ATE91712T1 - Enzymstabilisierung. - Google Patents
Enzymstabilisierung.Info
- Publication number
- ATE91712T1 ATE91712T1 AT89202954T AT89202954T ATE91712T1 AT E91712 T1 ATE91712 T1 AT E91712T1 AT 89202954 T AT89202954 T AT 89202954T AT 89202954 T AT89202954 T AT 89202954T AT E91712 T1 ATE91712 T1 AT E91712T1
- Authority
- AT
- Austria
- Prior art keywords
- enzyme stabilization
- polyelectolyte
- cationic
- protein
- comprises mixing
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 2
- 108090000790 Enzymes Proteins 0.000 title abstract 2
- 230000006641 stabilisation Effects 0.000 title 1
- 238000011105 stabilization Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 125000002091 cationic group Chemical group 0.000 abstract 1
- -1 cyclic polyol Chemical class 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920005862 polyol Polymers 0.000 abstract 1
- 230000003019 stabilising effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888826429A GB8826429D0 (en) | 1988-11-11 | 1988-11-11 | Enzyme stabilisation systems |
| EP89202954A EP0376361B2 (de) | 1988-11-11 | 1989-11-13 | Enzymstabilisierung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE91712T1 true ATE91712T1 (de) | 1993-08-15 |
Family
ID=10646706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89202954T ATE91712T1 (de) | 1988-11-11 | 1989-11-13 | Enzymstabilisierung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5240843A (de) |
| EP (2) | EP0444111A1 (de) |
| JP (1) | JPH04502105A (de) |
| AT (1) | ATE91712T1 (de) |
| AU (1) | AU637776B2 (de) |
| DE (1) | DE68907707T3 (de) |
| GB (1) | GB8826429D0 (de) |
| WO (1) | WO1990005182A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
| USRE38385E1 (en) | 1989-02-16 | 2004-01-13 | Nektar Therapeutics | Storage of materials |
| US5621094A (en) * | 1990-05-14 | 1997-04-15 | Quadrant Holdings Cambridge Limited | Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol |
| GB9010742D0 (en) * | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
| US5192657A (en) * | 1990-12-18 | 1993-03-09 | Ortho Diagnostic Systems, Inc. | Stabilized proteolytic solution and reagent kit |
| JP2562085B2 (ja) * | 1991-02-21 | 1996-12-11 | 天野製薬株式会社 | 酵素の安定化方法 |
| AU659645B2 (en) | 1991-06-26 | 1995-05-25 | Inhale Therapeutic Systems | Storage of materials |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| DE69332105T2 (de) | 1992-09-29 | 2003-03-06 | Inhale Therapeutic Systems, San Carlos | Pulmonale abgabe von aktiven fragmenten des parathormons |
| JP3470973B2 (ja) * | 1993-08-31 | 2003-11-25 | ロシュ ダイアグノスティックス コーポレーション | 試薬及びその使用方法 |
| GB9320782D0 (en) * | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
| EP0748213B1 (de) | 1994-03-07 | 2004-04-14 | Nektar Therapeutics | Verfahren und mittel zur verabreichung von insulin über die lunge |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US5593824A (en) * | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| US5565318A (en) * | 1994-09-02 | 1996-10-15 | Pharmacia Biotech, Inc. | Room temperature stable reagent semi-spheres |
| US5556771A (en) * | 1995-02-10 | 1996-09-17 | Gen-Probe Incorporated | Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification |
| US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
| GB9508691D0 (en) | 1995-04-28 | 1995-06-14 | Pafra Ltd | Stable compositions |
| US6689265B2 (en) | 1995-10-11 | 2004-02-10 | Therasense, Inc. | Electrochemical analyte sensors using thermostable soybean peroxidase |
