molecular Biology Resources, Inc. Method and formulation for stabilization of enzymes
US5998216A (en) * 1996-10-01 1999-12-07 Beth Israel Deaconess Medical Center Stabilizing formulation for preserving the integrity of proteins present in a body fluid sampled ex-vivo for evaluation as a specimen
GB9708641D0 (en) 1997-04-29 1997-06-18 Knoll Ag Enzyme concentrate
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
US6599722B2 (en) 1998-12-22 2003-07-29 Genencor International, Inc. Method for producing ascorbic acid intermediates
BR0009516B1 (pt) 1999-03-31 2013-09-10 vetor recombinante e célula hospedeira microbiana.
US6841370B1 (en) 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
WO2001085136A2 (en) 2000-05-10 2001-11-15 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
DK1373480T3 (da) * 2001-04-04 2009-05-11 Genencor Int Ukoblede produktive og katabolske værtscellebaner
DK1383903T3 (da) * 2001-04-04 2009-03-23 Genencor Int Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler
US6960466B2 (en) 2001-05-31 2005-11-01 Instrumentation Laboratory Company Composite membrane containing a cross-linked enzyme matrix for a biosensor
US6896894B2 (en) 2001-10-30 2005-05-24 Battelle Memorial Institute Proteins stabilized with polysaccharide gums
EP1450627B1 (de) 2001-10-31 2012-09-05 Phytex, Llc Verwendung eines phytase-haltigen tierfutters
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
EP1585817B1 (de) * 2002-02-20 2009-09-02 The General Hospital Corporation Konjugate mit biologisch abbaubarem polymer und verwendung dafür
MXPA04011129A (es) * 2002-05-13 2005-02-17 Becton Dickinson Co Sistema de recoleccion de muestra de inhibidor de proteasa.
EP1604008B1 (de) 2002-09-13 2010-12-22 Cornell Research Foundation, Inc. Verwendung von mutationen zur verbesserung von aspergillus-phytasen
AU2003279946A1 (en) * 2002-10-10 2004-05-04 Becton Dickinson And Company Sample collection system with caspase inhibitor
US6927062B2 (en) * 2002-11-25 2005-08-09 Agdia, Inc. Controls and standards for assays and method for manufacture thereof
US20050124965A1 (en) * 2003-12-08 2005-06-09 Becton, Dickinson And Company Phosphatase inhibitor sample collection system
US20060099567A1 (en) * 2004-04-08 2006-05-11 Biomatrica, Inc. Integration of sample storage and sample management for life science
WO2005113147A2 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US20070031914A1 (en) * 2005-08-05 2007-02-08 Wei Zhu Devices for analyte assays and methods of use
US7919297B2 (en) 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
US8540984B2 (en) 2006-08-03 2013-09-24 Cornell Research Foundation, Inc. Phytases with improved thermal stability
WO2008036544A1 (en) * 2006-09-18 2008-03-27 Ge Healthcare Bio-Sciences Corp. Preparation of glassified biological reagents
US20080268514A1 (en) * 2007-04-24 2008-10-30 Rolf Muller Sample storage for life science
US20110306120A1 (en) 2008-07-15 2011-12-15 L3 Technology Limited Assay device and methods
US20110212127A1 (en) * 2008-09-24 2011-09-01 Stabilitech Ltd. Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine
US20110236412A1 (en) * 2008-09-24 2011-09-29 Stabilitech Ltd. Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine
CA2688174C (en) * 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
WO2010132508A2 (en) * 2009-05-11 2010-11-18 Biomatrica, Inc. Compositions and methods for biological sample storage
IT1394539B1 (it) * 2009-05-19 2012-07-05 Sentinel Ch S P A Uso di uno stabilizzante delle polimerasi per la liofilizzazione e la preparazione di kit pronti per l'uso
CA2795047C (en) 2010-03-31 2019-04-09 Stabilitech Ltd. Stabilised liquid formulations
DK2552410T3 (en) 2010-03-31 2019-02-18 Stabilitech Biopharma Ltd PROCEDURE FOR THE CONSERVATION OF ALUNADUVANCES AND VACCINES WITH ALUNADUVANCES
EP2898890B1 (de) 2010-03-31 2019-08-21 Stabilitech Biopharma Ltd Stabilisierung von Virenpartikeln
EP2598661B1 (de) 2010-07-26 2017-09-27 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
EP2934572A4 (de) 2012-12-20 2016-11-23 Biomatrica Inc Formulierungen und verfahren zur stabilisierung von pcr-reagenzien
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
JP6661554B2 (ja) 2014-06-10 2020-03-11 バイオマトリカ,インク. 周囲温度における血小板の安定化
JP6827048B2 (ja) 2015-12-08 2021-02-10 バイオマトリカ,インク. 赤血球沈降速度の低下
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
EP4077645A1 (de) * 2019-12-18 2022-10-26 Danisco US Inc. Stabilisierung von oxidasen durch trocknung unter vermindertem sauerstoffpartialdruck