| US5876992A (en) * | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| US5998216A (en) * | 1996-10-01 | 1999-12-07 | Beth Israel Deaconess Medical Center | Stabilizing formulation for preserving the integrity of proteins present in a body fluid sampled ex-vivo for evaluation as a specimen |
| GB9708641D0 (en) | 1997-04-29 | 1997-06-18 | Knoll Ag | Enzyme concentrate |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6451572B1 (en) | 1998-06-25 | 2002-09-17 | Cornell Research Foundation, Inc. | Overexpression of phytase genes in yeast systems |
| US6599722B2 (en) | 1998-12-22 | 2003-07-29 | Genencor International, Inc. | Method for producing ascorbic acid intermediates |
| BR0009516B1 (pt) | 1999-03-31 | 2013-09-10 | vetor recombinante e célula hospedeira microbiana. | |
| US6841370B1 (en) | 1999-11-18 | 2005-01-11 | Cornell Research Foundation, Inc. | Site-directed mutagenesis of Escherichia coli phytase |
| WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| DK1373480T3 (da) * | 2001-04-04 | 2009-05-11 | Genencor Int | Ukoblede produktive og katabolske værtscellebaner |
| DK1383903T3 (da) * | 2001-04-04 | 2009-03-23 | Genencor Int | Fremgangsmåder til fremstilling af askorbinsyre-intermediater i vært-celler |
| US6960466B2 (en) | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
| US6896894B2 (en) | 2001-10-30 | 2005-05-24 | Battelle Memorial Institute | Proteins stabilized with polysaccharide gums |
| EP1450627B1 (de) | 2001-10-31 | 2012-09-05 | Phytex, Llc | Verwendung eines phytase-haltigen tierfutters |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| EP1585817B1 (de) * | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| MXPA04011129A (es) * | 2002-05-13 | 2005-02-17 | Becton Dickinson Co | Sistema de recoleccion de muestra de inhibidor de proteasa. |
| EP1604008B1 (de) | 2002-09-13 | 2010-12-22 | Cornell Research Foundation, Inc. | Verwendung von mutationen zur verbesserung von aspergillus-phytasen |
| AU2003279946A1 (en) * | 2002-10-10 | 2004-05-04 | Becton Dickinson And Company | Sample collection system with caspase inhibitor |
| US6927062B2 (en) * | 2002-11-25 | 2005-08-09 | Agdia, Inc. | Controls and standards for assays and method for manufacture thereof |
| US20050124965A1 (en) * | 2003-12-08 | 2005-06-09 | Becton, Dickinson And Company | Phosphatase inhibitor sample collection system |
| US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| WO2005113147A2 (en) | 2004-04-08 | 2005-12-01 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
| US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
| US7919297B2 (en) | 2006-02-21 | 2011-04-05 | Cornell Research Foundation, Inc. | Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase |
| US8540984B2 (en) | 2006-08-03 | 2013-09-24 | Cornell Research Foundation, Inc. | Phytases with improved thermal stability |
| WO2008036544A1 (en) * | 2006-09-18 | 2008-03-27 | Ge Healthcare Bio-Sciences Corp. | Preparation of glassified biological reagents |
| US20080268514A1 (en) * | 2007-04-24 | 2008-10-30 | Rolf Muller | Sample storage for life science |
| US20110306120A1 (en) | 2008-07-15 | 2011-12-15 | L3 Technology Limited | Assay device and methods |
| US20110212127A1 (en) * | 2008-09-24 | 2011-09-01 | Stabilitech Ltd. | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine |
| US20110236412A1 (en) * | 2008-09-24 | 2011-09-29 | Stabilitech Ltd. | Method for Preserving Polypeptides Using a Sugar and Polyethyleneimine |
| CA2688174C (en) * | 2008-12-19 | 2018-08-07 | F. Hoffmann-La Roche Ag | Dry composition of reaction compounds with stabilized polymerase |
| WO2010132508A2 (en) * | 2009-05-11 | 2010-11-18 | Biomatrica, Inc. | Compositions and methods for biological sample storage |
| IT1394539B1 (it) * | 2009-05-19 | 2012-07-05 | Sentinel Ch S P A | Uso di uno stabilizzante delle polimerasi per la liofilizzazione e la preparazione di kit pronti per l'uso |
| CA2795047C (en) | 2010-03-31 | 2019-04-09 | Stabilitech Ltd. | Stabilised liquid formulations |
| DK2552410T3 (en) | 2010-03-31 | 2019-02-18 | Stabilitech Biopharma Ltd | PROCEDURE FOR THE CONSERVATION OF ALUNADUVANCES AND VACCINES WITH ALUNADUVANCES |
| EP2898890B1 (de) | 2010-03-31 | 2019-08-21 | Stabilitech Biopharma Ltd | Stabilisierung von Virenpartikeln |
| EP2598661B1 (de) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen |
| WO2012018638A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| EP2934572A4 (de) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | Formulierungen und verfahren zur stabilisierung von pcr-reagenzien |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| JP6661554B2 (ja) | 2014-06-10 | 2020-03-11 | バイオマトリカ,インク. | 周囲温度における血小板の安定化 |
| JP6827048B2 (ja) | 2015-12-08 | 2021-02-10 | バイオマトリカ,インク. | 赤血球沈降速度の低下 |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| EP4077645A1 (de) * | 2019-12-18 | 2022-10-26 | Danisco US Inc. | Stabilisierung von oxidasen durch trocknung unter vermindertem sauerstoffpartialdruck |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133001A (en) * | 1959-11-26 | 1964-05-12 | Muset Pedro Puig | Stabilization of enzymes |
| US3413198A (en) * | 1966-06-30 | 1968-11-26 | Calbiochem | Reagents and method for assaying biological samples |
| GB1253137A (de) * | 1969-03-27 | 1971-11-10 | ||
| US3950133A (en) * | 1971-10-20 | 1976-04-13 | Mallinckrodt, Inc. | Reagent formulations for assaying biological specimens and methods of preparing and using same |
| JPS5536317B2 (de) * | 1972-04-22 | 1980-09-19 | ||
| JPS5137343B2 (de) * | 1972-12-07 | 1976-10-15 | ||
| US4011169A (en) * | 1973-06-29 | 1977-03-08 | The Procter & Gamble Company | Stabilization and enhancement of enzymatic activity |
| SU615933A1 (ru) * | 1976-07-19 | 1978-07-25 | Ленинградский Ордена Трудового Красного Знамени Научно-Исследовательский Институт Гематологии И Переливания Крови | Способ лиофильного высушивани иммуноглобулинов |
| US4465770A (en) * | 1979-09-11 | 1984-08-14 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
| GB2090599B (en) * | 1981-01-05 | 1984-06-13 | Novo Industri As | Stabilized plasmin compositions and method for preparation thereof |
| US4464469A (en) * | 1981-09-01 | 1984-08-07 | John & E. Sturge Limited | Stabilized lactase solutions and processes for stabilization |
| JPS58107178A (ja) * | 1981-12-22 | 1983-06-25 | Mitsui Toatsu Chem Inc | ベ−タ−ガラクトシダ−ゼ又はその複合体の安定な凍結乾燥品 |
| JPS58111686A (ja) * | 1981-12-22 | 1983-07-02 | Sumitomo Chem Co Ltd | 安定な酵素含有製剤の製造法 |
| US4562151A (en) * | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
| JPS60258125A (ja) * | 1984-06-06 | 1985-12-20 | Hayashibara Biochem Lab Inc | 蛋白性生理活性物質を含有する水溶性乾燥物 |
| DK8502857A (de) * | 1984-06-25 | 1985-12-26 | ||
| US4950596A (en) * | 1985-03-04 | 1990-08-21 | The Dow Chemical Company | Stabilization of intracellular enzymes |
| US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| JPH01139384A (ja) * | 1987-11-13 | 1989-05-31 | Toshiba Corp | 鉄道用コンテナ冷却装置 |
| JPH0236189A (ja) * | 1988-07-26 | 1990-02-06 | Tsumura & Co | 新規フエネチルアルコール誘導体およびフエネチルアルコール誘導体を有効成分とするアルドースリダクターゼ阻害剤 |