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133001A (en) * 1959-11-26 1964-05-12 Muset Pedro Puig Stabilization of enzymes
US3413198A (en) * 1966-06-30 1968-11-26 Calbiochem Reagents and method for assaying biological samples
GB1253137A (de) * 1969-03-27 1971-11-10
US3950133A (en) * 1971-10-20 1976-04-13 Mallinckrodt, Inc. Reagent formulations for assaying biological specimens and methods of preparing and using same
JPS5536317B2 (de) * 1972-04-22 1980-09-19
JPS5137343B2 (de) * 1972-12-07 1976-10-15
US4011169A (en) * 1973-06-29 1977-03-08 The Procter & Gamble Company Stabilization and enhancement of enzymatic activity
SU615933A1 (ru) * 1976-07-19 1978-07-25 Ленинградский Ордена Трудового Красного Знамени Научно-Исследовательский Институт Гематологии И Переливания Крови Способ лиофильного высушивани иммуноглобулинов
US4465770A (en) * 1979-09-11 1984-08-14 Modrovich Ivan Endre Stabilized enzymic solutions for determining urea
GB2090599B (en) * 1981-01-05 1984-06-13 Novo Industri As Stabilized plasmin compositions and method for preparation thereof
US4464469A (en) * 1981-09-01 1984-08-07 John & E. Sturge Limited Stabilized lactase solutions and processes for stabilization
JPS58107178A (ja) * 1981-12-22 1983-06-25 Mitsui Toatsu Chem Inc ベ−タ−ガラクトシダ−ゼ又はその複合体の安定な凍結乾燥品
JPS58111686A (ja) * 1981-12-22 1983-07-02 Sumitomo Chem Co Ltd 安定な酵素含有製剤の製造法
US4562151A (en) * 1983-09-06 1985-12-31 Monsanto Company Stabilization of L-phenylalanine ammonia-lyase enzyme
JPS60258125A (ja) * 1984-06-06 1985-12-20 Hayashibara Biochem Lab Inc 蛋白性生理活性物質を含有する水溶性乾燥物
DK8502857A (de) * 1984-06-25 1985-12-26
US4950596A (en) * 1985-03-04 1990-08-21 The Dow Chemical Company Stabilization of intracellular enzymes
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
JPH01139384A (ja) * 1987-11-13 1989-05-31 Toshiba Corp 鉄道用コンテナ冷却装置
JPH0236189A (ja) * 1988-07-26 1990-02-06 Tsumura & Co 新規フエネチルアルコール誘導体およびフエネチルアルコール誘導体を有効成分とするアルドースリダクターゼ阻害剤
US5102788A (en) * 1988-11-21 1992-04-07 Hygeia Sciences, Inc. Immunoassay including lyophilized reactant mixture

Also Published As

Publication number Publication date
EP0376361B2 (de) 1997-02-05
GB8826429D0 (en) 1988-12-14
DE68907707T2 (de) 1994-03-31
EP0376361B1 (de) 1993-07-21
DE68907707D1 (de) 1993-08-26
EP0376361A3 (en) 1990-08-01
AU4639589A (en) 1990-05-28
AU637776B2 (en) 1993-06-10
WO1990005182A1 (en) 1990-05-17
DE68907707T3 (de) 1997-07-03
EP0376361A2 (de) 1990-07-04
EP0444111A1 (de) 1991-09-04
US5240843A (en) 1993-08-31
JPH04502105A (ja) 1992-04-16

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time