| US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
-
1988
- 1988-11-11 GB GB888826429A patent/GB8826429D0/en active Pending
-
1989
- 1989-11-13 DE DE68907707T patent/DE68907707T3/de not_active Expired - Lifetime
- 1989-11-13 EP EP89913230A patent/EP0444111A1/de active Pending
- 1989-11-13 EP EP89202954A patent/EP0376361B2/de not_active Expired - Lifetime
- 1989-11-13 JP JP2500226A patent/JPH04502105A/ja active Pending
- 1989-11-13 AU AU46395/89A patent/AU637776B2/en not_active Expired
- 1989-11-13 US US07/721,424 patent/US5240843A/en not_active Expired - Lifetime
- 1989-11-13 AT AT89202954T patent/ATE91712T1/de not_active IP Right Cessation
- 1989-11-13 WO PCT/GB1989/001346 patent/WO1990005182A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0376361B2 (de) | 1997-02-05 |
| GB8826429D0 (en) | 1988-12-14 |
| DE68907707T2 (de) | 1994-03-31 |
| EP0376361B1 (de) | 1993-07-21 |
| DE68907707D1 (de) | 1993-08-26 |
| EP0376361A3 (en) | 1990-08-01 |
| AU4639589A (en) | 1990-05-28 |
| AU637776B2 (en) | 1993-06-10 |
| WO1990005182A1 (en) | 1990-05-17 |
| DE68907707T3 (de) | 1997-07-03 |
| EP0376361A2 (de) | 1990-07-04 |
| EP0444111A1 (de) | 1991-09-04 |
| US5240843A (en) | 1993-08-31 |
| JPH04502105A (ja) | 1992-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE91712T1 (de) | Enzymstabilisierung. | |
| CA2040815A1 (en) | Enzyme stabilisation | |
| ATE330622T1 (de) | Mit aminosäuren stabilisierte erythropoietinlösung | |
| DE68917729D1 (de) | Reinigung und verabreichung von dns-reparatur-enzymen. | |
| FI91160B (fi) | Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi | |
| ATE250131T1 (de) | Abschaltung von genfunktionen (gen silencing) | |
| FI960977A7 (fi) | Bakteeriperäiset eksportoidut proteiinit ja niihin perustuvat asellulaariset rokotteet | |
| DE3782762D1 (de) | Raeumliche stabilisierung von stehenden kapillaroberflaechenwellen. | |
| DK314989A (da) | Fremgangsmaade til fremstilling af optisk aktive alfa-substituerede organiske syrer, samt mikroorganismer og enzymer anvendelige ved fremgangsmaaden | |
| DE68908919D1 (de) | Halbleiterlaser mit verteilter Rückkoppelung und Strominjektions-Verfahren dafür. | |
| ATE232237T1 (de) | Herstellung von funktionellen, menschlichen urokinaseproteinen | |
| FI872345A7 (fi) | Multivitamiinia ja hivenaineita sisältävien valmisteiden stabilointi. | |
| FI885504A0 (fi) | Vaskulaera antikoagulerande proteiner, dessa koderande dna, deras framstaellningsfoerfarande och deras anvaendning. | |
| SE8801701D0 (sv) | Production technology based on enzymic method | |
| DE3889085D1 (de) | Gleichtaktmessung und -regelung in Ketten von symmetrischen Verstärkern. | |
| ATE71658T1 (de) | Verfahren zur herstellung von humanlysozym. | |
| NO874905L (no) | Hirudinvariant og fremgangsmaate til dens fremstilling. | |
| ATE209252T1 (de) | Rekombinante d-hydantoinase, verfahren zur herstellung und verwendung | |
| SE8502540D0 (sv) | Stable dentifrice containing dextranase | |
| NO905561D0 (no) | Proteiner og nukleinsyrer. | |
| DE69435058D1 (de) | Vektor zur vielfachklonierung, expressionsvektor und herstellung von fremdprotein mit expressionsvektor | |
| DE3880825D1 (de) | Anordnung zur schnellen addition von binaerzahlen. | |
| ATE172492T1 (de) | Stabilisierte kontroll- oder kalibrierungsflüssigkeit für kreatinkinase | |
| DE68917536D1 (de) | Methode zur Reduktion von aromatischen Amino-Gruppen. | |
| DE68905638D1 (de) | Herstellung von alkansulfonylhaliden und alkansulfonsaeuren. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |